血清可溶性凝集素样氧化型低密度脂蛋白受体-1水平与男性吸烟者合并冠心病的相关性研究

血清可溶性凝集素样氧化型低密度脂蛋白受体-1水平与男性
吸烟者合并冠心病的相关性研究
刘军;任引刚;张利华;佟雅文;康黎
【期刊名称】《中国医药导报》
【年(卷),期】2013(10)6
【摘要】目的探讨血清可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)水平与男性吸烟者合并冠心病相关性.方法该研究共纳入216例男性吸烟者,根据患者是否合并冠心病将所有患者分为冠心病组(n = 95)及非冠心病组(n = 121),比较两组的血清sLOX-1水平,通过Logistic回归分析评价血清sLOX-1水平与合并冠心病的相关性.结果冠心病组患者血清sLOX-1水平(678~2 104 ng/L,平均1 652 ng/L)显著高于非冠心病组患者(382~1 334 ng/L,平均829 ng/L)(P < 0.01).多元Logistic回归分析显示血清sLOX-1水平与男性吸烟者合并冠心病存在正相关性(优势比为2.136,95%可信区间为1.227~3.401,P < 0.01).结论高血清sLOX-1水平是男性吸烟者罹患冠心病的独立危险因子,检测血清sLOX-1水平可能成为预测男性吸烟者合并冠心病风险的一种重要的手段.%Objective To explore whether serum soluble lectin -like oxidized low -density lipoprotein receptor-1 (sLOX-1) levels are associated with the presence of coronary artery disease in male smokers. Methods 216 male smokers were enrolled in this cross-sectional study. All the smokers were divided into coronary artery disease group (n = 95) and patients without CAD (not-CAD group, n = 121) based on the presence of coronary artery disease or not. Serum sLOX-1 levels were compared between the two groups. The correlation between serum
sLOX-1 levels and the presence of coronary artery disease was investigated by Logistic analysis. Results Serum sLOX-1 levels were significantly higher in CAD group than those in not-coronary artery disease group [(678-2 104 ng/L, average 1 652 ng/L) vs (382-1 334 ng/L, average 829 ng/L)], P < 0.01). Multiple Logistic analysis showed that serum sLOX-1 levels were independently associated with the presence of Coronary artery disease (odds ratio: 2.136, 95% confidence interval: 1.227-3.401, P < 0.01). Conclusion Higher serum sLOX-1 levels is an independent risk factor for the presence of coronary artery disease in male smokers. The determination of serum sLOX-1 levels might be a useful method for predicting the risk of coronary artery disease in male smokers.
【总页数】3页(P33-34,39)
【作者】刘军;任引刚;张利华;佟雅文;康黎
【作者单位】第四军医大学唐都医院惠宾病房,陕西西安,710038;第四军医大学唐都医院惠宾病房,陕西西安,710038;第四军医大学唐都医院惠宾病房,陕西西
安,710038;第四军医大学唐都医院惠宾病房,陕西西安,710038;第四军医大学唐都医院惠宾病房,陕西西安,710038
【正文语种】中文
【中图分类】R541.4
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