叶酸、维生素B12、同型半胱氨酸代谢与脑梗死患者脂质水平、炎症反应程度的相关性

叶酸、维生素B12、同型半胱氨酸代谢与脑梗死患者脂质水
平、炎症反应程度的相关性
丁莉
【期刊名称】《海南医学院学报》
【年(卷),期】2017(023)005
【摘要】Objective: To study the correlation of folic acid, vitamin B12 and homocysteine metabolism with lipid level and inflammatory response in patients with cerebral infarction.Methods: A total of 86 patients with cerebral infarction treated in our hospital between January 2015 and June 2016 were collected as cerebral infarction group and 70 healthy subjects receiving physical examination in our hospital during the same period were selected as normal control group.Immediately after admission, RIA method was used to detect peripheral blood folic acid, Vit12 and Hcy levels;automatic biochemical analyzer was used to determine lipid level;enzyme-linked immunosorbent assay (ELISA) was used to detect serum inflammatory factor levels.Results: Serum folic acid and VitB12 levels of cerebral infarction group were lower than those of normal control group while Hcy level was significantly higher than that of normal control group (P<0.05);serum TC, LDL-C and ApoA1 levels of cerebral infarction group were significantly higher than those of normal control group while HDL-C level was significantly lower than that of normal control group
(P<0.05);serum IL-4 and IL-10 levels of cerebral infarction group were
significantly lower than those of normal control group while IL-8, CRP and TNF-α levels were significantly higher than those of normal control group (P<0.05).The Spearman correlation analysis showed that the folic acid,
VitB12 and Hcy levels in patients with cerebral infarction were directly correlated with lipid levels and inflammatory response.Conclusions: Folic acid, vitamin B12 and homocysteine metabolism can directly affect the
lipid levels and inflammatory response in patients with cerebral infarction, and are the reliable indexes to early judge the disease severity and guide clinical treatment.%目的:探讨叶酸、维生素B12、同型半胱氨酸代谢与脑梗死患者脂质水平、炎症反应程度的相关性.方法:收集2015年1月~2016年6月间攀钢总医院密地院区收治的脑梗死患者86例作为脑梗死组,另取同期在本院接受体检的健康人群70例作为正常对照组.入院后即刻,采用放射免疫法检测外周血叶酸、
Vit12、Hcy含量;采用全自动生化分析仪测定脂质水平;采用酶联免疫吸附法(ELISA)检测血清炎症因子含量.结果:脑梗死组患者的血清叶酸、VitB12含量低于正常对照组,Hcy含量高于正常对照组(P<0.05);脑梗死患者的血清TC、LDL-C、ApoA1含
量高于正常对照组,HDL-C含量低于正常对照组(P<0.05);脑梗死组患者的血清IL-4、IL-10含量低于正常对照组,IL-8、CRP、TNF-α含量高于正常对照组(P<0.05).经Spearman相关性分析发现,脑梗死患者的叶酸、VitB12、Hcy含量与脂质水平、
炎症反应呈直接相关关系.结论:叶酸、维生素B12、同型半胱氨酸代谢可直接影响脑梗死患者的脂质水平及炎症反应,是早期判断病情严重程度、指导临床治疗的可
靠指标.
【总页数】4页(P610-612,616)
【作者】丁莉
【作者单位】攀钢总医院密地院区神经内科,四川攀枝花 617063
【正文语种】中文
【中图分类】R743.3
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