超前镇痛对老年妇科患者开腹手术术后认知功能和应激反应的影响
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世界最新医学信息文摘 2019 年第 19 卷第 52 期
1ห้องสมุดไป่ตู้
·论著·
超前镇痛对老年妇科患者开腹手术术后认知功能和应激反应的影响
李红霞 *，肖军，刘志杰，霍晓强，苏春
( 遵化市人民医院，河北 唐山 )
摘要：目的 探索超前镇痛对妇科开腹手术患者术后认知功能和应激反应的影响。方法 将观察对象均为为 A、B 和 C 组，执行麻醉前 10min 静脉给予曲马多粉剂 50mg+100mL 生理盐水（A 组）、氟比洛芬酯 50mg+100mL 生理盐水（B 组），C 组仅给等量生理盐水。术前、术后 12、24 和 48h，抽取静脉血检测患者血清 s-100β、Ang- Ⅱ和 NE 表达水平，并对各患者分别进行 MMSE 评分。结果 MMSE 评分：T1 时，C 组与 A、B 两组存在差异，差值分别为 3.41、2.59，但 B 与 C 组间无显著差异；T2 时 C 组患者得分高于 AB 两组，差值分别为 3.27、1.75， 同时 BC 两组存在差异，差值为 1.52；T3 时，三组无显著差异。血清 s-100β：T1 时，AB 组血清 s-100β 水平低于 C 组，A 组 B 组血清 s-100β 表达不同；T2 时三组两两比较差异 P<0.05；T3 时与 C 组 A B 两组相比均存在差异，BC 两组两两比较，两组差异 P<0.05。应激因子：T1、 T2 和 T3 时，A 组和 B 组患者血清 Ang- Ⅱ和 NE 均低于 C 组。T1 和 T2 时，AB 两组 Ang- Ⅱ和 NE 水平存在差异 P<0.05；T3 时 A 组与 B 组 比较，Ang- Ⅱ无显著差异，NE 差异结果 P<0.5。结论 超前麻醉对妇科开腹手术患者术后认知功能和应激反应的影响低；曲马多和氟比洛芬 酯超前麻醉方式对妇科开腹手术患者术后认知功能和应激反应效应有差异。 关键词：超前镇痛；认知功能障碍；Ang- Ⅱ 中图分类号：R711 文献标识码：A DOI: 10.19613/ki.1671-3141.2019.52.001 本文引用格式：李红霞 , 肖军 , 刘志杰 , 等 . 超前镇痛对老年妇科患者开腹手术术后认知功能和应激反应的影响 [J]. 世界最新医学信息文 摘 ,2019,19(52):1-2,4.
(Zunhua people’s hospital,Tangshan Heibei)
ABSTRACT: Objective To explore the effect of preemptive analgesia on postoperative cognitive function and stress response in patients undergoing gynecological open surgery. Methods All 57 subjects were divided into 3 groups. Groups A and B were given tramadol + 100 mL 0.9% NaCl and fluoride ratio+100mL 0.9%NaCl. Group C was given an equal amount of normal saline. The MMSE scores were performed before operation, 12h after operation, 24h after operation and 48h after operation. The venous blood was also taken and the serum levels of s-100β, Ang-II and NE were detected. Results MMSE score: At T1, there was a difference between group C and group A and B, and the difference was 3.41 and 2.59, respectively, group B and C was no different; The scores of the patients in the group were higher than those in the A and B group (P<0.05), and the differences were 3.27 and 1.75. There were differences between the two groups (P<0.05), and the difference was 1.52. After 48 hours (T3), there were no different in the three groups (P>0.05). Serum s-100β: T1, serum s-100β level in group AB was different with group C (P<0.05), serum group s-100β expression in group B was different (P<0.05); T2 group three groups were different P<0.05; there was a significant difference between group A and group C (P<0.05), and the difference between group B was P>0.05. the two groups were significantly different. Stress factors: T1, T2 and T3, serum Ang-II and NE in group A and group B were lower than group C (P<0.05). At T1 and T2, the levels of Ang-II and NE in AB group were different (P<0.05). There was no significant difference in Ang-II between group A and B at T3, and the difference of NE was P<0.5. Conclusions The effects of tramadol and flurbiprofen avalanche on gynecologic open surgery have different effects on postoperative cognitive function and stress response. KEY WORDS: Preemptive analgesia; Cognitive dysfunction; Ang-II
Effect of Preemptive Analgesia on Postoperative Cognitive Function and Stress Response in Patients Undergoing Gynecological Open Surgery
LI Hong-xia*, XIAO Jun, LIU Zhi-jie, HUO Xiao-qiang, SU Chun
1ห้องสมุดไป่ตู้
·论著·
超前镇痛对老年妇科患者开腹手术术后认知功能和应激反应的影响
李红霞 *，肖军，刘志杰，霍晓强，苏春
( 遵化市人民医院，河北 唐山 )
摘要：目的 探索超前镇痛对妇科开腹手术患者术后认知功能和应激反应的影响。方法 将观察对象均为为 A、B 和 C 组，执行麻醉前 10min 静脉给予曲马多粉剂 50mg+100mL 生理盐水（A 组）、氟比洛芬酯 50mg+100mL 生理盐水（B 组），C 组仅给等量生理盐水。术前、术后 12、24 和 48h，抽取静脉血检测患者血清 s-100β、Ang- Ⅱ和 NE 表达水平，并对各患者分别进行 MMSE 评分。结果 MMSE 评分：T1 时，C 组与 A、B 两组存在差异，差值分别为 3.41、2.59，但 B 与 C 组间无显著差异；T2 时 C 组患者得分高于 AB 两组，差值分别为 3.27、1.75， 同时 BC 两组存在差异，差值为 1.52；T3 时，三组无显著差异。血清 s-100β：T1 时，AB 组血清 s-100β 水平低于 C 组，A 组 B 组血清 s-100β 表达不同；T2 时三组两两比较差异 P<0.05；T3 时与 C 组 A B 两组相比均存在差异，BC 两组两两比较，两组差异 P<0.05。应激因子：T1、 T2 和 T3 时，A 组和 B 组患者血清 Ang- Ⅱ和 NE 均低于 C 组。T1 和 T2 时，AB 两组 Ang- Ⅱ和 NE 水平存在差异 P<0.05；T3 时 A 组与 B 组 比较，Ang- Ⅱ无显著差异，NE 差异结果 P<0.5。结论 超前麻醉对妇科开腹手术患者术后认知功能和应激反应的影响低；曲马多和氟比洛芬 酯超前麻醉方式对妇科开腹手术患者术后认知功能和应激反应效应有差异。 关键词：超前镇痛；认知功能障碍；Ang- Ⅱ 中图分类号：R711 文献标识码：A DOI: 10.19613/ki.1671-3141.2019.52.001 本文引用格式：李红霞 , 肖军 , 刘志杰 , 等 . 超前镇痛对老年妇科患者开腹手术术后认知功能和应激反应的影响 [J]. 世界最新医学信息文 摘 ,2019,19(52):1-2,4.
(Zunhua people’s hospital,Tangshan Heibei)
ABSTRACT: Objective To explore the effect of preemptive analgesia on postoperative cognitive function and stress response in patients undergoing gynecological open surgery. Methods All 57 subjects were divided into 3 groups. Groups A and B were given tramadol + 100 mL 0.9% NaCl and fluoride ratio+100mL 0.9%NaCl. Group C was given an equal amount of normal saline. The MMSE scores were performed before operation, 12h after operation, 24h after operation and 48h after operation. The venous blood was also taken and the serum levels of s-100β, Ang-II and NE were detected. Results MMSE score: At T1, there was a difference between group C and group A and B, and the difference was 3.41 and 2.59, respectively, group B and C was no different; The scores of the patients in the group were higher than those in the A and B group (P<0.05), and the differences were 3.27 and 1.75. There were differences between the two groups (P<0.05), and the difference was 1.52. After 48 hours (T3), there were no different in the three groups (P>0.05). Serum s-100β: T1, serum s-100β level in group AB was different with group C (P<0.05), serum group s-100β expression in group B was different (P<0.05); T2 group three groups were different P<0.05; there was a significant difference between group A and group C (P<0.05), and the difference between group B was P>0.05. the two groups were significantly different. Stress factors: T1, T2 and T3, serum Ang-II and NE in group A and group B were lower than group C (P<0.05). At T1 and T2, the levels of Ang-II and NE in AB group were different (P<0.05). There was no significant difference in Ang-II between group A and B at T3, and the difference of NE was P<0.5. Conclusions The effects of tramadol and flurbiprofen avalanche on gynecologic open surgery have different effects on postoperative cognitive function and stress response. KEY WORDS: Preemptive analgesia; Cognitive dysfunction; Ang-II
Effect of Preemptive Analgesia on Postoperative Cognitive Function and Stress Response in Patients Undergoing Gynecological Open Surgery
LI Hong-xia*, XIAO Jun, LIU Zhi-jie, HUO Xiao-qiang, SU Chun