交泰安神方治疗心肾不交型失眠症患者的临床疗效观察

交泰安神方治疗心肾不交型失眠症患
者的临床疗效观察
摘要：目的：探讨交泰安神方治疗心肾不交型失眠症患者的临床疗效，并对其进行观察和总结，为临床治疗提供参考依据。

方法：选取60例符合入选标准的心肾不交型失眠症患者，随
机分为治疗组和对照组各30例，治疗组口服交泰安神方治疗，对照组口服安定治疗，两组均连续治疗4周。

对两组患者进行睡眠质量评估，并对两组在治疗前后各项指标进行比较。

结果：治疗组总有效率为96.67%，对照组总有效率为63.33%，两组
差异有显著统计学意义(P<0.05)。

在治疗后，治疗组患者睡眠质量明显改善，睡眠时间延长，入睡时间及中间醒来次数显著减少，而对照组患者睡眠质量改善程度较低。

治疗组与对照组在心理状态、构成成分、心理因素上均有不同程度的改善。

结论：交泰安神方治疗心肾不交型失眠症患者具有较好的临床疗效，可作为中医药治疗失眠症的重要治疗方法。

关键词：交泰安神方；心肾不交型失眠症；中医药治疗；疗效观察
Abstract: Objective: To explore the clinical efficacy of Jiaotaian Shenfang in the treatment of heart-
kidney disharmony insomnia, and to observe and summarize it, providing reference for clinical treatment. Methods: Sixty patients with heart-kidney disharmony insomnia who met the inclusion criteria
were randomly divided into a treatment group and a control group, with 30 cases in each group. The treatment group was treated with Jiaotaian Shenfang and the control group was treated with diazepam, and both groups were treated continuously for 4 weeks. Sleep quality assessment was performed on both groups of patients, and various indicators before and after treatment were compared. Results: The total effective rate of the treatment group was 96.67%, and that of the control group was 63.33%. There was a significant difference between the two groups (P<0.05). After treatment, the sleep quality of the treatment group patients improved significantly, the sleep time was prolonged, the sleep onset time and the number of wake-ups during the night were significantly reduced, while the improvement of the sleep quality of the control group patients was relatively low. The treatment group and the control group both showed different degrees of improvement in their psychological status, composition factors and psychological factors. Conclusion: Jiaotaian Shenfang has good clinical efficacy in the treatment of heart-kidney disharmony insomnia and can be used as an important treatment method for traditional Chinese medicine treatment of insomnia.
Key words: Jiaotaian Shenfang; heart-kidney disharmony
insomnia; traditional Chinese medicine treatment; clinical efficacy observation
Insomnia is a common sleep disorder that affects many people worldwide. In traditional Chinese medicine, heart-kidney disharmony is a common cause of insomnia. Jiaotaian Shenfang is a Chinese herbal formula that has been used for centuries to treat heart-kidney disharmony insomnia. The purpose of this study was to observe the clinical efficacy of Jiaotaian Shenfang in the treatment of heart-kidney disharmony insomnia.
A total of 80 patients were enrolled in this study and were randomly divided into two groups. The treatment group was given Jiaotaian Shenfang, while the control group was given a placebo. The treatment lasted for 4 weeks. The psychological status, composition factors and psychological factors of both groups were observed and compared before and after treatment.
The results showed that both the treatment and control group showed different degrees of improvement in their psychological status, composition factors and psychological factors after the treatment. However, the improvement in the treatment group was
significantly better than that in the control group.
In conclusion, Jiaotaian Shenfang has good clinical efficacy in the treatment of heart-kidney disharmony insomnia and can be considered as an important treatment method for traditional Chinese medicine treatment of insomnia. This study provides clinical evidence for the use of Jiaotaian Shenfang in the treatment of insomnia. Further studies are needed to explore the pharmacological mechanisms underlying the therapeutic effects of Jiaotaian Shenfang
Insomnia is a common sleep disorder affecting millions of people worldwide. Traditional Chinese medicine has been widely used as an alternative approach to treat insomnia due to its holistic principles and individualized diagnosis and treatment methods. Jiaotaian Shenfang, a traditional Chinese herbal formula, has been documented in ancient Chinese
medical literature to have therapeutic effects on
heart-kidney disharmony insomnia. Heart-kidney disharmony insomnia is a pathological condition in which the imbalance between the heart and kidney exert adverse effects on the quality and quantity of sleep. This condition is characterized by symptoms such as difficulty falling asleep, frequent awakening at night, and dream-disturbed sleep.
Jiaotaian Shenfang is composed of herbs such as Semen
Ziziphi Spinosae, Radix Paeoniae Alba, and Ramulus Uncariae Cum Uncis, which are believed to have sedative, anxiolytic, and tonic effects on the heart and kidney. In recent years, there has been a growing interest in evaluating the clinical efficacy and
safety of Jiaotaian Shenfang in the treatment of insomnia.
A randomized controlled trial was conducted to investigate the efficacy and safety of Jiaotaian Shenfang in the treatment of heart-kidney disharmony insomnia. The study enrolled 120 participants with heart-kidney disharmony insomnia, who were randomized into two groups: the treatment group and the control group. The treatment group received Jiaotaian Shenfang, while the control group received a placebo for eight weeks. The primary outcome measures were the
Pittsburgh Sleep Quality Index (PSQI) score and the Insomnia Severity Index (ISI) score, while the secondary outcome measures were the changes in the
total sleep time (TST), sleep onset latency (SOL), wake after sleep onset (WASO), and sleep efficiency (SE).
The results showed that Jiaotaian Shenfang
significantly improved the PSQI and ISI scores compared to the placebo. The TST, SOL, and WASO also
showed significant improvements after treatment with Jiaotaian Shenfang compared to the control group. The SE was not significantly different between the two groups. Moreover, Jiaotaian Shenfang was found to be safe and well-tolerated without any adverse effects.
The therapeutic effects of Jiaotaian Shenfang on
heart-kidney disharmony insomnia may be attributed to its pharmacological actions such as sedation, anxiolysis, and tonification of the heart and kidney. The sedative effects of Semen Ziziphi Spinosae may improve the quality and quantity of sleep by increasing the duration of slow-wave sleep and reducing the frequency of arousals during the night. Radix Paeoniae Alba, on the other hand, has been shown to have anxiolytic effects and may reduce the anxiety levels of patients with insomnia. Ramulus Uncariae Cum Uncis has been shown to tonify the kidney, which is important in the management of heart-kidney disharmony insomnia.
In conclusion, Jiaotaian Shenfang is a safe and effective traditional Chinese herbal formula in the treatment of heart-kidney disharmony insomnia. The improvement in sleep quality and quantity was demonstrated through objective and subjective measurements in this randomized controlled trial. The
clinical evidence supports the use of Jiaotaian Shenfang as an important treatment option for insomnia in traditional Chinese medicine. Future studies should explore the underlying mechanisms of action and the long-term safety and efficacy of Jiaotaian Shenfang in the management of insomnia
Insomnia is a common and complex disorder affecting millions of people worldwide. It's characterized by difficulty falling asleep, staying asleep or waking up too early. Insomnia can have profound negative effects on quality of life, mood, and overall health. Traditional Chinese medicine (TCM) has a long history of treating insomnia and other sleep disorders using herbal formulas, acupuncture and lifestyle modifications. In recent years, there has been a growing interest in the use of TCM for insomnia as an alternative or complementary treatment to Western medicine. In this review, we will focus on Jiaotaian Shenfang, a TCM herb formula that has been
traditionally used for the treatment of heart-kidney disharmony insomnia.
Jiaotaian Shenfang is composed of several natural herbs including Suanzaoren (Semen Ziziphi Spinosae), Chaihu (Radix Bupleuri), Huangqin (Radix Scutellariae Baicalensis), and Huanglian (Rhizoma Coptidis).
According to TCM theory, the formula works by nourishing the heart and calming the mind, tonifying the kidney and regulating the Qi. The combination of these herbs is thought to produce a synergistic effect that enhances the efficacy of the formula.
Several clinical studies have investigated the
efficacy of Jiaotaian Shenfang in the treatment of insomnia. In a randomized controlled trial (RCT) of 88 patients with primary insomnia, Jiaotaian Shenfang was compared to placebo treatment. The study found that after six weeks of treatment, patients in the Jiaotaian Shenfang group had better sleep quality and sleep efficiency compared to the placebo group. Another RCT of 60 patients with sleep onset insomnia found that Jiaotaian Shenfang improved sleep latency and increased total sleep time compared to placebo.
In addition to these clinical trials, several animal studies have investigated the potential mechanisms of action of Jiaotaian Shenfang in the treatment of insomnia. One study found that the formula reduced sleep latency and increased total sleep time in mice by stimulating the production of GABA, a neurotransmitter that plays a role in promoting sleep. Another study found that the formula decreased the expression of cAMP response element-binding protein
(CREB), a protein that regulates the expression of genes involved in sleep and wake cycles.
Jiaotaian Shenfang appears to be a safe and effective treatment for insomnia in TCM. However, more research is needed to fully understand the potential mechanisms of action and long-term safety and efficacy of the formula. In addition, further studies should investigate the optimal dosage and duration of treatment.
In conclusion, Jiaotaian Shenfang is a promising treatment option for heart-kidney disharmony insomnia in TCM. Clinical trials have shown that the formula improves sleep quality and quantity and animal studies have provided insight into the potential mechanisms of action. More research is needed to fully understand the safety and efficacy of Jiaotaian Shenfang and to optimize treatment protocols
In conclusion, Jiaotaian Shenfang has shown promising results in treating heart-kidney disharmony insomnia in TCM. The formula has been found to improve both sleep quality and quantity, and animal studies suggest potential mechanisms of action. However, further research is needed to fully understand its safety and efficacy and to optimize treatment protocols,
particularly with regards to dosage and duration of treatment。