老年性黄斑病变患者眼底自发荧光的变化及其与视功能的相关性:一项前瞻性研究

老年性黄斑病变患者眼底自发荧光的变化及其与视功能的相关
性：一项前瞻性研究
Einbock W.;Moessner A.;Schnurrbusch U.E.K.;S. Wolf;杜兆江
【期刊名称】《世界核心医学期刊文摘：眼科学分册》
【年(卷),期】2005(000)010
【摘要】Background: As members of the Fundus Autofluorescence in Age-related Macular Degeneration Study Group (FAM Study Group), we report changes of fundus autofluo rescence (AF)-in patients with multiple soft drusen in correlation to visual fu nction. Methods: Inclusion criteria were age > 50 years, the presence of soft dr usen, visual acuity of 20/100 or better, and no previous laser treatment in the study eye. All patients underwent a detailed ophthalmological examination includ ing ETDRS visual acuity, binocular funduscopy, and color fundus photography. AF imaging was performed with a confocal scanning laser ophthalmoscope following a standard protocol. We used the classification of the International Fundus Auto- fluorescence Classification Group (IFAG) for the description of the AF patterns. Results: One hundred and twenty-five patients (81 women, 44 men) aged from 55 t o 86 years (mean 70±7 years) were included in this prospective study. During f ollow-up (mean 18±6 months), 6 of 35 eyes with patchy AF pattern developed exu dative changes, as well as 2 eyes with focal-plaque-like AF pattern and 1 eye with reticular pattern at baseline. Geographic atrophy was seen in two eyes with
focal AF pattern and one eye with focal-plaque-like pattern at baseline. A to tal of 11 eyes presented with severe visual loss ( 6 ETDRS lines). Ten (91%) o f these had patchy AF pattern. Conclusion: Imaging of fundus AF
in patients with age-related maculopathy allows identification of different patterns of fundus AF. Our preliminary data suggest that a patchy pattern of AF indicates a relativ ely high risk of progression to age-related macular degenerationwith visual los s.
【总页数】1页(P34-34)
【作者】Einbock W.;Moessner A.;Schnurrbusch U.E.K.;S. Wolf;杜兆江
【作者单位】Department of Opht halmology University of Leipzig Liebigstrasse 10-14 04103 Leipzig Germany
【正文语种】中文
【中图分类】R774.5
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