右美托咪定在成人鼾症手术苏醒期的应用研究

右美托咪定在成人鼾症手术苏醒期的应用研究
周红刚;徐红梅
【期刊名称】《中国医药导报》
【年(卷),期】2017(014)007
【摘要】目的观察右美托咪定对成人鼾症手术苏醒期不良事件的影响.方法收集2014年6月～2016年5月淮安市第一人民医院分院ASA Ⅰ～Ⅱ级全麻下施行鼾症手术患者70例,随机分为观察组和对照组,每组35例.观察组于手术结束前30 min静脉泵注右美托咪定0.5μg/kg,输注时间为15 min;对照组输注等量的生理盐水.记录两组患者手术结束前30 min(T0)、手术结束时(T1)、气管拔管时(T2)和气管拔管后5 min (T3)、气管拔管后15 min(T4)、气管拔管后30 min(T5)的平均动脉压(MAP)和心率(HR);观察两组患者麻醉苏醒期恢复情况及术后24 h不良反应的发生情况.结果观察组T1～T4时点MAP、HR较T0时无明显变化(P＞0.05);对照组T1～T4时点的MAP、HR较T0时明显增高(P＜0.05);观察组T1～T4时点的MAP、HR明显低于对照组T1～T4时,差异有统计学意义(P＜0.05).术后苏醒期观察组躁动、镇静、镇痛评分均优于对照组(P＜0.05).观察组寒战发生率明显低于对照组(P＜0.05),余不良反应两组差异无统计学意义(P＞0.05).结论右美托咪定能明显减轻成人鼾症手术患者全麻苏醒期气管拔管的心血管反应,且无明显不良反应.%Objective To observe the effect of Dexmedetomidine on adverse events in the recovery period of surgery for adult with sleep
apnea.Methods From June 2014 to May 2016,70 patients who recieved surgery for sleep apnea with general anesthesia of ASA Ⅰ-Ⅱ grade in Branch Hospital of Huai'an First People's Hospital were randomly divided
into the observation group and the control group,each group had 35 cases.30 min before the end of the operation,the observation group patients were given Dexmedetomidine 0.5 μg/kg by intravenous pumping,and the infusion time was 15 min.In the control group,the same amount of saline was infused by the same way.Mean arterial pressure (MAP) and heart rate (HR) were recorded at the following time points:30 min before the end of the surgery (T0),the end of the operation
(T1),tracheal extubation (T2),5 min after tracheal extubation (T3),15 min after tracheal extubation (T4),and 30 min after tracheal extubation (T5).The recovery of anesthesia and the incidence of adverse reactions at 24 h after operation were observed.Results Compared with those at T0,there were no significant differences in MAP and HR at T1-T4 in the observation group (P ＞ 0.05).In the control group,the MAP and HR at T1-T4 were significantly higher than those at T0 (P ＜ 0.05).The MAP and HR at T1-T4 in the observation group were significantly lower than those at T1-T4 in the control group (P ＜ 0.05).The restlessness,scores of sedation and analgesic in the observation group were superior to the control group in the postoperative recovery period (P ＜ 0.05).The incidence of chills in the observation group was significantly lower than that in the control group,with statistically significant differences (P ＜ 0.05).There were no statistical differences between the two groups in the other adverse events (P ＞ 0.05).Conclusion Dexmedetomidine can significantly reduce the cardiovascular response of tracheal extubation in the recovery period of
general anesthesia in adults with surgery for sleep apnea,and there is no obvious adverse effects.
【总页数】4页(P61-64)
【作者】周红刚;徐红梅
【作者单位】江苏省淮安市第一人民医院分院麻醉科,江苏淮安223002;江苏省淮安市第一人民医院分院麻醉科,江苏淮安223002
【正文语种】中文
【中图分类】R614.2
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