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美国贝克曼库尔特流式细胞分析仪

美国贝克曼库尔特流式细胞分析仪（Beckman coulter cell）产品型号：Cell Lab Quanta SC当前价格：0.00元产品数量：0新旧程度：全新有效期至：0000-00-00所在地：产品简介：仪器简介：T细胞亚群检测的CD45/CD4/CD8/CD3、CD45/CD56/CD19/CD3；阵发性血红蛋白尿（PNH）检测的CD55、CD59；血小板无力症（GT）检测的CD41、CD61等等详细信息仪器简介：T细胞亚群检测的CD45/CD4/CD8/CD3、CD45/CD56/CD19/CD3；阵发性血红蛋白尿（PNH）检测的CD55、CD59；血小板无力症（GT）检测的CD41、CD61等等。

但对于白血病/淋巴瘤免疫分型，国际上迄今为止也没有统一的抗体组合。

在2000年国际细胞分析学会（ISAC）大会上，临床血细胞计数协会组织了一次国际专家会议，以期对检测血液淋巴系统肿瘤所需最少、最有效的单抗数达成共识。

75%与会者一致认为，对于慢性淋巴系统增殖性疾病（CLD）有9种单抗：CD5,CD19,κ,λ,CD3,CD20,CD23,CD10,CD45对初诊来说是最基本的。

淋巴瘤和CLD相似，需要至少12-16种单抗。

对于急性白血病（AL），75%的与会者认为大约13-15种单抗是最基本的：CD10,CD19,CD79a,CD13,CD33,CD34,CD45,CD2,MPO，CD7,CD14,CD3,HLA-DR等，对初步鉴别白血病系列是必需的。

其他一些（CD16,CD56,CDw65,TdT,cyCD3）可能对某些病例有用。

几乎所有的投票者都认为，要对急性白血病完善分类所需单抗的恰当数量平均为20-24种。

但这些抗体之间组合也是一大难题，目前也无统一规定（如表二）。

大会多数发言者(11/13)指出，对已确诊病人的监护和分期来说，仅需较少单抗。

抗体的质量控制是实验的关键环节。

抗体的质量包括其特异性、灵敏度、精密度。

Nipro 产品数据册：单用途翼型肾脏细胞注射器说明书

H O S P I T A L P R O D U C T WING CATHSTERILE, SINGLE-USE WINGED CATHETER WITH INJECTION PORT FOR IV INFUSIONPRODUCT DATA SHEET2PRODUCT COMPLIANCE• CE-marked, Class IIa Medical Devices, Rule 7, MDD 93/42/EEC, UMDNS 10727• Complies with the following norms, directives, and regulations: ―ISO 594-1: 1986 ―EN 980:2008 ―EN 1041:2008 ―EN 1707:1996 ―ISO 7864:2016―ISO 9626:2016 ―EN ISO 10555-1:2013 ―EN ISO 10993-1/4/5/7/11 ―ISO 10993-10:2010 ―EN ISO 11135-1:2014―EN ISO 11607-1:2009 /AMD 2014 ―EN ISO 13485:2016 ―EN ISO 14971: 2012• Labels contain 12 languagesMANUFACTURING DETAILSLegal manufacturer: Nipro Corporation Country of origin: ThailandSTERILIZATION AND SHELF LIFESterilizationSingle-use only Indicator stickerShelf lifeEtO (Ethylene oxide)Each outer box (or shipping carton) contains a chemical indicator that indicates sterility. This indicator comes in the form of a [blue] sticker that turns[red] when sterilized.5 yearsWING CATHSTERILE, SINGLE-USE WINGED CATHETER WITH INJECTION PORT FOR IV INFUSION• Ultra sharp three-beveled needle to minimize discomfort • Radiopaque• Injection port with universal luer fitting • Flexible wings for easy grip• Color-coded wings and hub to indicate gauge• Siliconization of needle minimizes penetration and gliding force• T ransparent ETFE catheter tube for quick visualization of blood in the flashback chamber to facilitate insertion • Flashback in hub means the needle is correctly in the vein • Flashback in catheter means the catheter is correctly in the vein • Latex-free, DEHP-free, PVC-free • Available in 16-18-20-22-24 G• IV infusion duration: hours to several days • For use by healthcare professionals onlyClass IIa Medical DevicesRule 7MDD 93/42/EEC UMDNS 1072701233MATERIALS USEDDEHP-free Latex-free PVC-free PRODUCT RANGE OVERVIEWPACKAGING DETAILSLanguages12 languages on inner and outer box:English (EN), French (FR), Dutch (NL), German (DE), Spanish (ES), Italian (IT), Portuguese (PT), Greek (EL), Swedish (SV), Danish (DA), Norwegian (NO), and Finnish (FI)GlueMaterial: Acrylic resinNeedle (cannula)Material:Stainless steel SUS-304Needle hub Material:Polycarbonate (PC)Catheter hubMaterial: Polypropylene (PP)Port capMaterial: Polyethylene (PE)Catheter tubeMaterial: Ethyltetrafluoroethylene (ETFE)Cutting angleThree-beveledLuer capMaterial: Polypropylene (PP)Cap connectorMaterial: Polypropylene (PP)Caulking pinMaterial: Stainless steel SUS-304One-way valveMaterial: Silicone tubeLubricantMaterial: Silicone PolydimethylsiloxaneMembrane filterMaterial: Random micro glass filterVent fittingMaterial: Polypropylene (PP)Catheter wingMaterial: Polypropylene (PP)Nipro Medical Europe : European Headquarters, Blokhuisstraat 42, 2800 Mechelen, Belgium T: +32 (0)15 263 500 | F: +32 (0)15 263 510 |***********************| D a t a s h e e t - W i n g _C a t h - T H A - 27.N o v 2019Label detailsTransport conditionsClosed and dryStorage conditions Open the packaging only immediately before use to guarantee sterility.。

抗单纯疱疹病毒1_型的IgY_制备及其生物学活性检测

第 50 卷第 2 期2024年 3 月吉林大学学报（医学版）Journal of Jilin University（Medicine Edition）Vol.50 No.2Mar.2024DOI：10.13481/j.1671‐587X.20240202抗单纯疱疹病毒1型的IgY制备及其生物学活性检测苏海涛1, 翟玥2, 宋秀玲2, 徐坤2,3（1. 吉林省疾病预防控制中心寄生虫病预防控制所，吉林长春130062；2. 吉林大学公共卫生学院卫生检验教研室，吉林长春130021；3. 湖南师范大学医学院食品与营养卫生教研室，湖南长沙410013）［摘要］目的目的：制备抗单纯疱疹病毒1型（HSV-1）的卵黄抗体（IgY），探讨该抗体的生物学活性，阐明其抗HSV-1的能力。

方法方法：制备HSV-1灭活疫苗，采用鸡胸多点注射法免疫高产蛋鸡，采用聚乙二醇-6000（PEG-6000）法提纯IgY，采用间接ELISA法、十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS-PAGE）技术和蛋白浓度定量试剂盒测定IgY效价、纯度及蛋白水平，采用间接ELISA法检测IgY中和病毒的能力，测定病毒阻断率，以Vero细胞为病毒感染靶细胞，测定不同抗体浓度（0.015 60、0.031 25、0.062 50、0.125 00、0.500 00、和1.000 00 g·L－1）作用后细胞病变效应（CPE），根据CPE程度测定IgY体外抗HSV-1能力。

结果结果：制备的IgY效价随免疫时间逐渐升高，达到1/1 024 000后保持稳定；IgY轻链重链条带清晰；IgY平均蛋白水平为11.544 g·L－1；IgY对HSV-1的阻断率可高达77.90%；HSV-1致CPE程度随抗体浓度升高而逐渐降低，当IgY浓度达到0.500 00 g·L－1及以上时，25%以下细胞（甚至无细胞）发生病变。

结论结论：成功制备出抗HSV-1的IgY，该抗体对HSV-1具有明显的中和阻断能力和体外抑制活性，可用于药物及诊断方法的开发。

SPEX CertiPrep 合规标准说明说明书

enefits of SPEX CertiPrep’s Compliance- S PEX CertiPrep’s Compliance Standards can be used in many worldwide testing methods and directives for phthalates and heavy metals- C oncentration of components guaranteed- S tability of each standard guaranteed- C ustom packaging readily available- C ustom blends manufactured upon request based on your individual needsL and A2LA Stamp of Approval- Q uality system complies withISO 9001:2008 — Registered with UL-DQS.- A queous standards manufactured to meet therequirements of ISO 17025:2005 andISO Guide 34:2009 — Accredited by A2LA.n S PEX CertiPrep Consumer Safety Compliance Standards can be used with the following instrumentation-I CP: Inductively Coupled Plasma-I CP-MS: Inductively Coupled Plasma-MassSpectroscopy-G C/MS: Gas Chromatography-Mass Spectrometry(IE, CI)-G C: Gas Chromatography (FID, ECD, PID, TCD)-H PLC: High Performance Liquid Chromatography- H PLC/MS: High Performance LiquidChromatography - Mass Spectrometryn V alue of SPEX CertiPrep Compliance Standards- S PEX CertiPrep provides the highest quality ofstandards available- U ncertainty of standard is reported on theCertificate of Analysis- W eights used are traceable to NIST- M anufactured by experienced chemists to ensurehighest quality standardsC E R T I F I E DR E F E R E NC EM AT E R I AL SThe recent regulations worldwide have restricted levels of heavy metals in consumer, ICP-MS, IC, GC, GC/MS, LC, LC/MS, and many other products thatINORGANIC& ORGANICSPEX CertiPrep is theindustry leader forover 60 years inthe CRM marketplacemeeting the needs oflaboratories worldwidewith innovationand research.Accredited by A2LA for ISO 17025 and Guide 34,and Certified by UL-DQS for ISO 9001.1Polyethylene (PE) is one of the world’s most common plastics. PE is used in a variety of common consumer products including children’s toys and care items. Current US regulations limit the concentrations of certain phthalates (DBP , BBP , DEHP , DNOP , DIDP and DINP) in childcare articles and children’s toys. Laboratories are now tasked with the analysis of children’s toys for these potentially hazardous phthalates.SPEX CertiPrep’s Phthalates in Polyethylene QC standards are designed to be used with the current regulations and testing methods including:US Methods:- CPSC-CH-C1001-09.3- ASTM D7823 - 13EU Directive:- 2005/84/ECPolyvinyl chloride or PVC is a very common plastic used in a wide range of common consumer products from children’s toys and care items to building and construction materials. In the US, ASTM and the CPSC have designated methods for testing children’s toys and childcare articles for compliance with the restriction of use for six designated phthalates: DBP , BBP , DEHP , DNOP , DIDP , and DINP .SPEX CertiPrep is proud to offer the first Certified Reference Material for phthalates in polyvinyl chloride produced under the guidelines of ISO 9001, 17025 and Guide 34. SPEX CertiPrep standards are designed for use with the most common US and EU methods for the testing of children’s products for phthalates including:US Methods:- CPSC-CH-C1001-09.3- ASTM D7823 - 13EU Directive:- 2005/84/ECComponentConcentrationDiisodecyl phthalate (DIDP)30000 µg/g Diisononyl phthalate (DINP)30000 µg/g Bis-(2-Ethylhexyl) phthalate (DEHP)3000 µg/g Butylbenzyl phthalate (BBP)3000 µg/g Diethyl phthalate (DEP)3000 µg/g Dimethyl phthalate (DMP)3000 µg/g Di-n-butyl phthalate (DBP)3000 µg/g Di-n-octyl phthalate (DOP)3000 µg/gPoly(vinyl chloride) Phthalate BlankPart #: CRM-PVCBLK Volume: 1.5 g Matrix: Poly(vinyl Chloride)ComponentConcentrationDiisononyl phthalate (Branched) (DINP)30000 µg/g Diisodecyl phthalate (DIDP)30000 µg/g Di-n-butyl phthalate (DBP)3000 µg/g Di-n-octyl phthalate (DOP)3000 µg/g Diethyl phthalate (DEP)3000 µg/g Dimethyl phthalate (DMP)3000 µg/g Bis-(2-Ethylhexyl) phthalate (DEHP)3000 µg/g Butylbenzyl phthalate (BBP)3000 µg/gComponentConcentrationDiisononyl phthalate (DINP)30000 µg/g Diisodecyl phthalate (DIDP)30000 µg/g Bisphenol A (BPA)3000 µg/g Bis-(2-Ethylhexyl) phthalate (DEHP)3000 µg/g Butylbenzyl phthalate (BBP)3000 µg/g Di-n-butyl phthalate (DBP)3000 µg/g Di-n-octyl phthalate (DOP)3000 µg/g Diethyl phthalate (DEP)3000 µg/g Dimethyl phthalate (DMP)3000 µg/gPolyethylene QC Standard BlankPart #: CRM-PEBLK Volume: 5 g Matrix: PolyethyleneComponentConcentrationButylbenzyl phthalate (BBP)1000 µg/g Di-n-butyl phthalate (DBP)1000 µg/g Bis-(2-Ethylhexyl) phthalate (DEHP)1000 µg/g Diisodecyl phthalate (DIDP)1000 µg/g Diisononyl phthalate (DINP)1000 µg/g Di-n-octyl phthalate (DOP)1000 µg/g2Acetaldehyde is one of the most common aldehydes that occur in nature and industrial processes. Naturally occurring, acetaldehyde is found as a product of ethanol fermentation in alcoholic beverages, and yeast products such as bread and ripe fruit. Acetaldehyde forms by degradation of PET exposed to high temperatures or high pressures.Acetaldehyde in WaterPart #: S-125-W1.8 Volume: 1.8 mL Matrix: H2OPlastic Additives or Plasticizers are chemicals added to increase the plasticity or fluidity of many polymer materials. Additives for plastic can be used to change the physical properties of polymers, add colorants or fragrances, or provide a finish to the final product.These plastic additives are most commonly found as phthalate esters. The safety of the use of these phthalate esters or phthalates has been a topic of great discussion and regulation. Many phthalates are under governmental restriction for use in a wide variety of consumer products. The use of phthalates in the consumer world is ubiquitous and many analytical labs are now tasked to quantify the regulated plasticizers while ruling out the presence of other similar plasticizers.Standards are a critical part of the analysis of plasticizers in order for a laboratory to determine the concentration of the truly regulated plasticizer from possibly a similar type or form of plasticizer.SPEX CertiPrep’s full line of plasticizer compound standards can assist the analytical laboratory with all their plasticizer analyses by all thecurrent analytical methods including GC/MS and LC/MS.CompoundMatrixPart #Bis-(2-ethoxyethyl) phthalate Methanol S-4550Bis-(2-ethylhexyl) hexahydro phthalateMethanol S-4927Bis-(2-ethylhexyl) isophthalate Methanol S-4928Bis-(2-Ethylhexyl) phthalate Methanol S-1970Bis-(2-ethylhexyl) terephthalate Methanol S-5459Bis-(2-methoxyethyl) phthalate Methanol S-4156Bis-(2-n-butoxyethyl) phthalate Methanol S-4152Bis-(4-methyl-2-pentyl) phthalate Methanol S-4154Butylbenzyl phthalateMeCI2S-680-MECL 1,2-Cyclohexane dicarboxylic acid di-isononyl ester Methanol S-5104Diallyl phthalate Methanol S-4931Diamyl phthalate Methanol S-4157Dibenzyl phthalate MeCI2S-1186Dicapryl phthalate Methanol S-4932Dicyclohexyl phthalate Methanol S-4151Diethyl phthalate Methanol S-1515Diisobutyl phthalate Methanol S-4150Diisodecyl phthalate Methanol S-4464Diisoheptyl phthalate MeCI2S-1553Diisononyl phthalate (Unbranched)MethanolS-57011 mL Diisononyl phthalate Acetone S-1559Di-iso-octyl Phthalate Methanol S-5738Dimethoxyethyl phthalate Methanol S-1575Dimethyl isophthalate Methanol S-1594Dimethyl phthalate Methanol S-1590Dimethyl terephthalate Methanol S-1595Di-n-butyl phthalate Methanol S-1770Di-n-decyl phthalate Methanol S-4933Di-n-hexyl phthalate Methanol S-4155Di-n-hexyl phthalate Hexane S-4155-H Di-n-octyl phthalate Methanol S-1775Dinonyl phthalate Methanol S-4153Dioctyl isophthalate Methanol S-4937Diphenyl isophthalate Methanol S-4449Diphenyl phthalate Methanol S-4448Dipropyl phthalate Methanol S-4491Ditridecyl phthalate Methanol S-4929Diundecyl phthalate Methanol S-4930Hexyl 2-ethylhexyl phthalate Methanol S-4158Isopentyl pentyl phthalateMethanolS-6109Volume: 1 mL CompoundMatrixPart #3SPEX CertiPrep’s Extractable Metals in Toys Standards can assist the analyst in their testing for heavy metals in children’s products. These standards are designed for use in many testing methods including:US Methods:- CPSC-CH-C1001-09.3 - CPSC-CH-E1001-08- ASTM D7823 - 13EU Directive:- 94/62/EC Art.11- 91/388 ECCan’t find the standards you are looking for?SPEX CertiPrep can make custom PVC/PE standards to meet your exact needs.Call your local sales representative for more information.ComponentsContentsMatrixEMPT-1A (not available separately)1000 μg/mL: As, Cd, Cr, Pb, Se, Sb 10% HNO3/tr. Tart/Tr. HFEMPT-1B (not available separately)1000 μg/mL : Ba, Hg10% HNO3Part #: EMPT-1 125 mL ComponentsContentsMatrixEMPT-1A (not available separately)1000 μg/mL: As, Cd, Cr, Pb, Se, Sb 10% HNO3/tr. Tart/Tr. HFEMPT-1B (not available separately)1000 μg/mL : Ba, Hg 10% HNO3INT-EM1: Interference Check Standard (not available separately)2000 μg/mL : Al, Ca, Fe, Mg 20 μg/mL : As, Cd, Cr, Pb, Se, Sb10% HNO3/tr. Tart/Tr. HFPart #: EMPT-2125 mL UK Address:SPEX Europe2 Dalston Gardens StanmoreMiddlesex, HA7 1BQ UK Tel: +44 (0) 20 8204 6656Fax: +44 (0) 20 8204 6654E-mail:*******************Web: SPEX Europe is a trading name of SPEX CertiPrep, Inc.US Address:SPEX CertiPrep, Inc.203 Norcross Avenue Metuchen, NJ 08840Tel: 1-800-LAB-SPEX Fax: 732-603-9647E-mail:********************Web: ©2016 SPEX CertiPrep. All Rights Reserved.。

安捷伦产品目录

15
Real-Time PCR
16
Mx3000P QPCR System
17
Brilliant III Ultra-Fast SYBR Green QPCR and QRT-PCR Reagents
18
Brilliant III Ultra-Fast QPCR and QRT-PCR Reagents
Agilent / STRATAGENE
Agilent website: /genomics
Welgene | Agilent Stratagene
威健股份有限公司 | Stratagene 總代理
Table of Content
Table of Contents
/ XL1-Red Competent Cells SoloPack Gold Supercompetent Cells
/ TK Competent Cells Specialty Cells
/ Classic Cells / Fine Chemicals For Competent Cells
適用於 UNG 去汙染或 bisulphite
sequencing
適用於 TA Cloning
最高敏感性
取代傳統 Taq 的好選擇
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2
威健股份有限公司 | Stratagene 總代理
PCR Enzyme & Instrument
Agilent SureCycler 8800
市場上領先的 cycling 速度和 sample 體積 10 ～ 100 μL 簡易快速可以選擇 96 well 和 384 well 操作盤優秀的溫控設備讓各個 well 都能保持溫度的穩定七吋的高解析度觸控螢幕讓操作上更為簡便可以透過網路遠端操控儀器及監控儀器 Agilent 專業的技術支援可以幫助您應對各種 PCR 的問題

植物病害诊断试剂盒

植物病害诊断试剂盒美国阿格迪agdia 公司是全球最大的植物病害诊断试剂生产商，产品品种最多，可检测项目多达200多个。

包装规格最全,不同的包装规格适合不同规模的实验室。

从中您一定能发现适合您使用的产品。

选购试剂说明，请仔细阅读。

1，kit, 订货号PSAxxxxx/xxxx 或PSPxxxxx/xxxx 为完整的试剂盒包装，包括样品提取缓冲液、包被好抗体的微孔板（可拆分）、酶标记物、稀释液、缓冲液、底物发色剂、阳性质控（如果应该供应）。

特别注明Indirect ELISA 方法的kit 包括未包被的微孔板及联接用的抗体，所含有的其他组分同上。

2， Reagent Set, 订货号SRAxxxxx/xxxx ,XRAxxxxx/xxxx或SRPxxxxx/xxxx 只含有未包被的微孔板、包被需要的抗体或联接用的抗体、酶标记物。

其他试剂如样品提取缓冲液、稀释液、缓冲液、底物发色剂、质控物需另外订购或自己配制。

我公司销售原厂的上述试剂，详见目录。

3， Bacterial Reagent Set, 订货号BRAxxxxx/xxxx 只含有未包被的微孔板、包被需要的抗体或联接用的抗体、酶标记物。

其他试剂如样品提取缓冲液、稀释液、缓冲液、底物发色剂、质控物需另外订购或自己配制。

我公司销售原厂的上述试剂，详见目录。

4， Bacterial ID订货号BIDxxxxx/xxxx 为完整的试剂盒包装，包括样品提取缓冲液、包被好抗体的微孔板（可拆分）、酶标记物、稀释液、缓冲液、底物发色剂、质控（如果应该供应）。

用于鉴定培养基中或有病症植物提取液中的细菌。

操作简便快速。

5， PS A或SR A中的A代表碱性磷酸酶标记；PS P或SR P中的P代表过氧化物酶标记。

6， Immunostrip test, 为检试纸条，操作简单，几分钟内得到结果，非常适合于现场检测。

该试条必须与相应的样品提取缓冲液配套使用。

实验室需要单独购买该样品提取缓冲液，详见目录。

Shimadzu - LCMS-2020 Vacuum System Main Unit ESI P

6 month Service X
X X X
X X X X X X X X
36 month Service 48 month Service 60 month Service
X X
X X X
X X X
Note: These time frames are only suggestions and items may need to be replaced more frequently depending on sample throughput and use
X
Note: These time frames are only suggestions and items may need to be replaced more frequently depending on sample throughput and use
Shop online ~ or call Shimadzu at 800-477-1227
Shop online ~ or call Shimadzu at 800-477-1227
2
LCMS-8030/8040
Triple Quadrupole Mass Spectrometer
LCMS-8030
LCMS-8040
Vacuum System
Main Unit
SSI-LCMS-11-2015
Liquid Chromatography Mass Spectrometry
LCMS Consumables
LCMS-2020
Single Quadrupole Mass Spectrometer
Inspection/Maintenance Schedule

超高效液相色谱-串联质谱法测定化妆品中15种N-亚硝胺化合物

第42 卷第 11 期2023 年11 月Vol.42 No.111469~1478分析测试学报FENXI CESHI XUEBAO（Journal of Instrumental Analysis）超高效液相色谱-串联质谱法测定化妆品中15种N-亚硝胺化合物汪毅1，梁文耀1，何国山1，陈张好2，周智明2，吴谦1，席绍峰1，谭建华1*（1．广州质量监督检测研究院，国家化妆品质量检验检测中心（广州），广东广州511447；2．广东省药品检验所，广东广州510663）摘要：采用超高效液相色谱-串联质谱（UPLC-MS/MS）建立了化妆品中15种痕量N-亚硝胺化合物的分析方法。

水剂样品以水或乙腈分组超声提取，膏霜乳液样品采用亚铁氰化钾-乙酸锌溶液沉淀大分子或者饱和氯化钠-乙腈盐析分组处理后，以Agilent Poroshell 120 SB-Aq（100 mm×3.0 mm，2.7 μm）色谱柱分离，经大气压化学电离源（APCI）电离，多反应监测模式检测，以同位素内标法定量。

结果表明，15种N-亚硝胺化合物在相应质量浓度范围内线性关系良好（r2＞0.995），检出限和定量下限分别为5~15 ng/g和15~45 ng/g。

水、乳、膏霜3种化妆品基质在25、50、100 ng/g加标水平下的平均回收率为88.0%~111%，相对标准偏差（RSD，n=6）为1.4%~9.8%。

该方法用于市售化妆品检测，发现13批次样品检出N-亚硝基二乙醇胺（NDELA），其中1批次超限量值。

方法的专属性强，灵敏度高，精密度好，解决了N-亚硝胺化合物稳定性差、易被干扰等问题，适用于化妆品中15种N-亚硝胺化合物的痕量测定。

关键词：N-亚硝胺化合物；化妆品；超高效液相色谱-串联质谱法（UPLC-MS/MS）；大气压化学电离源中图分类号：O657.63；O623.732文献标识码：A 文章编号：1004-4957（2023）11-1469-10 Determination of Fifteen N-nitrosamine Compounds in Cosmetics by Ultra Performance Liquid Chromatography-TandemMass SpectrometryWANG Yi1，LIANG Wen-yao1，HE Guo-shan1，CHEN Zhang-hao2，ZHOU Zhi-ming2，WU Qian1，XI Shao-feng1，TAN Jian-hua1*（1．Guangzhou Quality Supervision and Testing Institute，National Quality Supervision and Testing Center for Cosmetics（Guangzhou），Guangzhou　511447，China；2．Guangdong Institute for Drug Control，Guangzhou　510663）Abstract：An ultra performance liquid chromatography-tandem mass spectrometric（UPLC-MS/MS）method was established for detecting 15 trace N-nitrosamine compounds in cosmetics. The final estab⁃lished method involved ultrasonic extraction of cosmetics using water or acetonitrile for different com⁃pounds. The samples were treated with potassium ferrocyanide-zinc acetate solution for precipitating macromolecules or saturated sodium chloride-acetonitrile for salting out.An Agilent Poroshell 120 SB-Aq（100 mm × 3.0 mm，2.7 μm） chromatography column was used for separation，followed by atmospheric pressure chemical ionization（APCI） source and multiple reaction monitoring mode detec⁃tion in the isotope internal standard method for quantification. The result showed good linearity（r2> 0.995） for the 15 N-nitrosamine compounds in their respective concentration ranges，with detection and quantitation limits of 5-15 ng/g and 15-45 ng/g，respectively.The average recoveries for the three cosmetic matrices（aqueous，emulsion，cream） at spiked levels of 25，50，100 ng/g were be⁃tween 88.0% and 111%，with relative standard deviations（RSD，n=6） of 1.4%-9.8%. The method was applied to the detection of commercial cosmetics and N-nitrosodiethanolamine（NDELA） was de⁃tected in 13 batches，with one batch exceeding the limit. The strong specificity，high sensitivity，and good precision made the method could solve the problems of poor stability and easy interference ofdoi：10.19969/j.fxcsxb.23051602收稿日期：2023－05－16；修回日期：2023－06－10基金项目：广东省药品监督管理局化妆品风险评估重点实验室专项（2021ZDZ03）；广东省市场监督管理局科技项目（2022CZ06）∗通讯作者：谭建华，博士，正高级工程师，研究方向：色谱－质谱检测技术研究，E-mail：tanjianhua0734@第 42 卷分析测试学报N-nitrosamine compounds，and was suitable for the trace determination of 15 N-nitrosamine com⁃pounds in cosmetics.Key words：N-nitrosamine compounds；cosmetics；ultra performance liquid chromatography-tan⁃dem mass spectrometry（UPLC-MS/MS）；atmospheric pressure chemical ionization（APCI） sourceN-亚硝胺化合物是一类具有N-亚硝基结构的化合物，因取代基的不同，形成了种类繁多的同系物，目前已发现超过300种［1］。

NVP-BKM120 Hydrochloride_1312445-63-8_DataSheet_MedChemExpress

Product Name:NVP-BKM120 Hydrochloride CAS No.:1312445-63-8Cat. No.:HY-15180Product Data SheetMWt:446.85Formula:C18H22ClF3N6O2Purity :>98%Solubility:DMSO ≥80mg/mL Water <1mg/mLy Mechanisms:Biological Activity:NVP BKM120Hcl(BKM120)is a selective PI3K inhibitor of p110with IC50of 52nM/166Pathways:PI3K/Akt/mTOR; Target:PI3K g g Ethanol ≥20mg/mLNVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with littleactivity to PI4K β.IC50 value: 52 nM/166 nM/116 nM/262 nM(p110α/β/δ/γ) [1]Target: p110α/β/δ/γin vitro: BKM120 is not sensitive to Class III and Class IV PI3K's or PI4K. NVP-BKM120 shows great antiproliferation activity to PI3K deregulated cell lines including A2780, U87MG, MCF7 and DU145with GI50 of 0.1-0.7 nM [1]. BKM120 induces multiple myeloma cells (ARP1, ARK, MM.1S, MM1.R and U266) apoptosis, which results in increased G1-phase cells and decreased S-phase cells.References:[1]. Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable ClassI PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett, 2011, 2 (10), 774–779.[2]. Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in )p p ,p pBKM120 induced CD138+ primary MM cell apoptosis and has significant lower cytotoxicity toward CD138? stromal cells. BKM120 exposure could cause upregulation of BimS and downregulation of XIAP [2]. BKM120 demonstrates antiproli...myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl),2011 Dec 30.[3]. Park E, et al. NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor inhuman gastric cancer cells harboring KRAS mutations. Int J Oncol, 2012, 40(4), 1259-1266.Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。

本试剂仅供研究使用

本试剂仅供研究使用兔纤溶酶抗纤溶酶复合物(PAP)elisa试剂盒使用说明书试剂盒组成：48孔配置/96孔配置说明书：1份封板膜：2片（48）/2片（96）密封袋：1个目的：【兔纤溶酶抗纤溶酶复合物(PAP)elisa试剂盒说明书】本试剂盒用于测定兔血清，血浆及相关液体样本中纤溶酶抗纤溶酶复合物(PAP)的含量。

服务承诺：供货期：款到发货。

工作时间内免费的技术咨询和指导。

请来电咨询为客户提供来样检测服务，最大限度实验结果的有效性(免费代测)。

试剂盒性能：1.样品线性回归与预期浓度相关系数R值为0.95以上。

2.批内与批见应分别小于9%和11%保存条件及有效期：1.试剂盒保存：2-8℃。

2．有效期：6个月检测范围：0.2IU/L - 6IU/L试剂盒组成：实验原理：【兔纤溶酶抗纤溶酶复合物(PAP)elisa试剂盒说明书】本试剂盒应用双抗体夹心法测定标本中兔纤溶酶抗纤溶酶复合物(PAP)水平。

用纯化的兔纤溶酶抗纤溶酶复合物(PAP)抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入纤溶酶抗纤溶酶复合物(PAP)，再与HRP标记的纤溶酶抗纤溶酶复合物(PAP)抗体结合，形成抗体-抗原-酶标抗体复合物，经过彻底洗涤后加底物TMB显色。

TMB在HRP酶的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。

颜色的深浅和样品中的纤溶酶抗纤溶酶复合物(PAP)呈正相关。

用酶标仪在450nm波长下测定吸光度（OD值），通过标准曲线计算样品中兔纤溶酶抗纤溶酶复合物(PAP)浓度。

样本处理及要求：1. 血清：室温血液自然凝固10-20分钟，离心20分钟左右（2000-3000转/分）。

仔细收集上清，保存过程中如出现沉淀，应再次离心。

2. 血浆：应根据标本的要求选择EDTA或柠檬酸钠作为抗凝剂，混合10-20分钟后，离心20分钟左右（2000-3000转/分）。

仔细收集上清，保存过程中如有沉淀形成，应该再次离心。

TCS-PIM-1-4a_327033-36-3_MSDS_MedChemExpress

MSDS1 Composition7 Accident Release MeasureProduct Name:TCS-PIM-1 4aChemical Name:PROCEDURE(S) OF PERSONAL PRECAUTION(S)-Wear respirator, chemical safety goggles, rubber boots, and heavyrubber gloves.METHODS FOR CLEANING UP-Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area andwash spill site after material pickup is complete.2,4-Thiazolidinedione, 5-[[3-(trifluoromethyl)phenyl]methylene]-CAS No.:327033-36-38 Accident Release MeasureAppearance:White to off-white(solid)Formula:C11H6F3NO2S9 Toxicological InformationSolubility:To the best of our knowledge, the chemical, physical, andtoxicological properties have not been thoroughly investigated.No data available.p p p p DMSO ≥ 100 mg/mL Ethanol2 Handling and Storage10 Regulary Information3 Stability and Reactivity11Disposal ConsiderationsCLASSIFICATION- Substance not yet fully tested.SAFETY PHASES- 26-36 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.) 36/37/38 (Irritating to eyes,respiratory system and skin.)STABILITY- Stable under normal handling conditions.HANDLING- Do not breathe dust. Avoid contact with eyes,skin,and clothing.Avoid prolonged or repeated exposure.STORAGE- Store in a properly sealed container store at -20℃,shelflife is 2 years.11 Disposal Considerations 4 Hazards Identification12 Transport Information5First Aid RID/ADR- Non-hazardous for road transport. IMDG- Non-hazardous for sea transport.IATA - Non-hazardous for air transport.As specific country, federal, state and local environmentalregulations vary and change frequently we suggest you contact a local, authorized waste disposal contractor for adequate disposal.Special indication of hazards to humans and the environment.Irritating to eyes, respiratory system and skin.MATERIALS TO AVOID- Strong oxidizing agents.REACTIVITY- May emit toxic gasses like Carbon monoxide,Carbon dioxide, Nitrogen oxides upon thermal decomposition.5 First Aid13 Other InformationThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Medchemexpress LLC shall not be held liable for any damage resulting from h dli f t t ith th b d tINHALATION- If inhaled, remove to fresh air. If not breathing give, artificial respiration. If breathing is difficult, give oxygen.SKIN CONTACT- In case of contact, immediately wash skin withsoap and copious amounts of water.EYE CONTACT- In case of contact, immediately flush eyes withcopious amounts of water for at least 15 minutes.INGESTION- If swallowed, wash out mouth with water provided person is conscious. Call a physician.6 Fire Fighting Measureshandling or from contact with the above product.EXTINGUISHING MEDIA Water spray- Carbon dioxide, dry chemical powder, or appropriate foam.SPECIAL RISKS Specific Hazard(s)- Emits toxic fumes under fire conditions. SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS Wear self-contained breathing apparatus and protective clothing Caution: Not fully tested. For research purposes onlyMedchemexpress LLCto prevent contact with skin and eyes.18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。

顺铂热化疗灌注联合肝动脉灌注化疗栓塞术在肝癌患者治疗中的应用

药物与临床China &Foreign Medical Treatment 中外医疗顺铂热化疗灌注联合肝动脉灌注化疗栓塞术在肝癌患者治疗中的应用马建增，曹文丽，刘淑荣阳光融和医院肿瘤科，山东潍坊 261000［摘要］目的研究肝癌患者采用顺铂热化疗灌注联合肝动脉灌注化疗栓塞术方案进行治疗的临床效果。

方法简单随机选取2021年1月—2022年6月在阳光融和医院接受治疗的80例肝癌患者，根据治疗方案的不同将其分成对照组和治疗组。

对照组40例患者单纯采用肝动脉灌注化疗栓塞术方案进行治疗，治疗组40例患者在对照组的基础上联用顺铂热化疗灌注治疗。

对比两组不良反应情况、治疗效果治疗前后肿瘤相关指标、炎症反应相关指标、免疫功能相关指标、生活质量评分、疼痛程度评分水平。

结果治疗组患者不良反应略多于对照组，差异无统计学意义（P >0.05）；治疗组病情控制总有效率为90.00%，高于对照组，差异有统计学意义（χ2=6.050，P <0.05）；治疗组治疗后肿瘤相关指标、炎症反应相关指标、免疫功能相关指标、生活质量评分、疼痛程度评分水平的改善幅度大于对照组，差异有统计学意义（P <0.05）。

结论采用顺铂热化疗灌注联合肝动脉灌注化疗栓塞术方案进行治疗，能够帮助控制炎症反应，改善机体免疫力和生活质量，减轻疼痛，且不会增加不良反应，使治疗效果得到显著提升。

［关键词］肝癌；顺铂热化疗灌注；肝动脉灌注化疗栓塞术；不良反应；疼痛［中图分类号］ R47 ［文献标识码］ A ［文章编号］ 1674-0742（2023）01(b)-0121-05Application of Cisplatin Thermochemotherapy Infusion Combined with Hepatic Arterial Infusion Chemoembolization in the Treatment of Patients with Liver CancerMA Jianzeng, CAO Wenli, LIU ShurongDepartment of Oncology, Sunshine Harmony Hospital, Weifang, Shandong Province, 261000 China[Abstract] Objective To study the clinical effect of cisplatin thermochemotherapy infusion combined with hepatic ar⁃terial infusion chemoembolization in patients with liver cancer.Methods Selected 80 liver cancer patients who re⁃ceived treatment at Sunshine Ronghe Hospital from January 2021 to June 2022 were simple random selected, and di⁃vided them into a control group and a treatment group based on different treatment plans. The control group consisted of 40 patients who were treated solely with hepatic artery infusion chemotherapy embolization, while the treatment group consisted of 40 patients who were treated with cisplatin thermal chemotherapy infusion on the basis of the con⁃trol group. Compared the adverse reactions, treatment effect, tumor related indicators, inflammatory response related indicators, immune function related indicators, quality of life scores, and pain level scores between the two groups be⁃fore and after treatment. Results The treatment group had slightly more adverse reactions than the control group, and the difference was not statistically significant (P >0.05). The total effective rate of disease control in the treatment group was 90.00%, which was higher than that in the control group, and the difference was statistically significant (χ2=6.050, P <0.05). The improvement in tumor related indicators, inflammatory response related indicators, immune func⁃tion related indicators, quality of life scores, and pain severity scores after treatment in the treatment group was greater than that in the control group, and the difference was statistically significant (P <0.05).Conclusion The treatment of cis⁃platin hyperthermia chemotherapy combined with hepatic arterial infusion chemoembolization can help control the in⁃DOI ：10.16662/ki.1674-0742.2023.02.121[作者简介] 马建增（1986-），男，硕士，主治医师，主要从事肿瘤内科工作。

NVS-PAK1-1_SDS_MedChemExpress

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Jul.-19-2017Print Date:Jul.-19-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :NVS-PAK1-1Catalog No. :HY-100519CAS No. :1783816-74-91.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C23H25ClF3N5OMolecular Weight:479.93CAS No. :1783816-74-94. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

Trypsin Antigen Retrieval Solution (ab970) 使用说明书

Product nameTrypsin Antigen Retrieval Solution Tested applicationsSuitable for: IHC-P General notes Trypsin-based antigen retrieval solution for Protease-Induced Epitope Retrieval (PIER) (ab970).Contains colored pH indicator for easy pH confirmation.Protocol Notes: 1) Deparaffinize tissues and hydrate to water. If necessary perform a hydrogenperoxide block, wash in water, and rinse in PBS or TBS. The tissue section is ready for trypsindigestion. 2) Combine 1 part trypsin concentrate with 1 part buffer (working solution stable for 5working days at 2-8ºC). Incubate section for 5-10 minutes at 37°C or 15 minutes at roomtemperature. Then, rinse well in PBS or TBS buffer and proceed with immunostaining procedure.This product utilises a color-coded pH indicator (rose) for easy identification. The end-user canvisually inspect the solution and see that the mixture or buffer is at the proper pH. If the mixedsolution is purple, the pH is too high for optimum digestion. If the buffer or trypsin solution turnsorange or yellow, the pH is too low for optimum digestion.Trypsin is a commonly used digestive enzyme. In formalin-fixed, paraffin-embedded tissues,certain antibody protocols required enzyme pretreatment for proper immunohistochemicalstaining.Other products for IHCOther enzymes for antigen retrieval include: Proteinase K Antigen Retrieval Solution ab64220 and Pepsin Solution ab64201.Find more kits and reagents for antigen retrieval, blocking, signal amplification, visualization,counterstaining, and mounting in the IHC kits and reagents guide .FormLiquid Storage instructionsStore at +4°C.Storage bufferPreservative: 0.05% Sodium azide Constituents: PBS, Carrier protein Reagent notes Trypsin is a commonly used digestive enzyme. In formalin-fixed, paraffin-embedded tissues,certain antibody protocols required enzyme pretreatment for proper immunohistochemicalstaining.Product datasheetTrypsin Antigen Retrieval Solution ab9701 Abreviews 24 ReferencesOverview PropertiesThe Abpromise guarantee ApplicationsOur Abpromise guarantee covers the use of ab970 in the following tested applications.The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.ApplicationAbreviews Notes IHC-P Use at an assay dependent dilution. Ratio for 25ml concentratedtrypsin and 25 ml buffer is 1:1 - 1:3.Please note: A ll products are "FOR RESEA RCH USE ONLY . NOT FOR USE IN DIA GNOSTIC PROCEDURES"Our Abpromise to you: Quality guaranteed and expert technical support Replacement or refund for products not performing as stated on the datasheet Valid for 12 months from date of delivery Response to your inquiry within 24 hours We provide support in Chinese, English, French, German, Japanese and Spanish Extensive multi-media technical resources to help youWe investigate all quality concerns to ensure our products perform to the highest standardsIf the product does not perform as described on this datasheet, we will offer a refund or replacement. For full details of the Abpromise,please visit https:///abpromise or contact our technical team.Terms and conditions Guarantee only valid for products bought direct from Abcam or one of our authorized distributors。

Germ-X Aloe Hand Sanitizer – With Fragrance 产品说明书

Safety Data SheetThe supplier identified below generated this SDS using the UL SDS template. UL did not test, certify, or approve the substance described in this SDS, and all information in this SDS was provided by the supplier or was reproduced from publically available regulatory data sources. UL makes no representations or warranties regarding the completeness or accuracy of the information in this SDS and disclaims all liability in connection with the use of this information or the substance described in this SDS. The layout, appearance and format of this SDS is © 2014 UL LLC. All rights reserved.Product identifierProduct Name 089AA Germ-X Aloe Hand Sanitizer – With FragranceOther means of identificationSynonyms NoneRecommended use of the chemical and restrictions on useRecommended Use Hand sanitizerUses advised against Use only as directed.Details of the supplier of the safety data sheetSupplier Name Vi-Jon Inc.Supplier Address Vi-Jon Inc.8800 Page AvenueSaint LouisMO63114USSupplier Phone Number Phone: 314-427-1000 (M-F 8am-4pm CST)Fax:3144271010Supplier EmailEmergency telephone number Chemtrec: 1-800-424-9300 (24-Hour)ClassificationThis chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200).GHS Label elements, including precautionary statementsPrecautionary Statements - PreventionKeep away from heat/sparks/open flames/hot surfaces. - No smokingKeep container tightly closedGround/bond container and receiving equipmentUse explosion-proof electrical/ ventilating/ lighting/ equipmentUse only non-sparking toolsTake precautionary measures against static dischargeWear protective gloves/protective clothing/eye protection/face protectionPrecautionary Statements - ResponseSkinIF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/showerFireIn case of fire: Use CO2, dry chemical, or foam for extinctionPrecautionary Statements - StorageStore in a well-ventilated place. Keep coolPrecautionary Statements - DisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC)Not applicableUnknown Toxicity2E-06 % of the mixture consists of ingredient(s) of unknown toxicityOther informationToxic to aquatic lifePROLONGED OR REPEATED CONTACT MAY DRY SKIN AND CAUSE IRRITATIONMay cause slight eye irritationInteractions with Other ChemicalsNo information available.First aid measuresEye contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Keepeye wide open while rinsing. Do not rub affected area. Remove contact lenses, if presentand easy to do. Continue rinsing.Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes.Inhalation Remove to fresh air.Ingestion Rinse mouth immediately and drink plenty of water. Never give anything by mouth to anunconscious person.Self-protection of the first aider Remove all sources of ignition. Ensure that medical personnel are aware of the material(s)involved, take precautions to protect themselves and prevent spread of contamination. Usepersonal protective equipment as required. Wear personal protective clothing (see section8).Most important symptoms and effects, both acute and delayedMost Important Symptoms andNo information available.EffectsIndication of any immediate medical attention and special treatment neededNotes to Physician Treat symptomatically.Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment. Dry chemical. Carbon dioxide (CO2). Water spray. Alcohol resistant foam.Unsuitable extinguishing mediaCAUTION: Use of water spray when fighting fire may be inefficient.Specific hazards arising from the chemicalRisk of ignition. Keep product and empty container away from heat and sources of ignition. In the event of fire, cool tanks with water spray. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations.Uniform Fire Code Flammable Liquid: I-CExplosion DataSensitivity to Mechanical Impact None.Sensitivity to Static Discharge Yes.Protective equipment and precautions for firefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.Personal precautions, protective equipment and emergency proceduresPersonal precautions Evacuate personnel to safe areas. Use personal protective equipment as required. Seesection 8 for more information. Avoid contact with skin, eyes or clothing. Ensure adequateventilation. Keep people away from and upwind of spill/leak. ELIMINATE all ignition sources(no smoking, flares, sparks or flames in immediate area). Pay attention to flashback. Takeprecautionary measures against static discharges. All equipment used when handling theproduct must be grounded. Do not touch or walk through spilled material.Other Information Ventilate the area.Environmental precautionsEnvironmental precautions Refer to protective measures listed in Sections 7 and 8. Prevent further leakage or spillageif safe to do so. Prevent product from entering drains.Methods and material for containment and cleaning upMethods for containment Prevent further leakage or spillage if safe to do so. Do not touch or walk through spilledmaterial. A vapor suppressing foam may be used to reduce vapors. Dike far ahead of spillto collect runoff water. Keep out of drains, sewers, ditches and waterways.Methods for cleaning up Take precautionary measures against static discharges. Dam up. Soak up with inertabsorbent material. Pick up and transfer to properly labeled containers.Precautions for safe handlingHandling Handle in accordance with good industrial hygiene and safety practice. Avoid contact withskin, eyes or clothing. Use personal protection equipment. Avoid breathing vapors or mists.Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Use grounding andbonding connection when transferring this material to prevent static discharge, fire orexplosion. Use with local exhaust ventilation. Use spark-proof tools and explosion-proofequipment. Keep in an area equipped with sprinklers. Use according to package labelinstructions.Conditions for safe storage, including any incompatibilitiesStorage Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away fromheat, sparks, flame and other sources of ignition (i.e., pilot lights, electric motors and staticelectricity). Keep in properly labeled containers. Do not store near combustible materials.Keep in an area equipped with sprinklers. Store in accordance with the particular nationalregulations. Store in accordance with local regulations.Incompatible Products None known based on information supplied.Control parametersExposure Guidelines There is no exposure data pertaining to the Product. This section reflects exposure datapertaining to individual ingredients.Administration - Permissible Exposure Limits NIOSH IDLH Immediately Dangerous to Life or HealthOther Exposure Guidelines Vacated limits revoked by the Court of Appeals decision in AFL-CIO v. OSHA, 965 F.2d962 (11th Cir., 1992)Appropriate engineering controlsEngineering Measures ShowersEyewash stationsVentilation systemsIndividual protection measures, such as personal protective equipmentEye/face protection Tight sealing safety goggles.Skin and body protection Wear protective gloves and protective clothing. Long sleeved clothing. Chemical resistantapron. Impervious gloves. Antistatic boots.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approvedrespiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.Hygiene Measures Handle in accordance with good industrial hygiene and safety practice. Do not eat, drink orsmoke when using this product. Contaminated work clothing should not be allowed out ofthe workplace. Regular cleaning of equipment, work area and clothing is recommended.Wash hands before breaks and immediately after handling the product.Physical and Chemical PropertiesPhysical state Gel-like LiquidAppearanceClear to Slightly Hazy, Pale Green, Slightly Viscous Gel-like Liquid OdorAlcohol, FloralColorColorlessOdor ThresholdNo information availableProperty Values Remarks MethodpH 7.0 None known Melting / freezing point No data available None known Boiling point / boiling range 78 °C / 172 °F None known Flash Point 23 C / 73 F None known Evaporation Rate No data available None known Flammability (solid, gas) No data available None known Flammability Limit in AirUpper flammability limit No data availableLower flammability limit No data availableVapor pressure No data available None known Vapor density No data available None known Specific Gravity 0.90 None known Water Solubility Miscible in water None known Solubility in other solvents No data available None known Partition coefficient: n-octanol/water No data available None known Autoignition temperature No data available None known Decomposition temperature No data available None known Kinematic viscosity No data available None known Dynamic viscosity No data available None knownExplosive properties No data available Oxidizing properties No data availableOther Information Softening Point No data availableVOC Content (%) No data available Particle SizeNo data available Particle Size DistributionNo data availableReactivityNo data available.Chemical stabilityStable under recommended storage conditions.Possibility of Hazardous Reactions None under normal processing.Hazardous PolymerizationHazardous polymerization does not occur.Conditions to avoidHeat, flames, and sparks.Incompatible materials None known.Hazardous Decomposition Products None known.There is no data for this product. The information included in this section describes the potential hazards of the individual ingredients.Information on likely routes of exposureProduct InformationInhalation Specific test data for the substance or mixture is not available.Eye contact Specific test data for the substance or mixture is not available.Skin contact Specific test data for the substance or mixture is not available.Ingestion Specific test data for the substance or mixture is not available.Component InformationInformation on toxicological effectsSymptoms No information available.Delayed and immediate effects as well as chronic effects from short and long-term exposureSensitization No information available.Mutagenic Effects No information available.Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.Ethanol has been shown to be carcinogenic in long-term studies ONLY when consumed asalcoholic beverage.A3 - Animal CarcinogenIARC (International Agency for Research on Cancer)Group 1 - Carcinogenic to HumansGroup 3 - Not Classifiable as to Carcinogenicity in HumansNTP (National Toxicology Program)Known - Known CarcinogenOSHA (Occupational Safety and Health Administration of the US Department of Labor)X - PresentReproductive toxicity No information available.STOT - single exposure No information available.STOT - repeated exposure No information available.Chronic Toxicity No known effect based on information supplied.Target Organ Effects None known.Aspiration Hazard No information available.Numerical measures of toxicity Product InformationThe following values are calculated based on chapter 3.1 of the GHS documentATEmix (oral)13,058.00 mg/kgATEmix (inhalation-dust/mist)230.60 mg/lThere is no ecological data on the Product. The Product ingredients are expected to be safe for the environment at concentrations predicted under normal use and accidental spill scenarios. Packaging components are compatible with the conventional solid waste management practices.EcotoxicityToxic to aquatic organisms.Persistence and DegradabilityNo information available.BioaccumulationNo information available.Other adverse effectsNo information available.Waste treatment methodsDisposal methods This material, as supplied, is a hazardous waste according to federal regulations (40 CFR261).Contaminated Packaging Dispose of contents/containers in accordance with local regulations.US EPA Waste Number D001California Hazardous Waste Codes 311This product contains one or more substances that are listed with the State of California as a hazardous waste.DOTProper Shipping Name CONSUMER COMMODITYHazard Class ORM-DDescription CONSUMER COMMODITY, ORM-DEmergency Response Guide127NumberTDGUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIDescription UN1170, ETHANOL SOLUTION, 3, IIIMEXUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIDescription UN1170, ETHANOL SOLUTION, 3, IIIICAOUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIDescription UN1170, ETHANOL SOLUTION, 3, IIIIATAUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIERG Code 3LDescription UN1170, ETHANOL SOLUTION, 3, IIIIMDG/IMOUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIEmS-No. F-E, S-DDescription UN1170, ETHANOL SOLUTION, 3, III, (23°C C.C.)RIDUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIClassification code F1Description UN1170, ETHANOL SOLUTION, 3, III, ENVIRONMENTALLY HAZARDOUS ADRUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIClassification code F1Tunnel restriction code D/EDescription UN1170, ETHANOL SOLUTION, 3, III, ENVIRONMENTALLY HAZARDOUS ADNUN-No. UN1170Proper Shipping Name ETHANOL SOLUTIONHazard Class 3Packing Group IIIClassification code F1Special Provisions 144, 601Description UN1170, ETHANOL SOLUTION, 3, III, ENVIRONMENTALLY HAZARDOUS Hazard Labels 3Limited Quantity 5 LVentilation VE01International InventoriesTSCA CompliesDSL All components are listed either on the DSL or NDSL.IECSC -TSCA - United States Toxic Substances Control Act Section 8(b) InventoryDSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances ListUS Federal RegulationsSARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372 SARA 311/312 Hazard CategoriesAcute Health Hazard NoChronic Health Hazard NoFire Hazard YesSudden release of pressure hazard NoReactive Hazard NoCWA (Clean Water Act)This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42)CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level pertaining to releases of this materialUS State RegulationsCalifornia Proposition 65 - NONEThis product does not contain any Proposition 65 chemicals.U.S. State Right-to-Know RegulationsInternational RegulationsMexicoCanadaWHMIS Hazard ClassNot determinedIssuing Date: January 12, 2016Revision Date: None Revision Number: 0Page 11 / 11 NFPA Health Hazards 1 Flammability 3 Instability 0Physical and Chemical Hazards - N/A HMIS Health Hazards 1 Flammability 3Physical Hazard 0 Personal Protection XPrepared By Product Stewardship23 British American Blvd.Latham, NY 121101-800-572-6501Issuing Date January 12, 2016Revision Date NoneRevision NoteNoneGeneral DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.Approved and Updated by Vi-Jon, Inc.Disclaimer:The information and recommendations contained in the Safety Data Sheet (SDS) are supplied pursuant to 29 CFR 1910.1200 of the Occupational Safety and Health Standards Hazard Communication Rule. The information and recommendations set forth herein are presented in good faith and believed to be correct as of this date hereof.Vi-Jon, however, makes no representation as to the completeness or accuracy thereof, and information is supplied upon the expresscondition that the persons receiving the information will be required to make their own determination as to its suitability for their purposes prior to use. In no event will Vi-Jon be responsible for any damages of any nature whatsoever resulting from the use of, reliance upon, or the misuse of this information.No representations or warranties, either expressed or implied, of merchantability, fitness for a particular purpose, or of any other nature, are made hereunder with respect to information or the product to which the information refers. The information as supplied herein is simply to be informative and intended solely to alert the user of the substance which is the subject matter of this SDS. The ultimate compliance with federal, state or local regulations concerning the use of this compound, or compliance with respect to product liability, rests solely upon the purchaser thereof.End of Safety Data Sheet。

NVS PAK1 1_CAS号1783816-74-9_M7068说明书_AbMole中国

分子量479.93溶解性（25°C ）DMSO 分子式C H ClF N O Water CAS 号1783816-74-9Ethanol储存条件3年 -20°C 粉末状生物活性NVS PAK1 1 is a potent and selective PAK1 inhibitor (IC = 5 nM). Selective for PAK1 over PAK2 and a panel of 442 kinases. Inhibits autophosphorylation of PAK1 in KRAS-mutated pancreatic cancer cell lines.不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA 指南）小鼠大鼠兔豚鼠仓鼠狗重量 (kg)0.020.15 1.80.40.0810体表面积 (m )0.0070.0250.150.050.020.5K 系数36128520动物 A (mg/kg) = 动物 B (mg/kg) ×动物 B 的K 系数动物 A 的K 系数例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的K 系数（3），再除以大鼠的K 系数（6），得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg 。

参考文献In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.Shima, et al . Proc Natl Acad Sci USA. 2013;110: 8182. PMID: 23630290.NVS PAK1 1 目录号M7068化学数据232535502m m m m m。

RMS1 Spray 说明书

RMS1 SprayProduct identifierRelevant identified uses of the substance or mixture and uses advised againstUse of the substance/mixtureCleaning agentDetails of the supplier of the safety data sheetHottinger Brüel & Kjaer Company name:Street:Im Tiefen See 45Place:D-64293 DarmstadtTelephone:+49 (0)6151 Internet:Responsible Department:+49-30-18412-0Emergency telephone number:Classification of the substance or mixture Regulation (EC) No 1272/2008Aerosol 1; H222-H229Eye Irrit. 2; H319STOT SE 3; H336Full text of hazard statements: see SECTION 16.Label elementsRegulation (EC) No 1272/2008Signal word:DangerPictograms:H222Extremely flammable aerosol.H229Pressurized container: may burst if heated.H319Causes serious eye irritation.H336May cause drowsiness or dizziness.Hazard statementsP210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.P211Do not spray on an open flame or other ignition source.P251Do not pierce or burn, even after use.P280Wear protective gloves/protective clothing/eye protection/face protection.P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Precautionary statements Restricted to professional users.Special labelling of certain mixturesLabelling of packages where the contents do not exceed 125 mlDanger Signal word:Pictograms:H222-H229Hazard statementsP210-P211-P251Precautionary statementsNo information available.Other hazardsMixturesHazardous componentsQuantity Chemical nameCAS No 35 - < 40 %67-64-1acetone; propan-2-one; propanone 35 - < 40 %67-63-0propan-2-ol; isopropyl alcohol; isopropanolFull text of H statements: see section 16.Further InformationNo information available.Description of first aid measuresRemove affected person from the danger area and lay down. If unconscious but breathing normally, place in recovery position and seek medical advice. First aider: Pay attention to self-protection!General informationWhen in doubt or if symptoms are observed, get medical advice. Provide fresh air.In case of respiratory tract irritation, consult a physician.After inhalationAfter contact with skin, wash immediately with plenty of water and soap. Remove contaminated, saturated clothing immediately. In case of skin irritation, consult a physician.After contact with skinIn case of contact with eyes flush immediately with plenty of flowing water for 10 to 15 minutes holding eyelids apart and consult an ophthalmologist.After contact with eyesRinse mouth immediately and drink plenty of water. Never give anything by mouth to an unconscious person or a person with cramps. Do NOT induce vomiting.After ingestionMost important symptoms and effects, whether acute or delayedNo information available.Indication of immediate medical attention and special treatment neededNo information available.Extinguishing mediaWater spray jet, Dry extinguishing powder, Foam Suitable extinguishing mediaFull water jetUnsuitable extinguishing mediaSpecific hazards arising from the hazardous productHighly flammable.Vapours can form explosive mixtures with air.Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.Wear a self-contained breathing apparatus and chemical protective clothing. Co-ordinate fire-fighting measures to the fire surroundings.Pressurised container: May burst if heated.Special protective equipment and precautions for fire-fightersUse water spray jet to protect personnel and to cool endangered containers. Suppress gases/vapours/mists with water spray jet.Additional informationPersonal precautions, protective equipment and emergency proceduresRemove all sources of ignition. Provide adequate ventilation. Do not breathe gas/fumes/vapour/spray. Use personal protection equipment.Treat the recovered material as prescribed in the section on waste disposal. Provide adequate ventilation.General adviceDo not allow uncontrolled discharge of product into the environment.Environmental precautionsMethods and material for containment and cleaning upTake up mechanically, placing in appropriate containers for disposal.Other informationSafe handling: see section 7Personal protection equipment: see section 8Disposal: see section 13Reference to other sectionsPrecautions for safe handlingIf local exhaust ventilation is not possible or not sufficient, the entire working area should be ventilated by technical means.Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. @1501.B150663Advice on safe handlingKeep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. In case of insufficient ventilation and/or through use, explosive/highly flammable mixtures may develop.Advice on protection against fire and explosionPressurised container: May burst if heated.Wear personal protection equipment (refer to section 8). Do not empty into drains. When using do not eat, drink, smoke, sniff.Further information on handlingConditions for safe storage, including any incompatibilitiesKeep container tightly closed in a cool, well-ventilated place.Requirements for storage rooms and vesselsDo not store together with: Oxidising agent, strong , Organic peroxides and self-reactive substances Combustible substances of acute toxicity, category 1 and 2 / very toxic substances Non-combustible substances of acute toxicity, category 1 and 2 / very toxic substances Hints on joint storageNo further relevant information available.Further information on storage conditionsControl parametersNo information available.Additional advice on limit valuesExposure controlsIf handled uncovered, arrangements with local exhaust ventilation should be used if possible. In use, may form flammable/explosive vapour-air mixture. Use explosion-proof electrical equipment. Use non-sparking tools.Appropriate engineering controlsWhen using do not eat or drink.Do not breathe gas/fumes/vapour/spray.After contact with skin, take off immediately all contaminated clothing, and wash immediately with plenty of water and soap.Wear suitable protective clothing, gloves and eye/face protection.Draw up and observe skin protection programme.Protective and hygiene measuresWear eye/face protection.Eye/face protectionWhen handling with chemical substances, protective gloves must be worn with the CE-label including the four control digits. EN ISO 374The quality of the protective gloves resistant to chemicals must be chosen as a function of the specific working place concentration and quantity of hazardous substances. Thickness of the glove material: >= 0,7mm Suitable gloves type NBR (Nitrile rubber) Breakthrough time::>480 minFor special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.Hand protectionUsed working clothes should not be worn outside the work area. Separate storage of work clothes.Skin protectionWear anti-static footwear and clothing If technical exhaust or ventilation measures are not possible or insufficient, respiratory protection must be worn. Filtering device (full mask or mouthpiece) with filter: aRespiratory protectionDo not allow to enter into surface water or drains.The vapour of the product is heavier than air and may accumulate below ground level, in pits, channels and basements in higher concentration.Environmental exposure controlsAEROSOLS Physical state:Information on basic physical and chemical propertiesColour:light brown AminesOdour:pH-Value:not determined Changes in the physical state not determined Melting point/freezing point:not determined Sublimation point:not determined Softening point:not determined Pour point:not determined:Sustaining combustion:No data available Flammabilitynot determined Solid/liquid:not determinedGas:In use, may form flammable/explosive vapour-air mixture.Explosive propertiesnot determined Lower explosive limits:not determinedUpper explosive limits:365 °CAuto-ignition temperature:Self-ignition temperaturenot determined Solid:not determined Gas:not determinedDecomposition temperature:not determinedOxidizing properties8327 hPa Vapour pressure: (at 20 °C)Vapour pressure: (at 50 °C)17081 hPa Density (at 20 °C):not determined Bulk density:not determined Water solubility:not determinedSolubility in other solventsnot determined not determined Partition coefficient n-octanol/water:Viscosity / dynamic:not determinedViscosity / kinematic:not determined Flow time:not determined Relative vapour density:not determined Evaporation rate:not determined not determinedSolvent separation test:80,00 %Solvent content:Other informationnot determinedSolid content:ReactivityNo information available.Chemical stabilityThe substance is chemically stable under recommended conditions of storage, use and temperature.Possibility of hazardous reactionsNo hazardous reaction when handled and stored according to provisions.No information available.Conditions to avoidNo information available.Incompatible materialsNo information available.Hazardous decomposition productsNo information available.Further informationInformation on toxicological effectsAcute toxicityBased on available data, the classification criteria are not met.Causes serious eye irritation.Skin corrosion/irritation: Based on available data, the classification criteria are not met.Irritation and corrosivitySensitizing effectsBased on available data, the classification criteria are not met.Carcinogenic/mutagenic/toxic effects for reproductionBased on available data, the classification criteria are not met.STOT-single exposureMay cause drowsiness or dizziness. (acetone; propan-2-one; propanone; propan-2-ol; isopropyl alcohol; isopropanol)Based on available data, the classification criteria are not met.STOT-repeated exposureAspiration hazardBased on available data, the classification criteria are not met.No information available.Specific effects in experiment on an animalNo information available.Additional information on testsNo information available.Practical experienceInformation on other hazardsOther informationNo information available.Further informationNo information available.Persistence and degradabilityNo information available.Bioaccumulative potentialNo information available.No information available.Mobility in soilThis product does not contain a substance that has endocrine disrupting properties with respect to non-target organisms as no components meets the criteria.Endocrine disrupting propertiesNo information available.Other adverse effectsWaste treatment methodsDisposal recommendationsDispose of waste according to applicable legislation.Canadian TDGUN number or ID number:UN 1950AEROSOLS Proper shipping name:Hazard classes: 2.1Packing group:III Hazard label: 2.1Limited quantity:1 LMarine transport (IMDG)UN number:UN 1950AEROSOLSUnited Nations proper shippingname:Transport hazard class(es): 2.1Packing group:-Hazard label: 2.1Special Provisions:63, 190, 277, 327, 344, 381,959 Limited quantity:1000 mLExcepted quantity:E0EmS:F-D, S-UAir transport (ICAO-TI/IATA-DGR)UN number:UN 1950AEROSOLS, flammable United Nations proper shippingname:2.1Transport hazard class(es):-Packing group:Hazard label: 2.1Special Provisions:A145 A167 A802Limited quantity Passenger:30 kg GPassenger LQ:Y203Excepted quantity:E0IATA-packing instructions - Passenger:203 IATA-max. quantity - Passenger:75 kgIATA-packing instructions - Cargo:203 IATA-max. quantity - Cargo:150 kg Environmental hazardsENVIRONMENTALLY HAZARDOUS:NoCanadian regulationsClassification for mixtures and used evaluation method according to GHS ClassificationClassification procedureAerosol 1; H222-H229On basis of test dataEye Irrit. 2; H319Bridging principle "Aerosols"STOT SE 3; H336Bridging principle "Aerosols"Relevant H statements (number and full text)H222Extremely flammable aerosol.H225Highly flammable liquid and vapour.H229Pressurized container: may burst if heated.H319Causes serious eye irritation.H336May cause drowsiness or dizziness.EUH018In use may form flammable/explosive vapour-air mixture.EUH066Repeated exposure may cause skin dryness or cracking.(The data for the hazardous ingredients were taken respectively from the last version of the sub-contractor's safetydata sheet.)。

3-甲基丙烯酰氧-丙基三甲氧基硅烷

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