CCT128930_LCMS_05054_MedChemExpress

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EL-102_SDS_MedChemExpress

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :EL-102Catalog No. :HY-16187CAS No. :1233948-61-21.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:EL 102; EL102Formula:C19H16N2O3S2Molecular Weight:384.47CAS No. :1233948-61-24. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance Light yellow to yellow (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

低聚甘露糖醛酸或其药用盐在制备防治白细胞减少症药物中的应用[

专利名称：低聚甘露糖醛酸或其药用盐在制备防治白细胞减少症药物中的应用
专利类型：发明专利
发明人：管华诗,李春霞,李海花,胡婷,李全才,于广利
申请号：CN201210439029.0
申请日：20121106
公开号：CN102920729A
公开日：
20130213
专利内容由知识产权出版社提供
摘要：本发明提供了一种低聚甘露糖醛酸或其药用盐在制备防治白细胞减少症药物中的应用。

在体外细胞实验中，低聚甘露糖醛酸能明显促进CFU-GM的形成，同时能促进骨髓基质细胞的增殖，促进骨髓基质细胞分泌GM-CSF，促进脾淋巴细胞分泌白介素-3。

体内实验进一步表明低聚甘露糖醛酸能明显抑制环磷酰胺所致的小鼠白细胞的减少，提高小鼠的骨髓有核细胞数量，提高CFU-GM的形成。

实验结果证明本发明提供的低聚甘露糖醛酸可以开发成为一种临床上有效的防治白细胞减少症的药物。

申请人：中国海洋大学
地址：266003 山东省青岛市市南区鱼山路5号
国籍：CN
代理机构：青岛联智专利商标事务所有限公司
代理人：崔滨生
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一种获取年龄、预测肿瘤疾病发生的实时荧光PCR试剂盒[发明专利]

专利名称：一种获取年龄、预测肿瘤疾病发生的实时荧光PCR 试剂盒
专利类型：发明专利
发明人：黄志伟,辛叶,陈冉冉,朱倩,史萍,孔颖颖,张晓宇
申请号：CN201910667078.1
申请日：20190723
公开号：CN110295234A
公开日：
20191001
专利内容由知识产权出版社提供
摘要：本发明涉及一种获取年龄、预测肿瘤疾病发生的实时荧光PCR试剂盒，利用甲基化特异性聚合酶链反应和Real‑time绝对定量PCR方法探索hTERT基因启动子区域CpG位点甲基化程度与人的年龄和肿瘤疾病发生的关系，建立回归模型。

本发明方法可用于法医学年龄的预测和临床医学肿瘤疾病发生的辅助诊断。

申请人：东华大学
地址：201620 上海市松江区松江新城人民北路2999号
国籍：CN
代理机构：上海泰能知识产权代理事务所
代理人：黄志达
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胱氨酸蛋白酶抑制剂在制备治疗或预防紫外光诱导的皮肤损伤药物中

专利名称：胱氨酸蛋白酶抑制剂在制备治疗或预防紫外光诱导的皮肤损伤药物中的应用
专利类型：发明专利
发明人：殷卫海,张铭超
申请号：CN201711227254.7
申请日：20171129
公开号：CN108355134A
公开日：
20180803
专利内容由知识产权出版社提供
摘要：本发明公开了胱氨酸蛋白酶抑制剂在制备防治紫外光诱导的皮肤损伤药物中的应用。

其中，胱氨酸蛋白酶抑制剂，包括可以抑制半胱氨酸蛋白酶活力的胱氨酸蛋白酶抑制剂和半胱氨酸蛋白酶抑制剂均可以显著减少紫外光诱导的皮肤损伤，例如细胞死亡和组织损伤。

申请人：上海交通大学
地址：200240 上海市闵行区东川路800号
国籍：CN
代理机构：北京安杰律师事务所
代理人：袁沁菲
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一种石斑鱼胰岛素样生长因子Ⅱ基因、含有该基因的载体、重组株及

专利名称：一种石斑鱼胰岛素样生长因子Ⅱ基因、含有该基因的载体、重组株及其应用
专利类型：发明专利
发明人：李文笙,石锋涛,林浩然
申请号：CN03139770.0
申请日：20030710
公开号：CN1487083A
公开日：
20040407
专利内容由知识产权出版社提供
摘要：本发明公开了一种石斑鱼胰岛素样生长因子II基因，该基因是以石斑鱼肝脏总RNA为模板，经RT－PCR和RACE方法而得到的具有石斑鱼胰岛素样生长因子II基因全长cDNA序列的基因片段；本发明还构建了含该基因的载体和重组株；利用本发明可以获得来源稳定、成本便宜的石斑鱼胰岛素样生长因子II重组蛋白，并进一步制备适合海水鱼类使用的鱼苗苗种促生长剂或添加剂。

申请人：中山大学
地址：510275 广东省广州市新港西路135号
国籍：CN
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一种预测慢性粒细胞白血病患者对酪氨酸激酶抑制剂敏感性的标志物及其应用

专利名称：一种预测慢性粒细胞白血病患者对酪氨酸激酶抑制剂敏感性的标志物及其应用
专利类型：发明专利
发明人：杨承刚,常鹏,李昭然
申请号：CN202111437129.5
申请日：20211130
公开号：CN113970639A
公开日：
20220125
专利内容由知识产权出版社提供
摘要：本发明公开了一种预测慢性粒细胞白血病患者对酪氨酸激酶抑制剂敏感性的标志物及其应用，所述的标志物包括CTSS、CXCL3和/或RAB27B。

通过检测标志物的表达水平能判断慢性粒细胞白血病患者对酪氨酸激酶抑制剂耐药与否，从而便于实现针对性治疗，具有很好的临床应用前景。

申请人：青岛泱深生物医药有限公司
地址：266000 山东省青岛市崂山区科苑纬一路1号青岛国际创新园二期D2栋千山大厦2503室国籍：CN
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