慢性肾脏病5期患者血清BMP-2及BMP-7与颈动脉钙化的相关性研究

慢性肾脏病5期患者血清BMP-2及BMP-7与颈动脉钙化的
相关性研究
王冬梅;王科;方媛;刘静静;江洁龙;任伟
【期刊名称】《安徽医科大学学报》
【年(卷),期】2016(51)5
【摘要】52 patients with CKD5(experimental group) were recruited in nephrology department, while 40 people in good health ( control group) were included as control. The color Doppler ultrasonography was conducted in 52 pa-tients with CKD5 stage and the carotid media thickness was recorded to evaluate the carotid artery calcification. The serum concentrations of bone morphogenetic protein 2(BMP-2), bone morphogenetic protein 7(BMP-7), HDL-C, LDL-C,Ca, P, and iPTH were all included as items of inspection. The concentration of BMP-7 in experimental group was lower than that in control one. On the contrary, the concentration of BMP-2 was higher in experimental group. The incidence of carotid artery calcification in experimental group was higher than that in control one. This phenomenon was associated with the higher concentration of BMP-2 and the lower of BMP-7 . Serum BMP-2 is nega-tively correlated with BMP-7 .%选取慢性肾脏病5期( CKD5期)住院患者52例,予以颈动脉多普勒检查,并记录颈动脉中膜厚度以评估血管钙化情况,同期健康体检人员40例为对照组。

参加者均检测血清骨形态蛋白2(BMP-2)、骨形态蛋白
7(BMP-7)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、钙
( Ca)、磷( P)、全段PTH( iPTH)指标。

结果显示病例组血清BMP-7低于对照组,BMP-2高于对照组。

病例组中颈动脉钙化发生率高于对照组,与高 BMP-2、低BMP-7相关；血清BMP-2与BMP-7呈负相关性。

【总页数】3页(P762-764)
【作者】王冬梅;王科;方媛;刘静静;江洁龙;任伟
【作者单位】安徽医科大学附属省立医院肾脏内科，合肥 230001;安徽医科大学附属省立医院肾脏内科，合肥 230001;安徽医科大学附属省立医院肾脏内科，合肥 230001;安徽医科大学附属省立医院肾脏内科，合肥 230001;安徽医科大学附属省立医院肾脏内科，合肥 230001;安徽医科大学附属省立医院肾脏内科，合肥230001
【正文语种】中文
【中图分类】R692.5;R543.4
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