替罗非班对急性心肌梗死患者PCI术后慢血流或无复流的临床影响

替罗非班对急性心肌梗死患者PCI术后慢血流或无复流的临
床影响
关贤颂
【期刊名称】《中国医药导刊》
【年(卷),期】2012(14)2
【摘要】目的探讨替罗非班(Tiro.ban) 对急性心肌梗死患者介入术后无复流的临床影响.方法选取我院收治的335 例急性心肌梗死行经皮冠脉支架植入术(PCI) 患者的临床资料,其中80 例患者发生慢血流或无复流现象,随机分为治疗组(40 例)和对照组(40 例),对照组患者给予冠状动脉入维拉帕米治疗,治疗组患者冠状动脉内注入替罗非班,比较两组患者注射药物后及PCI 结束前末次冠状动脉造影图像,评估心肌梗死溶栓试验(TIMI) 血流分级,比较两组患者TIMI3 级血流比例.结果冠状动脉注射药物后及PCI 结束前末次冠状动脉造影图像均显示治疗组患者TIMI3 级血流比例明显高于对照组,两组患者比较差异有统计学意义(P<0.05).结论替罗非班可促进微血管灌注,明显改善急性心肌梗死患者PCI 术后无复流,增加心肌组织灌注,疗效满意.%Objective:To investigate the clinical impact of Tirofiban on slow flow or no-reflow of post-PCI in patients with acute myocardial
infarction.Methods:A total of 335 patients with acute myocardial infarction were treated with percutaneous coronary stent implantation (PCI),and slow flow or no-reflow phenomenon occurred in 80 patients.Those 80 patients were randomly divided into the treatment group (40 cases) and the control group (40 cases).The control group was treated with coronary injection of verapamil treatment,while the treatment group was treated with coronary
injection of Tirofiban.The flow grade of myocardial infarction trial (TIMI) was assessed and the flow ratio of TIMI3 level was compared by the coronary angiography of both the last image during PCI and post-injection.Results:The flow ratio of TIMI3 level of the coronary angiography of both the last image during PCI and post-injection was higher in the treatment group than the control group (P＜0.05).Conclusion:Tirofiban can promote microvascular perfusion,increase myocardial perfusion and improve the no-reflow of post-PCI in patients with acute myocardial infarction.The clinical results are satisfactory.
【总页数】2页(P268,243)
【作者】关贤颂
【作者单位】湖南省长沙市中心医院心血管内科,长沙410004
【正文语种】中文
【中图分类】R542.2+2
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1.替罗非班对急性冠脉综合征患者PCI术后慢血流/无复流的影响及安全性 [J], 罗茜元
2.急性心肌梗死患者术前血浆NT-proBNP水平与急诊PCI术后发生慢血流、无复流及其近期预后的相关性分析 [J], 侯琳琳; 王邦宁; 冯俊; 陈振飞
3.PCI术中冠脉推注不同剂量替罗非班治疗慢血流或无复流急性冠脉综合征患者的临床效果观察 [J], 吴一帆;简春燕;彭畅;江金
4.替罗非班对急性冠脉综合征患者PCI术后慢血流/无复流的影响及安全性 [J], 李艳君
5.替罗非班对急性冠脉综合征患者PCI术后慢血流/无复流的影响及安全性 [J], 李艳君
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