血清肌红蛋白、心肌肌钙蛋白Ⅰ和超敏C反应蛋白联合检测对急性心肌梗死患者的诊断价值

血清肌红蛋白、心肌肌钙蛋白Ⅰ和超敏C反应蛋白联合检测
对急性心肌梗死患者的诊断价值
钟文军
【期刊名称】《临床和实验医学杂志》
【年(卷),期】2011(010)015
【摘要】Objective To study the significance of serum myoglobin ( Myo ), cardiac troponin Ⅰ ( cTnI ) and high sensitive C - reactive protein ( hs - CRP ) in diagnosis of acute myocardial infarction. Methods Forty patients with acute myocardial infarction in this hospital were selected as observation group and 40 healthy persons without history of cerebrovascular diseases were selected as control group. Serum levels of Myo,cTnI and hs - CRP were detected in patients of these two groups. Results Serum levels of Myo, cTnI and hs - CRP in patients of observation group were significantly higher than those of controls, and their difference was statistically significant ( P ＜ 0.05 ). The results of examination demonstrated that serum level of Myo began to elevate in 0 ～ 4 h after onset of AMI, it reached the peak within 8 ～ 12 h, it dropped down in
12 ～ 24 h after the onset, and it returned to normal at 3 days later. Serum level of cTnI began to elevate in 4 ～ 8 h after onset of AMI, it reached the peak within 8 ～ 12 h, it sustained in keeping high level for 12 ～24 h, then it began to fall after 3 days. Serum level of hs - CRP gradually increased after the onset of AMI, it reached to peak within 12 ～ 24 h, and it returned
to normal in 3 d later. Conclusion The examination of serum levels of cTnI, Myo and hs - CRP has their own advantages and disadvantages, hence the combined examination of these three items is a very practical method for early diagnosis of AMI and it is worthy to be recommended.%目的探讨血清肌红蛋白(Myo)、心肌肌钙蛋白Ⅰ(cTnI)和超敏C反应蛋白( hs-CRP)联合检测对急性心肌梗死(AMI)诊断的价值.方法选择40例急性心肌梗死患者为观察组,同时选择进行体检的无心脑血管疾病史的40例健康体检者为对照组,分别检测两组受检者的Myo、cTnI和hs-CRP含量.结果观察组Myo、cTnI 和hs-CRP水平明显高于对照组,两组比较差异有统计学意义(P＜0.05).检测结果还显示Myo在AMI发生后0～4 h开始升高,8～12 h达到高峰,12～24 h后开始回落,3 d 后回落到正常水平;cTnI在AMI发生后4～8 h开始升高,8～12 h 达到高峰,12～24 h保持在高水平,3 d后开始回落;hs-CRP在AMI后逐渐升高,12～24 h 达到峰值,3 d后回落到正常水平.结论 cTnI、Myo、hs-CRP各有优缺点,三者联合应用能取长补短,是一种很有实用价值的检测方法,对早期诊断AMI具有较高应用价值,值得推广.
【总页数】2页(P1144-1145)
【作者】钟文军
【作者单位】深圳市龙岗区第二人民医院内一科,广东,深圳,518112
【正文语种】中文
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