Gli-1蛋白在食管鳞癌组织的表达及其临床意义

Gli-1蛋白在食管鳞癌组织的表达及其临床意义
肖锋;张晓伟;张杰;胡建功
【期刊名称】《泰山医学院学报》
【年(卷),期】2016(037)002
【摘要】Objective:Objective To observe the expression of Gli - 1 in esophageal squamous cell carcinoma( ESCC), tumor - adjacent tissues and normal tissues ,and to investigate the expression and clinical significance
of Gli - 1 protein in esophageal squamous cell carcinoma. Methods:The expression of Gli - 1 protein was detected by immunohistochemistry in 36 cases ESCC,tumor - adjacent tissues and 9 cases normal esophageal tissues. Results:In esophageal squamous cell car-cinoma,tumor - adjacent tissues and normal tissues,the positive expression rate of Gli - 1 were 55. 6% ,13. 9% ,and 11. 1% respectively,there was significant difference between group( P ﹤ 0. 05). The expression of Gli - 1 protein in tumor - adjacent and normal tissues was lower than that in esophageal squamous cell carcinoma. The difference was statisti-cally significant(P ﹤ 0. 05). No difference was found between tumor - adjacent and normal tissues about the expression of Gli - 1 protein(P ﹥ 0. 05). The expression of Gli - 1was not only much lower in T1 ~ T2 than that in T3 ~ T4( P ﹤ 0. 05) but also much lower in clinical stage Ⅰ ~ Ⅱ than that in Ⅲ ~ Ⅳ( P ﹤ 0. 05). The expression of Gli - 1 was higher in nodal metastases group than that in group without nodal metastases( P ﹤ 0. 05). No correlations were found between Gli -1 protein
and age,gender,tumor location,Tumor diameter,the degree of differentiation(P ﹥ 0. 05). Conclusions:Up -regulation of Gli - 1 might be involved in the development of esophageal squamous cell carcinoma,and it might play a pro-moting role in the invasion and metastasis of esophageal squamous cell carcinoma.%目的：检测食管鳞癌及其癌旁组织和食管正常组织的中 Gli -1的表达水平，并探究其与食管鳞癌的临床及病理因素之间的关系。

方法免疫组化法测36例食管癌及其癌旁组织和9例食管正常组织 Gli -1表达水平。

结果 Gli -1在食管鳞癌阳性表达率为55.6%；癌旁为13.9%；食管正常组织中为11.1%；组间差异有统计学意义（P ﹤0.05）；Gli -1在癌旁和正常组织中均显著低于鳞癌（P ﹤0.05）；Gli -1在癌旁和正常食管中表达差异无统计学意义（P ﹥0.05）。

其阳性表达率在Ⅰ~Ⅱ期远低于Ⅲ~Ⅳ期（P ﹤0.05），T1~ T2远低于 T3~ T4（P ﹤0.05），无淋巴转移的远低于转移（ P ﹤0.05）。

但其表达与年龄、性别、肿瘤位置、直径及分化程度无关（ P ﹥0.05）。

结论 Gli -1参与了食管鳞癌的发展进程，高表达的 Gli -1可能是促进食管鳞癌浸润转移的因素之一。

【总页数】3页(P121-123)
【作者】肖锋;张晓伟;张杰;胡建功
【作者单位】泰山医学院附属医院，山东泰安 271000;泰山医学院附属医院，山东泰安 271000;泰山医学院附属医院，山东泰安 271000;泰山医学院附属医院，山东泰安 271000
【正文语种】中文
【中图分类】R571
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