维药买朱尼对骨关节炎大鼠模型关节软骨中基质金属蛋白酶1和基质金属蛋白酶抑制剂1的影响

维药买朱尼对骨关节炎大鼠模型关节软骨中基质金属蛋白酶1和基质金属蛋白酶抑制剂1的影响
张耀武;方锐;刘振峰;艾力江·阿斯拉;孟庆才
【期刊名称】《中国组织工程研究》
【年(卷),期】2011(015)052
【摘要】背景:骨关节炎患者关节软骨的损害与基质金属蛋白酶1和基质金属蛋白酶抑制剂失平衡有关.目的:观察基质金属蛋白酶1、基质金属蛋白酶抑制剂1在关
节软骨中的表达及维药买朱尼对其影响.方法:将20只SD大鼠采用改良Hulth造
模法建立大鼠膝骨关节炎模型,按随机数字表法随机等分为买朱尼组和模型组,建模
第2周开始分别灌胃维药买朱尼和生理盐水,连续4周.结果与结论:相比于模型组,
买朱尼组大鼠膝关节软骨退变程度减轻,软骨大体评分及Mankin评分降低(P <
0.05),且膝关节软骨细胞中基质金属蛋白酶1的表达降低,基质金属蛋白酶抑制剂1的表达增加(P < 0.05).说明维药买朱尼可以通过下调基质金属蛋白酶1的表达水平、上调抑制剂的表达水平,对软骨产生保护作用.%BACKGROUND: Articular cartilage damage in osteoarthritis patients is related to the imbalance between matrixmetalloproteinase 1 and tissue inhibitors of matrix metalloproteinase.OBJECTIVE: To investigate the expression of matrix metalloproteinase 1 and tissue inhibitor of matrix metalloproteinase 1 inarticular cartilage and the intervention effects of Uygur medicine Maizhuni.METHODS: Knee osteoarthritis model was constructed using modified Hulth method. A total of 20 healthy SD rats were randomlydivided into Maizhuni group and model group. Rats were treated
with Uygur medicine Maizhuni or saline by gavage in the 2ndweek after model construction for 4 weeks.RESULTS AND CONCLUSION: Compared with model group, the degree of rat knee joint cartilage degeneration in Maizhunigroup was alleviated. The cartilage general score and Mankin score in Maizhuni group was lower than that in the model group (P< 0.05). The expression of matrix metalloproteinase 1 in knee joint chondrocytes of Maizhuni group decreased than that of thecontrol group (P < 0.05); the expression of tissue inhibitor of matrix metalloproteinase 1 in Maizhuni group increased than that inthe model group (P < 0.05). These findings indicate that Uyghur medicine Maizhuni may protect articular cartilage bydown-regulating the expression of matrix metalloproteinase 1 and up-regulating the expression of tissue inhibitor of matrixmetalloproteinase 1.【总页数】5页(P9696-9700)
【作者】张耀武;方锐;刘振峰;艾力江·阿斯拉;孟庆才
【作者单位】新疆医科大学,新疆维吾尔自治区乌鲁木齐市,830054;新疆维吾尔自治区中医医院,新疆维吾尔自治区乌鲁木齐市,830000;新疆维吾尔自治区中医医院,新疆维吾尔自治区乌鲁木齐市,830000;新疆维吾尔自治区中医医院,新疆维吾尔自治区乌鲁木齐市,830000;新疆维吾尔自治区中医医院,新疆维吾尔自治区乌鲁木齐市,830000
【正文语种】中文
【中图分类】R318
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