The role of eosinophils in asthma

The role of eosinophils in asthma
Faris Q. Alenzi;Fahad G. B. Alanazi;Abdulaziz D. Al-Faim;Mohamed W. Al-Rabea;Waleed Tamimi;Bassel Tarakji;Omar Kujan;Ali Al-Jabri;Richard K. H. Wyse
【期刊名称】《健康（英文）》
【年(卷),期】2013(5)2
【摘要】Asthma is a chronic inflammatory disorder of the airways characterized by recurring episodes of reversible airway obstruction, hyper-responsiveness, wheezing, breathlessness and coughing. Clinical diagnosis of asthma is based on the pattern of clinical symptoms and pulmonary fuction tests. Asthma affectes 5% - 10% of the population and the number of worldwide cases is approximately 300 milliones. The incidence of this disease is increasing particulry in western countries [1]. It is the cause of a huge economic burden to national healthcare services. In a minority of cases, asthma is potentially fatal. After a period when fatalities appeared to be increasing [2], in recent years asthma-related mortality has progressively declined due to the develop- ment of specific asthma disease management programs, as well as the extensive use of in- haled corticosteroids [3]. Inflammation of the airways is a central component in asthma. In- flammation is associated with infliltration of the airway wall with eosinophiles and or neutron- philes mast cell degranulation and T cell active- tion. Other pathological features include, sub- basement membrane thickening, loss of epithet- lial cell integrity,
goblet cells hyperplasia In- crease in airway smooth muscle mass. Eosino- phils are thought to be vital in the development of airway hyperreactivity, with the eosinophil cationic protein playing a crucial role [4]. The fact that treatment of asthma with corticos-teroids reduces eosinophils numbers and decreases airway reactivity further supports this hypothesis.
【总页数】5页(P339-343)
【关键词】Eosinophils;Asthma
【作者】Faris Q. Alenzi;Fahad G. B. Alanazi;Abdulaziz D. Al-Faim;Mohamed W. Al-Rabea;Waleed Tamimi;Bassel Tarakji;Omar Kujan;Ali Al-Jabri;Richard K. H. Wyse
【作者单位】College of Applied Medical Sciences, Salman bin Abdulaziz University, Al-Kharj, Saudi Arabia;College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;Department of Microbiol & Immunology, College of Medicine, Sultan Qaboos University, Muscat, Oman;Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia;Department of Pathology, Al-Farabi Medical College, Riyadh, Saudi Arabia;Department of Pharmacy, Ministry of Health, Riyadh, Saudi Arabia;Department of Preventive Medicine, Ministry of Health, Riyadh, Saudi Arabia;Imperial College of Medicine, London, UK
【正文语种】中文
【中图分类】R5
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