固体制剂生产线设备

固体制剂生产线设备
Individual Team Member Document
Role:Equipment Dongkai Li
The equipment used in our process is listed below.
The specifications of every piece of equipment and its advantages are included below.
Milling:
Fig.1HammerWitt 3
Specifications:Particle Size Range 2cm-30μm Capacity (Kg/h)Up to 700Density (kg/dm 3)2Temperature Range (℃) -20~60
Process Equipment Milling HammerWitt 3
Blending Tapasya SAI-V-5V-Blender Granulation PHARMX px 250Drying
SEJONG D1000(E)Tablet Compression SEJONG P580D 51S Tablet Coating Riddhi Automatic Coating System 1675mm Packaging
NJM Turnkey Line
Advantages:
Hammer mill process.
Very broad scope of application ranging from all types of dry to wet powders.
High level of production safety and operation safety.
Easy and quick Cleaning-in-place.
Clear GMP-capable concept for smooth,reproducible production.
Blending:
Fig.2Tapasya SAI-V-5V-Blender
Specifications:
Dimensions(L X W X H)(mm)2900X1600X3300
Gross Capacity(L)500
Working Capacity(L)300
Power(KW) 5.5
Available Options PLC controls,integrated vacuum loading Maximum batch size is300L,suppose the density is0.5g/mL,then the batch size is150kg,and it takes about15minutes for one batch.The maximum output is600kg/h.
Advantages:
Easy to clean.
Minimum maintenance.
Material of construction is SS316.
Particle size reduction and attrition are minimized due to the absence of any moving blades.
The absence of shaft projection eliminates product contamination.
Granulation
Fig.3PHARMX px250
Specifications:
Total Bowl Volume(L)274
Maximum Charge Volume(L)246
Impeller Speed(RPM)172
Chopper Speed(RPM)500-4000
Power(KW)37
Suppose the density is0.5g/mL,the maximum batch size is123kg,and it takes10minutes for one batch.
Advantages:
Wet granulation process.
Optimized bowl geometry permits operation up to90%capacity for larger batches.
Equipped with auto-cleaning and liftable tool systems for easy clean-up and inspection.
Robust variable speed chopper and impeller drive systems for maximum energy transfer. Drying:
Fig.4SEJONG D1000(E)
Specifications:
Container Capacity(L)1000
Dimensions(L X W X H)(mm)1600X2050X5100
Suppose the density is0.5g/mL,the maximum batch size is500kg,and it takes1hour for one batch. Advantages: Fluid bed drying process.
Fast drying rate.
Tablet Compression:
Fig.5SEJONG P580D51S
Specifications:
Number of Stations20
Pre Compression Force(KN)30
Main Compression Force(KN)100
Maximum Tablet Diameter(mm)19
Depth of Fill(mm)8.5
Maximum Production Rate(tablets/h)550800
Advantages:
Fully automated production tablet compress.
Prevent powder inflow with dust seal.
Tablet Coating:
Fig.6Riddhi Automatic Coating system1675mm
Specifications:
Capacity(Kg)350-500
Pan Mouth Diameter(mm)520
Pan Speed2-8RPM
Power(KW)14.6
Advantages:
Film coating process.
Single stage with relatively short production time.
Packaging Line:
Fig.7NJM Turnkey Line
This integrated packaging line is fully automatic,includes unscrambler,desiccant inserter,tablet counter,cottoner,capper,weigher,labeling equipment,as well as automatic inspection system and optional cartoner.It’s TEF(Tablet Entrapment Free)conveyor is designed for solid dose packaging ease of inspection of trapped products,easy in-line clearance during product changeovers,increasing
uptime and eliminating foreign product cross contamination.
This packaging line has a design speed of160bpm based on100-count bottles,packaging finished tablets in plastic bottles.Suppose the density is0.5g/ml,and each tablet is0.5g,the maximum output is480kg/h.
Capacity:
The production process and the maximum output per hour of every equipment is as Fig.8,two pieces of compressing and coating equipment are used because of its relatively low capacity.
Fig.8Production process
If a batch of100kg size is being delivered,the required time in each unit operation is as below:
Pre-blending:15minutes.
Milling:8.4minutes.
Granulation:10minutes.
Drying:1hour.
Final blending:15minutes.
Compressing:10.9minutes.
Coating:2hours.
Packaging:12.5minutes.
So,the total delivery time for a500kg batch is4.2hours.
If a batch of500kg size is being delivered,the required time in each unit operation is as below:
Pre-blending:60minutes.
Milling:42minutes.
Granulation:50minutes.
Drying:1hour.
Final blending:60minutes.
Compressing:54.5minutes.
Coating:2hours.
Packaging:62.4minutes.
So,the total delivery time for a500kg batch is8.5hours.
If a batch of1000kg size is being delivered,the required time in each unit operation is as below: Pre-blending:105minutes.
Milling:85.7minutes.
Granulation:90minutes.
Drying:2hours.
Final blending:105minutes.
Compressing:109.1minutes.
Coating:2hours.
Packaging:125minutes.
So,the total delivery time for a500kg batch is14.3hours.。