Gene therapy agent for Haemophilia B and its prepa
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专利名称：Gene therapy agent for Haemophilia B and its preparation method
发明人：Jiahui Xia
申请号：US10362916
申请日：20010829
公开号：US07361639B2
公开日：
20080422
专利内容由知识产权出版社提供
摘要：The invention relates to site-specific integrating expression vectors for therapy Hemophilia B and to methods of preparing them. A vector of the invention contains a human Factor IX gene in a vector constructed using as a chromosome targeting sequence a polynucleotide without any important physiological function-related gene homologous to DNA on the short arms of human group D and human group G chromosomes. The vector of the invention provides high stability of Factor IX expression, high expression efficiency, no immunogenicity and safety in use.
申请人：Jiahui Xia
地址：c/o National Lab of Medical Genetics of China, Central South University, 88 Xiangya Rd. Changsha, Hunan 410078 CN
国籍：CN
代理机构：Birch, Stewart, Kolasch & Birch, LLP
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