外周血白细胞与急性缺血性卒中的相关性研究

外周血白细胞与急性缺血性卒中的相关性研究
栗静;田婷;石正洪;冯斌
【期刊名称】《中国实用神经疾病杂志》
【年(卷),期】2017(020)006
【摘要】Objective To investigate the relationship between the early leukocyte counts and its subtypes in the peripheral blood with the incidence and development of acute ischemic stroke(AIS).Methods A total of 588 patients with AIS and 630 pa-tients free of stroke matched with gender and age were recruited in this study.The clinical data of the two groups were compared and the multi-factor Logistic regression was used.AIS patients were divided into lacunar AIS group(n=151)and non-lacunar AIS group(n=437)according to infarction size scanned by CT or MRI.The related leukocyte parameters of the two groups were com-pared and the multi-factor Logistic regression was used.Results The leukocyte counts,neutrophil counts and neutrophil to lym-phocyte ratio(NLR)in the AIS group were higher than those in the control group(P<0.05);the Logistic regression analysis showed that the leukocyte
counts(OR=1.073,95%CI:1.017~1.132,P=0.009)and neutrophil
counts(OR=1.068,95% CI:1.001~1.139,P=0.046)entered the regression pared with the lacunar AIS group,the leukocyte counts of the non-lacunar AIS group was higher,with a statistically significant difference(P<0.05);the Logistic regression analysis showed that the
leukocyte counts(OR=0.898,95%CI:0.811~0.995,P=0.040)entered the regression equation.Conclusion The elevated leu-kocyte and neutrophil counts are independent risk factors for AIS,and the low leukocyte counts is independent risk factor for lacu-nar AIS.So the leukocyte counts has a certain predictive value in the incidence and infarction volume of AIS.%目的探讨外周血早期白细胞及其亚型与急性缺血性卒中(AIS)发生、发展的关系.方法连续收集AIS住院患者588例,性别和年龄匹配的非脑卒中患者630例,比较2组患者的临床资料并进行多元Logistic回归分析.根据头颅CT或MRI梗死面积大小将AIS患者分为腔隙性AIS组151例和非腔隙性AIS组437例,比较2组白细胞参数并进行多元Logistic回归分析.结果 AIS组白细胞、中性粒细胞及中性粒细胞/淋巴细胞比值(NLR)高于对照组,差异有统计学意义(P<0.05);Lo-gistic回归分析显示,白细胞计数(OR=1.073,95%CI:1.017~1.132,P=0.009)和中性粒细胞计数(OR=1.068,95%CI:1.001~1.139,P=0.046)进入回归方程.非腔隙性AIS组白细胞计数高于腔隙性AIS组,差异有统计学意义(P<0.05);Logistic回归分析显示,白细胞计数(OR=0.898,95%CI:0.811~0.995,P=0.040)进入回归方程.结论白细胞和中性粒细胞升高是AIS的独立危险因素,低白细胞计数为腔隙性AIS的危险因素,白细胞计数对AIS的发生及梗死面积具有一定的预测价值.
【总页数】5页(P1-5)
【作者】栗静;田婷;石正洪;冯斌
【作者单位】兰州大学第二医院神经内科兰州 730000;兰州大学第二医院神经内科兰州 730000;兰州大学第二医院神经内科兰州 730000;兰州大学第二医院神经内科兰州 730000
【正文语种】中文
【中图分类】R743.33
【相关文献】
1.整合数CD11c/CD18在急性缺血性卒中患者外周血白细胞表达及意义 [J], 夏文伟;赵薛旭;李作汉
2.急性缺血性卒中患者外周血白细胞表面黏附分子β2整合素CD11c、CD18表达的研究 [J], 夏文伟;赵薛旭;李作汉;姜亚军;王玲;狄晴;石静萍
3.外周血白细胞计数、C反应蛋白/白蛋白比值与动脉瘤性蛛网膜下腔出血患者短期预后相关性研究 [J], 符传铰;夏鹰;陈华澎
4.新冠病毒肺炎与外周血白细胞检测的相关性研究 [J], 赵晶;贾丽丽;李文刚
5.2型糖尿病患者外周血白细胞、中性粒细胞/淋巴细胞比值与泌汗功能相关性研究 [J], 何莲莲;应瑞雪;艾李雅;张楠;章诗琪;孙小红;代芳
因版权原因，仅展示原文概要，查看原文内容请购买。