川崎病患儿血浆氨基末端脑钠肽前体、高敏C反应蛋白表达水平及其意义

川崎病患儿血浆氨基末端脑钠肽前体、高敏C反应蛋白表达
水平及其意义
顾勇;窦常胜;严颜
【期刊名称】《皖南医学院学报》
【年(卷),期】2014(33)2
【摘要】Objective:To assess the significance of detecting the plasma N-terminal prob-rain natriuretic peptide ( Nt-proBNP ) and high sensitive C-reactive protein (hsCRP) expression in children with Kawasaki disease ( KD ) .Methods:The plasma Nt-proBNP and hsCRP levels were measured by enzyme-linked immunosorbent assay ( ELISA) in 29 children with KD in their acute stage and recovery stage and another 29 patients with other febrile illnesses as well as 20 healthy subjects,respectively.Results:The serum levels of Nt-proBNP and hsCRP in KD children in acute stage were significantly higher than those in recovery stage and normal controls as well as other febrile diseases ( P <0 .01 ) ,yet the levels of hsCRP remained no significant differ-ence as compared with those with other febrile diseases.Conclusion:Plasma NT-pro BNP level can serve as a favorable serological marker for early diagno-sis of KD for its highly
specificity.Although hsCRP fails to be diagnostic index for early KD,it is still as one of the targets to estimate the activity this entity.%目的：检测川崎病（kawasaki disease，KD）患儿血浆中氨基末端脑钠肽前体（Nt -proBNP）及高敏C反应蛋白（hsCRP）的表达，并探讨其临床意义。

方法：采用ELISA法分
别测定29例KD患儿急性期、恢复期血浆NT-proBNP和hsCRP，并同时检测
29例其他发热性疾病患儿及20例健康对照儿童血浆NT-proBNP和hsCRP水平。

结果：KD急性期患儿血浆NT-proBNP和hsCRP水平明显高于恢复期患儿（ P
＜0．01）及健康对照儿童。

KD患儿NT-proBNP明显高于其他发热性疾病，但hsCRP水平与其他发热性疾病相比，差异无显著性。

结论：NT-proBNP具有较
强的特异性，可作为KD早期诊断较好的血浆学指标，hsCRP不能作为KD早期
诊断指标，但可作为判断疾病活动性的指标之一。

【总页数】3页(P117-118,124)
【作者】顾勇;窦常胜;严颜
【作者单位】皖南医学院附属弋矶山医院儿科，安徽芜湖 241001;皖南医学院附属弋矶山医院儿科，安徽芜湖 241001;皖南医学院附属弋矶山医院儿科，安徽
芜湖 241001
【正文语种】中文
【中图分类】R725.4
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