IL-6和IL-8在早产儿的早期变化及其与预后的关系

IL-6和IL-8在早产儿的早期变化及其与预后的关系
张小莉;王艳芬;南晓琴;傅葵;孙丽霞;刘鹏
【期刊名称】《中国临床实用医学》
【年(卷),期】2016(007)003
【摘要】Objective To investigate the changes of serum IL-6 and IL-8 and CRP the relationship between the expression and prognosis in premature infants. Methods The birth gestational age less than or equal to 34 weeks premature after birth respectively after admission was (<24 hours) and admission and on the seventh day the blood samples were taken for measurement of serum IL-6 and IL-8 and CRP levels, all infants were in admission after 3-7 days of cranial ultrasound examination;corrected gestational age 40 weeks of neonatal behavioral neurological capacity determination (NBNA) and cranial MRI+DWI scanning;corrected age 1 year old seasonal movement development index (PDI) and intelligent development index (MDI) assessment. PDI and MDI suspicious/abnormal column into a group A(n=11), normal were classified as group B (n=15) and retrospective analysis in the early neonatal IL-6, IL-8 and CRP levels. Results The levels of IL-6 and IL-8 in the two groups were statistically different, the A group was higher than that in B group, while the two groups had no significant difference between the two groups. The NBNA group had statistically significant difference between the 40 groups, while the MRI group was lower than that in A group, and the difference between
the two groups was not statistically significant.. Conclusion The levels of and IL-6 were significantly increased in the early stage of IL-8 and PDI, which was related to the decrease of and MDI.%目的：探讨早产儿生后一周
内血清白细胞介素-6（IL-6）和白细胞介素-8（IL-8）及C反应蛋白（CRP）的变化及其与预后的关系。

方法选取2013年1月至2014年6月在山西大医院儿科新生儿重症监护中心（NICU）住院的胎龄≤34周的早产儿共26例作为研究对象，
对出生时胎龄≤34周的早产儿于出生后分别于入院后当时（<24 h）和入院第7
天采血检测血清IL-6和IL-8及CRP水平，全部患儿均在入院后3～7 d进行头颅超声检查，纠正胎龄40周行新生儿行为神经能力（NBNA）测定和头颅
MRI+DWI扫描，纠正年龄1岁时行运动发育指数（PDI）和智能发育指数（MDI）评估，将PDI和MDI可疑/异常者列为A组（11例），正常者列为B组（15例），回顾性地分析其在新生儿早期的IL-6、IL-8及CRP水平。

结果两组早产儿早期的IL-6、IL-8水平差异有统计学意义，A组高于B组；而两组CRP水平差异无统计学意义；两组纠正年龄40周时的NBNA得分差异有统计学意义，A组低
于B组；而相应的头颅超生及MRI检查异常率二组之间的差异无统计学意义。

结论早期IL-6、IL-8水平的显著升高与纠正年龄1岁时降低的PDI和MDI有关。

【总页数】4页(P24-27)
【作者】张小莉;王艳芬;南晓琴;傅葵;孙丽霞;刘鹏
【作者单位】030032 山西大医院儿科;030032 山西大医院儿科;030032 山西大医院儿科;030032 山西大医院儿科;太原市妇幼保健院;030032 山西大医院儿科
【正文语种】中文
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