精神分裂症、神经症、抑郁症患者的脑电超慢涨落图分析

精神分裂症、神经症、抑郁症患者的脑电超慢涨落图分析蒋帅;吴银侠;王大刚;刘光雄;马文涛;杨来启
【期刊名称】《山东医药》
【年(卷),期】2014(000)020
【摘要】Objective To observe the differences of neurotransmitters , brain function and entropy values in 0-29 year-old outpatients with schizophrenia , neurosis, and depression by encephaloflugram technology (ETG).Methods The outpa-tients with schizophrenia , neurosis and depression were tested once by encephaloflugram technology , then the differences be-tween the neurotransmitters , brain function, and entropy values were analyzed .Results The Ach and INH were significantly higher in patients with schizophrenia than the normal (all P<0.05), but GABA and DA were significantly below the normal (all P<0.05).5-HT and Ach in patients with neurosis were significantly higher than normal (all P<0.05).Ach and INH in patients with depression were significantly higher than normal (all P<0.05), while GABA, NE and DA were significantly lower than the normal (all P<0.05).Comparison between different sexes with the same disease showed that the GABA of male patients with schizophrenia was significantly lower than that of females (P<0.05).Comparison between the same men suffering from different diseases showed that significant differences were found in GABA and age (all P<0.05).On brain function , the ratio in cerebral ischemia and hypoxia′s normal female patients with
depression was the least as well as excitato-ry and inhibitory male patients with neurosis .Comparison between different diseases′entropy and the normal showed that schizo phrenia, neurosis, depression′s brain entropy was in the normal range , patients with schizophrenia had maximum entro-py and worst orderly brain , and patients with neurosis had the minimum entropy and the best order .Three diseases′entropy analysis of var iance found that there were significant differences in C 4, T4, T5, P4, T6, O1 and
O2 leads (all P<0.05). Comparison between the different gender entropy values of the same disease found that there were significant difference in FP1 and F8 of patients with schizophrenia between men and women (all
P<0.05).Significant difference was found in T6 between neurosis men′s entropy values and women′s (P<0.05).Comparison between different diseases′lead entropy of the same female patients showed that there were significant differences in F7, C3, C4, T4, T5, P4, T6, O1 and O2 (all
P<0.05).Conclusion The decrease of the GABA function may be the main reason of neuropsychiatric diseases .Women with depression are accompa-nied by symptoms of ischemia and hypoxia, and the self-restraint of male neurotic patients is more evident.The differences of GABA levels, the brain order and temporal, occipital entropy may help in the differential diagnosis of the three diseases .%目的：利用脑电超慢涨落图
（ EFG）研究门诊0～29岁精神分裂症、神经症、抑郁症患者脑内神经递质、脑
功能、各导联熵值的差异。

方法采用脑电超慢涨落分析仪，对精神分裂症、神经症、抑郁症患者各检测一次，分析不同疾病、性别的精神疾病患者脑内神经递质、脑功能、各导联熵值的差异。

结果精神分裂症患者，乙酰胆碱（Ach）、深抑制递质
（INH）显著高于正常值（P均＜0．05），γ-氨基丁酸（GABA）、多巴胺（DA）显著低于正常值（P均＜0．05）。

神经症患者，5-羟色胺（5-HT）、Ach显著
高于正常值（P均＜0．05）。

抑郁症患者，Ach、INH显著高于正常值（P均＜0．05），GABA、NE、DA显著低于正常值（P均＜0．05）。

同疾病不同性别
的比较发现，精神分裂症男性患者GABA显著低于女性（P＜0．05）。

同为男性患不同疾病的比较发现，在GABA和年龄上存在统计学差异（P均＜0．05）。

脑功能上，脑缺血缺氧女性抑郁症患者正常比值最少，兴奋和抑制男性神经症患者正常比值最少。

不同疾病患者熵值与正常值之间比较发现，三种疾病患者的大脑熵值在正常值范围内且偏高，精神分裂症各导联熵值最高，大脑有序性最差，神经症在大多数导联熵值最低，大脑有序性最好。

三种疾病患者的熵值进行方差分析发现，在C4、T4、T5、P4、T6、O1、O2导联存在统计学差异（ P均＜0．05）。

同
一疾病不同性别患者熵值之间比较发现，精神分裂症在FP1、F8导联男女熵值存
在统计学差异（P均＜0．05）。

神经症在T6导联男女熵值存在显著性差异（P＜0．05）。

同为女性不同疾病患者熵值比较，在F7、C3、C4、T4、T5、P4、T6、O1、O2导联存在统计学差异（P均＜0．05）。

结论 GABA功能减低可能是神经精神类疾病的主要原因；女性抑郁症患者伴随缺血缺氧的症状较多，男性神经症患者的自我抑制较为明显；GABA水平、大脑有序性及颞部、枕部的熵值差异有助
于三种疾病的鉴别诊断。

【总页数】5页(P1-4,8)
【作者】蒋帅;吴银侠;王大刚;刘光雄;马文涛;杨来启
【作者单位】中国人民解放军第三医院全军精神卫生中心，陕西宝鸡721004;中
国人民解放军第三医院全军精神卫生中心，陕西宝鸡721004;中国人民解放军第
三医院全军精神卫生中心，陕西宝鸡721004;中国人民解放军第三医院全军精神
卫生中心，陕西宝鸡721004;中国人民解放军第三医院全军精神卫生中心，陕西宝鸡721004;中国人民解放军第三医院全军精神卫生中心，陕西宝鸡721004【正文语种】中文
【中图分类】R749
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