MVD和VEGF在乳腺癌组织中的表达及其临床意义

MVD和VEGF在乳腺癌组织中的表达及其临床意义
吴红革;刘履光
【期刊名称】《华中科技大学学报（医学版）》
【年(卷),期】2001(030)002
【摘要】The clinical implication of microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in breast cancer and the relationship between them were studied. Specimens of 53 cases of breast cancer were examined for MVD in tumor and VEGF expression by using immunohistochemical staining. The results showed that the mean MVD in node-positive breast cancers and in the patients with postoperative distant metastasis was higher than that in node-negative breast cancers and those without metastasis, respectively (both P<0.01). The expression rate of VEGF in breast cancer was 67.92 % and was closely relative to MVD. It was suggested that MVD was closely correlated with metastasis of the tumors and might be a useful prognostic indicator for breast cancer. VEGF might be an important factor responsible for the induction of angiogenesis in breast cancer.%运用免疫组织化学方法研究了53例乳腺癌石蜡切片中微血管密度(MVD)和血管内皮生长因子(VEGF)的表达,探讨二者的关系及其在乳腺癌预后中的价值.结果发现:腋下淋巴结阳性病例组的MVD明显高于腋下淋巴结阴性组
(P<0.01).术后出现转移病例中的MVD高于无转移病例(P<0.001).VEGF的表达率为67.92%,且与MVD具有相关性.提示MVD与肿瘤的转移密切相关,是乳腺癌的一个预后指标,而VEGF对肿瘤内的血管生成可能起重要作用.
【总页数】3页(P148-150)
【作者】吴红革;刘履光
【作者单位】华中科技大学同济医学院附属协和医院肿瘤科,;华中科技大学同济医学院附属协和医院肿瘤科,
【正文语种】中文
【中图分类】R737.9;Q56
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