急性脑水肿时血浆和脑脊液β-内啡肽的变化及其意义

急性脑水肿时血浆和脑脊液β-内啡肽的变化及其意义
李光乾;胡鸿文;郑美琴;张雅丽;林忠东;叶秀云
【期刊名称】《临床儿科杂志》
【年(卷),期】2001(19)1
【摘要】为探讨β-内啡肽(β-EP)在急性脑水肿发病中的作用，采用放射免疫法检
测了69例中枢神经系统感染患儿(脑水肿组39例，无脑水肿组30例)和19例对
照组小儿的血浆和脑脊液(CSF)中β-EP含量。

结果显示：脑水肿组、无脑水肿组
和对照组血浆β-EP含量分别为50.74ng/L±26.60ng/L、32.78ng/L±21.20ng/L 和14.83ng/L±6.55ng/L，三组CSF中β-EP含量分别为62.72ng/L±39.23ng/L、34.13ng/L±30.26ng/L和9.77ng/L±6.33ng/L；脑水肿组血浆和CSF中β-EP均显著高于其他两组(P＜0.01)。

结果表明，β-EP在脑水肿的发生发展中起着重要作用。

%To explore the role of β-endorphin (β-EP) in the pathogenesis of the acute encephaledema, the levels of β-EP in both of plasma and CSF were determined by radioimmunoassay in 69 children with infection of central nervous system consisting of 39 cases with encephaledema and 30 cases without encephaledema, respectively. Another 19 cases without intracranial infection were as the control group. The results showed that
the levels of plasma and CSF β-EP in the encephaledema group (50.74
ng/L±26.60ng/L，62.72ng/L±39.23ng/L) were significantly higher than those in without encephaledema group (32.78 ng/L±21.2ng/L，
34.13ng/L±30.26ng/L)and the normal group (14.83ng/L±6.55ng/L，
9.77ng/L±6.33ng/L)，respectively (P＜0.01).It is concluded that β-EP plays
an important role in the occurrence and development of encephaledema
in children with the infection of central nervous system.
【总页数】3页(P23-25)
【作者】李光乾;胡鸿文;郑美琴;张雅丽;林忠东;叶秀云
【作者单位】温州医学院育英儿童医院;温州医学院育英儿童医院;温州医学院育英儿童医院;温州医学院育英儿童医院;温州医学院育英儿童医院;温州医学院育英儿童医院
【正文语种】中文
【中图分类】R725;R742
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