甲状腺功能亢进患者131碘治疗前后骨密度的变化

甲状腺功能亢进患者131碘治疗前后骨密度的变化
王勇;丁勇;邢家骝;张友仁;管美超
【期刊名称】《临床荟萃》
【年(卷),期】2015(000)001
【摘要】目的：探讨甲状腺功能亢进患者131碘（131 I）治疗前后骨密度的变化特点及131 I 治疗甲状腺功能亢进的价值。

方法通过对我科甲状腺功能亢进患者按照治疗前后、性别及年龄（女性绝经后及男性＞50岁设定为高龄组，女性未绝经
及男性≤50岁设为青年组）等因素进行分组，通过对131 I 治疗前[经过抗甲状腺
药物（antithyroid drugs， ATD）治疗后]的骨密度及131 I 治疗后18个月的骨密度测定值进行分析；另选取同期健康体检者140例作为对照组。

结果本组甲状
腺功能亢进患者131 I 治疗前（ATD 治疗后）的骨密度较健康对照组减低，但同
组经131 I 治疗后各部位骨密度较治疗前明显好转（P ＜0．05）。

131 I 治疗前
及治疗后不同性别、不同年龄组骨密度均有差异，且治疗后女性骨密度的变化值与男性组比较差异有统计学意义，青年组骨密度的变化值与高龄组差异有统计学意义（P ＜0．05）。

男女高龄组骨密度的变化值差异亦有统计学意义（P ＜0．05）。

结论甲状腺功能亢进时对骨密度影响较大，与性别、年龄及ATD 的使用关系密切。

ATD 治疗甲状腺功能亢进对骨密度的改善不显著，131 I 治疗后骨密度显著改善，131 I治疗甲状腺功能亢进较 ATD 对骨密度的恢复更具优
势。

%ABSTRACT:Objective To investigate the characteristics of bone mineral density in hyperthyroidism patients before and after 131 I treatment and its clinical value for the disease.Methods Hyperthyroidism patients were grouped by the following factors:before and after
treatment,gender and age (postmenopausal women and men older than 50 years were grouped into elder group;premenopausal women and men younger than 50 years were grouped into youth group).Before 131 I treatment,patients were treated with antithyroid drug(ATD).Then,the bone mineral density was detected.At 18 months after 131 I treatment,bone mineral density was detected again.140 healthy individuals were enrolled as control group at the same time.Results The bone mineral density of hyperthyroidism patients before 131 I therapy but after ATD treatment was significantly reduced as compared with that of the healthy individuals.After 131 I treatment,bone mineral density of each part improved significantly (P <0.05).Before and after 131 I treatment,bone mineral density was remarkably different between gender or age groups.The change in females bone mineral density was markedly different from that in males after 131 I treatment (P < 0.05).The change in bone mineral density of youth group was also prominently different from that of the elder group (P <0.05).For the elder group,bone mineral density changes were also different between men and women (P <0.05).Conclusion Hyperthyroidism has a great effect on bone mineral density,which is closely corelated with gender,age and the use of ATD.ATD treatment for hyperthyroidism has little effect on bone mineral density,whereas 131 I therapy can significantly improve bone mineral density,indicating that 131 I treatment has better effect on the bone mineral density recovery of hyperthyroidism than ATD treatment.【总页数】4页(P74-77)
【作者】王勇;丁勇;邢家骝;张友仁;管美超
【作者单位】解放军第 307 医院核医学科，北京 100071;解放军第 307 医院核医学科，北京 100071;解放军第 307 医院核医学科，北京 100071;解放军第 307 医院核医学科，北京 100071;解放军第 307 医院核医学科，北京 100071
【正文语种】中文
【中图分类】R581.1
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