Broad Spectrum of Streptococcus Lyase and Use Ther
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专利名称：Broad Spectrum of Streptococcus Lyase and
Use Thereof
发明人：Hongping Wei,Hang Yang,Jing Wang,Junping
Yu
申请号：US15564063
申请日：20160412
公开号：US20180104316A1
公开日：
20180419
专利内容由知识产权出版社提供
专利附图：
摘要：This invention discloses a lysin that can kill many species of Streptococci. A new lysin, ClyR, was constructed by the gene splicing method. The ClyR can effectively kill
different species of Streptococci, including , and various Enterococci and . ClyR shows good stability and is not sensitive to EDTA and high concentration of NaCl. Moreover, the ClyR is active in a wide range of pH and maintains high activity in pH 5-11. Recombinant protein ClyR is well expressed in stain BL21 (DE3). High doses of ClyR showed no apparent toxicity in mice. Furthermore, administration of 0.8 mg per mouse once is able to completely protect the mouse infected with lethal doses of Group B Streptococci. The ClyR can be used alone or in combination with different forms of reagents and solutions, for the control of a variety of Streptococci and for the treatment of infections caused by these bacteria. It has a broad application prospect.
申请人：Wuhan Phagelux Bio-Tech Company Limited
地址：Wuhan City CN
国籍：CN
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