复发-缓解型多发性硬化患者血清中CRP及Hcy水平分析

复发-缓解型多发性硬化患者血清中CRP及Hcy水平分析陈左然;石富铭;董立平;邸明明;李颖
【期刊名称】《脑与神经疾病杂志》
【年(卷),期】2016(024)008
【摘要】目的：探讨复发—缓解型多发性硬化（RRMS）患者血清中C反应蛋白（CRP）、同型半胱氨酸（Hcy）、维生素B12及叶酸水平，并探讨上述因子与RRMS发病的关系。

方法选取21例急性期的RRMS患者作为RRMS组，21例同期住院的神经性头痛患者作为对照组，测定其血清中CRP、Hcy、叶酸及维生素B12水平，并比较两组之间的水平差异；并比较RRMS组中不同性别、不同残疾程度组之间的血清CRP、Hcy、叶酸及维生素B12水平。

结果 RRMS组患者血清中CRP及Hcy水平高于对照组，而叶酸及维生素B12水平低于对照组，
（P<0.05）。

而扩展残疾状况评分量表评分（EDSS）>4分的RRMS患者血清中Hcy及CRP水平高于EDSS评分≤4分的RRMS患者，（P<0.05）。

结论血清中高CRP、Hcy水平可能与RRMS发病及残疾程度有关。

%Objective To investigate the levels of serum C-reactive protein, homocysteine, vitamin B12 and folate in patients with relapsing remitting multiple
sclerosis(RRMS), and the relationship between the levels of factors and disease activity. Method We collected 21 cases of RRMS in acute phase as RRMS group, and 21 cases of neurologic headache as control group. The levels of serum C-reactive protein, homocysteine, vitamin B12 and folate were measured and compared in different groups. We also compared the levels of serum C-reactive protein, homocysteine, vitamin B12 and folate in
different genders and severity of RRMS. Results The levels of serum C-reactive protein and homocysteine in RRMS patients were significantly higher than those in patients of neurologic headache patients (P<0.05). The levels of serum vitamin B12 and folate in RRMS patients were lower than in patients of neurologic headache patients (P<0.05). The serum levels of C-reactive protein and homocysteine in the RRMS group with higher EDSS (>score 4) were significantly higher than the lower group (≤score 4). Conclusion The higher levels of serum C-reactive protein and homocysteine were probably correlated with the course and severity of RRMS.
【总页数】4页(P494-497)
【作者】陈左然;石富铭;董立平;邸明明;李颖
【作者单位】102600 北京，北京市大兴区人民医院神经内科;102600 北京，北京市大兴区人民医院神经内科;102600 北京，北京市大兴区人民医院神经内
科;102600 北京，北京市大兴区人民医院神经内科;102600 北京，北京市大兴区人民医院急诊科
【正文语种】中文
【中图分类】R745
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