Dictamine_484-29-7_DataSheet_MedChemExpress
BLU9931_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC 50 of 3 nM, about 297–, 184–, and 50–fold selectivity over FGFR1/2/3, respectively.IC50 & Target: IC50: 3 nM (FGFR4)In Vitro: In MDA–MB–453 cells, BLU9931 potently inhibits phosphorylation of FGFR4 signaling pathway. BLU9931 inhibitsproliferation of HCC cell lines that express an intact FGFR4 signaling complex, such as Hep 3B, HUH–7, and JHH–7 cell lines, with EC 50of <1 μM. BLU9931 also inhibits proliferation in PDX–derived cell lines with an intact FGFR4 signaling pathway [1]. BLU9931 induces tumor shrinkage in hepatocellular carcinoma models that express a functioning ligand/receptor complex consisting ofFGF19/FGFR4/KLB and adds to a growing list of anti–FGFR4 agents [2].In Vivo: BLU9931 (300 mg/kg, p.o.) leads to tumor regression and prevents this weight loss in mice bearing the FGF19–amplified Hep 3B liver tumors. In mice bearing the FGF19–overexpressing PDX–derived LIXC012 xenografts, treatment with BLU9931 (300mg/kg, p.o.) also leads to tumor regression [1].PROTOCOL (Extracted from published papers and Only for reference)Kinase Assay:[1]FGFR kinase inhibition assays are performed at KM for ATP. Picomolar to low nanomolar concentrations of FGFR proteins are incubated in 1× Kinase Reaction Buffer (KRB) with 1 μM of CSKtide and 50 to 250 of μM ATP at 25°C for 90 minutes in the presence or absence of a dosed concentration series of inhibitor. All reactions are terminated by the addition of Stop buffer, and plates are read on a Caliper EZReader2. IC 50 values are fit with a four–parameter log[Inhibitor] versus response model with floating Hill Slope.Cell Assay: BLU9931 is dissolved in DMSO.[1]established and PDX–derived HCC cell lines are seeded in 96–well plates in respective growth media, allowed to attach overnight, and treated with a dilution series of test compounds for two cell–doubling times. Cell viability is determined by CellTiter–Glo, and results represented as background–subtracted relative light units normalized to a DMSO–treated control. Relative EC 50 values are determined at 50% inhibition between the top and bottom plateau of thedose–response curve.Animal Administration: BLU9931 is formulated in 0.5% carboxymethylcellulose/1% Tween 80.[1]BLU9931 is formulated in 0.5%carboxymethylcellulose/1% Tween 80 and dosed orally as a suspension twice daily. Sorafenib is dissolved in Cremaphor:EtOH (1:1) and diluted with saline or water to yield the stock solution. Sorafenib is dosed orally once daily. All compound doses are expressed as mg/kg free base. For PK–PD studies, 3 mice are included in each treatment group. Mice receive four doses of compound or vehicle.Blood and tumors are collected 8, 12, 20, and 24 hours following the last dose. The concentration of BLU9931 in plasma is determined by LC/MS–MS. A section of each tumor is immediately frozen in liquid nitrogen and stored at -80°C.Product Name:BLU9931Cat. No.:HY-12823CAS No.:1538604-68-0Molecular Formula:C 26H 22Cl 2N 4O 3Molecular Weight:509.38Target:FGFR Pathway:Protein Tyrosine Kinase/RTK Solubility:DMSO: 17 mg/mLReferences:[1]. Hagel M, et al. First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway. Cancer Discov. 2015 Apr;5(4):424–37.[2]. Packer LM, et al. Paralog–Specific Kinase Inhibition of FGFR4: Adding to the Arsenal of Anti–FGFR Agents. Cancer Discov. 2015 Apr;5(4):355–7.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Dictamine_484-29-7_DataSheet_MedChemExpress
Caution: Not fully tested. For research purposes only Medchemexpress LLC
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Product Data Sheet
Dictamine 484-29-7 HY-N0849 199.21 C12H9NO2 >98%
Product Name: CAS No.: Cat. No.: MWt: Formula: PurMSO
Mechanisms: Pathways:Others; Target:Others Biological Activity: Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi. IC50 value: Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (∆ψ mm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2]....
Gelucire-14-44-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Nov.-23-2018Print Date:Nov.-23-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Gelucire 14/44Catalog No. :HY-Y1892CAS No. :121548-04-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:N/AMolecular Weight:N/ACAS No. :121548-04-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Pure form-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Oil)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
marked manuscript
Quality evaluation of Flos Lonicerae through a simultaneous determination of seven saponins by HPLC with ELSDXing-Yun Chai1, Song-Lin Li2, Ping Li1*1Key Laboratory of Modern Chinese Medicines and Department of Pharmacognosy, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China2Institute of Nanjing Military Command for Drug Control, Nanjing, 210002, People’s Republic of China*Corresponding author: Ping LiKey Laboratory of Modern Chinese Medicines and Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210009, People’s Republic of China.E-mail address: lipingli@Tel.: +86-25-8324-2299; 8539-1244; 135********Fax: +86-25-8532-2747AbstractA new HPLC coupled with evaporative light scattering detection (ELSD) method has been developed for the simultaneous quantitative determination of seven major saponins, namely macranthoidinB (1), macranthoidin A (2), dipsacoside B (3), hederagenin-28-O-β-D-glucopyranosyl(6→1)-O-β-D- glucopyranosyl ester (4), macranthoside B (5), macranthoside A (6), and hederagenin-3-O-α-L-arabinopyranosyl(2→1)-O-α-L-rhamnopyranoside (7)in Flos Lonicerae, a commonly used traditional Chinese medicine (TCM) herb.Simultaneous separation of these seven saponins was achieved on a C18 analytical column with a mixed mobile phase consisting of acetonitrile(A)-water(B)(29:71 v/v) acidified with 0.5% acetic acid. The elution was operated from keeping 29%A for 10min, then gradually to 54%B from 10 to 25 min on linear gradient, and then keep isocratic elution with 54%B from 25 to 30min.The drift tube temperature of ELSD was set at 106℃, and with the nitrogen flow-rate of 2.6 l/min. All calibration curves showed good linear regression (r2 0.9922) within test ranges. This method showed good reproducibility for the quantification of these seven saponins in Flos Lonicerae with intra- and inter-day variations of less than 3.0% and 6.0% respectively. The validated method was successfully applied to quantify seven saponins in five sources of Flos Lonicerae, which provides a new basis of overall assessment on quality of Flos Lonicerae.Keywords: HPLC-ELSD; Flos Lonicerae; Saponins; Quantification1. IntroductionFlos Lonicerae (Jinyinhua in Chinese), the dried buds of several species of the genus Lonicera (Caprifoliaceae), is a commonly used traditional Chinese medicine (TCM) herb. It has been used for centuries in TCM practice for the treatment of sores, carbuncles, furuncles, swelling and affections caused by exopathogenic wind-heat or epidemic febrile diseases at the early stage [1]. Though four species of Lonicera are documented as the sources of Flos Lonicerae in China Pharmacopeia (2000 edition), i.e. L. japonica, L. hypoglauca,L. daystyla and L. confusa, other species such as L. similes and L. macranthoides have also been used on the same purpose in some local areas in China [2]. So it is an important issue to comprehensively evaluate the different sources of Flos Lonicerae, so as to ensure the clinical efficacy of this Chinese herbal drug.Chemical and pharmacological investigations on Flos Lonicerae resulted in discovering several kinds of bioactive components, i.e. chlorogenic acid and its analogues, flavonoids, iridoid glucosides and triterpenoid saponins [3]. Previously, chlorogenic acid has been used as the chemical marker for the quality evaluation of Flos Lonicerae,owing to its antipyretic and antibiotic property as well as its high content in the herb. But this compound is not a characteristic component of Flos Lonicerae, as it has also been used as the chemical marker for other Chinese herbal drugs such as Flos Chrysanthemi and so on[4-5]. Moreover, chlorogenic acid alone could not be responsible for the overall pharmacological activities of Flos Lonicerae[6].On the other hand, many studies revealed that triterpenoidal saponins of Flos Lonicerae possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil [7-11]. Therefore, saponins should also be considered as one of the markers for quality control of Flos Lonicerae. Consequently, determinations of all types of components such as chlorogenic acid, flavonoids, iridoid glucosides and triterpenoidal saponins in Flos Lonicerae could be a better strategy for the comprehensive quality evaluation of Flos Lonicerae.Recently an HPLC-ELSD method has been established in our laboratory for qualitative and quantitative determination of iridoid glucosides in Flos Lonicerae [12]. But no method was reported for the determination of triterpenoidal saponins in Flos Lonicera. As a series studies on the comprehensive evaluation of Flos Lonicera, we report here, for the first time, the development of an HPLC-ELSD method for simultaneous determination of seven triterpenoidal saponins in the Chinese herbal drug Flos Lonicerae, i.e.macranthoidin B (1), macranthoidin A (2), dipsacoside B (3), hederagenin-28-O-β-D-glucopyranosyl(6→1)-O-β-D- glucopyranosyl ester (4), macranthoside B (5), macranthoside A (6), and hederagenin-3-O-α-L-arabinopyranosyl(2→1)-O-α-L-rhamnopyranoside (7) (Fig. 1).2. Experimental2.1. Samples, chemicals and reagentsFive samples of Lonicera species,L. japonica from Mi county, HeNan province (LJ1999-07), L. hypoglauca from Jiujang county, JiangXi province (LH2001-06), L. similes from Fei county, ShanDong province (LS2001-07), L. confuse from Xupu county, HuNan province (LC2001-07), and L. macranthoides from Longhu county, HuNan province (LM2000-06) respectively, were collected in China. All samples were authenticated by Dr. Ping Li, professor of department of Pharmacognosy, China Pharmaceutical University, Nanjing, China. The voucher specimens were deposited in the department of Pharmacognosy, China Pharmaceutical University, Nanjing, China. Seven saponin reference compounds: macranthoidin B (1), macranthoidin A (2), dipsacoside B (3), hederagenin-28-O-β-D-glucopyranosyl(6→1)-O-β-D- glucopyranosyl ester (4), macranthoside B (5), macranthoside A (6), and hederagenin-3-O-α-L-arabinopyranosyl(2→1)-O-α-L-rhamnopyranoside (7) were isolated previously from the dried buds of L. confusa by repeated silica gel, sephadex LH-20 and Rp-18 silica gel column chromatography, their structures were elucidated by comparison of their spectral data (UV, IR, MS, 1H- NMR and 13C-NMR) with references [13-15]. The purity of these saponins were determined to be more than 98% by normalization of the peak areas detected by HPLC with ELSD, and showed very stable in methanol solution.HPLC-grade acetonitrile from Merck (Darmstadt, Germany), the deionized water from Robust (Guangzhou, China), were purchased. The other solvents, purchased from Nanjing Chemical Factory (Nanjing, China) were of analytical grade.2.2. Apparatus and chromatographic conditionsAglient1100 series HPLC apparatus was used. Chromatography was carried out on an Aglient Zorbax SB-C18 column（250 4.6mm, 5.0µm）at a column temperature of 25℃.A Rheodyne 7125i sampling valve (Cotati, USA) equipped with a sample loop of 20µl was used for sample injection. The analog signal from Alltech ELSD 2000 (Alltech, Deerfield, IL, USA)was transmitted to a HP Chemstation for processing through an Agilent 35900E (Agilent Technologies, USA).The optimum resolution was obtained by using a linear gradient elution. The mobile phase was composed of acetonitrile(A) and water(B) which acidified with 0.5% acetic acid. The elution was operated from keeping 29%A for 10min, then gradually to 54%B from 10 to 25 min in linear gradient, and back to the isocratic elution of 54%B from 25 to 30 min.The drift tube temperature for ELSD was set at 106℃and the nitrogen flow-rate was of 2.6 l/min. The chromatographic peaks were identified by comparing their retention time with that of each reference compound tried under the same chromatographic conditions with a series of mobile phases. In addition, spiking samples with the reference compounds further confirmed the identities of the peaks.2.3. Calibration curvesMethanol stock solutions containing seven analytes were prepared and diluted to appropriate concentration for the construction of calibration curves. Six concentrationof the seven analytes’ solution were injected in triplicate, and then the calibration curves were constructed by plotting the peak areas versus the concentration of each analyte. The results were demonstrated in Table1.2.4. Limits of detection and quantificationMethanol stock solution containing seven reference compounds were diluted to a series of appropriate concentrations with methanol, and an aliquot of the diluted solutions were injected into HPLC for analysis.The limits of detection (LOD) and quantification (LOQ) under the present chromatographic conditions were determined at a signal-to-noise ratio (S/N) of 3 and 10, respectively. LOD and LOQ for each compound were shown in Table1.2.5. Precision and accuracyIntra- and inter-day variations were chosen to determine the precision of the developed assay. Approximate 2.0g of the pulverized samples of L. macranthoides were weighted, extracted and analyzed as described in 2.6 Sample preparation section. For intra-day variability test, the samples were analyzed in triplicate for three times within one day, while for inter-day variability test, the samples were examined in triplicate for consecutive three days. Variations were expressed by the relative standard deviations. The results were given in Table 2.Recovery test was used to evaluate the accuracy of this method. Accurate amounts of seven saponins were added to approximate 1.0g of L. macranthoides,and then extracted and analyzed as described in 2.6 Sample preparation section. The average recoveries were counted by the formula: recovery (%) = (amount found –original amount)/ amount spiked ×100%, and RSD (%) = (SD/mean) ×100%. The results were given in Table 3.2.6. Sample preparationSamples of Flos Lonicerae were dried at 50℃until constant weight. Approximate 2.0g of the pulverized samples, accurately weighed, was extracted with 60% ethanol in a flask for 4h. The ethanol was evaporated to dryness with a rotary evaporator. Residue was dissolved in water, followed by defatting with 60ml of petroleum ether for 2 times, and then the water solution was evaporated, residue was dissolved with methanol into a 25ml flask. One ml of the methanol solution was drawn and transferred to a 5ml flask, diluted to the mark with methanol. The resultant solution was at last filtrated through a 0.45µm syringe filter (Type Millex-HA, Millipore, USA) and 20µl of the filtrate was injected to HPLC system. The contents of the analytes were determined from the corresponding calibration curves.3. Results and discussionsThe temperature of drift tube and the gas flow-rate are two most important adjustable parameters for ELSD, they play a prominent role to an analyte response. In ourprevious work [12], the temperature of drift tube was optimized at 90°C for the determination of iridoids. As the polarity of saponins are higher than that of iridoids, more water was used in the mobile phase for the separation of saponins, therefore the temperature for saponins determination was optimized systematically from 95°C to 110°C, the flow-rate from 2.2 to 3.0 l/min. Dipsacoside B was selected as the testing saponin for optimizing ELSD conditions, as it was contained in all samples. Eventually, the drift tube temperature of 106℃and a gas flow of 2.6 l/min were optimized to detect the analytes. And these two exact experimental parameters should be strictly controlled in the analytical procedure [16].All calibration curves showed good linear regression (r2 0.9922) within test ranges. Validation studies of this method proved that this assay has good reproducibility. As shown in Table 2, the overall intra- and inter-day variations are less than 6% for all seven analytes. As demonstrated in Table 3, the developed analytical method has good accuracy with the overall recovery of high than 96% for the analytes concerned. The limit of detection (S/N=3) and the limit of quantification (S/N=10) are less than 0.26μg and 0.88μg respectively (Table1), indicating that this HPLC-ELSD method is precise, accurate and se nsitive enough for the quantitative evaluation of major non- chromaphoric saponins in Flos Lonicerae.It has been reported that there are two major types of saponins in Flos Lonicerae, i.e. saponins with hederagenin as aglycone and saponins with oleanolic acid as the aglycone [17]. But hederagenin type saponins of the herb were reported to have distinct activities of liver protection and anti-inflammatory [7-11]. So we adoptedseven hederagenin type saponins as representative markers to establish a quality control method.The newly established HPLC-ELSD method was applied to analyze seven analytes in five plant sources of Flos Lonicerae, i.e. L. japonica,L. hypoglauca,L. confusa,L. similes and L. macranthoides(Table 4). It was found that there were remarkable differences of seven saponins contents between different plant sources of Flos Lonicerae. All seven saponins analyzed could be detected in L. confusa and L. hypoglauca, while only dipsacoside B was detected in L. japonica. Among all seven saponins interested, only dipsacoside B was found in all five plant species of Flos Lonicerae analyzed, and this compound was determined as the major saponin with content of 53.7 mg/g in L. hypoglauca. On the other hand, macranthoidin B was found to be the major saponin with the content higher than 41.0mg/g in L. macranthoides,L. confusa, and L. similis, while the contents of other analytes were much lower.In our previous study [12], overall HPLC profiles of iridoid glucosides was used to qualitatively and quantitatively distinguish different origins of Flos Lonicerae. As shown in Fig.2, the chromatogram profiles of L. confusa, L. japonica and L. similes seem to be similar, resulting in the difficulty of clarifying the origins of Flos Lonicerae solely by HPLC profiles of saponins, in addition to the clear difference of the HPLC profiles of saponins from L. macranthoides and L. hypoglauca.Therefore, in addition to the conventional morphological and histological identification methods, the contents and the HPLC profiles of saponins and iridoids could also be used as accessory chemical evidence toclarify the botanical origin and comprehensive quality evaluation of Flos Lonicerae.4. ConclusionsThis is the first report on validation of an analytical method for qualification and quantification of saponins in Flos Lonicerae. This newly established HPLC-ELSD method can be used to simultaneously quantify seven saponins, i.e. macranthoidin B, macranthoidin A, dipsacoside B, hederagenin-28-O-β-D-glucopyranosyl(6→1)-O-β-D- glucopyranosyl ester, macranthoside B, macranthoside A, and hederagenin-3-O-α-L-arabinopyranosyl(2→1)-O-α-L-rhamnopyranoside in Flos Lonicerae. Together with the HPLC profiles of iridoids, the HPLC-ELSD profiles of saponins could also be used as an accessory chemical evidence to clarify the botanical origin and comprehensive quality evaluation of Flos Lonicerae.AcknowledgementsThis project is financially supported by Fund for Distinguished Chinese Young Scholars of the National Science Foundation of China (30325046) and the National High Tech Program（2003AA2Z2010）.[1]Ministry of Public Health of the People’s Republic of China, Pharmacopoeia ofthe People’s Republic of China, V ol.1, 2000, p. 177.[2]W. Shi, R.B. Shi, Y.R. Lu, Chin. Pharm. J., 34(1999) 724.[3]J.B. Xing, P. Li, D.L. Wen, Chin. Med. Mater., 26(2001) 457.[4]Y.Q. Zhang, L.C. Xu, L.P. Wang, J. Chin. Med. Mater., 21(1996) 204.[5] D. Zhang, Z.W. Li, Y. Jiang, J. Pharm. Anal., 16(1996) 83.[6]T.Z. Wang, Y.M. Li, Huaxiyaoxue Zazhi, 15(2000) 292.[7]J.ZH. Shi, G.T. Liu. Acta Pharm. Sin., 30(1995) 311.[8]Y. P. Liu, J. Liu, X.SH. Jia, et al. Acta Pharmacol. Sin., 13 (1992) 209.[9]Y. P. Liu, J. Liu, X.SH. Jia, et al. Acta Pharmacol. Sin., 13 (1992) 213.[10]J.ZH. Shi, L. Wan, X.F. Chen.ZhongYao YaoLi Yu LinChuang, 6 (1990) 33.[11]J. Liu, L. Xia, X.F. Chen. Acta Pharmacol. Sin., 9 (1988) 395[12]H.J. Li, P. Li, W.C. Ye, J. Chromatogr. A 1008(2003) 167-72.[13]Q. Mao, D. Cao, X.SH. Jia. Acta Pharm. Sin., 28(1993) 273.[14]H. Kizu, S. Hirabayashi, M. Suzuki, et al. Chem. Pharm. Bull., 33(1985) 3473.[15]S. Saito, S. Sumita, N. Tamura, et al. Chem Pharm Bull., 38(1990) 411.[16]Alltech ELSD 2000 Operating Manual, Alltech, 2001, p. 16. In Chinese.[17]J.B. Xing, P. Li, Chin. Med. Mater., 22(1999) 366.Fig. 1 Chemical structures of seven saponins from Lonicera confusa macranthoidin B (1), macranthoidin A (2), dipsacoside B (3), hederagenin-28-O-β-D-glucopyranosyl(6→1)-O-β-D- glucopyranosyl ester (4), macranthoside B (5), macranthoside A (6), and hederagenin-3-O-α-L-arabinopyranosyl(2→1)-O-α-L-rhamnopyranoside (7)Fig. 2Representative HPLC chromatograms of mixed standards and methanol extracts of Flos Lonicerae.Column: Agilent Zorbax SB-C18 column（250 4.6mm, 5.0µm）, temperature of 25℃; Detector: ELSD, drift tube temperature 106℃, nitrogen flow-rate 2.6 l/min.A: Mixed standards, B: L. confusa, C: L. japonica, D: L. macranthoides, E: L. hypoglauca, F: L. similes.Table 1 Calibration curves for seven saponinsAnalytes Calibration curve ar2Test range(μg)LOD(μg)LOQ(μg)1 y=6711.9x－377.6 0.9940 0.56–22.01 0.26 0.882 y=7812.6x－411.9 0.9922 0.54–21.63 0.26 0.843 y=6798.5x－299.0 0.9958 0.46–18.42 0.22 0.724 y=12805x－487.9 0.9961 0.38–15.66 0.10 0.345 y=4143.8x－88.62 0.9989 0.42–16.82 0.18 0.246 y=3946.8x－94.4 0.9977 0.40–16.02 0.16 0.207 y=4287.8x－95.2 0.9982 0.42–16.46 0.12 0.22a y: Peak area; x: concentration (mg/ml)Table 2 Reproducibility of the assayAnalyteIntra-day variability Inter-day variability Content (mg/g) Mean RSD (%) Content (mg/g) Mean RSD (%)1 46.1646.2846.2246.22 0.1346.2245.3647.4226.33 2.232 5.385.385.165.31 2.405.285.345.045.22 3.043 4.374.304.184.28 2.244.284.464.024.255.204 nd1)-- -- nd -- --5 1.761.801.821.79 1.701.801.681.841.77 4.706 1.281.241.221.252.451.241.341.201.26 5.727 tr2)-- -- tr -- -- 1): not detected; 2): trace. RSD (%) = (SD/Mean) ×100%Table 3 Recovery of the seven analytesAnalyteOriginal(mg) Spiked(mg)Found(mg)Recovery(%)Mean(%)RSD(%)1 23.0823.1423.1119.7122.8628.1042.7346.1351.0199.7100.699.399.8 0.722.692.672.582.082.913.164.735.515.7698.197.6100.698.8 1.632.172.152.091.732.182.623.884.404.6598.8103.297.799.9 2.94nd1)1.011.050.980.981.101.0297.0104.8104.1102.0 4.250.880.900.910.700.871.081.561.752.0197.197.7101.898.9 2.660.640.620.610.450.610.751.081.211.3397.796.796.096.8 0.97tr2)1.021.101.081.031.111.07100.9102.799.1100.9 1.81): not detected; 2): trace.a Recovery (%) = (Amount found –Original amount)/ Amount spiked ×100%, RSD (%) = (SD/Mean) ×100%Table 4 Contents of seven saponins in Lonicera spp.Content (mg/g)1 2 3 4 5 6 7 L. confusa45.65±0.32 5.13±0.08 4.45±0.11tr1) 2.04±0.04tr 1.81±0.03 L. japonica nd2)nd 3.44±0.09nd nd nd nd L. macranthoides46.22±0.06 5.31±0.13 4.28±0.10 tr 1.79±0.03 1.25±0.03 tr L. hypoglauca11.17±0.07 nq3)53.78±1.18nd 1.72±0.02 2.23±0.06 2.52±0.04 L. similes41.22±0.25 4.57±0.07 3.79±0.09nd 1.75±0.02tr nd 1): trace; 2): not detected.. 3) not quantified owing to the suspicious purity of the peak.。
Presatovir产品说明书
1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Presatovir Catalog No. :HY-16727CAS No. :1353625-73-61.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA Tel:609-228-6898Fax:609-228-5909E-mail:1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:GS-5806Formula:C 24H 30ClN 7O 3S Molecular Weight:532.06CAS No. :1353625-73-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician. Skin contactSafety Data SheetRevision Date:Jun.-3-2021Print Date:Feb.-17-2023Inhibitors •Screening Libraries•ProteinsRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance SolidOdor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 2Additional informationThis information is based on our current knowledge. However the chemical, physical, and toxicological properties have not been completely investigated.12. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)Proper shipping name: Not dangerous goodsUN number: -Class: -Packing group: -IMDGProper shipping name: Not dangerous goodsUN number: -Class: -Packing group: -IATAProper shipping name: Not dangerous goodsUN number: -Class: -Packing group: -15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2023 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel:609-228-6898Fax:609-228-5909E-mail:***********************Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
A939572_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:A939572 is a potent, and orally bioavailable SCD1 inhibitor with IC 50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.IC50 & Target: IC50: <4 nM (mSCD1), 37 nM (hSCD1)[1]In Vitro: A939572 exhibits robust in vivo activity with dose–dependent desaturation index lowering effects [1]. A939572 is a small molecule that specifically inhibits SCD1 enzymatic activity. A939572 demonstrates a significant dose–dependent decrease in proliferation in Caki1, A498, Caki2, and ACHN at day 5 (IC 50s of 65 nM, 50 nM, 65 nM, and 6 nM, respectively). In A939572 (SCDi)treated Caki1 and A498 cells, all five ER stress related genes are expressed at significantly increased levels compared to DMSO+BSA control, and this elevated expression can be blocked with the addition of OA–BSA [2].In Vivo: Athymic nude (nu/nu) mice bearing A498 ccRCC xenografts are treated with A939572 (30mg/kg, p.o.) and Tem individually or in combination over the course of four weeks, and tumor volume (mm 3) is recorded. A939572 and Tem monotherapy generate similar growth responses with approximately 20–30% reductions in tumor volume (vs. placebo control) being observed upon study completion, with values reaching statistical significance only within the last week of treatment. The combination group yields over a 60% decrease in tumor volume (vs. placebo control) by study completion with significant reductions recorded after approximately 1week of treatment [2].PROTOCOL (Extracted from published papers and Only for reference)Cell Assay: A939572 is dissolved in DMSO and stored, and then diluted with appropriate media before use [2].[2]Cells are plated (0.5 or 1×105/well) in 24–well plates in triplicate. Cells are counted using a Coulter Particle Counter. Oleic acid–albumin isadded to media at 5μMol. A939572 stocks are prepared in DMSO. Temsirolimus dosing is performed. Soft agar cultures are prepared by diluting 2× growth medium 1:1 in 1.5% Seaplaque ®GTG ® agarose, with 500 cells/plate in 60mm culture dishes.Colonies are stained with Giemsa and counted after 3wks [2].Animal Administration: A939572 is re–suspended in strawberry flavored Kool–Aid ® in sterilized H 2O (Mice)[2].[2]Mice [2]A498 cells are subcutaneously implanted in athymic nu/nu mice at 1×106 cells/mouse in 50% Matrigel. Tumors reach ~50 mm 3 prior to 4 wk treatment. A939572 is re–suspended in strawberry flavored Kool–Aid ® in sterilized H 2O (0.2 g/mL) vehicle at 30 mg/kg in a 50μL dose. Mice are orally fed by using a syringe to administer the 50 μL dose twice daily/mouse. This modified method is found to be effective and less stressful on the mice. Temsirolimus is solubilized in 30% ethanol/saline and administered via intraperitoneal injection at 10 mg/kg in a 50 μL dose once every 72 hrs/mouse. Tumor volumes are calculated using the formula 0.5236 (L*W*H) and body weight are measured every 3 days.References:[1]. Xin Z, et al. Discovery of piperidine–aryl urea–based stearoyl–CoA desaturase 1 inhibitors. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298–302.Product Name:A939572Cat. No.:HY-50709CAS No.:1032229-33-6Molecular Formula:C 20H 22ClN 3O 3Molecular Weight:387.86Target:Stearoyl–CoA Desaturase (SCD)Pathway:Metabolic Enzyme/Protease Solubility:DMSO: ≥ 56 mg/mL[2]. von Roemeling CA, et al. Stearoyl–CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013 May 1;19(9):2368–80.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
MK-2894-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Oct.-12-2018Print Date:Oct.-12-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :MK-2894Catalog No. :HY-10413CAS No. :1006036-87-81.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C25H22F3NO3SMolecular Weight:473.51CAS No. :1006036-87-84. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
中药单体中英对照
中药单体中英对照货号英文名称中文名称019-14621 Aconitine std. 乌头碱012-14091 Albiflorin std 芍药内酯苷018-13231 Alisol B acetate,98.0% 乙酸泽泻酯B010-13431 Alisol B std 泽泻醇B015-11921 Arbutin std 熊果苷012-14611 Atractylenolide III std. 苍术内酯016-11691 Atropine sulfate std. 硫酸阿托品016-10351 Aucubin std. 桃叶珊瑚苷027-07751 Baicalein std. 黄岑素020-07741 Baicalin std. 黄岑苷022-08161 Barbaloin std. 芦荟苷022-07681 Berberine chloride std. 氯化黄连素028-12051 Bergenin std. 岩白菜内酯025-10121 Bufalin std. 蟾毒灵024-10691 Bufotalin std. 蟾毒它灵030-10611 Capillarisin std. 茵陈色原酮036-10613 Capillarisin std. 茵陈色原酮031-15141 Capsaicin std. 辣椒素032-10551 Catalpol std. 梓醇038-13711 Cinobufagin std. 华蟾毒精035-13721 Cinobufotalin std. 华蟾毒它灵036-11311 Coptisine chloride 氯化黄连碱036-14971 Corydaline std. 紫堇碱032-13731 Costunolide std. 木香烃内酯043-27611 Dehydrocorydaline nitrate std. 硝酸脱氢紫堇碱040-21881 Dehydrocostuslactone std. 脱氢广木香内酯044-25321 Dihydrocapsaicin std. 二氢辣椒素042-18911 Dimethylesculetin std. 二甲基七叶树内酯052-04921 Ergosterol std. 麦角甾醇056-05161 β-Eudesmol std. β-桉油醇050-04601 Evodiamine std. 吴茱萸碱070-02241 Geniposide std. 京尼平苷078-02301 Geniposidic acid std. 京尼平苷酸077-02871 6-Gingerol std. 6-姜辣醇079-02191 Ginsenoside Rb1 std. 人参皂苷Rb1078-03261 Ginsenoside Rc 人参皂苷Rc072-03301 Ginsenoside Rd std. 人参皂苷Rd075-03271 Ginsenoside Re std. 人参皂苷Re072-02201 Ginsenoside Rg1 std. 人参皂苷Rg1071-02271 Glycyrrhizin std. 甘草甜素089-04951 Honokiol std. 和厚朴酚081-06851 (E)-10-Hydroxy-2-decenoic acid std. (E)-10-羟基-2-癸烯酸084-07061 Hypaconitine 次乌头碱099-03651 Isofraxidine std.125-03361 Liquiritin std. 甘草甙125-03621 Loganin std. 番木鳖苷137-09081 Magnolol std. 厚朴酚130-12261 Mesaconitine 中乌头碱140-06211 Naringin std. 柚皮甙151-01801 Osthole std. 甲氧基欧芹酚150-01511 Oxymatrine std. 氧化苦参碱167-11711 Paeoniflorin std. 芍药苷163-11713 Paeoniflorin std. 芍药苷169-12871 Paeonol std. 牡丹酚166-17641 Palmatine chloride std. 氯化巴马亭164-14091 (+)-phyllodulcin std. (+)-叶甜素162-14071 Puerarin std. 葛根素184-00951 Resibufogenin std. 残余蟾蜍配基183-00921 Rutaecarpine std. 吴茱萸次碱190-08411 Saikosaponin a std. 柴胡皂甙a194-10021 Saikosaponin b2 std. 柴胡皂甙b2197-08421 Saikosaponin c std. 柴胡皂甙c194-08431 Saikosaponin d std. 柴胡皂甙d192-10441 Schizandrin std. 五味子素197-09261 Scopolamine hydrobromide, 99.0% 氢溴酸莨菪胺190-08531 Sennoside A std. 番泻苷A194-09271 Sennoside B, 96% 番泻苷B199-11811 Sennoside B std. 番泻苷B191-08681 Shikonin std. 紫草素193-09361 Sinomenine std. 青藤碱197-08541 Swertiamarin std. 獐牙菜苦苷231-00811 Wogonin std. 汉黄岑素A订货号英文名称中文名称0702 Abietic acid 松香酸0072 Abietic 刺槐素1101 Acacetin 刺槐素0596 3-Acetamidocumarin 3-乙酰氨基香豆素6001 Acetosyringone 乙酰丁香酮6002 Acetovanillone 香草乙酮4941 Acetoveratrone 乙酰藜芦酮0575 o-Acetylcolumbianetin o-乙酰二氢欧山芹酯0506 3-Acetylcoumarin 3-乙酰香豆素0582 8-Acetyl-6,7-dimethoxycoumarin 8-乙酰-6,7-二甲氧基香豆素5151 Acetyl eugenol 乙酸丁香酚酯4014 N-Acetyl-D-galactosamine N-乙酰-D-半乳糖胺4015 N-Acetyl-D-glucosamine N-乙酰-D-葡糖胺0583 8-Acetyl-7-hydroxycoumarin 8-乙酰-7-羟基香豆素0584 8-Acetyl-6-hydroxy-7-methoxycoumarin 8-乙酰-6-羟基-7-甲氧基香豆素0585 8-Acetyl-7-methoxycoumarin 8-乙酰-7-甲氧基香豆素1778 2-Acetyl-3-methylpyrazine 2-乙酰-3-甲基吡嗪4016 N-Acetyl-neuraminic acid N-乙酰-神经氨(糖)酸0806 3-Acetyl--strophanthidin 3-乙酰-毒毛旋花子甙元0703 cis-Aconitic acid 顺乌头酸0782 trans-Aconitic acid 反乌头酸5389 Adamantane 金刚烷7001 Adenine 腺嘌呤7002 Adenosine 腺嘌呤核苷8801 L-Adrenaline L-肾上腺素8031 Agar-Agar 琼脂1692 Ajmalicine0622 Ajmalicine hydrochloride 盐酸阿吗碱0623 Ajmaline 阿吗灵5578 DL-Alanine DL-丙氨酸5501 L-Alanine L-丙氨酸5502 β-Alanine β-丙氨酸3001 Aleuritic acid 紫胶酮酸4021 Alginic acid 藻酸4022 Alginic acid ammonium salt 藻酸铵盐4023 Alginic acid sodium salt 藻酸钠盐0441 Alkannin 紫草素0411 Alizarin 茜素8572 Allantoin 尿囊素7253 Alliin 蒜氨酸5001 Allocymene4024 β-D-Allose β-D-阿洛糖0413 Aloe-emodin 芦荟大黄素0450 Aloe-emodin 芦荟大黄素0458 Aloin A 芦荟素A4025 D-Altrose D-阿卓糖1057 Amentoflavone 穗花杉双黄酮6004 4-Aminoacephenone 4-氨基苯乙酮1699 4-Aminoantipyrin0706 4-Aminobutyric acid 4-氨基丁酸0569 3-Aminocoumarin 3-氨基香豆素4032 4-Aminophenyl-1-thio-β-D-galactopyranoside 4-氨基苯-1-硫代-β-D-吡喃半乳糖苷7201 Amygdalin 扁桃苷5137 Amyl acetate 乙酸戊酯4035 Amylopectine0015 α-Amyrin α-香树素0016 β-Amyrin β-香树素1610 DL-Anabasine DL-毒藜碱3721 Andrographolide 雄茸交酯4464 1,4-Anhydroerythritol6006 2-Anisaldehyde 2-茴香醛6007 3-Anisldehyde 3-茴香醛6211 4-Anisaldehyde 4-茴香醛6008 4-Anisaldehyde 4-茴香醛6332 4-Anisic acid 4-茴香酸2141 Anthranilic acid methylester 氨茴酸甲酯0469 Anthraquinone 蒽醌0487 1,4-Anthraquinone 1,4-蒽醌0051 Apigenin 芹菜素1102 Apigenin 芹菜素9004 Apigenin 芹菜素1004 Apigenin-7-o-glucoside 芹菜苷配基-7-o-葡糖苷9001 Apigenin-7-o-glucoside 芹菜苷配基-7-o-葡糖苷0921 Apigeninidin chloride 氯化芹菜定1324 Apignein-4,5,7-trimethylether 芹菜素-4,5,7-三甲醚5390 Apiole4368 Arabinic acid 阿糖酸4044 D-(-)-Arabinose D-(-)-阿拉伯糖4045 L-(+)-Arabinose L-(+)-阿拉伯糖4046 DL-Arabinose DL-阿拉伯糖4047 D-(+)-Arabitol D-(+)-阿糖醇4048 L-(-)Arabitol L-(-)-阿糖醇3377 Arachidic acid 花生酸3005 Arachidic acid methylester 花生酸甲酯0414 Arbutin 熊果苷1702 Arcaine sulfate 硫酸魁蛤素1703 Arecoline hydrobromide 溴化氢槟榔碱5508 L-Arginine L-精氨酸5509 L-Arginine monohydrochloride 单盐酸L-精氨酸5510 DL-Arginine monohydrochloride 单盐酸DL-精氨酸0707 Aristolochic acid 马兜铃酸0784 Aristollchic acid sodium salt 马兜铃酸钠盐5391 (+)-Aromadendrene (+)-香橙烯7501 Artemisinin 青蒿素6009 α-Asarone α-细辛脑6010 β-Asarone β-细辛脑0708 L-(+)-Ascorbic acid L-(+)-抗坏血酸0709 L-Ascorbic acid sodium salt L-抗坏血酸钠盐2815 L-(+)-Ascorbylpalmitate0027 Asiatic acid 积血草酸0120 Asiaticoside 积血草苷9014 Asiaticoside 积血草苷5771 D-Asparagine D-天冬酰胺5772 DL-Asparagine DL-天冬酰胺5773 L-Asparagine L-天冬酰胺5778 D-Aspartic acid D-天冬氨酸5779 L-Aspartic acid L-天冬氨酸5511 DL-Aspartic acid DL-天冬氨酸1705 Aspidosine hydrobromide0328 Astaxanthin 虾青素0710 Atractyloside Sodium salt 苍术苷钠盐6012 Atranorin0615 Atropine sulfate 硫酸阿托品0227 Aucubin 桃叶珊瑚苷0201 Aucubin 桃叶珊瑚苷8972 Azadirachtin 印楝素8574 8-Azaxanthin5003 Azulene 甘菊环/甘菊蓝B1171 Baicalein 黄岑素1250 Baicalein-7-methylether 黄岑素-7-甲醚1323 Baicalein-5, 6,7-trimethylether 黄岑素-5,6,7-三甲醚1280 Baicalin 黄岑苷8575 Balsam canada 加拿大香脂8037 Balsam peru 秘鲁香脂3008 (+)-Batylalcohol (+)-鲨肝醇1237 Bavachinin A 甲基补骨脂黄酮A3009 Behenic acid 山嵛酸/二十二碳烷酸3492 Behenic acid 山嵛酸/二十二碳烷酸3223 Behenic acid 山嵛酸/二十二碳烷酸3010 Behenic acid methylester 山嵛酸甲酯/二十二碳烷酸甲酯1644 Belladonin hydrogen sulfate6013 Benzaldehyde 苯甲醛1007 5,6-Benzoflavone 5,6-苯并黄酮1008 7,8-Benzoflavone 7,8-苯并黄酮6014 Benzoic acid 苯甲酸6005 Benzoic acid ethylester 苯甲酸乙酯5458 Benzoic acid eugenylester 苯甲酸丁子香酯6182 Benzoic acid methylester 苯甲酸甲酯7323 Benzo-(α)-pyrene 苯并芘4950 omega-Benzoyloxyphloracetophenone4951 omega-Benzoyloxyresacetophenone6226 Benzylacetate 乙酸苄酯6177 Benzylalcohol 苯甲醇7022 6-Benzylaminopurine 6-苄胺嘌呤0550 Bergamotin0503 Bergapten 香柠檬烯0552 Bergapten 香柠檬烯0590 Bergaptol8826 Bergenin 岩白菜宁1656 Berlambine0605 Betonicine 左旋水苏碱0018 Betulin 桦木脑0026 Betulin diacetate 桦木脑二乙酸0004 Betulinic acid 桦木酸0031 Betulinic acid 桦木酸0004 Betulinic acid0032 Betulinic acid methylester 桦木酸甲酯1203 Biochanin A 鹰嘴豆芽素A/鸡豆黄素A5244 α-(-)-Bisabolol α-(-)红没药醇1555 Boldine 波尔定碱1857 Boldine hydrochloride 盐酸波尔定碱5421 (+)-Borneol (+)-冰片5006 (-)-Borneol (-)-冰片5007 L-Bornyl acetate L-乙酸冰片酯4544 Bromelain(Bromelin) 菠萝蛋白酶6339 2-Bromocinnamic acid 2-溴代肉桂酸6340 3-Bromocinnamic acid 3-溴代肉桂酸6341 4-Bromocinnamic acid 4-溴代肉桂酸7007 5-Bromo-2ˊ-deoxyuridine 5-Br-2’-脱氧尿苷1711 DL-6ˊ-Bromolaudanosin DL-6’-溴代劳丹素0579 4-Bromomethyl-7-methoxycoumain 4-溴甲基-7-甲氧基香豆素5219 2,3-Butanediol 2,3-丁二醇1103 Butein 紫铆因5352 Butyl acetate 乙酸丁酯5204 n-Butyl alcohol 正丁醇1784 2-Butyl-3-methylpyrazine 2-丁基-3-甲基吡嗪2862 Butyric acid 丁酸3315 Butyric acid amylester 丁酸戊酯3316 Butyric acid butylester 丁酸丁酯3317 Butyric acid ethylester 丁酸乙酯3496 Butyric acid hexylester 丁酸己酯3497 Butyric acid isoamylester 丁酸异戊酯3318 Butyric acid methylester 丁酸甲酯2704 gamma-Butyrolactone gamma-丁内酯C6018 Caffeic acid 咖啡酸0907 Callistephin chloride 氯化翠菊苷5485 Camphene 莰烯5231 Camphene 莰烯5448 (+)-Camphor (+)-樟脑5455 DL-Camphor DL-樟脑5233 DL-Camphor DL-樟脑5342 (1S)-(-)-Camphor (1S)-(-)-樟脑0769 D-(+)-Camphoric acid D-(+)-樟脑酸5516 L-Canavanine sulfate L-硫酸刀豆氨酸6513 Cantharidin 斑螯素0314 Canthaxanthin 角黄素/裸藻酮3322 Capric acid 癸酸3016 Capric acid 癸酸3320 Capric acid ethylester 癸酸乙酯3321 Capric acid methylester 癸酸甲酯3018 Capric aldehyde 癸醛3325 Caproic acid 己酸3019 Caproic acid 己酸3020 Caproic acid ethylester 己酸乙酯3324 Caproic acid methylester 己酸甲酯3326 Caproic aldehyde 己醛3329 Caprylic acid 辛酸3218 Caprylic acid ethylester 辛酸乙酯2853 Caprylic acid methylester 辛酸甲酯8986 Capsaicin pure 辣椒素/辣椒碱0312 Capsanthin 辣椒红/辣椒质5932 (1S-cis)-2-Carene (1S-cis)-2-蒈烯5393 delta-3-Carene delta-3-蒈烯8039 Carmine 胭脂红0470 Carminic acid 胭脂红酸5974 L-Carnitine L-肉碱5584 DL-Carnitine hydrochloride DL-盐酸肉碱0303 β-Carotene β-胡萝卜素0315 β-Carotene β-胡萝卜素6659 kappa-Carrageenan kappa-角叉菜4375 iota-Carrageenan iota-角叉菜5440 Carvacrol 香芹酚5236 Carvacryl acetate 香芹基乙酸5098 (-)-Carveol (-)-香芹酚5076 (-)-Carvone (-)-香芹酮5012 (-)-Carvone (-)-香芹酮5013 (+)-Carvone (+)-香芹酮5014 (-)-trans-Caryophyllene (-)-trans-石竹烯5493 Caryophyllene oxide 石竹烯氧化物0233 Catalpol0976 (+)-Catechin (+)-儿茶素0952 (+)-Catechin (+)-儿茶素0954 (+)-Catechin aqueous0953 DL-Catechin DL-儿茶素0980 Catechin Kit 儿茶素试剂包0970 Catechol 儿茶酚0005 Caulophyllogenin5432 (-)-α-Cedrene (-)-α-雪松烯5444 β-Cedrene β-雪松烯5162 Cedrol 雪松醇4065 Cellobiose 纤维素二糖8578 Cerulenin 浅蓝菌素3331 Cetyl alcohol 鲸蜡醇/十六烷醇1553 α-Chaconine1041 Chalcone 查耳酮5347 Chamazulen1558 Chelerythrine 白屈菜赤碱1559 Chelerythrine chloride 氯化白屈菜赤碱0701 Chelidonic acid 白屈菜酸0603 (+)-Chelidonine1714 (+)-Chelidonine hydrochloride3552 Chenodeoxycholic acid 鹅(脱氧)胆酸4068 Chitin 几丁质4400 Chitobiose 壳二糖4071 Chitosan 脱乙酰壳多糖8579 Chloramphenicol 氯霉素6019 Chlorogenic acid 绿原酸/咖啡单宁酸6519 Chlorophyll A 叶绿素A6520 Chlorophyll B 叶绿素B8582 Chlororphyll 叶绿素8583 Chlorophyllin 叶绿酸1785 2-Chloropyrazine 2-氯吡嗪3553 (5α-)-Cholestane (5α)-胆甾烷3573 (5α)-Cholestan-3-β-ol3551 Cholesterol 胆固醇3506 Cholesterol 胆固醇3562 Cholesteryl acetate 胆甾醇乙酸酯3508 Cholesteryl benzoate 胆甾醇苯甲酸酯3509 Cholesteryl chloride 胆甾醇氯酯3510 Cholesteryl oleate 胆甾醇油酸酯3511 Cholesteryl palmitate 胆甾醇棕榈酸酯3512 Cholesteryl stearate 胆甾醇硬脂酸酯3502 Cholic acid 胆酸3513 Cholic acid methylester 胆酸甲酯3540 Cholic acid sodium salt 胆酸钠盐4073 Chondroitin sulfate 硫酸软骨素6622 4-Chromanol6623 4-Chromanone 苯并二氢吡喃-4-酮0141 Chrysanthellin A0112 Chrysanthellin B5498 (1R)-Chrysanthemolactone (1R)-5499 (1S)-Chrysanthemolactone (1S)-0798 Chrysanthemyl alcohol1009 Chrysin 柯因1010 Chrysin dimethylether 柯因二甲醚1104 Chrysoeriol0402 Chrysophanol 大黄酚0452 Chrysophanol 大黄酚0613 Cinchonidine 辛可尼定0612 Cinchonine 辛可宁5456 1,4-Cineole 1,4-按树脑6023 trans-Cinnamaldehyde trans-肉桂醛6024 trans-Cinnamic acid trans-肉桂酸6184 Cinnamic acid benzylester 肉桂酸苯甲酯6206 Cinnamic acid benzylester 肉桂酸苯甲酯6207 Cinnamic acid ethylester 肉桂酸乙酯4966 Cinnamic acid methylester 肉桂酸甲酯5139 Cinnamyl acetate 乙酸肉桂酯6025 trans-Cinnamyl alcohol trans-肉桂醇5016 Citral 柠檬醛5080 Citral 柠檬醛0714 Citric acid 柠檬酸0800 Citrinin 桔霉素5017 (-)-Citronellal 香茅醛5195 L-Citronellol L-香茅醇5179 DL-β-Citronellol DL-β-香茅醇5018 D-Citronellol D-香茅醇5238 Citronellol 香茅醇5214 DL-Citronellyl acetate DL-香茅醇乙酸酯0581 Citropten5807 L-Citrulline L-瓜氨酸8725 Cnicin6522 Cochineal 胭脂虫1532 Colchicine 秋水仙素8726 Colophony 松香1865 Conessine 康丝碱6028 Coniferyl alcohol 松柏醇1504 DL-Coniine hydrochloride DL-盐酸毒芹碱1663 Convolvamine hydrochloride 盐酸旋花胺1534 Conyrin 康尼碱1719 (-)-Coralyne Chloride (-)-0626 Corynanthine 柯喃因1851 Corynanthine hydrochloride 盐酸柯喃因6029 2-Coumaric acid 2-香豆酸6030 3-Coumaric acid 3-香豆酸6031 4-Coumaric acid 4-香豆酸0507 Coumarin 香豆素0545 Coumarin 香豆素0535 Coumestrol4839 m-Cresyl acetate m-乙酸甲苯酯4840 m-Cresyl acetate m-乙酸甲苯酯0311 trans-Crocetin trans-藏花酸0329 Crocin0716 Crotonic acid 巴豆酸0317 β-Cryptoxanthin β-隐黄质/玉米黄质8727 Cubebin 荜澄茄素0020 Cucurbitacin E 葫芦素 E0021 Cucurbitacin I 葫芦素 I5164 Cuminaldehyde 枯茗醛/对异丙基苯醛8729 Cuminylalcohol 枯茗醇5433 (+)-Cuparene1281 Cupressuflavone6033 Curcumin 姜黄素4832 Curcumin 姜黄素0909 Cyanidin chloride 氯化氰定0932 Cyanin chloride 氯化花青苷0010 Cycloartenol 环阿屯醇0011 Cycloartenol acetate 乙酸环阿屯酯4438 α-Cyclodextrin α-环糊精4439 β-Cyclodextrin β-环糊精4440 gamma-Cyclodextrin gamma-环糊精2709 Cyclohexanol 环己醇2710 Cyclohexanone 环己酮0809 Cymarin 磁麻苷0810 Cymarol5020 4-Cymene 4-伞花烃5525 L-Cysteine L-半胱氨酸5526 L-Cysteine hydrochloride L-盐酸半胱氨酸5528 L-Cystine L-胱氨酸0692 Cystine 胱氨酸1561 Cytochalasin A 松胞菌素A1562 Cytochalasin B 松胞菌素B1563 Cytochalasin C 松胞菌素C1564 Cytochalasin D 松胞菌素D1565 Cytochalasin E 松胞菌素E1695 Cytochalasin H 松胞菌素H1696 Cytochalasin J 松胞菌素J7032 Cytosine 胞嘧啶D1048 Daidzein 黄豆苷原1096 Daidzin 黄豆苷/异黄酮苷0595 Dalbergin 黄檀素5491 Damascone0508 Daphnetin 瑞香素0549 Daphnetin-7-methylether 瑞香素-7-甲醚1141 Datiscetin 橡精0086 Datiscoside0811 Deactyllanatoside C 脱乙酰毛花(洋地黄)苷5227 delta-Decalactone5167 gamma-Decalactone7101 n-Decane 正癸烷0717 Dehydroascorbic acid 脱氢抗坏血酸3517 Dehydrocholic acid 脱氢胆酸3518 Dehydrocholic acid sodium salt 脱氢胆酸钠盐0904 Delphinidin chloride 氯化翠雀啶1566 Demissdine 垂茄定3541 Deoxycholic acid 脱氧胆酸3543 Deoxycholic scid sodium salt 脱氧胆酸钠盐3526 Deoxycorticosterone 脱氧皮质(甾)酮4077 2-Deoxy-D -galactose 2-脱氧-D-半乳糖4080 2-Deoxy-D-glucose 2-脱氧-D-葡萄糖1251 5-Deoxykaempferol 5-脱氧莰非醇1252 4-Deoxyphloridzin 4-脱氧根皮苷8827 Deoxyrhapontin4083 2-Deoxy-D-ribose 2-脱氧-D-核糖8665 Dextran 4 葡聚糖48666 Dextran 8 葡聚糖88667 Dextran 15 葡聚糖158668 Dextran 35 葡聚糖358669 Dextran 60 葡聚糖608670 Dextran 200 葡聚糖2004443 Dextran T 40 葡聚糖T404445 Dextran T 70 葡聚糖T704444 Dextran T 250 葡聚糖T2504448 Dextran T 500 葡聚糖T5007204 Dhurrin 蜀黍苷1166 Didymin1787 2,3-Diethylpyrazine 2,3-二乙基吡嗪0140 Digitonin 毛地黄皂苷0820 Digitoxigenin 毛地黄毒苷配基0825 Digitoxin 毛地黄毒苷4087 D-(+)-Digitoxose D-(+)-毛地黄毒素糖0826 Digoxigenin 地谷新配基/毛地黄毒苷0828 Digoxigenin-tetra-digitoxoside 毛地黄毒苷-tetra-毛地黄毒糖苷0830 Digoxin 地谷新6036 Dihydrocaffeic acid 二氢咖啡酸6660 Dihydrocapsaicin 二氢辣椒素5175 Dihydrocarveol 二氢香芹醇5099 (+)-Dihydrocarveol (+)-二氢香芹醇5100 (+)-Dihydrocarvone (+)-二氢香芹酮6041 Dihydroconiferyl alcohol 二氢松柏醇0510 3,4-Dihydrocoumarin 3,4-二氢香豆素6527 Dihydrojasmone 二氢茉莉酮0835 Dihydroouabain 二氢乌本(箭毒)苷1037 Dihydrorobinetin6044 Dihydrosinapyl alcohol 二氢芥子醇4956 3,4-Dihydroxyacetophenone 3,4-二羟基苯乙酮0429 1,4-Dihydroxyanthraquinone 1,4-二羟基蒽醌0417 1,8-Dihydroxyanthraquinone 1,8-二羟基蒽醌0433 2,6-Dihydroxyanthraquinone 2,6-二羟基蒽醌6046 2,3-Dihydroxybenzoic acid 2,3-二羟基苯甲酸1042 2′,4-Dihydroxy-4’,6′-dimethoxychalcone 2’,4-二羟基-4’,6’-二甲氧基查耳酮1080 2′,6′-Dihydroxy-4,4′-dimethoxychalcone 2’,6’-二羟基-4,4’-二甲氧基查耳酮1082 2′,6′-Dihydroxy-4,4′-dimethoxy dihydrochalcone 2’,6’-二羟基-4,4’-二甲氧基二氢查耳酮1204 3′,4’-Dihydroxyflavone 3’,4’-二羟基黄酮1012 6,7-Dihydroxyflavone 6,7-二羟基黄酮1259 7, 4′-Dihydroxyflavone 7,4’-二羟基黄酮1013 7,8-Dihydroxyflavone 7,8-二羟基黄酮0721 Dihydroxyfumaric acid 二羟基富马酸6053 2,3-Dihydroxy-4-methoxybenzoic acid 2,3-二羟基-4-甲氧基苯甲酸1081 2′,6′-Dihydroxy-4′-methoxychalcone 2’,3’-二羟基-4’-甲氧基查耳酮1286 2’,6’-Dihydroxy-4-methoxychalcone-4′-o-neohesperidoside 2’,6’-二羟基-4-甲氧基查耳酮-4’-新橙皮苷6058 2,3-Dihydroxy-4-methoxycinnamic acid 2,3-二羟基-4-甲氧基肉桂酸6231 3,5-Dihydroxy-4-methylbenzoic acid 3,5-二羟基-4-甲氧基苯甲酸0511 5,7-Dihydroxy-4-methylcoumarin 5,7-二羟基-4-甲基香豆素0512 6,7-Dihydroxy-4-methylcoumarin 6,7-二羟基-4-甲基香豆素0458 5,8-Dihydroxy-1,4-naphthoquinone 5,8-二羟基-1,4-萘醌2073 3,4-Dihydroxyphenylacetic acid 3,4-二羟基苯乙酸1039 5,7-Dihydroxy-3′,4′,5′-trimethoxyflavanone 5,7-二羟基-3’,4’,5’-三甲氧基黄烷酮1293 3,7-Dihydroxy--3′,4′,5′-trimethoxyflavone 3,7-二羟基-3’,4’,5’-三甲氧基黄酮1106 5,7-Dihydroxy-3′,4′,5′-trimethoxyflavone 5,7-二羟基-3’,4’,5’-三甲氧基黄酮4089 1,2:3,5-Di-o-isopropylidene-α-D-apiose 1,2:3,5-Di-o-异亚丙基-α-D-芹菜糖4098 1,2:5,6-Di-o-isopropylidene-D-mannitol 1,2:5,6-Di-o-异亚丙基-D-甘露糖醇5423 Dillapiole6063 2,3-Dimethoxybenzoic acid 2,3-二甲氧基苯甲酸6064 2,4-Dimethoxybenzoic acid 2,4-二甲氧基苯甲酸6065 2,5-Dimethoxybenzoic acid 2,5-二甲氧基苯甲酸1294 3,4-Dimethoxychalcone 3,4-二甲氧基查耳酮1295 4,4’-Dimethoxychalcone 4,4’-二甲氧基查耳酮6070 2,4-Dimethoxycinnamic acid 2,4-二甲氧基肉桂酸6071 2,5-Dimethoxycinnamic acid 2,5-二甲氧基肉桂酸6073 3,5-Dimethoxycinnamic acid 3,5-二甲氧基肉桂酸1296 5,7-Dimethoxyflavanone 5,7-二甲氧基黄烷酮1297 3’,4’-Dimethoxyflavone 3’,4’-二甲氧基黄酮1175 7,8-Dimethoxyflavone 7,8-二甲氧基黄酮1263 2,3-Dimethoxy-2’-hydroxychalcone 2,3-二甲氧基-2’-羟基查耳酮4959 trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde trans-3,5-二甲氧基-4-羟基肉桂醛1299 4’,7-Dimethoxyisoflavone 4’7-二甲氧基异黄酮0597 6,7-Dimethoxy-4-methylcoumarin 6,7-二甲氧基-4-甲基香豆素6021 4-Dimethylaminocinnamaldehyde 4-二甲基氨基肉桂醛8550 2,6-Dimethylaniline 2,6-二甲基苯胺0486 1,4-Dimethylanthraquinone 1,4-二甲基蒽醌0482 2,3-Dimethylanthraquinone 2,3-二甲基蒽醌6404 3,4-Dimethylbenzaldehyde 3,4-二甲基苯甲醛6411 Dimethylcaffeic acid 二甲基咖啡酸0586 6,7-Dimethylesculetin 6,7-二甲基七叶亭0565 Dimethylfraxetin 二甲基白蜡树亭0462 2,3-Dimethylhydroquinone 2,3二甲基氢醌6189 2,3-Dimethylphenol 2,3-二甲基苯酚6219 2,4-Dimethylphenol 2,4-二甲基苯酚0572 3,4-Dimethylumbelliferone 3,4二甲基伞形酮6417 3,5-Dinitrobenzoic acid 3,5-二硝基苯甲酸3519 Diosgenin 薯蓣皂苷配基0082 Diosmetin1108 Diosmetin0922 Diosmetinidin chloride0081 Diosmin 香叶木甙1109 Diosmin 香叶木甙2711 1-Dodecanol 1-十二烷醇4108 Dulcitol 卫矛醇/半乳糖醇E1567 (-)-Eburnamonine (-)-象牙(洪达木)酮宁3576 α-Ecdysone α-蜕皮激素3566 β-Ecdysone β-蜕皮激素0033 Echinocystic acid 刺囊酸0110 Echinocystic acid-3-ο-glucoside 刺囊酸-3-o-葡糖苷1843 DL-Eleagnin DL-胡秃子碱1721 DL-Eleagnin hydrochloride DL-盐酸胡秃子碱0046 β-Elemonic acid β-岚香酮酸6075 Ellagic acid 鞣花酸1597 Ellipticine6629 Embelin 恩贝酸/恩贝灵6190 Embonic acid0617 Emetine dihydrochloride 二盐酸吐根碱0401 Emodin 大黄素0453 Emodin 大黄素0957 (-)-Epicatechin (-)-表儿茶素0977 (-)-Epicatechin (-)-表儿茶素0978 (-)-Epicatechin gallate (-)-表儿茶素没食子酸酯3802 (-)-Epicedrol0979 (-)-Epigallocatechin 表没食子儿茶素0981 (-)-Epigallocatechin gallate 表没食子儿茶素没食子酸酯1268 (+/-)-Equol3522 Ergosterol 麦角甾醇1110 Eriocitrin 圣草次甙0056 Eriodictyol 圣草酚1111 Eriodictyol 圣草酚1112 Eriodictyol-7-o-glucoside 圣草酚-7-o-葡糖苷3228 Erucic acid 芥酸3033 Erucic acid 芥酸4100 meso-Erythritol 内赤藓醇0007 Erythrodiol 高根二醇0040 Erythrodiol 高根二醇0115 β-Escin β-七叶素0502 Esculetin 七叶亭0514 Esculetin dibenzylether 七叶亭二苄醚0501 Esculin 七叶苷1619 Eserine salicylate 水杨酸毒扁豆碱1620 Eserine sulfate 硫酸毒扁豆碱5125 Estragole 蒿脑/对甲氧基苯丙烯6429 4-Ethoxybenzoic acid 4-乙氧基苯甲酸0548 4-Ethoxycoumarin 4-乙氧基香豆素0515 7-Ethoxycoumarin 7-乙氧基香豆素0574 7-Ethoxy-4-methylcoumarin 7-乙氧基-4-甲基香豆素6446 Ethylgallate 倍酸乙酯6451 Ethyl-3-hydroxybenzoate 乙基-3-羟基苯甲酸酯6452 Ethyl-4-hydroxybenzoate 乙基-4-羟基苯甲酸酯4103 4,6-o-Ethylidene-α-D-glucopyranoside 4,6-o-亚乙基-α-D-吡喃葡糖苷3271 Ethylisobutyrate 异丁酸乙酯3335 Ethylisovalerate 异戊酸乙酯1871 2-Ethyl-3-methylpyrazine 2-乙基-3-甲基吡嗪4829 Ethylvanillin 乙基香兰素5009 Eucalyptol 桉叶油素5364 Eucalyptol 桉叶油素6178 Eugenol 丁子香酚5180 Eugenol methylether 丁子香酚甲醚1014 Eupatorin 半齿泽兰素1015 Eupatorin-5-methylether 半齿泽兰素-5-甲醚6274 Evernic acid 扁枝衣二酸F5021 Farnesol 法呢醇/金合欢醇5022 (cis+trans)-Farnesyl acetate (cis+trans)-乙酸法呢酯5394 (+)-Fenchone (+)-葑酮5103 (-)-Fenchone (-)-葑酮5118 (-)-Fenchone (-)-葑酮5181 Fenchyl alcohol 葑醇5104 Fenchyl alcohol 葑醇6077 Ferulic acid 阿魏酸6275 Ferulic acid ethylester 阿魏酸乙酯6276 Ferulic acid methylester 阿魏酸甲酯1167 Fisetin 非瑟酮/漆树黄酮0068 Fisetin 非瑟酮/漆树黄酮0926 Fisetinidin chloride 氯化非瑟酮定0058 Flavanomarein1038 Flavanone 黄烷酮1208 Flavanone diacetyl hydrazone 黄烷酮二乙酰腙1209 Flavanone hydrazone 黄烷酮腙7013 Flavine adenine dinucleotide disodium salt 黄素腺嘌呤二核苷酸二钠盐(FAD) 1016 Flavone 黄酮0251 Folic acid 叶酸(维生素Bc)2133 Formic acid benzylester 甲酸苯甲酯1049 Formononetin 7-羟基-4’甲氧异黄酮1248 Formononetin 7-羟基-4’甲氧异黄酮1617 N-Formyldeacetylcolchicine N-甲酰脱乙酰秋水仙碱8607 Forskolin1146 Fortunellin0435 Frangulin A 泻鼠李皮苷A0436 Frangulin B 泻鼠李皮苷B0532 Fraxetin 白蜡树亭0525 Fraxidin0588 Fraxin 白蜡树苷0014 Friedelin 无羁萜/软木三萜酮0034 Friedelin 无羁萜/软木三萜酮4104 Fructose 果糖4078 D-Fucose D-岩藻糖4079 L-Fucose L-岩藻糖3577 Fucosterol 岩皂甾醇0723 Fumaric acid 富马酸5185 Furfural 糠醛5141 Furfuryl acetate 乙酸糠酯5186 Furfuryl alcohol 糠醇1035 Fustin 黄颜木素G4106 Galactan 半乳聚糖4109 Galactomannane 半乳甘露聚糖4409 Galactomannane 半乳甘露聚糖4342 D-Galactosamine hydrochloride D-盐酸半乳糖胺4115 D-Galactosamine pentaacetate D-半乳糖胺五乙酸酯4117 D-Galactose D-半乳糖4116 L-Galactose L-半乳糖4119 β-D-(+)-Galactose pentaacetate β-D-(+)-半乳糖五乙酸酯0067 Galangin 高良姜精1114 Galangin 高良姜精6079 Gallic acid 五倍子酸/没食子酸1177 Gardenin A 栀子宁8974 GDHB(gamma-Glutaminyl-3,4-dihydroxybenzene) gamma-谷氨酰胺酰-3,4-二羟基苯0619 Gelsemine 钩吻碱0636 Gelsemine hydrochloride 盐酸钩吻碱1097 Genistein 染料木黄酮1298 Genistein-4’,7-dimethylether 染料木黄酮-4’,7-二甲醚1325 Genistin 染料木苷1147 Genkwanin 芫花素4319 Gentianose 龙胆三糖4125 β-Gentiobiose β-龙胆二糖4324 β-Gentiobiose octaacetate β-龙胆二糖八乙酸酯0216 Gentiopicroside6048 Gentisic acid 2,5-二羟基苯甲酸0071 Geraldol1168 Geraldol5023 Geraniol 香叶醇5073 Geraniol 香叶醇0560 5-Geranoxy-7-methoxycoumarin5024 Geranyl acetate 香叶醇乙酸酯8975 GHB(gamma-Glutaminyl-4-hydroxybenzene) gamma-谷氨酰胺酰-4-羟基苯6536 Gibberellic acid 赤霉素/赤霉酸4982 6-Gingerol 6-姜辣醇4983 8-Gingerol 8-姜辣醇8821 Ginkgolide A 银杏内酯A8822 Ginkgolide B 银杏内酯B0105 Ginsenoside Rb1 人参皂苷Rb10104 Ginsenoside Rb2 人参皂苷Rb20106 Ginsenoside Rc 人参皂苷Rc0102 Ginsenoside Rd 人参皂苷Rd0103 Ginsenoside Re 人参皂苷Re0107 Ginsenoside Rf 人参皂苷Rf0101 Ginsenoside Rg1 人参皂苷Rg10119 Ginsenosides Kit 人参皂苷试剂包0842 Gitoxigenin 芰皂配基0844 Gitoxin 芰皂素5429 (-)-Globulol 蓝桉醇4344 D-Gluconic acid-delta-lactone D-葡糖酸-delta-内酯4339 1-o-α-D-Glucopyranosyl-D-mannitol 1-o-α-D-吡喃葡萄糖基-D-甘露糖醇4133 D-(+)-Glucosamine hydrochloride D-(+)-盐酸葡糖胺4139 D-Glucosaminic acid D-葡糖胺酸4141 L-Glucose L-葡萄糖4378 D-Glucose D-葡萄糖4143 α-D-Glucose pentaacetate α-D-葡萄糖五乙酸酯4144 β-D-Glucose pentaacetate β-D-葡萄糖五乙酸酯4517 β-Glucosidase β-葡糖苷酶4149 D-glucurono-3,6-lactone D-葡糖醛酸-3,6-内酯5589 D-Glutamic acid D-谷氨酸5505 L-Glutamic acid L-谷氨酸3046 Glutaric acid 戊二酸5537 Glutathione(oxidized form) 谷胱甘肽5538 L-Glutathione(reduced form) L-谷胱甘肽3137 Glyceryl-1-monostearate 甘油酰-1-单硬脂酸5592 Glycine 甘氨酸3514 Glycocholic acid 甘氨胆酸0028 18-α-Glycyrrhetinic acid 18-α-甘草亭酸0044 18-α-Glycyrrhetinic acid with GC methylester 18-α-甘草亭酸0013 18-β-Glycyrrhetinic acid 18-β-甘草亭酸0043 18-β-Glycyrrhetinic acid 18-β-甘草亭酸0045 18-β-Glycyrrhetinic acid methylester 18-β-甘草亭酸甲酯0128 Glycyrrhizin ammoniacal 氨化甘草甜1260 Gossypetin-3,3’,4’,7-tetramethylether 棉子皮亭-3,3’,4’,7-四甲醚1178 Gossypin 棉纤维素6193 Gossypol acetate 棉子酚乙酸酯0637 Gramine 芦竹碱8504 Griseofulvin 灰黄霉素8045 Guaiac 愈创树酯6208 Guaiacol 愈创木酚6084 Guaiacol 愈创木酚6468 Guaiacol methylether 愈创木酚甲醚5025 Guaiazulene3803 Guaiol 愈创醇5540 Guanidine carbonate 碳酸胍7023 Guanine 鸟嘌呤4320 D-Gulono-gamma-lactone D-古洛糖酸-gamma-内酯H0958 Hamamelitannin 金缕梅单宁0638 Harmaline 骆驼蓬灵1832 Harmaline hydrochloride 盐酸骆驼蓬灵0639 Harmalol hydrochloride 盐酸骆驼蓬酚0640 Harman 哈尔满0641 Harman hydrochloride 盐酸哈尔满0642 Harmine 哈尔明/骆驼蓬碱1727 Harmine hydrochloride 盐酸哈尔明0644 Harmol hydrochloride 盐酸哈尔酚0202 Harpagoside0229 Harpagoside3582 Hecogenin 核柯配基3527 Hecogenin acetate 核柯配基乙酸酯0114 Hederacoside C0135 Hederacoside C0022 Hederagenin 常春(藤苷)配基0035 Hederagenin 常春(藤苷)配基0113 α-Hederin α-常春藤素0136 α-Hederin α-常春藤素0308 Helenien 堆心菊素/土木香素6194 Helicin 绣线菊苷0801 Helveticoside3076 1-Heneicosanol3080 1-Heptacosanol 二十七烷醇3083 Heptadecanoic acide 十七烷酸5188 gamma-Heptalactone5142 Heptyl acetate 乙酸庚酯0516 Herniarin 7-甲氧基香豆素0087 Hesperetin 橙皮素1115 Hesperetin 橙皮素0084 Hesperidin 橙皮苷1116 Hesperidin 橙皮苷9005 Hesperidin 橙皮苷1269 3’,4’,5,5’,6,7-Hexamethoxyflavone 3’,4’,5,5’,6,7-六甲氧基黄酮3468 1-Hexanol 己醇3360 trans-2-Hexen-1-al3097 trans-2-Hexen-1-ol3275 Hexylacetate 乙酸己酯6286 Hexylcinnamaldehyde 己基肉桂醛1017 Hinokiflavone 日本扁柏黄酮5512 Hippuric acid 马尿酸1672 Homatropine 后马托品1574 Homatropine hydrobromide 氢溴酸后马托品1117 Homobutein1283 (-)-Homoeriodictyol0091 Homoeriodictyol1118 Homoeriodictyol6059 Homogentisic acid 尿黑酸1055 Homoorientin9003 Homoorientin6088 Homovanillic acid 高香草酸8677 Humic acid sodium salt tech. 腐殖酸钠盐5424 α-Humulene 律草烯4326 Hyaluronic acid potassium salt 透明质酸钾盐1842 Hydrastine hydrochloride 盐酸白毛莨碱6474 Hydrocinnamic acid 氢化肉桂酸6015 Hydrocinnamic acid ethylester 氢化肉桂酸乙酯1729 Hydrocotarnine hydrobromide 溴化氢氢化可塔宁6475 Hydroferulic acid 氢化阿魏酸0419 Hydroquinone diacetate 氢醌二乙酸酯0420 Hydroquinone diethylether 氢醌二乙基醚0422 Hydroquinone monoethylether 氢醌单乙基醚0423 Hydroquinone monomethylether 氢醌单甲基醚6477 6-Hydroxy-3-anisic acid 6-羟基-3-茴香酸6095 3-Hydroxybenzaldehyde 3-羟基苯甲醛6096 4-Hydroxybenzaldehyde 4-羟基苯甲醛6098 3-Hydroxybenzoic acid 3-羟基苯甲酸6099 4-Hydroxybenzoic acid 4-羟基苯甲酸6290 4-Hydroxybenzoic acid propylester 4-羟基苯甲酸丙酯6102 3-Hydroxybenzylalcohol 3-羟基苯甲醇6103 4-Hydroxybenzylalcohol 4-羟基苯甲醇1270 2-Hydroxychalcone 2-羟基查耳酮1271 2’-Hydroxychalcone 2’-羟基查耳酮1272 4-Hydroxychalcone 4-羟基查耳酮1273 4’-Hydroxychalcone 4’羟基查耳酮0505 3-Hydroxycoumarin 3-羟基香豆素0517 4-Hydroxycoumarin 4-羟基香豆素6484 2-Hydroxy-3,4-dimethoxybenzoic acid 2-羟基-3,4-二甲氧基苯甲酸1180 2’-Hydroxyflavanone 2’-羟基黄烷酮1181 4’-Hydroxyflavanone 4’-羟基黄烷酮1182 6-Hydroxyflavanone 6-羟基黄烷酮1212 7-Hydroxyflavanone 7-羟基黄烷酮1026 3-Hydroxyflavone 3-羟基黄酮1019 5-Hydroxyflavone 5-羟基黄酮1059 6-Hydroxyflavone 6-羟基黄酮1060 7-Hydroxyflavone 7-羟基黄酮1258 7-Hydroxyflavonol 7-羟基黄烷醇0048 3-α-Hydroxyfriedelan-2-one5636 o-Hydroxyhippuric acid o-羟基马尿酸6486 5-Hydroxyisovanillic acid 5-羟基异香草酸6488 2-Hydroxy-4-methoxybenzoic acid 2-羟基-4-甲氧基苯甲酸0566 4-Hydroxy-6-methylcoumarin 4-羟基-6-甲基香豆素1149 7-Hydroxy-5-methylflavone 7-羟基-5-甲基黄酮6118 4-Hydroxyphenylacetic acid 4-羟基苯乙酸2081 4-Hydroxyphenylacetic acid methylester 4-羟基苯乙酸甲酯8825 4-(4-Hydroxyphenyl)-2-butanone 4-(4-羟苯基)-2-丁酮1817 4-Hydroxyquinoline 4-羟基喹啉1043 2’-Hydroxy-4,4’,6’-trimethoxy chalcone 2’-羟基-4,4’,6’-三甲氧基查耳酮1575 6-Hydroxytropinone 6-羟基托品酮3807 Hydroxyvalerenic acid0669 L-Hyoscyamine L-天仙子胺0670 Hyoscyamine hydrobromide 溴化氢天仙子胺1590 Hyoscyamine sulfate 硫酸天仙子胺0468 Hypericin 金丝桃素1027 Hyperoside 金丝桃甙9002 Hyperoside 金丝桃甙7015 Hypoxanthine 次黄嘌呤I7352 Ibotenic acid 鹅膏蕈氨酸0923 Ideain chloride0519 Imperatorin 白茅苷0357 Indigo 靛蓝0650 Indole 吲哚7024 Inosine 次黄苷/肌苷4349 meso-Inositol meso-肌醇4350 Inulin 菊粉/旋复花粉5027 α-Ionone α-芷香酮/紫罗酮5368 β-Ionone β-芷香酮/紫罗酮5028 β-Ionone β-芷香酮/紫罗酮8049 Isatin 靛红3473 Isoamyl alcohol 异戊醇2043 Isoascorbic Acid 异抗坏血酸0538 Isobergapten 异香柠檬烯5030 Isoborneol 异冰片5031 Isobornyl acetate 乙酸异冰片酯5032 Isobornyl isovalerate 异戊酸异冰片酯5033 Isobutanol 异丁醇5143 Isobutyl acetate 乙酸异丁酯2884 Isocaproic acid 异己酸0733 DL-Isocitric acid trisodium salt DL-异柠檬酸三钠盐1853 (+)-Isocorydine hydrochloride (+)-异紫堇定5366 Isoeugenol 异丁子香酚5417 Isoeugenylacetate 异乙酸丁子香氛酯6114 Isoferulic acid 异阿魏酸5594 L-Isoleucine allofree L-异亮氨酸1279 Isoliquiritigenin5438 Isolongifolene 异长叶烯5467 (-)-Isolongifolol (-)-异长叶醇4155 Isomaltose 异麦芽糖4154 Isomaltotriose 异麦芽三糖5165 D-Isomenthol D-异薄荷醇5442 DL-Isomenthol DL-异薄荷醇5034 Isomenthone 异薄荷酮1577 Isopilocarpine nitrate 硝化异毛果芸香碱0536 Isopimpinellin 异茴芹灵5468 (+)-Isopinocampheol (+)-异松蒎醇5110 （-）-Isopinocampheol4960 Isopropylgallate 没食子酸异丙酯4158 1,2-Isopropylidene-α-D-glucofuranose 1,2-异亚丙基-α-D-呋喃葡萄糖4162 1,2-Isopropylidene-D-xylofuranose 1,2，-异亚丙基-D-呋喃木糖5036 (-)-Isopulegol (-)-异蒲勒醇/异胡薄荷醇0065 Isorhamnetin 异鼠李素1120 Isorhamnetin 异鼠李素9007 Isorhamnetin 异鼠李素1228 Isorhamnetin-3-o-glucoside 异鼠李素-3-o-葡萄糖苷1229 Isorhamnetin-3-o-rutinoside 异鼠李素-3-o-芸香糖苷1121 Isorhoifolin。
血清同型半胱氨酸水平与HFpEF患者NT-proBNP水平及凝血功能的相关性
- 65 -[9]尹薇.为自身免疫性溶血性贫血患者用利妥昔单抗联合输血疗法进行治疗的效果观察[J].当代医药论丛，2021，19（9）：109-110.[10]王梦杰，张莉，戴书明.血浆置换和输入洗涤红细胞联合治疗对自身免疫性溶血性贫血患者血清铁蛋白、叶酸和维生素B 12短期水平的影响[J].川北医学院学报，2022，37（9）：1215-1218.[11]王艳琴，郑惠心，邹雪.去白红细胞及洗涤红细胞在自身免疫性溶血性贫血治疗中的应用观察[J].中国医学创新，2019，16（32）：158-161.[12]阚文君，赵迪，余泽波，等.直接Cooms 阳性患者输注悬浮红细胞和洗涤红细胞疗效分析[J].中国输血杂志，2022，35（4）：412-415.[13]徐晓玲.洗涤红细胞输注联合血液置换在自身免疫性溶血性贫血治疗中的应用[J].标记免疫分析与临床，2018，25（6）：815-817.[14] RUQAYYAH A，JASON A. Platelet vesicles are potentinflammatory mediators and washing red blood cell products with an automated cell processor reduces the inflammatory phenotype[J]. Transfusion Medicine Reviews，2020，34（1）：64.[15]王莹.血浆置换与去白细胞红细胞悬液输血在自身免疫性溶血性贫血中的应用[J].临床与病理杂志，2021，41（12）：2889-2893.[16] BAKER S A，WONG L K，WIELAND R，et al. Validatedtransport conditions maintain the quality of washed red blood cells[J]. Transfusion，2022，62（9）：1860-1870.（收稿日期：2023-07-09）*基金项目：2022年佛山市自筹经费类科技计划项目（2220001005219）①佛山市三水区人民医院 广东 佛山 528100通信作者：邹文毕血清同型半胱氨酸水平与HFpEF患者NT-proBNP水平及凝血功能的相关性*黄光秀① 廖思钦① 廖美艳① 池青① 罗冰① 邹文毕①【摘要】 目的：探讨血清同型半胱氨酸（Hcy）水平与射血分数保留的心力衰竭（HFpEF）患者N 末端B 型脑钠肽前体（NT-proBNP）水平及凝血功能的相关性。
药用辅料中英文对照
药用辅料中英文对照1 阿拉伯胶(Acacia)2 乙酰舒泛钾(Acesulfame Potassium)3 冰醋酸(Acetic Acid,Glacial)4 乙酰枸橼酸三丁酯(AcetyltributylCitrate)5 乙酰枸橼酸三乙酯(AcetyltriethylCitrate)6 人血白蛋白(Albumin)7 乙醇(Ethanol)8 海藻酸(Alginic Acid)9 脂肪族聚酯(Aliphatic Polyesters)10 阿力糖(Alitame)11 杏仁油(Almond Oil)12 维生素E(Alpha Tocopherol)13 氨溶液(Ammonia Solution)14 维生素C(Ascorbic Acid)15 棕榈酸维生素C酯(Ascorbyl Palmitate)16 阿司帕坦(Aspartame)17 绿坡缕石(Attapulgite)18 皂土(Bentonite)19 苯扎氯铵(Benzalkonium Chloride)20 苄索氯铵(Benzethonium Chloride)21 苯甲酸(Benzoic Acid)22 苯甲醇(Benzyl Alcohol)23 苯甲酸苄酯(Benzyl Benzoate)24 溴硝丙二醇(Bronopol)25 丁羟茴醚(Butylated Hydroxyanisole)26 丁羟甲苯(Butylated Hydroxytoluene)27 羟苯丁酯(Butylparaben)28 碳酸钙(Calcium Carbonate)29 无水磷酸氢钙(Calcium Phosphate,Dibasic Anhydrous)30 磷酸氢钙二水合物(Calcium Phosphate,Dibasic Dihydrate)31 磷酸钙(Calcium Phosphate,Tribasic)32 硬脂酸钙(Calcium Stearate)33 硫酸钙(Calcium Sulfate)34 低芥酸菜籽油(Canola Oil)35 卡波姆(Carbomer)36 二氧化碳(Carbon Dioxide)37 羧甲纤维素钙(Carboxymethylcellulose Calcium)38 羧甲纤维素钠(Carboxymethylcellulose Sodium)39 角叉菜胶(Carrageenan)40 蓖麻油(Castor Oil)41 氢化蓖麻油(Castor Oil,Hydro-genated)42 微晶纤维素(Cellulose,Microcrystalline)43 粉状纤维素(Cellulose,Powdered)44 微粉硅胶微晶纤维素(Cellulose, Silicified Microcrystalline)45 醋酸纤维素(Cellulose Acetate)46 纤维醋法酯(Cellulose Acetate Phthalate)47 角豆胶(Ceratonia)48 十八十六醇(Cetostearyl Alcohol)49 西曲溴铵(Cetrimide)50 十六醇(Cetyl Alcohol)51 壳聚糖(Chitosan)52 氯己定(Chlorhexidine)53 三氯叔丁醇(Chlorobutanol)54 氯甲酚(Chlorocresol)55 一氯二氟乙烷(Chlorodifluoroe-thane)56 氟里昂(Chlorofluorocabons)57 对氯间二甲酚(Chloroxylenol)58 胆固醇(Cholesterol)59 枸橼酸(Citric Acid Monohydrate)60 胶态二氧化硅（微粉硅胶）(Colloidal Silicon Dioxide)61 着色剂(Coloring Agents)62 玉米油(Corn Oil)63 棉籽油(Cottonseed Oil)64 甲酚(Cresol)65 交联羧甲纤维素钠(Croscarmellose Sodium)66 交联聚维酮(Crospovidone)67 环糊精(Cyclodextrins)68 环甲基硅酮(Cyclomethicone)69 苯甲地那铵(Denatonium Benzoate)70 葡萄糖结合剂(Dextrates)71 糊精(Dextrin)72 葡萄糖(Dextrose)73 邻苯二甲酸二丁酯(Dibutyl Phthalate)74 癸二酸二丁酯(Dibutyl Sebacate)75 二乙醇胺(Diethanolamine)76 邻苯二甲酸二乙酯(Diethyl Phthalate)77 二氟乙烷(Difluoroethane)78 二甲硅油(Dimethicone)79 二甲醚(Dimethyl Ether)80 邻苯二甲酸二甲酯(Dimethyl Phthalate)81 二甲亚砜(Dimethyl Sulfoxide)82 多库酯钠(Docusate Sodium)83 依地酸（乙二胺四乙酸）(Edetic Acid)84 乙酸乙酯(Ethyl Acetate)85 乙基麦芽酚(Ethyl Maltol)86 油酸乙酯(Ethyl Oleate)87 乙基香草醛(Ethyl Vanillin)88 乙基纤维素(Ethylcellulose)89 硬脂酸棕榈酸乙二醇酯(Ethylene Glycol Palmitostearate)90 羟苯乙酯(Ethylparaben)91 果糖(Fructose)92 富马酸(Fumaric Acid)93 明胶(Gelatin)94 液体葡萄糖(Glucose,Liquid)95 甘油(Glycerin)96 山萮酸甘油酯(Glyceryl Behenate)97 单油酸甘油酯(Glyceryl Monooleate)98 单硬脂酸甘油酯(Glyceryl Monostearate)99 硬脂酸棕榈酸甘油酯(Glyceryl Palmitostearate)100 四氢呋喃聚乙二醇醚(Glycofurol)101 瓜耳胶(Guar Gum)102 七氟丙烷(HFC)(Heptafluoro-propane)103 海克西定(Hexetidine)104 烷烃类（HC) (Hydrocarbons)105 盐酸(Hydrochloric Acid)106 羟乙纤维素(Hydroxyethyl Cellulose)107 羟乙甲纤维素(Hydroxyethylmethyl Cellulose)108 羟丙纤维素(Hydroxypropyl Cellulose)109 低取代羟丙纤维素(Hydroxypropyl Cellulose,Low-substituted) 110 羟丙甲纤维素(Hypromellose)111 羟丙甲纤维素酞酸酯(Hypromellose Phthalate)112 咪唑烷脲(Imidurea)113 异丙醇(Isopropyl Alcohol)114 肉豆蔻酸异丙酯(Isopropyl Myristate)115 棕榈酸异丙酯(Isopropyl Palmitate)116 白陶土(Kaolin)117 乳酸(Lactic Acid)118 拉克替醇(Lactitol)119 乳糖(Lactose)120 羊毛脂(Lanolin)121 含水羊毛脂(Lanolin,Hydrous)122 羊毛醇(Lanolin Alcohols)123 卵磷脂(Lecithin)124 硅酸镁铝(Magnesium Aluminum Silicate)125 碳酸镁(Magnesium Carbonate)126 氧化镁(Magnesium Oxide)127 硅酸镁(Magnesium Silicate)128 硬脂酸镁(Magnesium Stearate)129 三硅酸镁(Magnesium Trisilicate)130 苹果酸(Malic Acid)131 麦芽糖醇(Maltitol)132 麦芽糖醇溶液(Maltitol Solution)133 麦芽糖糊精(Maltodextrin)134 麦芽酚(Maltol)135 麦芽糖(Maltose)136 甘露醇(Mannitol)137 中链脂肪酸甘油三酯(Medium-chain Triglycerides)138 葡甲胺(Meglumine)139 薄荷脑(Menthol)140 甲基纤维素(Methylcellulose)141 羟苯甲酯(Methylparaben)142 液体石蜡(Mineral Oil)143 轻质液体石蜡(Mineral Oil,Light)144 液体石蜡羊毛醇(Mineral Oil and Lanolin Alcohols)145 单乙醇胺(Monoethanolamine)146 谷氨酸一钠(Monosodium Glutamate)147 硫代甘油(Monothioglycerol)148 氮(Nitrogen)149 一氧化二氮(Nitrous Oxide)150 油酸(Oleic Acid)151 橄榄油(Olive Oil)152 石蜡(Paraffin)153 花生油(Peanut Oil)154 凡士林(Petrolatum)155 凡士林羊毛醇(Petrolatum and Lanolin Alcohols)156 苯酚(Phenol)157 苯氧乙醇(Phenoxyethanol)158 苯乙醇(Phenylethyl Alcohol)159 醋酸苯汞(Phenylmercuric Acetate)160 硼酸苯汞(Phenylmercuric Borate)161 硝酸苯汞(Phenylmercuric Nitrate)162 磷酸(Phosphoric Acid)163 波拉克林钾(Polacrilin Potassium)164 泊洛沙姆(Poloxamer)165 葡聚糖(Polydextrose)166 聚乙二醇(Polyethylene Glycol)167 聚氧乙烯(Polyethylene Oxide)168 聚(甲基)丙烯酸树脂(Polymethacr-ylates)169 聚氧乙烯烷基醚(Polyoxyethylene Alkyl Ethers)170 聚氧乙烯蓖麻油衍生物(Polyoxyeth-ylene Castor Oil Derivatives) 171 聚山梨酯(Polyoxyethylene Sorbitan Fatty Acid Esters)172 硬脂酸聚氧乙烯酯(Polyoxyethylene Stearates)173 聚醋酸乙烯酞酸酯(Polyvinyl Acetate Phthalate)174 聚乙烯醇(Polyvinyl Alcohol)175 苯甲酸钾(Potassium Benzoate)176 碳酸氢钾(Potassium Bicarbonate)177 氯化钾(Potassium Chloride)178 枸橼酸钾(Potassium Citrate)179 氢氧化钾(Potassium Hydroxide)180 焦亚硫酸钾(Potassium Metabisulfite)181 山梨酸钾(Potassium Sorbate)182 聚维酮(Povidone)183 丙酸(Propionic Acid)184 没食子酸丙酯(Propyl Gallate)185 碳酸丙烯酯(Propylene Carbonate)186 丙二醇(Propylene Glycol)187 海藻酸丙二醇酯(Propylene Glycol Alginate)188 羟苯丙酯(Propylparaben)189 糖精(Saccharin)190 糖精钠(Saccharin Sodium)191 芝麻油(Sesame Oil)192 虫胶(Shellac)193 二氧化硅二甲硅油(Simethicone)194 海藻酸钠(Sodium Alginate)195 抗坏血酸钠(Sodium Ascorbate)196 苯甲酸钠(Sodium Benzoate)197 碳酸氢钠(Sodium Bicarbonate)198 氯化钠(Sodium Chloride)199 枸橼酸钠二水合物(Sodium Citrate Dihydrate)200 环拉酸钠(Sodium Cyclamate)201 氢氧化钠(Sodium Hydroxide)202 月桂硫酸钠(十二烷基硫酸钠)(Sodium Lauryl Sulfate)203 焦亚硫酸钠(偏亚硫酸钠)(Sodium Metabisulfite)204 磷酸氢二钠(Sodium Phosphate,Dibasic)205 磷酸二氢钠(Sodium Phosphate ,Monobasic)206 丙酸钠(Sodium Propionate)207 羧甲淀粉钠(Sodium Starch Glycolate)208 硬脂富马酸钠(Sodium Stearyl Fumarate)209 山梨酸(Sorbic Acid)210 山梨坦酯Sorbitan Esters(Sorbitan Fatty Acid Esters) 211 山梨醇(Sorbitol)212 大豆油(Soybean Oil)213 淀粉(Starch)214 预胶化淀粉(Starch,Pregelatinized)215 灭菌玉米淀粉(Starch,Sterilizable Maize)216 硬脂酸(Stearic Acid)217 硬脂醇(Stearyl Alcohol)218 羟糖氯(Sucralose)219 蔗糖(Sucrose)220 可压性蔗糖(Sugar,Compressible)221 蔗糖粉(Sugar,Confectioner’s)222 蔗糖球形颗粒(Sugar Spheres)223 硫酸(Sulfuric Acid)224 葵花籽油(Sunflower Oil)225 氢化植物油（硬脂）栓剂基质(Sup-pository Bases,Hard Fat) 226 滑石粉(Talc)227 酒石酸(Tartaric Acid)228 四氟乙烷(HFC)(Tetrafluoroe-thane)229 硫柳汞(Thimerosal)230 二氧化钛(Titanium Dioxide)231 西黄蓍胶(Tragacanth)232 海藻糖(Trehalose)233 三醋汀(Triacetin)234 枸橼酸三丁酯(Tributyl Citrate)235 三乙醇胺(Triethanolamine)236 枸橼酸三乙酯(Triethyl Citrate)237 香草醛(Vanillin)238 氢化植物油(Vegetable Oil,Hydrogenated)239 纯化水(Water)240 阴离子乳化蜡(Wax,Anionic Emulsifying)241 巴西棕榈蜡(Wax,Carnauba)242 十六醇酯蜡(Wax,Cetyl Esters)243 微晶蜡(Wax,Microcrystalline)244 非离子乳化蜡(聚西托醇乳化蜡)(Wax,Nonionic Emulsifying) 245 白蜡(Wax,White)246 黄蜡(Wax,Yellow)247 黄原酸胶(Xanthan Gum)248 木糖醇(Xylitol)796249 玉米朊（玉米蛋白）(Zein)250 硬脂酸锌(Zinc Stearate)。
生物梅里埃API说明书_part1(1-49)
NaCl 0.85% NaCl 5ml
8.5g 1000ml
5ml TDA 5ml JAMES 5ml
NIT 1 5ml
NIT 2 5ml
FeCl3 H2O J 2183 HCl 1N
S 24 / 25
()
10
H2O
R34 S2 S23 S26
N, N-
H2O
R34 S2 S23 S26
3.4g 100ml
+ -
-/+ + -
69280 Marcy-l'Etoile/France tel.(33) 04 78 87 20 00 /fax(33) 04 78 87 20 90
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+
2
bioMérieux sa
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20-25 37
bioMérieux sa
69280 Marcy-l'Etoile/France tel.(33) 04 78 87 20 00 /fax(33) 04 78 87 20 90
ONPG GLU ARA LDC ODC CIT H2S URE TDA IND OX NO2
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Enzalutamide_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:Enzalutamide is an androgen–receptor (AR) antagonist with IC 50 of 36 nM in LNCaP cells.IC50 & Target: IC50: 36 nM (androgen–receptor, in LNCaP cells)[1]In Vitro: Enzalutamide has greater affinity to AR than Bicalutamide does in a competition assay with 16β–[18F]fluoro–5α–DHT (18–FDHT) in castration–resistant LNCaP/AR cells (AR–overexpressing). While Enzalutamide shows no agonism in LNCaP/AR prostate cells. Enzalutamide antagonizes induction of prostate–specific antigen (PSA) and transmembrane serine protease 2(TMPRSS2), combination with the synthetic androgen R1881 in parental LNCaP cells. Enzalutamide inhibits the transcriptional activity of a mutant AR protein (W741C, mutation of Trp741 to Cys)[1]. Enzalutamide also prevents nuclear translocation and co–activator recruitment of the ligand–receptor complex [2].In Vivo: Enzalutamide induces great tumor regression in castrate male mice bearing LNCaP/AR xenografts at a dose of 10 mg/kg [1].Enzalutamide shows dose–independent pharmacokinetics at intravenous and oral doses of 0.5–5 mg/kg [4].PROTOCOL (Extracted from published papers and Only for reference)Cell Assay: Enzalutamide is dissolved in DMSO and stored, and then diluted with appropriate medium before use [1]. [1]LNCaP cells (107 cells/condition) are grown in RPMI media supplemented with 5% charcoalstripped serum for 22 days, then treated with DMSO or 1 nM R1881, combined with an antiandrogen (DMSO, 1 μM Bicalutamide, 10 μM Bicalutamide, 1 μM RD162, 10 μM RD162, 1 μM MDV3100, or 10 μM MDV3100) for 8 hours. An aliquot of cells are harvested for qRT–PCR of PSA and TMPRSS2 mRNA. Theremaining cells are cross–linked using 1% paraformaldehyde for 10 minutes, then glycine is added and samples centrifuged (4°C,4000 rpm, 5 minutes) to stop further crosslinking. Chromatin immunoprecipitation is performed using a chromatinimmunoprecipitation assay kit. Immunoprecipitated DNA is amplified by real–time PCR. Primers are PSA enhancerforward–ATGTTCACATTAGTACACCTTGCC and reverse–TCTCAGATCCAGGCTTGCTTACTGTC and TMPRSS2 enhancerforward–TGGTCCTGGATGATAAAAAAAGTTT and reverse–GACATACGCCCCACAACAGA [1].Animal Administration: Enzalutamide is dissolved in vehicle (10 % DMSO, 45 % polyethylene glycol 400, and 45 %saline) (Rat)[4].[3][4]Mice [3]Following a 5–day acclimation period, 5– to 9–week–old male CB17SCID mice are castrated and allowed to recover for an additional 5days before inoculation with tumor cells. LNCaP cells co–expressing exogenous AR and the AR–dependent reporter construct ARR2–Pb–Luc (LNCaP–AR–Lux cells) are used to generate a xenograft model of human prostate cancer. Before implantation,LNCaP–AR–Lux cells are prepared by the addition of trypsin–EDTA, washed with complete medium, collected and resuspended at 20×106 cells/mL. Cell suspensions are diluted with Matrigel to 2×106 cells/0.2 mL and delivered subcutaneously in the suprascapularregion. Tumor growth is monitored to the volume of 100 mm 3 when treatment begins (80 days). The observed rate of tumor take with LNCaP–AR–Lux cells is between 70% and 80%. Body weight and tumor volumes (width 2×length/2) are measured two to three times per week with a digital caliper, and the average tumor volumes are determined. Test drugs are diluted in TweenProduct Name:Enzalutamide Cat. No.:HY-70002CAS No.:915087-33-1Molecular Formula:C 21H 16F 4N 4O 2S Molecular Weight:464.44Target:Androgen Receptor; Autophagy Pathway:Others; Autophagy Solubility:10 mM in DMSO80:PEG 400, and stored at 4°C until administration by oral gavage. Each group of mice (n=7) is treated daily for 28 consecutive days with 1, 10, or 50 mg/kg Enzalutamide, vehicle control, or 50 mg/kg Bicalutamide. At the end of the treatment period or when tumor volume exceeded 1,000 mm3, animals are euthanized and blood and tissue samples are collected for analysis.Rat[4]Male SD rats (n=3) are administered Enzalutamide through the tail vein (intravenous) and by oral gavage at 1 mg/kg and are kept in metabolic cages after dosing. Urine and feces samples are collected over the following time intervals after dosing: 0–2, 2–4, 4–6, 6–10, 10–24, 24–48, and 48–72 h. The metabolic cages are rinsed with distilled water, and residues are added to the urine samples at 72 h. To extract the Enzalutamide present in the feces, samples are shaken vigorously for 12 h with 50 % methanol.References:[1]. Tran C, et al. Development of a second–generation antiandrogen for treatment of advanced prostate cancer. Science, 2009, 324 (5928), 787–790.[2]. Scher HI, et al. Antitumour activity of MDV3100 in castration–resistant prostate cancer: a phase 1–2 study. Lancet, 2010, 375(9724), 1437–1446.[3]. Guerrero J, et al. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration–resistant prostate cancer. Prostate. 2013 Sep;73(12):1291–305.[4]. Kim TH, et al. Pharmacokinetics of enzalutamide, an anti–prostate cancer drug, in rats. Arch Pharm Res. 2015 Nov;38(11):2076–82.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Etomoxir_DataSheet_MedChemExpress
Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:Etomoxir is a potent inhibitor of carnitine palmitoyltransferase–I (CPT–1).IC50 & Target: CPT–1[1]In Vitro: Etomoxir binds irreversibly to the catalytic site of CPT–1 inhibiting its activity, but also upregulates fatty acid oxidation enzymes. Etomoxir is developed as an inhibitor of the mitochondrial carnitine palmitoyltransferase–1 (CPT–1) located on the outer mitochondrial membrane. Etomoxir, in the liver can act as peroxisomal proliferator, increasing DNA synthesis and liver growth.Thus, etomoxir, in addition of being a CPT1 inhibitor could be considered as a PPARalpha agonist [1]. Etomoxir is a member of the oxirane carboxylic acid carnitine palmitoyl transferase I inhibitors and has been suggested as a therapeutic agent for the treatment of heart failure. Acute Etomoxir treatment irreversibly inhibits the activity of carnitine palmitoyltransferase I. As a result, fatty acid import into the mitochondria and β–oxidation is reduced, whereas cytosolic fatty acid accumulates and glucose oxidation is elevated. Prolonged incubation (24 h) with Etomoxir produces diverse effects on the expression of several metabolic enzyme [2].In Vivo: Etomoxir is an inhibitor of free fatty acid (FFA) oxidation–related key enzyme CPT1. P53 interacts directly with Bax, which is inhibited by Etomoxir, further confirming the direct interaction of P53 and Bax, and the involvement of FAO–mediatedmitochondrial ROS generation in db/db mice [3]. Rats are injected daily with Etomoxir, a specific CPT–I inhibitor, for 8 days at 20mg/kg of body mass. Etomoxir–treated rats display a 44% reduced cardiac CPT–I activity. The treatment of Lewis rats for 8 days with 20 mg/kg Etomoxir does not alter blood glucose, which is in line with comparable etomoxir–feeding studies. Similarly, Etomoxir feeding does not affect general growth characteristics such as gain in body mass, nor does it affect hindlimb muscle mass.However, heart mass and liver mass are both significantly increased by 11% in Etomoxir–treated rats [4].PROTOCOL (Extracted from published papers and Only for reference)Cell Assay: Etomoxir is dissolved in DMSO and stored, and then diluted with appropriate medium before use [2]. [2]Rat heart H9c2 myoblastic cells are incubated in DMEM containing 10% fetal bovine serum until near confluence. In some experiments,cells are preincubated for 2 h with DMEM (serum–free) in the absence or presence of 1–80 μM Etomoxir and then incubated for 2 h with 0.1 mM [1–14C]oleic acid (10 μCi/dish, binds to BSA in a 1:1 molar ratio). In other experiments, cells arepreincubated for 2 h plus or minus 40 μM Etomoxir and then incubated for 2 h with 0.1 μM or 0.1 mM [1,3–3H]glycerol (10μCi/dish), 0.1 mM [1–14C]oleic acid (2 μCi/dish, binds to BSA in a 1:1 molar ratio), 0.1 mM [1–14C]palmitic acid (2μCi/dish, binds to BSA in a 1:1 molar ratio), 28 μM [3H]ethanolamine (2 μCi/dish), 28 μM [methyl–3H]choline (2 μCi/dish), 0.4mM [3H]serine (20 μCi/dish), or 40 μM myo–[3H]inositol (10 μCi/dish). The medium is removed and the cells washed twice withice–cold saline and then harvested from the dish with 2 mL methanol–water (1:1, v/v) for lipid extraction. An aliquot of thehomogenate is taken for the determination of total uptake of radioactivity into cells. Phospholipids are then isolated andradioactivity in these determined [2].Animal Administration: Etomoxir is dissolved in 0.9% (w/v) NaCl (Rat)[4].[3][4]Mice [3]Product Name:Etomoxir Cat. No.:HY-50202CAS No.:124083-20-1Molecular Formula:C 17H 23ClO 4Molecular Weight:326.82Target:Others Pathway:Others Solubility:10 mM in DMSO80 male C57BLKS/J lar–Lepr db/db mice and 20 wild type littermates (8 week) are used. db/db mice are randomly divided into four groups: db/db group, Etomoxir group, MitoQ group, and PFT–α group. In the Etomoxir group, mice are intraperitoneally injected with 1 mg/kg Etomoxir twice every week. In the MitoQ group, 50 μM MitoQ is given to the mice in water. Water bottles, containing either MitoQ, are covered with aluminum foil, and all bottles are refilled every 3 days. In the PFT–α group, mice are intraperitoneally injected with 1 mg/kg PFT–α twice every week. WT mice are administrated with vehicle instead. The experimental period is 8 weeks. At the end, peripheral blood samples and bone marrow cells are harvested for the assays.Rat[4]Male Lewis rats, weighing 150–200 g, are used in the present study. Animals are kept on a 12 h:12 h light/dark cycle and fed a Purina Chow diet and water ad libitum. The rats are divided into two groups: (1) control and (2) Etomoxir. Etomoxir (20 mg/kg of body weight) is dissolved in 0.9% (w/v) NaCl and administered intraperitoneally for 8 days. Control rats receive saline. The last injection is given 24 h before the experiment. Animals are anaesthetized with an intraperitoneal injection of a nembutal and heparin (3:1) mixture. Subsequently, the heart is removed for LCFA uptake studies and for analyses of transporter protein contents.References:[1]. Rupp H, et al. The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz. 2002 Nov;27(7):621–36.[2]. Xu FY, et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003 Feb; 44(2):415–23.[3]. Li J, et al. FFA–ROS–P53–mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep. 2015 Jul 31;5:12724.[4]. Luiken JJ, et al. Etomoxir–induced partial carnitine palmitoyltransferase–I (CPT–I) inhibition in vivo does not alter cardiac long–chain fatty acid uptake and oxidation rates. Biochem J. 2009 Apr 15;419(2):447–55.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
与药物设计有关的数据库
Organic Syntheses(有机合成手册), John Wiley & Sons(免费)PubMed: MEDLINE和PREMEDLINE(免费)从ChemWeb检索Beilstein Abstracts (formerly known as NetFire)(免费)中药化学数据库TCMDChem Sources (化学品目录、价格)(部分免费)Glossary of Biochemistry and Molecular Biology (生物化学和分子生物学术语)(免费)分子的3D显示: WebMolecules(免费)美国国家生物技术信息中心NCBI提供的免费数据库Entrez(免费)美国引地安那大学测试的X光衍射晶体结构数据(1348个样品)(部分免费)欧洲生物信息学所EBI提供的免费数据库(免费)日本GenomeNet提供的分子生物学免费数据库(免费)物性、质谱、晶体结构数据库(Kelvin, Dalton, Angstrom), JST(免费)小分子生物活性数据库ChemBank(免费)药物使用指南, USP DI(免费)Ashley Abstracts Database (药物研发、市场文献摘要)(免费)CASREACT - Chemical Reactions Database(CAS的化学反应数据库)CA TH Protein Structure Classification (蛋白质结构分类)(免费)Databases and Tools for 3-D Protein Structure Comparison and Alignment (三维蛋白质结构对比)(免费)Natural Product Updates (NPU)Properties of Organic Compounds on CD ROM, Version 5.0Protein Data Bank (PDB, 蛋白质数据库)(免费)QCLDB (量子化学文献数据库)(部分免费)Sigma-Aldrich Library of Rare Chemicals (2002 CD-ROM Database)The Merck Index: CDROM Windows Version 12.3从检索MDL的化学品/厂家目录:ACD(部分免费)从检索药物交易信息库PharmaDeals(部分免费)从ChemWeb检索CCD (Chapman & Hall/CRC Combined Chemical Dictionary)(部分免费)从ChemWeb检索有机药物用途及别名库Negwer: organic-chemical drugs and theirsynonyms(部分免费)酶命名数据库(ENZYME-Enzyme nomenclature database)(免费)美国常用药品索引库RxList(免费)美国斯克利普斯研究院：金属蛋白质结构和设计项目(Metalloprotein Structure and Design Program at the Scripps Research Institute)(免费)日本丰桥大学Jinno实验室的研究数据库(液相色谱、多环芳烃/药物/杀虫剂的紫外谱、物性)(免费)有机合成文献综述数据库Synthesis Reviews(免费)2-D聚丙烯酰胺凝胶电泳数据库(丹麦，Danish Centre for Human Genome Research's 2-D PAGE Databases)(免费)AntiBase (微生物、高等真菌)AQUASOL dATAbASE of Aqueous Solubility (水溶液溶解度数据)Arachnova药物研究机构数据库CRO(免费)ASINEX Ltd. (组合化学样品库)BBID-Biological Biochemical Image DatabaseBIND - The Biomolecular Interaction Network Database.(免费)BioCatalysis (生物催化数据库)BioMagResBank (BMRB): 多肽、蛋白质、核酸等的核磁共振数据存储库(免费)BIOSTER (相似生物活性数据库)Biotransformations (生物转化数据库)CAZY - Carbohydrate -Active enZYmes (法国，有关碳水化合物和酶的数据库)(免费)CBS Data Sets (丹麦生物信息数据库)(免费)CHIRBASE (手性色谱分离数据库)COMe-the bioinorganic motif database (生物无机模体数据库)(免费)Comprehensive Medicinal Chemistry (CMC)Cytokine Family Database (dbCFC) (细胞因子数据库)(免费)Database of Macromolecular Movements(免费)DNA Methylation Database (DNA 甲基化数据库)(免费)Drug Database: 一些药物分子的2D和3D结构(免费)DTP Data Search, Developmental Therapeutics Program, NIHECDYBASE (The Ecdysone Handbook)(免费)ERMS:欧洲海洋生物物种库GenBank:美国健康研究院基因序列数据库(NIH genetic sequence database)(免费) GlycoSuiteDB (多糖/聚糖/多聚糖结构库)(部分免费)GlycoSuiteDB (有关聚糖结构的数据库，总部在澳大利亚)IHC World (免疫组织化学在线资源)(免费)ILL's 3D structure gallery in VRML (各种有趣的无机材料的3D结构)IMB Jena Image Library of Biological Macromolecules (生物大分子三维结构图片库)(免费) INTERACT - Protein-Protein Interaction database at The University of ManchesterIRIS, EPA (对人体有害物质信息库)(免费)KEGG: Kyoto Encyclopedia of Genes and Genomes(免费)Klotho: Biochemical Compounds Declarative Database(免费)LIPIDAT (脂类数据库)LIPIDBANK for Web (脂类数据库)Marinlit (海洋天然产物文献数据库)MDL Drug Data Report (MDDR)MedChem/Biobyte QSAR database(免费)Merck Synopsis online(制药原料库)(部分免费)Metabolism database (代谢数据库)Metalloprotein Database and Browser (有关金属蛋白的数据库)(免费)Methods in Organic Synthesis (可结构检索)MINT: a Molecular INTeraction database(免费)NCI-3D库, NLM, NIH (2D子结构检索、3D结构显示)(免费)NIH的DTP可下载的数据库(免费)NUTRACEUT (营养保健品文献库)Pesticide Action Network Pesticide DatabasePharmaprojects(在研新药动态)PlantsP: Functional Genomics of Plant PhosphorylationPROMISE: 蛋白质活性位点的辅基和金属离子(免费)Protecting Groups (保护基团数据库)Receptor Database (RDB, 受体数据库)(免费)RNA modification databaseRNA Structure Database (RNA 结构数据库)Science of Synthesis: Houben-Weyl Methods of Molecular Transformation Separation of enantiomers by chiral chromatography/chiral HPLC (对映异构体的分离) Solid-Phase Synthesis database (固相有机合成)SweeT-DB (糖类化合物数据库)(免费)Synthline: 药物合成数据库光盘The MIPS Comprehensive Yeast Genome Database (CYGD)(免费)WFCC-MIRCEN 国际微生物数据中心氨基酸结构、性质, U. C. 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药用辅料翻译汇编
课程论文课程题目：制剂技术与工程学院：药学院专业：制药工程与技术姓名：刘晶晶学号：030131092聚丙烯酸树脂1 通用名英国药典：甲基丙烯酸铵共聚物（A型）甲基丙烯酸铵共聚物（B型）基本丁基甲基丙烯酸酯共聚物甲基丙烯酸 - 丙烯酸乙酯共聚物（1:1）分散30％甲基丙烯酸 - 甲基丙烯酸甲酯共聚物（1:1）甲基丙烯酸 - 甲基丙烯酸甲酯共聚物（1:2）聚丙烯酸酯分散体（30％）欧洲药典：甲基丙烯酸铵共聚物（A型）甲基丙烯酸铵共聚物（B型）基本丁基甲基丙烯酸酯共聚物甲基丙烯酸 - 丙烯酸乙酯共聚物（1:1）分散30％甲基丙烯酸 - 甲基丙烯酸甲酯共聚物（1:1）甲基丙烯酸 - 甲基丙烯酸甲酯共聚物（1:2）聚丙烯酸酯分散体30％美国药典：氨基甲基丙烯酸酯共聚物甲基丙烯酸铵共聚物甲基丙烯酸铵共聚物分散体丙烯酸乙酯和甲基丙烯酸甲酯共聚物分散甲基丙烯酸共聚物甲基丙烯酸共聚物分散体注意：在美国药典20中收载了3个聚丙烯酸树脂品目；见第9项。
在这些品目中介绍几种型号的剧丙烯酸树脂。
在欧洲药典2002中收载了4个聚丙烯酸树脂的专门品目。
2 别名Acryl-EZE; acidi methacrylici et ethylis acrylatis polymerisatum;acidi methacrylici et methylis methacrylatis polymerisatum; ammo-nio methacrylatis copolymerum; copolymerum methacrylatis buty-lati basicum; Eastacryl ; Eudragit ; Kollicoat MAE ; polyacrylatisdispersio 30 per centum; polymeric methacrylates. See also Table I.3 化学名和CAS注册号表Ⅰ聚丙烯酸树脂的化学名和CAS登记号化学名商品名公司名CAS登记号丙烯酸丁酯/甲基丙烯酸二甲胺基乙酯/甲基丙烯酸甲酯聚合物（1：2：1）丙烯酸乙酯/甲基丙烯酸甲酯聚合物（2：1）甲基丙烯酸/甲基丙烯酸甲酯聚合物（1：1）甲基丙烯酸/丙烯酸乙酯聚合物（1：1）甲基丙烯酸/甲基丙烯酸甲酯聚合物(1:2)Eudragit E 100Eudragit E 12.5Eudragit E POEudragit NE 30DEudragit NE 40Eudragit NM 30D Eudragit L 100Eudragit L 12.5Eudragit L 12.5 PAcr yl-EZEAcr yl-EZE 93AAcr yl-EZE MP30 D-55EvonikindustriesEvonikindustriesEvonikindustriesEvonikindustriesEvonikindustriesEvonikindustriesEvonikindustries[24938-16-7][9010-88-2][25212-88-8][25086-15-1[26936-24-3][33434-24-1]丙烯酸乙酯/甲基丙烯酸甲酯/甲基丙烯酸氯化三甲胺基乙酯聚合物（1：2：0.2）丙烯酸乙酯/甲基丙烯酸甲酯/甲基丙烯酸氯化三甲胺基乙酯聚合物（1：2：0.1）Eudragit L100-55 Eastacr yl30DKollicoatMAE30 DPKollicoatMAE100 PEudragit S 100Eudragit S 12.5Eudragit S 12.5 PEudragit RL 100EEudragit RL POEudragit RL 30 DEudragit RL1Eudragit RL100 EEudragit RL POEudragit RL 30 DEudragit RL12.52.5EvonikindustriesEvonikindustriesColorconColorconEvonikindustriesEvonikindustriesEastmanChemicalKollicoatMAE30 DPBASF FineChemicalsKollicoatMAE100 PBASF FineChemicaEvonikindustriesEvonikindustriesEvonikindustriesEvonikindustriesEvonikindustriesEvonikindustries4 分子式与分子量欧洲药典2002中载：甲基丙烯酸-丙烯酸乙酯共聚物（1：1）是甲基丙烯酸和丙烯酸乙酯的共聚物。
医学专业词汇记忆
医学素术语总是庞大的，就很容易理解了。
医学术语，并不限于本表所载的“器官+症状”这种形式。
例如：Acr o phobia 高处恐怖[acro- 尖端+ -phobia 恐怖]dyspepsia 消化不良[dys- 障碍,不良+ -pepsia 消化]hyp o glycemia 低血糖[hypo- 低+ glyco- 糖+-emia 血症]leuc o cytopenia 白细胞减少[leuco- 白+ cyto- 细胞+ -penia 减少]tachycardia 心搏过速[tachy- 速+ cardio- 心+ - ia 症]therm o plegia 热射病, 中暑(heat stroke) [thermo- 热+ - plegia 麻痹]这些词的第已词素并非器官名，而是hypo-、leuco-、tachy-、thermo-、acro- 和dys- 等具有形容词职能的复合形或词头leu-co-白，表示“色调”，此外于色调有关的还有rubro/erythro- 红、chloro- 绿、melo/ nigro/melano- 黑、xantho- 黄、cyano- 青和chromo- 色cyano–blue, vio—purple, albo/leuko/leuco/---white, polio—gray, glauco—gray/,greenish等。
还有一些表示“位置”的词头：ecto- 外侧、endo-侧、meso-中央、retro-后方，和para-周围、附近等。
还有表示“方向”的词头：dorso-背侧的方向、ventro-腹侧的方向、antero-前方，和postero-后方等。
1、医学术语的构成要了解医学术语的构成，必须先知道什么是词头(prefis)、词尾(suffix)、复合形(combining form)、复合词(compound word)和词干(word root)。
阿司匹林代谢相关基因PEAR1的多态性在河南人群中的分布研究
阿司匹林代谢相关基因PEAR1的多态性在河南人群中的分布研究王米香1周建华2吴干斌21南阳医学高等专科学校第一附属医院临床药学科，河南473000；2郑州大学第二附属医院药学部，郑州450014通信作者：王米香，Email ：【摘要】目的研究河南地区人群中阿司匹林代谢相关基因血小板内皮聚集受体1（PEAR1）多态性的分布情况。
方法采用荧光染色原位杂交检测法对2019年1月至12月来南阳医学高等专科学校第一附属医院体检的115名健康体检者的PEAR1（rs12041331）基因型进行检测。
115名健康体检者中，男性69名，女性46名，年龄（40.0±3.5）岁。
结果共发现PEAR1有3种基因型，即AA 、GA 和GG 型，每种基因型的分布频率分别为12.17%（14/115）、46.09%（53/115）和41.74%（48/115）。
将试验结果进行Hardy-Weinberg 定律的吻合度测验，通过计算检测符合Hardy-Weinberg 平衡定律（χ2=1.24，P =0.362）。
结论河南地区人群中PEAR1具有基因多态性，其中GA 型为较常见的基因型。
【关键词】阿司匹林；血小板内皮聚集受体1；基因多态性；频率分布基金项目：河南省医学科技攻关计划联合共建项目（2018020151）Distribution of polymorphism of aspirin-metabolic gene PEAR1in Henan populationWang Mixiang 1,Zhou Jianhua 2,Wu Ganbin 21Department of Clinical Pharmacy,First Hospital Affiliated to Nanyang Medical College,Nanyang 473000,China;2Department of Pharmacy,Second Hospital Affiliated to Zhengzhou University,Zhengzhou 450014,ChinaCorresponding author:Wang Mixiang,Email:【Abstract 】Objective To study the distribution of polymorphism of aspirin-metabolic gene platelet endothelial aggregation receptor-1(PEAR1)in Henan population.Methods The PEAR1(rs12041331)genotypes of 115healthy examinees taking physical examination at First Hospital Affiliated to Nanyang Medical College from January to December,2019,including 69males and 46females who were (40.0±3.5)years old,were determined by the polymerase chain reaction-restriction fragment length polymorphism method.Results Three PEAR1genotypes were found,including AA,GA,and GG;and their distribution frequencies were 12.17%(48/115),46.09%(53/115),and 41.74%(48/115).The results'coincidence was tested according to the Hardy-Weinberg equilibrium law,and conformed to the law (χ2=1.24,P =0.362).Conclusion There is PEAR1polymorphism in Henan population,with GA as the common genotype.【Key words 】Aspirin;Platelet endothelial aggregation receptor-1;Genetic polymorphism;Frequency distributionFund program:Co-construction Project of Problem-tackling Plan of Medical Science and Technique in Henan Province(2018020151)DOI ：10.3760/cma.j.issn.1007-1245.2021.11.007收稿日期2021-01-11本文编辑吴琴娟引用本文：王米香,周建华,吴干斌.阿司匹林代谢相关基因PEAR1的多态性在河南人群中的分布研究[J].国际医药卫生导报,2021,27(11):1611-1613.DOI:10.3760/cma.j.issn.1007-1245.2021.11.007.··1611阿司匹林目前在临床中广泛用于心脑血管病的防治，尤其在经皮冠状动脉介入治疗（PCI）后，其与氯吡格雷联用成为抗凝治疗的基石［1-2］。
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Product Data Sheet
Dictamine 484-29-7 HY-N0849 199.21 C12H9NO2 >98%
Product Name: CAS No.: Cat. No.: MWt: Formula: Purity :
ility:
DMSO
Mechanisms: Pathways:Others; Target:Others Biological Activity: Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi. IC50 value: Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (∆ψ mm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis [2]....
References: [1]. Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41. [2]. An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.