CC-401 hydrochloride_1438391-30-0_DataSheet_MedChemExpress

Product Name:

CC-401 hydrochloride CAS No.:

1438391-30-0Cat. No.:

HY-13022Product Data Sheet

MWt:

424.93Formula:

C22H25ClN6O Purity :>98%

Solubility:

DMSO

Mechanisms:

Biological Activity:

CC-401Hcl is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase Pathways:MAPK ; Target:JNK CC 401 Hcl is a second generation ATP competitive anthrapyrazolone c Jun N terminal kinase

(JNK) inhibitor with potential antineoplastic activity.

IC50 value:

Target: JNK In vitro: JNK inhibition decreased cytochrome c release, caspase 3 activation (P<0.05), and lipid peroxidation (P<0.05). JNK inhibition also transiently blocked phosphorylation of c-Jun at 60 minutes after reperfusion (P<0.05) without affecting other MAPK signaling, including p-38 and Erk activation

[1].in vivo: In acute disease, CC-401 blocked JNK signaling and reduced proteinuria in the first 24 h.References:

[1]. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK, Brenner DA.JNK mediates

hepatic ischemia reperfusion injury.J Hepatol. 2005 Jun;42(6):850-9. Epub 2005 Apr 7.[2]. Flanc RS, et al. A pathogenic role for JNK signaling in experimental anti-GBM The transient neutrophil influx seen at 3 h of disease was not affected, however. Continued CC-401treatment suppressed glomerular and tubulointerstitial damage usually seen at 14 days [2].

Administration of CC-401 to rats prior to bilateral renal I/R prevented acute renal failure and largely prevented...

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glomerulonephritis. Kidney Int. 2007 Sep;72(6):698-708.[3]. Kanellis J, et al. JNK signalling in human and experimental renal ischaemia/reperfusion injury.

Nephrol Dial Transplant. 2010 Sep;25(9):2898-908.Caution: Not fully tested. For research purposes only

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