多肽合成蛋白测序

多肽合成蛋白测序433Ａ多肽合成系统——公认的经典高效全自动合成系统合成规模0.1－1.0 mmol，可采用Fmoc和tBoc两种方法特有的涡流混合式反应腔和NMP溶剂系统：活化氨基酸与肽充分反应，偶联率高达99％以上专利的零死体积阀门设计：去除交叉污染，减少试剂消耗全套完备的试剂和树脂全自动电脑控制，程序编辑快速简便特有回馈监控功能，自动强化脱保护和偶联，保证高得率491型蛋白质测序仪Procise 系列HT和cLC，Ｃ型蛋白测序仪独一无二的高灵敏高效率蛋白序列测定系统适于各种方法制备样品的测序：电转移印迹法、PVDF膜上样品或HPLC等溶液样品，还适于各种蛋白的测序全自动电脑监控：对于未知蛋白测序编辑新程序即可，并可同步监测反应情况随时调整以获得最佳结果，便于GMP控制精确的试剂输送回馈调节系统：使试剂输送精确度，化学反应效率、灵敏度提高，达fmol 级样品独立的高精度HPLC系统分析PTH氨基酸Procise C 为Ｃ端测序系统173毛细管HPLC及微量蛋白印迹制备系统一体化的超微量高效液相色谱仪，样品分离收集一步完成灵敏度高，回收率高，可用于500fmol蛋白/多肽样品制备自动收集样品到PVDF膜上，避免了人为的误差PVDF膜可直接用于蛋白测序仪：可与质谱仪联用样品斑点只有2－3mm，无需进一步浓缩或转移，减少了样品的丢失及污染可能检测器灵敏度极高，专适于超微量分析和微量制备多肽合成试剂试剂分子量数量产品编号DCM 84.9 1000 mlGEN902017DIPEA (density 0.742 g/mL) 129.2 4 x 9 ml GEN075000DMAP 122.2 1 g GEN910015DMF (Peptide synthesis grade, low amine content, 2 ppm)(25 L DMF available on request) 122.2 1000 ml GEN9100032500 ml GEN002007Fmoc-succinimidyl carbonate(For introduction of Fmoc group) 337.3 5 g GEN91001620% (v/v) Piperidine/DMF 1000 ml GEN910008TFA 100 ml GEN910004脱保护试剂(20% (v/v) Piperidine(DMF) 4 升GEN903081DIPEA 1 升GEN903082DMF 4 升GEN903080DMF 25 升GEN002507活化试剂DIPCDI (density 0.806g/ml) 126.2 25 ml GEN910006HATU 380.2 5 g GEN07652125 g GEN076523100 g GEN0765251000 g GEN076527HOAt 136.1 5 g GEN07651125 g GEN076513100 g GEN0765151000 g GEN076517HOBt · H2O153.1 5 g GEN07600125 g GEN076003100 g GEN076005PyAOP 521.4 5 g GEN07653125 g GEN076533TBTU 321.1 5 g GEN030003Linker A-Opfp 348.2 1 g GEN910017Linker A 182.2 1 g GEN910009Linker B-Opfp 318.2 1 g GEN910018Linker B 152.2 1 g GEN910010Linker H-Opfp 378.3 1 g GEN910019Linker H 212.3 1 g GEN910011433A 试剂401466 Synergy Reagent Kit (~100 cycles) Includes: 2 Piperidine (P/N 400629), 2THF (P/N 401255), 2 DMF (P/N 400143), 1 HBTU (P/N 401278), 1 HOBt/DMSO/NMP (P/N 401279), and 1 DIEA/DMSO/NMP (P/N 401254).400629 Piperidine, 200 mL401255 THF, 200 mL400143 DMF, 4 L401278 HBTU, 8 mmoles401279 HOBt/DMSO/NMP, 0.2 M, 40 mL401254 DIEA/DMSO/NMP, 40 mLFmoc-L 氨基酸产品分子量包装产品号Ala-OH 311.3 5 g GEN91101125 g GEN911012100 g GEN758002β-Ala-OH 311.3 5 g GEN911071 Aib-OH 325.4 5 g GEN91107225 g GEN911073 Arg-OH 396.4 5 g GEN911013 Arg-(Pbf)-OH 648.8 5 g GEN911096 25 g GEN911097100 g GEN911098 Asn-OH 354.4 5 g GEN91101725 g GEN911018100 g GEN758004 Asn(Trt)-OH 596.7 1 g GEN911016 5 g GEN911019100 g GEN758178 Asp(OtBu)-OH 411.5 5 g GEN91102025 g GEN911021100 g GEN758005 Cys(Acm)-OH 414.5 1 g GEN9110235 g GEN911024 Cys(tBu)-OH 399.5 5 g GEN911029 25 g GEN911030 Cys(StBu)-OH 431.6 5 g GEN911031 Cys(Trt)-OH 585.7 5 g GEN911026 25 g GEN911027 100 g GEN758022 Gln-OH 368.4 5 g GEN911032 25 g GEN911033 100 g GEN758012 Gln(Trt)-OH 610.7 1 g GEN911034 5 g GEN911037 100 g GEN758179 Glu(OtBu)-OH 425.5 5 g GEN911035 25 g GEN911036 100 g GEN758021 Gly-OH 297.3 5 g GEN911038 25 g GEN911039 100 g GEN758013 His(Trt)-OH 619.7 5 g GEN077213 25 g GEN077215 100 g GEN758183 His(Fmoc)-OH 599.6 5 g GEN911041 25 g GEN911042 100 g GEN758111 Ile-OH 353.4 5 g GEN91104425 g GEN911045100 g GEN758014 Leu-OH 353.4 5 g GEN91104725 g GEN911048100 g GEN758015 Lys(Fmoc)-OH 590.7 1 g GEN9110935 g GEN91109425 g GEN911095 Lys(tBoc)-OH 468.6 5 g GEN911050 5 g GEN911051100 g GEN758006 Met-OH 371.5 5 g GEN91105325 g GEN911054100 g GEN758016 Nle-OH 353.4 1 g GEN07730125 g GEN911055100 g GEN758023 Orn(tBoc)-OH 454.5 5 g GEN911056 Phe-OH 387.4 5 g GEN91105725 g GEN911058100 g GEN758017 Pro-OH 337.4 5 g GEN91105925 g GEN911060100 g GEN758018 Ser(tBu)-OH 383.4 5 g GEN911061 25 g GEN911062100 g GEN758009 Thr(tBu)-OH 397.5 5 g GEN911063 25 g GEN911064100 g GEN758010 Trp-OH 426.5 5 g GEN91106525 g GEN911066100 g GEN758019 Trp(tBoc)-OH 526.6 1 g GEN911090 5 g GEN91109125 g GEN911092 Tyr(tBu)-OH 459.5 5 g GEN911067 25 g GEN911068100 g GEN75801Val-OH 339.4 5 g GEN91106925 g GEN911070100 g GEN758020烯丙基（Allyl ）保护的Fmoc 氨基酸烯丙基保护的Asp 和 Glu 主要用以合成环化和侧链多肽，以及磺化，糖基化，磷酸化肽链Asp(OAl)-OH 395.4 5 g GEN91120525 g GEN911206Asp(OH)-Oal 395.4 1 g GEN9113005 g GEN91130125 g GEN911302Glu(OAl)-OH 409.4 5 g GEN91120725 g GEN911208Glu(OH)-Oal 409.4 1 g GEN9113055 g GEN91130625 g GEN911307Lys(Aloc)-OH 452.5 5 g GEN91120925 g GEN911210Tyr(Al)-OH 443.5 5 g GEN91121125 g GEN911212Fmoc-D-氨基酸Ala-OH 311.3 1 g GEN911105Asn-OH 354.4 1 g GEN911109Asp(OtBu)-OH 411.5 1 g GEN911111Gln-OH 368.4 1 g GEN911113Glu(OtBu)-OH 425.5 1 g GEN911115His(Trt)-OH 619.7 1 g GEN911108Ile-OH 353.4 1 g GEN911128Leu-OH 353.4 1 g GEN911117Lys(tBoc)-OH 468.6 1 g GEN911119Met-OH 371.5 1 g GEN911121Nle-OH 353.4 1 g GEN911123Phe-OH 387.4 1 g GEN911126Pro-OH 337.4 1 g GEN911124Ser(tBu)-OH 383.4 1 g GEN911138Thr(tBu)-OH 397.5 1 g GEN911139Trp-OH 426.5 1 g GEN911132Tyr(tBu)-OH 459.5 1 g GEN911140Val-OH 339.4 1 g GEN911136--------------------------------------------------------------------------------Fmoc-L-氨基酸OPfps带OPfp 脂的活化氨基酸主要用于HOBt 或 HOAt 等催化剂作用Ala-Opfp 477.4 5 g GEN91201125 g GEN912060Asn-Opfp 520.4 5 g GEN91201325 g GEN912061 Asn(Trt)-Opfp 762.7 1 g GEN912008 5 g GEN912009 Asp(OtBu)-Opfp 577.5 5 g GEN91201525 g GEN912062 Cys(Acm)-Opfp 580.6 1 g GEN9120195 g GEN91202025 g GEN912063 Cys(tBu)-Opfp 565.6 1 g GEN912023 5 g GEN912024 Cys(Trt)-Opfp 751.8 5 g GEN912022 25 g GEN912064 Gln-Opfp 534.4 5 g GEN912026 25 g GEN912065 Gln(Trt)-Opfp 776.8 5 g GEN912081 25 g GEN912082 Glu(OtBu)-Opfp 591.5 5 g GEN912028 25 g GEN912066 Gly-Opfp 463.4 5 g GEN912018 25 g GEN912067 His(tBoc)-Opfp 643.6 5 g GEN912030 25 g GEN912068Ile-Opfp 519.5 5 g GEN912032 25 g GEN912069 Leu-Opfp 519.5 5 g GEN912034 25 g GEN912070 Lys(tBoc)-Opfp 634.6 5 g GEN912036 25 g GEN912071 Met-Opfp 537.5 5 g GEN912038 25 g GEN912072 Nle-Opfp 519.5 5 g GEN912054 Phe-Opfp 553.5 1 g GEN912040 5 g GEN91204125 g GEN912073 Pro-Opfp 503.4 5 g GEN912043 25 g GEN912074 Ser-(tBu)-Opfp 549.5 5 g GEN912087 25 g GEN912088Thr(tBu)-Opfp 563.5 5 g GEN91209025 g GEN912091Trp-Opfp 592.5 5 g GEN91204925 g GEN912077Tyr(tBu)-Opfp 625.6 5 g GEN912051 25 g GEN912078Val-Opfp 504.4 5 g GEN91205325 g GEN912079多肽合成相关文献Reviews and mini-reviews1. “Instrumentation for automated solid-phase peptide synthesis.” Cammish，L.E.，Kates，S.A. In Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Chan，W.，White，P.) Oxford University Press，Oxford，1998，in press.2. “Peptide technologies: Nuts & bolts intelligence on practical industry solutions for peptede design，purification and production.” Kates，S.A. Current Drugs Ltd，1998，in press.3. “Functionalized resins and linkers for solid-phase synthesis of small molecules.” Blackburn，C.，Albericio，F.，Kates，S.A. Drugs of the Future，1997，22，1007.4. “Polyethylene glycol-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.” Barany，G.，Albericio，F.，Kates，S.A.，Kempe，M. In Chemistry and Biological Application of Polyethylene Glycol，ACS Symposium Series(Harris，J.M.，Zalipsky，S.，Eds.) American Chemical Society Books，Washington，DC，1997，239.5. “Solid-phase peptide and small molecule synthesis.” Blackburn，C.，Albericio，F.，Kates，S.A. In Recent Research Developments in Organic Chemistry (Pandalai，S.G.，Ed.) Transworld Research Network，India 1997，1，477.6. “Solid-phase synthesis of cyclic homodetic peptides.” Blackburn，C.，Kates，S.A. In Methods of Enzymology(Fields，G.B.，Ed.) Academic Press，New York，1997，289，175.7.“N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-ylmethylene]-N-methylmet han-aminium hexafluorophosphate N-oxide.” Albericio，F.，Kates，S.A.，Carpino，L.A. In Encyclopedia of Reagents for Organic Synthesis(Paquette，L.A.，Ed.) Wiley， New York，1996，3，2026.8. “3-Hydroxy-3H-1,2,3- triazolo[4,5-b]pyridin.” Kates，S.A.，Albericio，F，Carpino，L.A. In Encyclopedia of Reagents for Organic Synthesis (Paquette，L.A.，Ed.) Wiley， New York，1996，4，2784.9. “Azidotris(dimethylamino)phosphonium hexafluorophosphaste.” Albericio，F.，Kates，S.A. In Encyclopedia of Reagents for Organic Synthesis (Paquette，L.A.，Ed.) Wiley， New York，1996，1，224.10. “1,1’-Axobis-1-cyclohexanenitrile(ACN).” Kates，S.A.，Albericio，F. In Encyclopedia of Reagents for Organic Synthesis (Paquette，L.A.，Ed.) Wiley， New York，1996，1，228.11. “1-Phenylsulfonyl-1H-tetrazole.” Eritja，R.，Kates，S.A.，Albericio，F. In Encyclopedia of Reagents for Organic Synthesis (Paquette，L.A.，Ed.) Wiley， New York，1996，6，4058.12. “1-benzotriazo lyl diethyl phosphate.” Albericio，F. Kates，S.A. In Encyclopedia of Reagents for Organic Synthesis (Paquette，L.A.，Ed.) Wiley， New York，1996，1，300.13. “O-Benzoriazol-1-yl-N,N,N’,N’-tetramethyluronium hexafluorophosphate (HBTU)”. Albericio，F.，Kates，S.A. In Encyclopedia of Reagents for Organic Synthesis (Paquette，L.A.，Ed.) Wiley， New York，1996，1，304.14. “4,4’-Bis(2-amino-6-methylpyrimidyl) disulfide.” Albericio，F.，Kates，S.A.，Eritja，R. In Encyclopedia of Reagents for Organic Synthesis(Paquette，L.A.，Ed.) Wiley， New York，1996，1，421.15. “Solid-phase synthesis of cyclic peptides.” Kates，S.A.，Solé，N.A.，Albericio，F.A.，Barany，G. In Peptides: design，synthesis and biological activity (Basava，C.，Anantharamaiah，G.M.Eds.) Birkhauser，Boston(Massachusetts)，1994，39.16. “Synthetic Peptides Come of Age.” Fishman，J.B.，Kates，S.A. Biomedical Products Review，1995，20，52.Article in refereed journals1. “Continuous-flow solid-phase peptide sysnthesis using polystryrene resins.” Kates，S.A.，Cammish，L.E.，Albericio，F.J. Peptide Science，1998，in press.2. “On the uniformity of product quality for peptides generated in service laboratories: Peptides containing phosphorylated tyrosone residues.” Bonewald，L.F.，Bibbs，L.，Kates，S.A.，Khatri，A.，McMurray，J.S.，Medzihradszky，K.F.，Weintraub，S.T. J. Peptide Science，1998，in press.3. “Improved synthesis and purification of Alzeimer’s Ab 1-42 and analogs.” Milton，S.C.F.，de Lisle Milton，R.C.，Kates，S.A.，Glabe，C. Letters in peptide Science，1998，in press.4. “High load” Polyethylene glycol-polystryrene (PEG-PS) graft supports for solid-phase synthesis.” Kates，S.A.，Blackburn，C.，McGuinness，B.F.，Griffin，G.W.，Solé，N.A.，Barany，G.，Albericio，F. Biopolymers: Peptide Science，1998，in press.5. “On the Use of Onium Salt-Based Coupling Reagents in Peptide Synthesis” Albericio，F.，Bofill，J.M.，Carpino，L.A.，El-Faham，A.，Kates，S.A. . Chem. 1998，in press.6. “Automated，high productivity purification and analysis of synthetic peptides.” Londo，T.R.，Kehoe，T.，Kates，S.A.，Hantman，S.，Gordon，N.F. Letters in Peptide Science，1998，in press.7. “On the use of PyAOP，a phosphonium salt derived from HOAt，in solid-phase peptide synthesis.” Albericio，F.，Cases，M.，Alsina，J,.，Triolo，S.A.，Carpino，L.A.，Kates，S.A. Tetrahedron Lett.，1997，38，4853.8. “N-Dependent transcriptional antitermination in phage λis mediated by an inducible RNA bridge.” Su，L.，Radek，J.T.，Labeots，L.A.，Hermanto，P.，Chem，H.，Nakagawa，S.，Zhao，M.，Kates，S.A.，Weiss，M.A. Genes & Development，1997，11，2214.9. “Optimization of the synthesis of peptide combinatorial libraries (SPCLs) usinga one-pot method.” Herman，L.W.，Tarr，G.，Kates，S.A. Molecular Diveristy，1996，1，147.10. “Solid-phase synthesis of angiotensin converting enzyme (ACE) inhibtor libraries derived from N-alkylated dipeptide.” Blackburn，C.，Pingali，A.，Kehoe，T.，Herman，L.W.，Wang，H.，Kates，S.A. Bioorg. Chem. Med. Lett.1997，7，823.11. “N-Piperidylalanine formation during the preparation of C-terminal Cys peptides with an Fmoc/t Bu strategy.” Lukszo，J.，Patterson，D.，Albericio，F.，Kates，S.A. Lett. Peptide Science，1996，3，157.12. “Labelin g of synthetic biomolecules with biotin and fluorescein by active esters of 1-phenylpyarzolin-5-ones.” Kremsky，J.N.，Pluskal，M.，Casey，S.，Perry-O’Keefe，H.，Sinha，N.D.，Kates，S.A. Tetrahedron Lett. 1996，37，4313.13. “Preparation and applications of xanthenylami de (XAL) handles for solid-phase synthesis of C-terminal peptide amides under particularly mild conditions.” Han，Y,.，Bontems，S.L.，Hegyes，P.，Munson，M.C.，Minor，C.A.，Kates，S.A.，Albericio，F.，Barany，G. J. Org. Chem.，1996，61，6326.14. “Optimized preparation of d eca(L-alanyl)-L-valinamide by 9-fluorenylmethyloxycarbonyl (Fmoc) Solid-phase synthesis on polyethylene glycol-polystyrene (PEG-PS) graft supports，with 1,8-diazobicyclo[5.4.0]-undec-7-ene (DBU) deprotection.” Kates，S.A.，Solé，N.A.，beyermann，M.，Barany，G.，Albericio，F. Peptide Res.，1996，9，106.15. “Novel carbozylic acid and carboxamide protective groups based on the exceptional stablization of the cyclopropylmethyl cation.” Carpino，L.A.，Chao，H.-G.，Ghassemi，S.，Mansour，E.M.E.，Riemer，C.，Warrass，R.，Sadat-Aalaee，D.，Truran，G.A.，Imazumi，H.，El-Faham，A.，Ionescu，D.，Ismail，M.，Kowaleski，T.L.，Han，C.H.，Wenschuh，H.，Beyermann，M.，Bienert，M.，Shroff，H.，Alericio，F.，Triolo，S.A.，Solé，N.A.，Kates，S.A，J. Org. Chem.，1995，60，7718.16. “Rearrangement of Glu(O t Bu) and Asp(O t Bu)-containing peptides upon fluoride treatment in solid-phase synthesis.” Kates，S.A.，Albericio，F. Lett.Pep.Sci.，1995，1，213.17. “Structural studies of reagents for peptide bond formation: Crystal and molecular structures of HBTU and HATU.” Abdelmoty，I.，Albericio，F.，Carpino，L.A，Foxman，B.M.，Kates，S.A. Lett. Peptide Science1994，1，57.18. “Solid-phase N-glycopeptide synthesis using allyl side-chain protected Fmoc-amino acids.” Kates，S.A.，De la Torre，B.G.，Erijua，R.，Albericio，F. Tetrahedron Lett. 1994，35，1033.19. “Automate a llyl deprotection for continuous-flow synthesis of cyclic and branch peptide.” Kates，S.A.，Daniels，S.B.，Albericio，F. Anal. Biochem. 1993，212，303.20. “A novel，convenient，three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides.” Ka tes，S.A.，Solé，N.A.，Johnson，C.R.，Hudson，D.，Barany，G.，Albericio，F. Tetrahedron Lett.1993，34，1549.21. “The development of high-performance liquid chromatographic analysis of allyl and allyloxycarbonyl side-chain-protected phenylthiohydanoin amino acids.” Fields，C.G.，Loffet，A.，Kates，S.A.，Fields，G.B. Anal. Biochem. 1992，203，245.22. “Manganese (Ⅲ) based oxidative free-radical cyclization of unsaturated β-keto esters，1,3-diketones and malonate diesters.” Kates，S.A.，Dombroski，M.A.，Snider，B.B. .Chem.1990，55，2427.23. “Manganese (Ⅲ) based oxidative free-radical tandem and triple cyclizations.” Dombroski，M.A.，Kates，S.A.，Snider，B.B. J.Am.Chem.Soc. 1990，112，2759.24. “Formation of seven- and eight-membered rings by manganese (Ⅲ) based oxidative free radical cycli zations.” Merritt，J.E.，Sasson，M.，Kates，S.A.，Snider，B.B. Tetrahedron Lett. 1988，29，5209.25. “Mechanism of manganese (Ⅲ) based oxidative ofβ-ketoesters.” Snider，B.B.，Patricia，J.J.，Kates，S.A. .Chem. 1988，53，2137.26. “Manganese (Ⅲ) based oxidative free-radical cyclization. 3.Polycyclization reactions proceeding through secondary radicals.” Mohan，R.，Kates，S.A.，Dombroski，M.A.，Snider，B.B. Tetrahedron Lett.1987，28，845.27. “Manganese (Ⅲ) based oxidative free-radical cyclization. 2.Polycyclization reactions proceeding through tertiary cations.” Snider，B.B.，Mohan，R.，Kates，S.A. Tetrahedron Lett.1987，28，841.28. “Manganese (Ⅲ) based oxidative free-radical cyclization. Synthesis of (±)-podocarpic acid.” Snider，B.B.，Mohan，R.，Kates，S.A. .Chem. 1985，50，3659.Other articles1. “A comparison of solid-phase techniques for the construction of chemokines.” McNamara，J.F.，Lombardo，H.，Pillai，S.K.，Jensen，I.，Kates，S.A. In Peptides 1998 Proceedings of the Twenty-Fifth European Peptide Symposium (Bajusz，S.，Judecz，F.，Eds.) Mayflower Worldwide Limited， Birmingham，England，1999，in press.2. “Design and synthesis of cyclic peptides for iron-sulfur cluster assembly and encapsulation.” Segal，B.M.，McNamara，J.F.，Jensen，I.，Kates，S.A.，Holm，R.H. In Peptides 1998 Proceedings of the Twenty-Fifth European Peptide Symposium (Bajusz，S.，Judecz，F.，Eds.) Mayflower Worldwide Limited， Birmingham，England，1999，in press.3. De novo peptide design as an approach for the synthesis of a sturctural representation of the center A active site of carbon monoxide dehydrogenase/acetyl-CoA synthase.” Laplaza，C.E.，McNamara，J.F.，Jensen，I.，Kates，S.A.，Holm，R.H. In Peptides 1998 Proceedings of the Twenty-Fifth European Peptide Symposium (Bajusz，S.，Judecz，F.，Eds.) Mayflower Worldwide Limited，Birmingham，England，1999，in press.4. “Design and synthesis of cyclic cysteine-containing peptides for transition metal incorporation.” Nivorozhkin，A.L.，Kates，S.A.，Holm，R.H. In Peptides 1998 proceedings of the Twenty-Fifth European Peptide Symposium (Bajusz，S.，Judecz，F.，Eds.) Mayflower Worldwide Limited，Birmingham，England，1998，in press.5. “Solid-phase synthesis of “head-to-tail” cyclic and C-terminal modified peptides.” Albericio，F.，Frieden，A.，Del Fresno，M.，Royo，M.，Alsina，J.，Jensen，K.J.，Kates，S.A.，Barany，G. In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Chemical Libraries (Epton，R.，ed.) Mayflower Worldwide Limited，Birmingham，England，1998，in press.6. “Homodetic cyclic peptides via solid-phase synthesis.” Blackburn，C.，Kates，S.A. In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Chemical Libraries (Epton，R.，ed.) Mayflower Worldwide Limited， Birmingham，England，1998，in press.7. “Handles for solid-phase chemistry: Progress from peptide to small molecule synthesis.” Blackburn，C.，Barany，G.，Albericio，F.，Kates，S.A. In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Chemical Libraries (Epton，R.，ed.) Mayflower Worldwide Limited， Birmingham，England，1998，in press.8. “A comparison of solid supports for PNA synthesis.” Casale，R.A.，Paul，C.H.，Jensen，I.S.，Moyer，M.L.，Kates，S.A.，Egholm，M. In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Chemical Libraries (Epton，R.，ed.) Mayflower Worldwide Limited， Birmingham，England，1998，in press.9. “Backbone ami de Linker (BAL) for solid-phase synthesis of 2,5-piperazinediones (DKP)，useful scaffolds for combinatorial chemistry.” Albericio，F.，del Fresnl，M.，Alsina，J.，Frieden，A.，Royo，M.，Jensen，K.J.，Kates，S.A.，Barany，G. In Peptides-Chemistry and Biology: Proceedings of the Fourteenth American Peptide Symposium (Tam，J.) 1998，Escom，in press.10. “Encoding schemes for application with polyethylene glycol-polystyrene graft (PEG-PS) supports in solid-phase peptide and small molecule synthesis.” Kates，S.A.，Hines，W.H.，Kelley，M.A.，Lynch，P.，Albericio，F.，Barany，G. In Peptides-Chemistry and Biology: Proceedings of the Fourteenth American Peptide Symposium (Tam，J.) 1998，Escom，in press.11. “1997 ABRF peptide synthesis research committee study on a peptide containinga phosphorylate d tyrosine.” Bonewald，L.F.，Bibbs，L.，Kates，S.A.，Khatri，A.，Medzihradxzky，K.F.，McMurray，J.S.，Weintraub，S. In Peptides-Chemistry and Biology: Proceedings of the Fourteenth American Peptide Symposium (Tam，J.) 1998，Escom，in press.12. “Polyethylene glycol-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.” Barany，G.，Albericio，F.，Kates，S.A.，Kempe，M. Polymer Preprints Am. Chem. Soc. Div. Polym. Chem.，1997，38，587.13. “Synthesis of Alzheimer’s (1-42) Aβ-amyloid peptide with preformed Fmoc-aminoacyl fluorides.” Milton，S.C.F.，Milton，R.C.d.L.，Kates，S.A.，Glabe，C. In Techniques in Protein Chemistry Ⅷ (Marshak，D.R.，Ed.) 1997，Academic Press，San Diego，CA，865.14. “Recent aspects of the use of tetramethylfluorofomamidinium hexafluor ophosphate (TFFH) as a convenient peptide coupling reagent.” Triolo, S.A., Ionescu, D., Wenschuh, H., Solé, N.A., El-Faham, A., Carpino, L.A., Kates, S.A. In Peptides 1996 Proceedings of the Twenty-Fourth European Peptide Symposium(Ramage, R., Ed.)1997, Mayflower Worldwide Limited, Birmingham, England, 839.15. “Pioneer TM: A continuous-flow peptide synthesis system.” Daniels, S.B., Solé, N.A., Hantman, S.F., Gibney, B.R., Rabanal, F., Kates, S.A., In Peptides 1996 Proceedings of the Twenty-Fourth European Peptide Symposium(Ramage, R., Ed.) 1997, Mayflower Worldwide Limited, Birmingham, England, 323.16. “Crystal and solution structures of HBPyU and HAPyU.” Henklein, P., Costisella,B., Wray, V., Domke, T., Carpino, L.A., El-Faham, A. Kates, S.A., Abdelmoty, I., Foxman, B.M. In Peptides 1996 Proceedings of the Twenty-Fourth European Peptide Symposium(Ramage, R., Ed.) 1997, Mayflower Worldwide Limited, Birmingham, England, 465.17. “New coupling techniques for solid-phase peptide synthesis.” Kates, S.A., Carpino, L.A., Albercio, F. In Peptides-Chemistry and Biology: Proceedings of the Fourteenth American Peptide Symposium (Kaumaya, P.T.P., Hodges, R.S., Eds.) 1996, Mayflowers Worldwide Limited, Birmingham, England, 893.18. “Recent developments in azaben zotriazole-based coupling reagents for use in solid-phase peptide synthesis: PyAOP and HAPyU.” Kates, S.A., Triolo, S.A., Diekmann, E., Carpino, L.A., El-Faham, A., Ionescu, D., Albericio, F. In Peptides-Chemistry and Biology: Proceedings of the Fourteenth American Peptide Symposium (Kaumaya, P.T.P., Hodges, R.S., Eds.) 1996, Mayflowers Worldwide Limited, Birmingham, England, 115.19. “High load polyethylene glycol-polystyrene graft supports for solid-phase peptide synthesis.” McGuinness, B.F., Kates, S.A.,Grifin, G.W., Herman, L.W., Solé, N.A., Vágner, J., Albercio, F., Barany, G. In Peptides-Chemistry and Biology: Proceedings of the Fourteenth American Peptide Symposium (Kaumaya, P.T.P., Hodges, R.S., Eds.) 1996, Mayflowers Worldwide Limited, Birmingham, England, 125.20. “On the use of novel coupling reagents for solid-phasepeptide synthesis.” Kates, S.A., Diekmann, E., El-Faham, A., Herman, L.W., Ionescu, D., McGuinness, B.F., Triolo, S.A., Albericio, F., Carpino, L.A., In Techniques in Protein Chemistry Ⅶ(Marshak, D.R., Ed.) 1996, Academic Press, San Diego, CA, 515.21. “Advances in the use of onium-based coupling reagents: application for solid-phase peptide synthesis and combinatorial libraries.” Kates, S.A., Triolo, S.A., Griffin, G.W., Herman, L.W., Tarr, G., Solé, N.A., Diekmann, E., El-Faham, A., Ionescu, I., Albericio, F., Carpino, L.A. In Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Chemical Librariers (Epton, R., Ed.) 1997 Mayflower Worldwide Limited, Birmingham, England, 41.22. “Use of XAL handles for solid-phase synthesis of peptide amides.” Kates, S.A., Minor, C.A., Han, Y., Albericio, F., Barany, G. In Peptides 1994: Proceedings of the Twenty-third European Peptide Symposium(Maia, H.L.S., Ed.) 1995,Escom, Science Publishers, Leiden, The Netherlands, 262.23.Practival Protocols for efficient solid-phasepeptide synthesis. Minimization of side-reactions.” Kates, S.A., Minor, C.A., Shroff, H., Haaseth, R.C., Triolo, S., El-Faham, A., Carpino, L.A., Albericio, F. In Peptides 1994: Proceedings of the Twenty-third European Peptide Symposium (Maia, H.L.S., Ed.) 1995, Escom, Science Publishers, Leiden, The Netherlands, 248.24.“Polyethylene glycol-polystryrene (PEG_PS) supports for Boc solid-phase peptide and PNA synthesis strateg ies.” Albericio, F,. Bacardit, J., Barany, G., Coull, J.M., Egholm, M., Giralt, E., Griffin, G.W., Kates, S.A., Nicolás, E., Solé, N.A. In Peptides 1994: Proceedings of the Twenty-third European Peptide Symposium (Maia, H.L.S., Ed.)1995, Escom, Science Publishers, Leiden, The Netherlands, 271.25.“Azabenzotriazole (HOAt) derivatives as superior coupling reagents for peptide synthesis.” Albericio, f., Abdelmoty, I., Bofill, J.M., Carpine, L.A., El-Faham,A., Foxman, B.M., Gairí, M. Giralt, E., Griffin, G.W., K ates, S.A., Lloyd-Williams, P., Minor, C.A., Scarmoutzos, L.W., Shroff, H., Triolo, S., henschuh, H. In Peptides 1994: Proceedings of the Twenty-third European Peptide Symposium(Maia, H.L.S., Ed.) 1995, Escom, Science Publishers, Leiden, The Netherlands, 23.26. “New approaches for extending the scope of solid-phase peptide synthesis.” Carpino, L.A., El-Faham. A., Truran, G.A., Minor, C.A., Kates, S.A., Griffin, G.W., Shroff, H., Triolo, S.A., Albericio,F. In Innovation and perspectives in Solid Phase Synthesis-Peptides, Proteins and Nucleic Acids (Epton, R., Ed.) 1994 Mayflower Worldwide Limited, Birmingham, England, 95.27. “Orthogonal Solid-phase synthesis of bicyclic peptides.” Solé, N.A., Kates, S.A., Albericio, F., Barany, G. In Innovation and perspectives in Solid Phase Synthesis-Peptides, Proteins and Nucleic Acids (Epton, R., Ed.) 1994 Mayflower Worldwide Limited, Birmingham, England, 105.28. “Orthogonal Solid-phase synthesis of bicyclic analogues of αconotoxin SI.” Solé, N.A., Kates, S.A., Alberic io, F., Barany, G. In Innovation and perspectives in Solid Phase Synthesis-Peptides, Proteins and Nucleic Acids(Epton, R., Ed.) 1994 Mayflower Worldwide Limited, Birmingham, England, 93.29. “Automated allyl chemistry forsolid-phase peptide synthesis: Applications to cyclic and Branched peptides.” Kates, S.A., Daniels, B.B., Solé, N.A., Barany, G., Albericio, F. In P eptides-Chemistry and Biology: proceedings of the Thirteenth American Peptide symposium (Hodges, R., S., Smith J.A., Eds.) 1994 Escom, Science Publishers, Leiden, The Netherlands, 113.30. “Azabenzotriazole-based coupling reagents in solid-phase peptide sythesis.” Carpino, L.A., El-Faham, A., Truran, G.A., Triolo, S.A., Shroff, H., Griffin, G.W., Minor, C.A., Kates, S.A., Albericio, F. In P eptides-Chemistry and Biology: proceedings of the Thirteenth American Peptide symposium (Hodges, R., S., Smith J.A., Eds.) 1994 Escom, Science Publishers, Leiden, The Netherlands,124.31. “Allyl-based orthogonal solid-phase peptide synthesis.” Albericio, F., Ba rany,G., Fields, G.B., Hudson, D., Kates, S.K., Lyttle, M.H., Sole N.A. In Peptides 1992: Proceedings of the Twenty-second European Peptide Symposium(Schneider, C.H., Eberle, Eds.) 1993, Escom , Science Publishers, Leiden, The Netherlands, 191. 32. “Nove l polyethylene glycol-polystyrene (PEG-PS) graft supports for solid-phase peptide synthesis.” Barany, G., Albericio, F., Sole, N.A., Griffin, G.W., Kates, A.A., Hudson, D. In Peptides 1992: Proceedings of the Twenty-second European Peptide Symposium(Schneider, C.H., Eberle, Eds.) 1993, Escom , Science Publishers, Leiden, The Netherlands, 267.33. “New approaches in solid-phase peptide synthesis.” Albericio, F., Carpino, L.A., Daniels, S.B., El-Faham, A., Fukuda, H., Griffin, G.W., Kates, S.A., Minor, C.A., Shroff, H.N., Triolo, S.A., Truran, G.T., Yamabe, K., In “Peptide Chemistry 1993: Proceedings of the 31th Symposium on Peptide Chemistry(Okada, Y, Ed.) 1994, Protein Research Foundation, 121.Patents:“Automated allyl deprotection in solid-phase synthesi s.” Albericio, F., Kates, S.A. submitted 1993, awarded 1998.Abstracts:1.Susumu Funakoshi, G. William Griffin, Derek Hudson, Steven A. Kates, Mattew H.Lyttle, Hitesh Shroff, Nuria A. Solé, and Salvatore A. Triolo. Effective strategies for chemical synthesis of peptides. Twenty-second European Peptide Symposium-Millipore Forum. September, 1992, Interlaked (Switzerland).2.Fernando Albericio, George Barany, Gregg. B. Fields, Hiroyuki Fukuda, SusumuFunakoshi, Hiroyuki Fukuda, Nobutaka Fjjii, Fernando Albericio, Steven A, Kates, Vishnu C. Solan, and Salvatore A. Triolo. Biolinker: An affinity purification procedure for synthetic peptides. Thirteenth American Peptide Symposium. June, 1993. Edmonton (Canada).3.Steven A. Kates, G. William Griffin, Charles A. Minor, Nuria A. Solé, George Barany,and Fernando Albericio. New methods for the solid-phase synthesis of cyclic, branched, and multiple antigenic (MAP) peptides. Seven Symposium of the Protein Society. July, 1993, San Diego (California).4.Fernando Albericio, Louis A. Carpino, Ayman El-Faham, G. William Griffin ,SteveA. Kates, Charles A. Minor, Hitesh N. Shroff, Salvatore A Triolo, George A. Truran.Science Innovation ’93 of the American Association for the Advancement of Science.August, 1993. Boston (Massachusetts.)5.Steven A. Kates, G. William Griffin, Yonxin Han, Brian F. McGuinness, Joan McNeil,Charles A. Minor, Nuriá A. Solé, Michael F. Songster, Josef Vágner, Fernando Albericio, and George Barany. Improved handles and supports for solid-phase peptide synthesis. Ninth symposium of the Protein Society. July, 1995. Boston (Massachusetts).6.Michael F. Songster, Steven A. Kates, Fernando Albericio, and George Barany. Useof HAL (hypersensitive acid-labile) handle for solid-phase synthesis of peptide acids. Fourteenth American Peptide Symposium June 1995, Columbus (Ohio).7.Iman Abdelmoty, Fernando Albericio, Josep M. Bofill, Burce M.Foxman, and StevenA. Kates. The solid state structures of HATU and HBTU: A reexamination. FourteenthAmerican Peptide Symposium June 1995, Columbus (Ohio).8.Steven A. Kates, Solid-phase synthesis of cyclic peptides. Peptide SynthesisWorkshop Tenth Annual Meeting of the Association of Biomolecular Resource Facilities, July 1995, Boston (Massachusetts).9.Aruna Pingali, Christopher Blackburn, Lee W. Herman, Hongqi Wang, Steven A. Kates.Solid-phase synthesis and affinity selection of ACE inhibitor libraries derived from N-alkylated dipeptides. First Annual Solid-Phase Synthesis. Developing Small Molecule Libraries, Cambridge HealthTech Institute, February 1996, San Diego (California).10.Christopher Blackburn, Lee W. Herman, Nuriá A. Solé, Salvatore A. Triolo, StevenA. Kates. Reagents for solid-phase peptide and small molecule combinatorialsynthesis. First Annual Solid-Phase Synthesis, Developing Small Molecule Libraries, Cambridge HealthTech Institute, February 1996, San Diego (California).11.Steven A. Kate, Christopher Blackburn, Lee W. Herman, Elizbeth A. Luchow,Savatore A. Triolo. Onium-based coupling reagent and high-load polyethylene glycol-polystyrene (PEG-PG) supports: Tools for solid-phase peptide and small molecule combinatorial synthesis.。