褪黑素可减轻脊髓损伤后的水肿

褪黑素可减轻脊髓损伤后的水肿
来自中国人民解放军沈阳军区总医院的刘欣伟所在团队的一项研究发现，褪黑素(100 mg/kg)腹腔注射可减轻损伤脊髓水肿，其可能的机制与水通道蛋白4和胶质纤维酸性蛋白的表达有关。

褪黑素由松果体分泌产生，不仅可以调节人体昼夜生理节律，还具有强大的抗氧化活性。

最近研究表明，褪黑素可用于脊髓损伤的治疗。

还有一些研究者通过动物实验发现褪黑素具有抗水肿作用。

有研究报道水通道蛋白4的变化可影响与血脊髓屏障通透性，星形胶质细胞如出现水肿可影响脊髓损伤的预后，胶质纤维酸性蛋白是星形胶质细胞的标志物，这两种因素均与脊髓水肿有密切关系。

刘欣伟等提出了褪黑素减轻损伤脊髓水肿的机制与水通道蛋白4和胶质纤维酸性蛋白的表达有关的假设，并通过在《中国神经再生研究（英文版）》杂志发表的研究成果验证了此假设。

文章结果可为临床脊髓损伤的治疗提供参考依据。

文章发表在《中国神经再生研究（英文版）》杂志2014年12月第24期。

Article: " Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells," by Cheng Li1, Xiao Chen1, Suchi Qiao1, Xinwei Liu2, Chang Liu1, Degang Zhu1, Jiacan Su1, Zhiwei Wang1 (1 Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China; 2 Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of Chinese PLA, Shen yang, Liaoning Province, China)
Li C, Chen X, Qiao SC, Liu XW, Liu C, Zhu DG, Su JC, Wang ZW. Melatonin lowers edema after spinal cord injury. Neural Regen Res. 2014;9(24):2205-2210.
Melatonin lowers edema after spinal cord injury
Xinwei Liu, General Hospital of Shenyang Military Area Command of Chinese PLA, China and his colleagues found that intraperitoneal injection of melatonin (100 mg/kg) could reduce the water content of the injured spinal cord and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. Melatonin, a major secretory product from pineal gland, not only acts as a synchronizer for the circadian rhythm but also has powerful antioxidant activities. Recent studies have demonstrated that melatonin can be used for treatment of spinal cord injury. Animal experiments also suggest that melatonin can alleviate edema. Previous research has confirmed that the changes in aquaporin-4 are strongly linked with the blood-spinal cord barrier and its permeability in spinal edema. Astrocyte swelling plays an important role in cellular edema after acute spinal cord injury. Xinwei Liu et al. hypothesized that the mechanism by which melatonin relieves spinal cord edema is related to the expression of aquaporin-4 and glial fibrillary acidic protein and validated this hypothesis in a study published in Neural Regeneration Research (Vol. 9, No. 24, 2014). These findings provide reference evidence for clinical treatment of spinal cord injury.
Article: " Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells," by Cheng Li1, Xiao Chen1, Suchi Qiao1, Xinwei Liu2, Chang Liu1, Degang Zhu1, Jiacan Su1, Zhiwei Wang1 (1 Department of Orthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China; 2 Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of Chinese PLA, Shen yang, Liaoning Province, China)
Li C, Chen X, Qiao SC, Liu XW, Liu C, Zhu DG, Su JC, Wang ZW. Melatonin lowers edema after spinal cord injury. Neural Regen Res. 2014;9(24):2205-2210.。