.固本活血泻浊汤治疗慢性肾衰竭临床观察
合集下载
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
结论 固本活血泻浊汤组方切合了慢性肾衰竭脾肾双亏、肾络瘀阻、浊毒壅滞的 病机，临床研究证实能有效改善慢性肾衰竭患者改善腰膝酸软、倦怠乏力、食少纳呆、 浮肿难消、畏寒喜暖、夜尿清长、大便稀溏等中医证候，降低血肌酐，升高血白蛋白、 血红蛋白，与对照组相比差异具有显著性，治疗组优于对照组，并且无明显不良反应 出现。本研究证实了固本活血泻浊汤能够延缓慢性肾衰竭进展，并且无明显不良反应， 值得临床进一步研究推广。
（保密论文在解密后应遵守此规定）
论文作者签名＿＿＿＿＿日 期： 论文导师签名＿＿＿＿＿日 期：
年月日 年月日
中文摘要
目的 观察固本活血泻浊汤治疗慢性肾衰竭的临床疗效和安全性，探讨本方治疗 慢性肾衰竭的临床依据。
方法 选取前来陕西中医学院附属医院就诊的慢性肾衰竭患者 98 例，按随机数字 表法分为两组，治疗组 49 例、对照组 49 例。对照组给予西医常规治疗；治疗组在西 医常规治疗基础上加用固本活血泻浊汤内服，以 1 月为 1 个疗程，共观察 6 个疗程， 分别观察两组治疗前后中医证候及血肌酐、尿素氮、血红蛋白、血白蛋白、电解质、 二氧化碳结合力等治疗指标，并观察肝功、心电图、血常规、尿常规、粪常规等安全 性指标的变化情况。
Comparison of efficacy between the treatment group and the control group, the treatment group 49 cases, 18 cases markedly effective in 23 cases, in 5 patients, 4 cases, the total efficiency of 91.84%. Control group 49 cases, 13 cases were markedly effective in 15 cases, stable in 13 cases, 8 cases, the total efficiency of 83.67%. The treatment group than the control group. Treatment group in improving the waist and knees, fatigue, poor appetite and indigestion, edema Nanxiao, chills, warm, nocturia clear long, loose stool TCM syndrome than the control group. The treatment group and the control group, serum creatinine, hemoglobin, serum albumin after treatment by Ridit analysis of P <0.05 were significant differences in the treatment group than the control group. Urea nitrogen, carbon dioxide combining power after treatment by Ridit analysis P> 0.05 two groups no significant difference. In the treatment group and the control group during the treatment, no adverse reactions occur.
Select 98 patients who come to Affiliated Hospital of Shaanxi University of Chinese Medicine for treatment of chronic renal failure, and we divided them into two groups by random number table, the treatment group and the control group. The control group received the Western conventional treatment; treatment group on the basis of conventional Western medicine treatment plus the Guben Huoxue Xiezhuo soup orally, in January for a course of treatment, were observed in six courses were observed before and after treatment TCM climate and blood creatinine, urea nitrogen, hemoglobin, serum albumin, electrolytes, carbon dioxide combining power and treatment indicators and observe the changes in liver function, electrocardiogram,blo od routine examination,urine routine examination, Stool examinationand other safety indicators. Results:
结果 临床实验室疗效比较，治疗组 49 例，显效 18 例，有效 23 例，稳定 5 例， 无效 4 例，总有效率 91.84%；对照组 49 例，显效 13 例，有效 15 例，稳定 13 例， 无效 8 例，总有效率 83.67%，治疗组疗效优于对照组。中医证候疗效比较，治疗组 在改善腰膝酸软、倦怠乏力、食少纳呆、浮肿难消、畏寒喜暖、夜尿清长、大便稀溏 等中医证候方面优于对照组。实验室指标比较，治疗组与对照组血肌酐、血红蛋白、 血白蛋白治疗后经 Ridit 分析 P<0.05 均有显著性差异，治疗组优于对照组。尿素氮、 二氧化碳结合力治疗后经 Ridit 分析 P>0.05 两组无显著性差异。安全性指标比较， 两组在肝功、心电图、血常规、尿常规、粪常规等指标方面比较均无显著性差异，治 疗组与对照组治疗过程中均无不良反应出现。
陕西中医学院学位论文独创性声明及使用授权声明 学位论文独创性声明
本人郑重声明： 所呈交的学位论文，是个人在导师的指导下，独立进行研究工 作所取得的成果，无抄袭及编造行为。除文中已经特别加以注明引用的内容外，本论 文不含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要贡 献的个人和集体，均已在文中以明确方式标明并致谢。本人完全意识到本声明的法律 结果并由本人所承担的法律责任。
Chronic renal failure;the Guben Huoxue Xiezhuo soup;random number table;efficacy observed.
Author:Wang Heyong Tutor: Liu Chunying
目录
引言 1 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 第一部分 临床研究 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1 资料与方法 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1.1 资料 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1.2 试验材料 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1.3 研究方法 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2 研究结果 6 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.1 一般资料 6 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.2 临床实验室疗效比较 6 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.3 中医证候比较 7 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.4 实验室指标变化比较 8 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.5 安全性指标比较 9 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 第二部分 讨 论 11 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1 组方依据 11 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2 方义分析 12 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3 主要中药研究进展 14 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4 检测指标的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4.1 肌酐、尿素氮的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4.2 血白蛋白的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4.3 血红蛋白的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 5 研究结论 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 6 不足与展望 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 第三部分 研究背景 19 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1 病名溯源 19 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2 病因病机 19 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3 治疗现状 21 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3.1 治则治法研究 21 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3.2 辨证治疗研究 22 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3.3 辨病治疗研究 22 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„
学论文作者签名＿＿＿＿＿ 日 期： 年 月 日
关于学位论文使用授权的声明
陕西中医学院有权保留使用本人学位论文，同意学院按规定向国家有关部门机构 送交论文的复印件和电子版，允许被查阅和借阅。本人授权陕西中医学院可以将本学 位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或其他复印 手段保存和汇编本学位论文。可以公布（包括刊登）论文的全部或部分内容。
Conclusion: The Guben Huoxue Xiezhuo soup suit the pathogenesis of chronic renal failure,
spleen and kidney loss, kidney collateral stasis, toxic cloud Yongzhi, clinical studies can effectively improve chronic renal failure patients improve Yaoxisuanruan, fatigue, foodless poor appetite, edema Nanxiao the, chills, warm, of nocturia clear long, loose stool, loose stools and other symptoms, lower serum creatinine, elevated serum albumin, hemoglobin, and the control group compared to the difference was significant, the treatment group were excellentin the control group, and no significant adverse reactions. This study demonstrated that the The Guben blood circulation Xiezhuo soup can delay the progress of chronic renal failure, and no significant adverse reactions is worthy of further research and promotion. Keywords:
关键词 慢性肾衰竭；固本活血泻浊汤；随机数字表法；临床观察。
Abstract
Objective: To observe the clinical effect and security of combination of the Guben Huoxue
Xiezhuo soup and western medicine on chronic renal failure patients, explore the Guben Huoxue Xiezhuo soup clinical basis for the treatment of patients with chronic renal failure. Methods:
（保密论文在解密后应遵守此规定）
论文作者签名＿＿＿＿＿日 期： 论文导师签名＿＿＿＿＿日 期：
年月日 年月日
中文摘要
目的 观察固本活血泻浊汤治疗慢性肾衰竭的临床疗效和安全性，探讨本方治疗 慢性肾衰竭的临床依据。
方法 选取前来陕西中医学院附属医院就诊的慢性肾衰竭患者 98 例，按随机数字 表法分为两组，治疗组 49 例、对照组 49 例。对照组给予西医常规治疗；治疗组在西 医常规治疗基础上加用固本活血泻浊汤内服，以 1 月为 1 个疗程，共观察 6 个疗程， 分别观察两组治疗前后中医证候及血肌酐、尿素氮、血红蛋白、血白蛋白、电解质、 二氧化碳结合力等治疗指标，并观察肝功、心电图、血常规、尿常规、粪常规等安全 性指标的变化情况。
Comparison of efficacy between the treatment group and the control group, the treatment group 49 cases, 18 cases markedly effective in 23 cases, in 5 patients, 4 cases, the total efficiency of 91.84%. Control group 49 cases, 13 cases were markedly effective in 15 cases, stable in 13 cases, 8 cases, the total efficiency of 83.67%. The treatment group than the control group. Treatment group in improving the waist and knees, fatigue, poor appetite and indigestion, edema Nanxiao, chills, warm, nocturia clear long, loose stool TCM syndrome than the control group. The treatment group and the control group, serum creatinine, hemoglobin, serum albumin after treatment by Ridit analysis of P <0.05 were significant differences in the treatment group than the control group. Urea nitrogen, carbon dioxide combining power after treatment by Ridit analysis P> 0.05 two groups no significant difference. In the treatment group and the control group during the treatment, no adverse reactions occur.
Select 98 patients who come to Affiliated Hospital of Shaanxi University of Chinese Medicine for treatment of chronic renal failure, and we divided them into two groups by random number table, the treatment group and the control group. The control group received the Western conventional treatment; treatment group on the basis of conventional Western medicine treatment plus the Guben Huoxue Xiezhuo soup orally, in January for a course of treatment, were observed in six courses were observed before and after treatment TCM climate and blood creatinine, urea nitrogen, hemoglobin, serum albumin, electrolytes, carbon dioxide combining power and treatment indicators and observe the changes in liver function, electrocardiogram,blo od routine examination,urine routine examination, Stool examinationand other safety indicators. Results:
结果 临床实验室疗效比较，治疗组 49 例，显效 18 例，有效 23 例，稳定 5 例， 无效 4 例，总有效率 91.84%；对照组 49 例，显效 13 例，有效 15 例，稳定 13 例， 无效 8 例，总有效率 83.67%，治疗组疗效优于对照组。中医证候疗效比较，治疗组 在改善腰膝酸软、倦怠乏力、食少纳呆、浮肿难消、畏寒喜暖、夜尿清长、大便稀溏 等中医证候方面优于对照组。实验室指标比较，治疗组与对照组血肌酐、血红蛋白、 血白蛋白治疗后经 Ridit 分析 P<0.05 均有显著性差异，治疗组优于对照组。尿素氮、 二氧化碳结合力治疗后经 Ridit 分析 P>0.05 两组无显著性差异。安全性指标比较， 两组在肝功、心电图、血常规、尿常规、粪常规等指标方面比较均无显著性差异，治 疗组与对照组治疗过程中均无不良反应出现。
陕西中医学院学位论文独创性声明及使用授权声明 学位论文独创性声明
本人郑重声明： 所呈交的学位论文，是个人在导师的指导下，独立进行研究工 作所取得的成果，无抄袭及编造行为。除文中已经特别加以注明引用的内容外，本论 文不含任何其他个人或集体已经发表或撰写过的作品成果。对本文的研究做出重要贡 献的个人和集体，均已在文中以明确方式标明并致谢。本人完全意识到本声明的法律 结果并由本人所承担的法律责任。
Chronic renal failure;the Guben Huoxue Xiezhuo soup;random number table;efficacy observed.
Author:Wang Heyong Tutor: Liu Chunying
目录
引言 1 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 第一部分 临床研究 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1 资料与方法 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1.1 资料 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1.2 试验材料 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1.3 研究方法 2 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2 研究结果 6 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.1 一般资料 6 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.2 临床实验室疗效比较 6 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.3 中医证候比较 7 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.4 实验室指标变化比较 8 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2.5 安全性指标比较 9 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 第二部分 讨 论 11 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1 组方依据 11 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2 方义分析 12 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3 主要中药研究进展 14 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4 检测指标的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4.1 肌酐、尿素氮的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4.2 血白蛋白的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 4.3 血红蛋白的意义 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 5 研究结论 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 6 不足与展望 17 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 第三部分 研究背景 19 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 1 病名溯源 19 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 2 病因病机 19 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3 治疗现状 21 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3.1 治则治法研究 21 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3.2 辨证治疗研究 22 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„ 3.3 辨病治疗研究 22 „„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„„
学论文作者签名＿＿＿＿＿ 日 期： 年 月 日
关于学位论文使用授权的声明
陕西中医学院有权保留使用本人学位论文，同意学院按规定向国家有关部门机构 送交论文的复印件和电子版，允许被查阅和借阅。本人授权陕西中医学院可以将本学 位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或其他复印 手段保存和汇编本学位论文。可以公布（包括刊登）论文的全部或部分内容。
Conclusion: The Guben Huoxue Xiezhuo soup suit the pathogenesis of chronic renal failure,
spleen and kidney loss, kidney collateral stasis, toxic cloud Yongzhi, clinical studies can effectively improve chronic renal failure patients improve Yaoxisuanruan, fatigue, foodless poor appetite, edema Nanxiao the, chills, warm, of nocturia clear long, loose stool, loose stools and other symptoms, lower serum creatinine, elevated serum albumin, hemoglobin, and the control group compared to the difference was significant, the treatment group were excellentin the control group, and no significant adverse reactions. This study demonstrated that the The Guben blood circulation Xiezhuo soup can delay the progress of chronic renal failure, and no significant adverse reactions is worthy of further research and promotion. Keywords:
关键词 慢性肾衰竭；固本活血泻浊汤；随机数字表法；临床观察。
Abstract
Objective: To observe the clinical effect and security of combination of the Guben Huoxue
Xiezhuo soup and western medicine on chronic renal failure patients, explore the Guben Huoxue Xiezhuo soup clinical basis for the treatment of patients with chronic renal failure. Methods: