杓型和非杓型高血压的T淋巴细胞亚群的差异与分析

杓型和非杓型高血压的T淋巴细胞亚群的差异与分析
杨琳
【期刊名称】《脑与神经疾病杂志》
【年(卷),期】2017(025)006
【摘要】Objective To investigate the differences of T lymphocyte subsets in dippers and non-dippers hypertension.Method From January 2015 to April 2016, two hundred and four cases hypertension patients in our hospital were divided into 2 groups: one hundred and one cases in the dipper group and a hundred and three cases in the non-dipper group. Eighty-five cases health volunteers and ninety-six cases cerebral infarction in recovery period patients were collected as the control groups.Results After treatment, 24-hour average systolic blood pressure,12-hour daily average systolic blood pressure and 12-hours night average systolic blood pressure had decreased in 2 hypertension groups(P<0.05). 24-hour average diastolic blood pressure, 12-hour daily average diastolic blood pressure and 12-hour night average diastolic blood pressure did not change in dipper group(P>0.05). 24-hour average diastolic blood pressure, 12-hour daily average diastolic blood pressure and 12-hour night average diastolic blood pressure had decreased in non-dipper group(P<0.05). Compared with dipper group, blood pressure had increased in non-dipper group (P<0.05). Compared with the health volunteers and cerebral infarction in recovery period groups, T lymphocyte subsets CD3+, CD4+
and CD4+/CD8+ had increased(P<0.05), CD8+ had decreased in 2 hypertensive group(P<0.05). After treatment, CD3+, CD4+ and
CD4+/CD8+ had decreased(P<0.05), CD8+had increased in 2 hypertensive groups(P<0.05). Compared with dipper group, CD3+, CD4+ and
CD4+/CD8+had increased(P<0.05), CD8+ had decreased significantly in non-dipper group(P<0.05).Conclusion T lymphocyte subsets participate in the occurrence and development of hypertension and play an important role in the abnormal blood pressure rhythm of 24h. Non-dipper hypertension is a risk factor for hypertension. T lymphocyte subsets have involved in the development and progression of hypertension, but the mechanism is not yet completely cleared, which needs deeper study.%目的考察和分析杓型和非杓型高血压的T淋巴细胞亚群的差异.方法收集2015年1月至2016年4月在本院收治的高血压患者204例,将患者分为2组:101例杓型组和103例非杓型组.并选择85例同期健康体检者,96例脑梗死恢复期的患者为对照组.结果治疗后,两组高血压的24h平均收缩压、日间平均收缩压和夜间平均收缩压明显降低(P<0.05),杓型组的舒张压、日间平均舒张压和夜间平均舒张压无明显降低(P>0.05),非杓型组的24h平均舒张压、日间平均舒张压和夜间平均舒张压均降低(P<0.05),与杓型组比,非杓型组的血压仍处于较高水平(P<0.05).与正常组和脑梗死恢复期组比,两组高血压患者的T淋巴细胞亚群的CD3+、CD4+和CD4+/CD8+明显升高(P<0.05),CD8+明显降低(P<0.05),治疗后,两组高血压的CD3+、CD4+和CD4+/CD8+均明显降低,CD8+明显增高.治疗前后,与杓型组比,非杓型组的CD3+、CD4+和CD4+/CD8+明显升高(P<0.05),CD8+明显降低(P<0.05).结论①T淋巴细胞亚群变化参与了高血压的发生发展过程,对24h血压节律异常产生重
要作用;②非杓型是高血压的危险因素,T淋巴细胞亚群异常参与其中,但机制尚未完全明确,仍有待深层次地研究.
【总页数】4页(P365-368)
【作者】杨琳
【作者单位】225500 江苏,泰州市第二人民医院心内科
【正文语种】中文
【中图分类】R544.1
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