雷米普利对压力超负荷左心室肥厚大鼠心肌Ⅰ型及III型胶原基因表达的影响

雷米普利对压力超负荷左心室肥厚大鼠心肌Ⅰ型及III型胶原
基因表达的影响
官功昌;张学军
【期刊名称】《陕西医学杂志》
【年(卷),期】2012(041)009
【摘要】目的:探讨压力超负荷左心室肥厚大鼠Ⅰ型及III型胶原基因表达及雷米普利的干预效果.方法:将24只雄性Spargue.Dawley大鼠随机分为假手术组、心肌肥厚模型组和雷米普利治疗组.采用腹主动脉缩窄手术制备心肌肥厚模型,造模12周后给予雷米普利l mg/kg,每天1次,连续12周.测定心脏重量指数和左心室重量指数;实时PCR法测定胶原I型和Ⅲ型胶原mRNA表达.结果:与假手术组相比,心肌肥厚模型组左心室重量及LVM I均显著升高,I型和Ⅲ型胶原mRNA表达明显上调(P＜0.05);与心肌肥厚模型组,雷米普利组左心室重量及LVM I均显著降低,I型和Ⅲ型胶原mRNA表达均明显下调(P＜0.05).结论:雷米普利能改善压力超负荷左心室肥厚大鼠的心肌肥厚状态和延缓心肌纤维化的病理进程.%Objective: To investigate the effec ts ramipril on left myocardium type I and Ⅲ collagen mRNA expression of rats with pressure-overloaded left ventricular hypertrophy. Methods: 24 male Spargue-Dawley rats were randomly divided into three groups: sham-operation group (n - 8) , left ventricular hypertrophy group(n - 8) and ramipril group (n = 8). Abdominal aorta constriction operation was performed to construct rat model of hypertensive left ventricular hypertrophy. Rats in each group were killed after 12 weeks of treatment with ramipril to weigh their body and their left
ventricular, and then left ventricular mass index(LVMI) was calculated, and determined the left myocardium type I and Ⅲ collagen mRNA expression by real-time PCR amplification. Results: Compared with that of sham operation group, LVM、LVMI and the left myocardium type I and Ⅲ collagen mRNA expression of left ventricular hypertrophy group significantly increased ( P<0. 05) ; Compared with that of left ventricular hypertrophy group, LVM 、LVMI and the left myocardium type I and Ⅲ collagen mRNA expression of ramipril group significantly reduced (P<0. 05). Conclusion: Ramipril may improve the ventricular hypertrophy and delay the process of myocardial fibrosis of rat with pressure-overloaded left ventricular hypertrophy.
【总页数】3页(P1112-1114)
【作者】官功昌;张学军
【作者单位】陕西省人民医院心内一科,西安,710068;陕西省人民医院心内一科,西安,710068
【正文语种】中文
【中图分类】R542.2
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