Bendamustine hydrochloride_3543-75-7_DataSheet_MedChemExpress

Product Name:
Bendamustine hydrochloride CAS No.:
3543-75-7Cat. No.:
HY-B0077Product Data Sheet
MWt:
394.72Formula:
C16H22Cl3N3O2Purity :>98%
Solubility:DMSO 79 mg/mL y Mechanisms:
Biological Activity:
Bendamustine Hcl(SDX105;EP 3101)is a DNA damaging agent with IC50of 50M
Pathways:Others; Target:Others
Water 15 mg/mL
Ethanol 17 mg/mL
Bendamustine Hcl(SDX105; EP-3101) is a DNA-damaging agent with IC50 of 50 μM.
Target: Others
Approved: March 2008Treatment with Bendamustine results in a 60% to 80% down-regulation of the mRNA expression of all three of these genes [polo-like kinase 1 (PLK-1), Aurora Kinase A, and cyclin B1] in SU-DHL-9cells. Twenty-six percent of the Bendamustine-treated MCF-7/ADR cells showed micronucleation compared with only 6% in DMSO control cells [1]. Using Bendamustine alone in concentrations from 1 μg/mL to 50 μg/mL, a dose- and time-dependent manner of cytotoxicity from 30.4% to 94.8% after
48 hours could be observed. The LD50 for untreated and pretreated CLL cells is 7.3 or 4.4
g /mL,References:
[1]. Wargon, M., et al., Acute effects of bisoprolol on respiratory sinus arrhythmia. Fundam Clin
Pharmacol, 1998. 12(4): p. 451-6.[2]. Schwanen, C., et al., In vitro evaluation of bendamustine induced apoptosis in B-chronic p μg respectively [2]. Myeloid and breast carcinoma cell lines are resistant towards Bendamustine with the exception of HL-60 cells which exhibit an intermediate sensitivity. Bendamustine is fou...[]p p
lymphocytic leukemia. Leukemia, 2002. 16(10): p. 2096-105.[3]. Konstantinov, S.M., et al., Cytotoxic efficacy of bendamustine in human leukemia and breast
cancer cell lines. J Cancer Res Clin Oncol, 2002. 128(5): p. 271-8.[4]. Ackler, S., et al., Navitoclax (ABT-263) and bendamustine +/- rituximab induce enhanced killing
of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol, 2012. 167(4): p. 881-91.Caution: Not fully tested. For research purposes only
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