文拉法辛对抑郁症患者认知功能及生活质量的影响观察

文拉法辛对抑郁症患者认知功能及生活质量的影响观察
王茜
【期刊名称】《河北医学》
【年(卷),期】2013(019)006
【摘要】Objective: To study on the clinical efficacy and safety of venlafaxine in the treatment of depression , as well as to improve cognitive function and quality of life in patients with depression. Method: 80 patients were randomly assigned to observation group and control group, each with 40 cases, observation group for venlafaxine, control group for mirtazapine, 8 weeks for a course. Result: After the treatment, total effective rate for the observation group was 92. 5% , significantly higher than the control group ( 70% ). There's differences statistically! P<0. 05 ). Having effect time of the observation group( 6. 22±1. 35 )days, significantly earlier than those in the control group( 8. 74±1. 68 )days, differences statistically( P<0. 05 ). After treatment, GQOLI-74 scores of the two groups were increased both( P<0. 05 ), but observation groupsrnof patients increased even more sharply( P<0. 05 ). Two groups of patients with long time memory score( P< 0.05 ), short time memory score, instant memory score, and memory quotient all improved(P<0. 05 ), but observer groups of patients increased even more sharply( P<0. 05 ). Observation group in patients with adverse reaction rate was 20% .control group was 25% ,the difference was not significant(P>0. 05 ). Conclusion: Venlafaxine
can effectively improve the quality of life and cognitive function of patients with depression , It's high safety and worthy of clinical promotion and application.%目的:探讨文拉法辛治疗抑郁症的临床疗效和安全性,以及对患者认知功能及生活质量的改善情况.方法:将80例患者随机分为观察组和对照组各40例,观察组给予文拉法辛,对照组给予米氮平,疗程8周.结果:疗程结束后,观察组患者总有效率为92.50%,明显高于对照组的70.00%,差异存在统计学意义(P＜0.05).观察组显效时间(6.22±1.35)d,明显早于对照组的(8.74±1.68)d,差异存在统计学意义(P ＜0.05).疗程结束后,两组患者GQOLI-74评分均升高(P＜0.05),但是观察组患者上升幅度更大(P＜0.05);两组患者长时记忆分、短时记忆分、瞬间记忆分和记忆商数均升高(P＜0.05),但是观察组患者上升幅度更大(P＜0.05).观察组患者不良反应率为20.00%,对照组为25.00%,差异无显著性(P＞0.05).结论:文拉法辛可以有效改善患者的认知功能及生活质量,安全性高,值得临床推广应用.
【总页数】4页(P855-858)
【作者】王茜
【作者单位】四川省成都市第四人民医院精神科,四川,成都,610036
【正文语种】中文
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