咪喹莫特乳膏联合艾拉-光动力疗法治疗尖锐湿疣的临床研究

咪喹莫特乳膏联合艾拉-光动力疗法治疗尖锐湿疣的临床研究陈加媛;贺勤;宋鹏飞;麦月好;孙立
【期刊名称】《内蒙古医学院学报》
【年(卷),期】2018(040)003
【摘要】目的:探讨咪喹莫特乳膏联合艾拉-光动力治疗尖锐湿疣( CA)的临床疗效.方法:选取2014-01～2017-03期间我院103例CA病人,根据治疗方案分为观察组(n＝52)与对照组(n＝51).对照组行单纯艾拉-光动力治疗,观察组行艾拉-光动力联合咪喹莫特乳膏治疗.对比两组临床疗效、治疗前后机体免疫功能[ T淋巴细胞亚群( CD3+、 CD4+、 CD4+/ CD8+)]、安全性,治疗结束后随访6mo,对比两组复发率、治疗前及治疗后6mo生活质量(SF-36评分).结果:(1)临床疗效:观察组治疗总有效率94.23%(49/52)高于对照组80.39%(41/51) (P＜0.05);(2)免疫功能:治疗前两组 CD3+、 CD4+、 CD4+/ CD8+比较无显著差异(均 P＞0.05),治疗后两组CD3+、 CD4+、 CD4+/ CD8+较治疗前提高(均P＜0.05),且观察组 CD3+、CD4+、 CD4+/ CD8+高于对照组(均P＜0.05);(3)安全性:艾拉-光动力治疗过程中,观察组出现2例局部轻度疼痛,对照组出现3例局部疼痛,照射治疗后对照组及观察组各出现1例轻度红肿;观察组涂抹咪喹莫特乳膏后部分病人有轻微烧灼(3例)、瘙痒(1例)、刺痛感(1例);(4)复发率:治疗后3mo观察组复发率1.92%(1/52)与对照组5.88%(3/51)比较无显著差异(P＞0.05),治疗后6mo观察组复发率3.85%(2/52)低于对照组17.65%(9/51) ( P＜0.05);(5)生活质量:治疗前两组SF-36评分比较无显著差异(P＞0.05),治疗后6mo两组SF-36评分较治疗前提高(均P＜0.05),且观察组SF-36评分高于对照组(P＜0.05).结论:艾拉-光动力联合咪喹莫特乳膏治疗CA疗效显著,可有效改善病人免疫功能、降低复发率,且具有一定安全性,有利于提
高病人生活质量.%Objective:To investigate the clinical effect of imiquimod cream combined with Ella photodynamic therapy in the treatment of condyloma acuminata(CA).Methods:A total of 103 cases of CA patients in our hospital from 2014-01 to 2017-03 were selected and divided into the observation group(n＝52)and the control group(n＝51)according to the treatment plan.The control group was trea-ted only with Ella -photodynamic therapy, and the observation group was treated with Ella -photodynamic combined with imiquimod cream.The clinical efficacy,the immune function Tlymphocyte subsets( CD3+, CD4+, CD4+/ CD8+) ,and the safety of the body before and after treatment of the two groups were compared.After 6months of follow-up,the recurrence rate,and the quality of life( SF-36 score)before and after 6months of the treatment of the two groups were compared.Results:(1)Clinical efficacy:the total effective rate of treatment in the observation group[94.23%(49/52)]was higher than that of the control group[80.39%(41/51)](P＜0.05).(2)Immune function:there were insignificant differences in CD3+, CD4+and CD4+/ CD8+between the two groups before treatment( each P＞0.05) . After treatment, CD3+, CD4+and CD4+/ CD8+of two groups were improved compared with those before treatment(each P＜0.05).And the CD3+, CD4+and CD4+/ CD8+in the observation group were higher than those in the control group(each P＜0.05).(3)Safety:during the Ella photodynamic therapy,there were 2 cases of mild local pain in the observation group and 3 cases in the control group.After irradia-tion,1 case in the control group and 1 case in the observation group appeared mild redness and swell-ing. The patients in
the observation group had mild cauterization ( 3 cases) , pruritus ( 1 cases) and prickle sensation(1 cases)after smearing Imiquimod Cream in the observation group.(4)Recurrence rate:there were insignificant differences in the recurrence rate between the observation group[ 1.92%(1/52)]and the control group[5.88%(3/51)]after 3months of treatment(P＞0.05).After 6months of treatment,the recurrence rate of the observation
group[3.85%(2/52)] was lower than that of the con-trol group
[17.65%(9/51)](P＜0.05).(5)Quality of life:before treatment,there were insignificant differences in the SF-36 scores between the two groups(P＞0.05).After 6months,the SF-36 scores of two groups were higher than those before treatment( P＜0.05) ,and the SF-36 score in the observation group was higher than that in the control group(P＜0.05).Conclusion:The effect of imiquimod cream combined with Ella photodynamic therapy in the treatment of CA is significant. It can effectively improve the immune function of the patients,and reduce the recurrence rate.It is safe to a certain de-gree,which is beneficial to the improvement of the quality of life of the patients.
【总页数】6页(P278-282,286)
【作者】陈加媛;贺勤;宋鹏飞;麦月好;孙立
【作者单位】中山大学附属第八医院皮肤科,广东深圳518000;中山大学附属第八医院皮肤科,广东深圳518000;中山大学附属第八医院皮肤科,广东深圳518000;中山大学附属第八医院皮肤科,广东深圳518000;内蒙古医科大学附属医院
【正文语种】中文
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