正交试验优化生胃颗粒的提取工艺

正交试验优化生胃颗粒的提取工艺
谭梅英;孙冬梅;李智勇
【期刊名称】《海峡药学》
【年(卷),期】2016(28)1
【摘要】ABSTRACT:OBJECTIVE To study extraction technology of Shengwei granules .METHODS The volatile oil were extracted from
5medicinal materials (Bupleuri Radix and Magnoliae Officinalis Cortex ,et al) by steam distil-lation method.The rest medical materials with herb residue were boiled with water .By orthogonal experiment design L9(34),with the content of paeoniflorin determined by HPLC and solid content as evaluating indexes ,the optimal wa-ter extracting technology was
studied .Three factors were selected including water
consumption ,extracting times and extracting time.RESULTS Adding 15 times water to 5 medicinal materials ( Bupleuri Radix and Magnoliae Offici-nalis Cortex,et al),the volatileoil were extracted for 5 hours.The rest medical materials with herb residue were boiled twice with 10 times water ,2 hours for each time.CONCLUSION The extraction technology of Shengwei granules is stable and feasible ,and it serves as a theoretical basis for the standardized production .%目的：研究生胃颗粒的提取工艺。

方法采用水蒸气蒸馏法提取柴胡、厚朴等5味药材的挥发油成分；再将药渣与黄芪、猴头菇、白
芍等药材采用水煎煮法提取，以高效液相色谱法测定的芍药苷含量以及固形物总量为评价指标，用L9（34）正交试验对加水量、提取时间、提取次数等因素进行考
察，优选提取工艺。

结果柴胡、厚朴等5味药材加15倍量水，蒸馏提取5h，收集含挥发油蒸馏液；药渣与黄芪等其余七味药材加10倍量水，提取2次，每次2h。

结论该工艺稳定、可行，可为生胃颗粒的规范化生产提供理论依据。

【总页数】4页(P35-38)
【作者】谭梅英;孙冬梅;李智勇
【作者单位】广东省第二中医院药学部广州510095;广东省中医院工程技术研究院广州510095;广东省中医院工程技术研究院广州510095
【正文语种】中文
【中图分类】R94
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