乳腺导管内癌与浸润性导管癌分子表型的关系

乳腺导管内癌与浸润性导管癌分子表型的关系
陈健;田茹;刘艺;董红梅;郭瑞峰;梁化印
【期刊名称】《临床与实验病理学杂志》
【年(卷),期】2015(000)008
【摘要】目的：探讨乳腺导管内癌( ductal carcinoma in situ, DCIS)与浸润性导管癌( invasive ductal carcinoma, IDC)分子表型之间的关系。

方法采用免疫组化法检测ER、PR、HER-2及CK5在165例乳腺癌组织中的表达,每例均包含DCIS 和IDC病变。

结果165例乳腺癌组织中,IDC与DCIS中ER、PR、HER-2及CK5表达呈正相关,IDC中基底细胞样型18例(10．9%),HER-2过表达型19例(11．5%),腺腔A型102例(61．8%),腺腔B型20例(12．1%),空白型6例(3．6%)；DCIS中基底细胞样型19例(11．5%),HER-2过表达型20例(12．1%),腺腔A型104例(63%),腺腔B型17例(10．3%),空白型5例(3．0%)。

IDC与DCIS表达一致者157例(95．2%),不一致者8例(4．8%),其中3例腺腔A型DCIS分别发展成为1例HER-2过表达型和2例空白型IDC,3例HER-2过表达型DCIS发展成为腺腔B型IDC,1例空白型DCIS发展成为1例腺腔A型,1例基底细胞样型发展成为HER-2过表达型IDC。

结论绝大多数DCIS进展为具有相同分子表型的IDC,少数可转化为其他类型。

%Purpose To investigate the relationship between molecular phenotype of ductal carcinoma in situ ( DCIS) and that of inva-sive ductal carcinoma ( IDC) of the breast. Methods Immunohistochemical method was used to detect ER, PR, HER-2 and CK5 ex-pression in 165 cases of breast cancer, with DCIS and IDC existed in every one of the samples. Results In the 165 cases of breast cancer, the ER,
PR, HER-2 and CK5 expression of IDC was positively correlated with that of DCIS, respectively. To evaluate IDC phenotype, the number of basal phenotype was 18 (10. 9%), HER-2-overexpression 20 (12. 1%), luminal A 102 (61. 8%), lumin-al B 20 (12. 1%), null phenotype 6 (3. 6%);to evaluate DCIS phenotype, the number of basal phenotype was 19 (11. 5%), HER-2-overexpression 20 (12. 1%), luminal A 104 (63%), luminal B 17 (10. 3%), null phenotype 5 (3%). 157 cases (95. 2%) of IDC had the same phenotype with DICS, but the rest 8 cases (4. 8%) not, three cases of luminal A DCIS transformed into one HER-2-overexpression and two null phenotype IDC, three of HER-2-overexpression DCIS transformed into luminal B IDC, one null pheno-type DCIS transformed into one luminal A IDC, and one basal phenotype DCIS transformed to HER-2-overexpression IDC. Conclusion Most of IDC have the same phenotype with DCIS, but there exist small part of DCIS which could transform into other phenotype IDC.
【总页数】4页(P877-879,884)
【作者】陈健;田茹;刘艺;董红梅;郭瑞峰;梁化印
【作者单位】解放军第252医院病理科，保定071000;解放军第252医院病理科，保定071000;解放军第252医院病理科，保定071000;解放军第252医院病理科，保定071000;解放军第252医院病理科，保定071000;解放军第252医院病理科，保定 071000
【正文语种】中文
【中图分类】R737.9
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