Methimazole_60-56-0_DataSheet_MedChemExpress
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Product Name:
Methimazole CAS No.:
60-56-0Cat. No.:
HY-B0208Product Data Sheet
MWt:
114.17Formula:
C4H6N2S Purity :>98%
Solubility:
DMSO 23 mg/mL (201 mM); Water
Mechanisms:
Biological Activity:
Methimazole(Tapazole Northyx)is an antithyroid medicine
Pathways:Others; Target:Others 23 mg/mL (201 mM)
Methimazole(Tapazole, Northyx) is an antithyroid medicine.
Target: Others Methimazole is an antithyroid drug, and part of the thioamide group. Like its counterpart
propylthiouracil, a major side effect of treatment is agranulocytosis. Methimazole is a drug used to treat hyperthyroidism, a condition that occurs when the thyroid gland begins to produce an excess of thyroid hormone. The drug may also be taken before thyroid surgery to lower thyroid hormone levels and minimize the effects of thyroid manipulation. Additionally, Methimazole is used in the veterinary
setting to treat hyperthyroidism in cats.Methimazole inhibits the enzyme thyroperoxidase, which normally acts in thyroid hormone synthesis References:
[1]. Nakamura H, et al. Comparison of methimazole and propylthiouracil in patients with
hyperthyroidism caused by Graves' disease. J Clin Endocrinol Metab. 2007 Jun;92(6):2157-62.Epub 2007 Mar 27.by oxidizing the anion iodide (I-) to iodine (I0), facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin, a necessary step in the synthe...
p [2]. Crescioli C, et al. Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes.
J Endocrinol. 2007 Oct;195(1):145-55.Caution: Not fully tested. For research purposes only
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