氟尿嘧啶植入剂在进展期胃癌术中应用的临床研究

氟尿嘧啶植入剂在进展期胃癌术中应用的临床研究
徐果;朱德祥
【期刊名称】《重庆医学》
【年(卷),期】2011(40)4
【摘要】目的探讨进展期胃癌术中使用氟尿嘧啶植入剂对术后患者生存率的影响.方法将100例进展期胃癌患者随机分为两组,治疗组于病灶切除及淋巴结清扫后在腹腔内给予氟尿嘧啶植入剂800 mg,术后4周进行6个周期常规化疗;对照组术中不进行腹腔内干预性治疗,术后化疗方案同治疗组.结果两组患者术后3年生存率分别为42.39%、30.54%,3年无瘤生存率分别为28.52%、8.79%,差异有统计学意义(P<0.05).结论术中使用氟尿嘧啶植入剂可以降低进展期胃癌根治术后肿瘤局部复发率并提高患者的生存率.%Objective To study the survival rate of patients with fluorouracil implants sustained release during operation. Methods 100 cases with advanced gastric cancer were randomly divided into two groups. The treatment group was implanted fluorouracil implants sustained release(800 mg) in abdominal cavity after radical operation. The control group was given no special therapy in abdominal cavity after the operation. Both of the two groups were given 6 cycles of regular chemotherapy within 4 weeks after operatior. Results The 3 years survival rate of treatment group was 42.39 ％,and 30.54 ％ of control group. The 3 years disease-free survival in treatment group was 28. 52％ ,and 8.79％ of control group. There was significant difference between the results in two groups(P＜0.05). Conclusion Implanting fluorouracil implants sustained
release during operation can reduce local recurrence rates and improve the 3 years survival rates in patients with advanced gastric cancer after radical operation.
【总页数】2页(P353-354)
【作者】徐果;朱德祥
【作者单位】江苏省淮安市第一人民医院普外科,223300;江苏省淮安市第一人民医院普外科,223300
【正文语种】中文
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