LED光源在皮肤医学中的应用

4.减轻炎症

已经有系列的研究表明LED具有抗炎的作用。研究发现635nm的LED光可以抑制牙龈的成纤维细胞释放炎症介质——前列腺环素E2(PGE2)，从而减轻牙龈的炎症反应。在脉冲

染料激光治疗皮肤光老化前如果采用LED光源提前照射，可以减轻染料激光引起的皮肤红斑、肿胀和疼痛等不适。在乳腺癌患者的放射治疗前采用LED光源提前照射可以减轻放疗的副作用。

5.疤痕的预防

瘢痕疙瘩是临床上影响美容而且治疗困难的一种皮肤疾患，是皮肤损伤后结缔组织过度增生所引起。患者往往具有瘢痕体质。在临床上开始为小而坚硬的红色丘疹，缓慢增大，产生圆形、椭圆形或不规则性瘢痕，高出皮面，呈蟹足状向外伸展，皮肤光滑、发亮，可伴有疼痛、瘙痒等不适。临床治疗困难、疗效不理想。有研究发现LED可明显改善患者的疼痛、瘙痒等不适感，使瘢痕变平，同时具有无创的优点。

6.其他作用

此外，LED还可作为一种不含紫外线的光疗仪器、用于光动力疗法、治疗脱发、减轻

紫外线照射后的皮肤损伤等等。

总之，LED作为一种新型的光源已经被逐步应用到皮肤医学中，随着对LED灯具的不

断创新以及医学上对于LED生物效应的机理研究，LED在皮肤医学上的应用将具有不可限量的前景。同时LED具有较高的安全性可作为家庭医疗设备而被人们更为广泛的使用。(全文来源自《半导体照明》杂志2011年8月刊编辑：maysoong)

参考文献

[1] Daniel Barolet, MD. Light-Emitting Diodes (LEDs) in Dermatology. Semin Cutan Med Surg 27:227-238.

[2] Trelles MA. Phototherapy in anti-aging and its photobiologic basics: a new approach to skin rejuvenation. J Cosmet Dermatol. 2006;5(1):87-91.

[3] Goldman MP, Weiss RA, Weiss MA. Intense pulsed light as a nonablative approach to photoaging. Dermatol Surg. 2005;31(9 Pt 2):1179-87.

[4] Weiss RA, McDaniel DH, Geronemus R, et al: Clinical trial of a novel

non-thermal LED array for reversal of photoaging: Clinical, histologic, and surface profilometric results. Lasers Surg Med 36:85-91, 2005

[5] Lee SY, Park KH, Choi JW, et al: A prospective, randomized, placebocontrolled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: Clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem Photobiol B 27:51-67, 2007

[6] Al-Watban FA: The comparison of effects between pulsed and CW lasers on wound healing. J Clin Laser Med Surg 22:15-18, 2004

[7] Lim W, Lee S, Kim I, et al: The anti-inflammatory mechanism of 635 nm light-emitting-diode irradiation compared with existing COX inhibitors. Lasers Surg Med 39:614-621, 2007

[8] Uitto J: IL-6 signaling pathway in keloids: a target for pharmacologic intervention? J Invest Dermatol 127:6-8, 2007

[9] Ghazizadeh M, Tosa M, Shimizu H, et al: Functional implications of the IL-6 signaling pathway in keloid pathogenesis. J Invest Dermatol 127:98-110, 2007

[10] Barolet D, Boucher A: Pre-PDT use of radiant IR LED exposure as skin preparation to enhance cystic acne treatment outcome, Lasers Surg Med 20:73, 2008 .