Rudi Klein - Exeter 01 10 2009

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真爱雷瑟斯商品规格

真爱雷瑟斯商品规格

真爱雷瑟斯◆商品规格:净含量: 15毫升/支适合人群:18-80岁女性,男性产地:美国制造商名称:美国莱科萨斯国际公司制造商地址:德克萨斯州达拉斯市75234汉顿道12901号主要成份:它所含的十余种成份均是可溶于水的纯天然可食用物质L精氨酸、硅卵酸、薄荷醇、可溶性维生素A、D、E等。

A、L精氨酸:有助于增加氧化氮的含量,而氧化氮正是通知血管松弛、扩张、保持血流畅的“信差”。

B、硅卵酸:增加肌肉弹性,润滑作用(不干涩)C、薄荷醇:清凉后产生热刺激具有消毒滋养作用。

适用人群:●18岁--80岁的所有关爱自己的女性●18-25未婚女性需要ALURA解除神经痉挛而产生痛经;●25-35岁女性需要ALURA来保养容颜和塑造优美身材;●30-40岁的女性需要ALURA来提高性生活的质量;●40=50岁的女性需要ALURA来解除妇科病的烦恼;●50岁以后女性需要ALURA来解决更年期症状,延长青春●更年期以后的女性需要ALURA来维持生殖系统的活力真愛雷瑟絲的功效:1.可調理女性生理機能。

2.改善婦女因年齡增加導至雌激素減少的種種生理不協調症狀。

3.滋润生殖器,延缓生殖器衰老,提高敏感度.保養女性生殖器官組織,減慢退化速度。

推迟更年期。

4.透過刺激作用,促使內分泌正常化,平衡荷爾蒙,改善荷尔蒙失调的常见现象.使女性保持身心健康,容光煥發。

5.日常使用有润滑,清洁,抗菌,除异味并促进女性阴道自净能,帮助阴道紧缩等功能。

长期使用生理方面功效:1、 ALURA 是诺贝尔医学奖的衍生商品,是以专利技术而成 L -精氨酸与薄荷醇而产生一氧化氮路径,采全天然成份,无任何副作用,这是仿间威XX类之伪制品是无法复制本产品的功效。

2、薄荷醇产生清凉及微热感,L -精氨酸、氧化氮通路,会刺激外阴及阴蒂神经,会促进身体制造释放出荷尔蒙。

自身自然分泌的荷尔蒙,会使女性皮肤变得更漂亮,更具有女人味。

3、因刺激产生的润滑液分泌出来的自然抗菌分泌物,能促进阴道自净能力提升有善改善解除女性朋友阴部异味的隐疾。

ANYTHING ON THE TRACK MAY OCCUR变数——2009F1德国、匈牙利大奖赛

ANYTHING ON THE TRACK MAY OCCUR变数——2009F1德国、匈牙利大奖赛


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NF EN 583-2

NF EN 583-2
FA045794
ISSN 0335-3931
norme européenne
NF EN 583-2
Octobre 2001
Indice de classement : A 09-340-2
ICS : 19.100
Essais non destructifs
Contrôle ultrasonore
Partie 2 : Réglage de la sensibilité et de la base de temps
Avant-propos national
Références aux normes françaises La correspondance entre les normes mentionnées à l'article «Références normatives» et les normes françaises identiques est la suivante : EN 12223 EN 27963 : NF EN 12223 (indice de classement : A 09-311) : NF EN 27963 (indice de classement : A 89-611)
La présente norme européenne a été adoptée par le CEN le 5 janvier 2001. Les membres du CEN sont tenus de se soumettre au Règlement Intérieur du CEN/CENELEC qui définit les conditions dans lesquelles doit être attribué, sans modification, le statut de norme nationale à la norme européenne. Les listes mises à jour et les références bibliographiques relatives à ces normes nationales peuvent être obtenues auprès du Secrétariat Central ou auprès des membres du CEN. La présente norme européenne existe en trois versions officielles (allemand, anglais, français). Une version faite dans une autre langue par traduction sous la responsabilité d'un membre du CEN dans sa langue nationale, et notifiée au Secrétariat Central, a le même statut que les versions officielles. Les membres du CEN sont les organismes nationaux de normalisation des pays suivants : Allemagne, Autriche, Belgique, Danemark, Espagne, Finlande, France, Grèce, Irlande, Islande, Italie, Luxembourg, Norvège, PaysBas, Portugal, République Tchèque, Royaume-Uni, Suède et Suisse.

伯克林斯4.248.2 Diesel Thru U108196N引擎维修工具包说明书

伯克林斯4.248.2 Diesel Thru U108196N引擎维修工具包说明书

APPLICATION: Forklifts: Cat T50D-150D (LG70109,LG70149); V80D, V80E, V90E (LG70067, LG70090);Forklifts: Cat VC60C (LG70069,LG70091); Clark C500Y110-155 (LG70107); IT50-80 (LG70106); Forklifts: Hyster H60E-110E (LG70063, LG70127); H60XL-110XL (LG70184);Tugs: Clark CTD20, CTD30, CTD40, CTD50 (LG70097);QTY ITEM # DESCRIPTION LETTERED ITEMSINCLUDED IN KIT1 974247 In-Frame Kit I1 975247 Out-of-Frame Kit O1 976247 Major Kit M1 977247 Premium Kit (979139 Valve Train Kit Included) P4 4 4 4 4 171373 171234 171132 171217 171468 Sleeve & Piston Asb (Re-entrant Bowl / Anodized / Grade L) Piston Assembly (Re-entrant Bowl / Anodized / Grade L) (1)Cylinder Liner (Finished / Fire Dam / 4.1025" OD)Cylinder Liner (Semi-Finished / Fire Dam / 4.1045" OD) (2)005 Liner ShimP M O I4 171265 Piston Ring Set, 3 Ring Upgrade (2-2.5MM 1-5MM)4 4 4 4 271151 271152 271153 271154 STD Rod Bearing .010 Rod Bearing.020 Rod Bearing.030 Rod Bearing "Additional Sizes (5)"P M O I1 1 1 1 271161 271162 271163 271164 STD Main Set, wo/Thrust Washers .010 Main Set, wo/Thrust Washers.020 Main Set, wo/Thrust Washers.030 Main Set, wo/Thrust Washers "Additional Sizes (6)"P M O I1 1 1 271119 271125 271126 STD Thrust Washer Set (Offset Lug) .007 Thrust Washer Set (Offset Lug).010 Thrust Washer Set (Offset Lug)P M O I1 1 1 8 8 4 371478 371116 371477 371143 371192 371318 Head Gasket Set (Valve Cover Bolts Thru Center Of Cover) Head GasketValve Cover Gasket (No Bolt Holes In Gasket)Valve Seal (Umbrella)Valve Seal (O-Ring)Nozzle Dust Seal Kit "Not In Sets Or Kits"P M O I1 1 1 1 371292 371149 371235 371282 Lower Gasket Set wo/Seals Timing Cover Gasket Fuel Line Seal Kit (23 Seals & Washers) "Not In Gkt Sets" Pan Gasket, Steel Pan P P M M O OI1 1 1 371146 371145 771159 Front Crank Seal (Viton Lip Type) (7) Rear Crank Seal (Viton Lip Type) (8) Rear Block Bridge PieceP P M M O O4 1 271176 271127 Pin Bushing (1.375" Pin) Cam Bearing (Finished ID) P P M M8 8 1 1 1 771151 771148 771282 771292 771293 Connecting Rod Bolt Connecting Rod Nut Head Stud/Bolt & Nut Kit, Thru U874811J (2 Studs/20 Bolts)Head Bolt Kit, U874812J-U027630M (22 Bolt/.125" Blk CB)Head Bolt Kit, After U027630M (Ribbed Blocks / .500" CB)P P M M(1)Grade H Piston - 171483 (Anodized Piston - DO NOT TOP ) (2).020 Oversize Semi-Finished Liner - 171478(5)Rod Bearings: .040 - 271155 / .050 - 271156 / .060 - 271157 (6)Main Bearings: .040 - 271165 / .050 - 271166 / .060 - 271167(7)Wear Sleeve - 301115 (8)Lip Seal Housing Gasket - 371187 / Wear Sleeve - 301143Forklifts: Cat VC60C (LG70069,LG70091); Clark C500Y110-155 (LG70107); IT50-80 (LG70106); Forklifts: Hyster H60E-110E (LG70063, LG70127); H60XL-110XL (LG70184);QTY ITEM # DESCRIPTION LETTERED ITEMSINCLUDED IN KIT1 979517 Camshaft Kit C1 979143 Valve Train Kit V1 979139 Valve Train Kit, w/Guides V1 571114 Camshaft "Cam Bolt Lock Plate - 571162" C1 271249 Camshaft Thrust Washer (1.750 X 2.873 X .217)8 571123 Tappet C4 4 471123 471128 STD Exhaust Valve (45º / Bi-Metal) (10) STD Intake Valve (45º / Alloy / Chromed Stem) (11) V V V V4 471132 Exhaust Guide: Service Repair or 1985 & Up V4 471131 Intake Guide: Service Repair or 1985 & Up V8 471134 Outer Valve Spring (8 Coils / 2.500" Free Length) V V8 471133 Inner Valve Spring (9 Coils / 2.000" Free Length) V V8 471219 Spring Seat, Integral Guides "With Service Guides - 471229"8 471222 Spring Retainer16 471146 Keeper (Half) V V4 471111 Exhaust Seat (1.248 x 1.681 x .374 Stepped Top)4 471113 Intake Seat (1.594 x 2.020 x .281)4 471224 LH Rocker Arm (Adj Screw & Lock Nut Not Included) (12)4 471225 RH Rocker Arm (Adj Screw & Lock Nut Not Included) (12)1 471227 Rocker Arm Shaft (13) "Includes 471176 Plugs"1 571112 Cam Gear: Except Below (Cast / 56 Teeth)1 571165 Cam Gear: LG70067, LG70090 (Steel / 56 Teeth) 1 571113 Crank Gear: Except Below (28 Teeth)1 571166 Crank Gear: LG70067, LG70090 (Steel / 28 Teeth)1 571163 Idler Gear: Except Below (Steel / 63T) (14)1 571167 Idler Gear: LG70067, LG70090 (Steel / 63 Teeth) (15)8 571117 Push Rod1 671112 Oil Pump1 671134 Oil Pump Idler Gear1 571124 Idler Gear Bushing1 671148 Relief Valve Assembly (Engines w/LH Oil Filter Only)1 671156 Relief Valve Assembly (Engines w/RH Oil Filter Only)1 771132 Crank Kit (Spline Nose / Lip Seal)4 771154 Connecting Rod (1.375" Pin)1 771264 Cylinder Head Assembly (Includes Valves & Springs)1 771286 Expansion Plug Kit (Includes 19 Plugs For Head & Block)1 871162 Thermostat: Except Below (2.125")1 871138 Thermostat: LG70149 (2.125" / Bypass)1 871147 Water Pump wo/Pulley: Except Below1 871173 Water Pump wo/Pulley: LG701491 871228 Block Heater (1.250")1 871152 Fuel Pump, Late (4 Bolt)(12)Adj Screw - 471226 / Lock Nut - 571139 (13)Snap Ring - 471228 (14)Includes 2 Bush - 571144 (15)Needle Bearings - 571168。

【国家自然科学基金】_黑洞质量_基金支持热词逐年推荐_【万方软件创新助手】_20140729

【国家自然科学基金】_黑洞质量_基金支持热词逐年推荐_【万方软件创新助手】_20140729

科研热词 推荐指数 辐射能通量 4 薄膜模型 3 广义stefan-boltzmann定律 3 黑洞 2 辐射功率 2 瞬时辐射能通量 2 热质点模型 2 引力透镜 2 静态球对称dilaton-maxwell黑洞 1 银河系 1 运动学和动力学 1 视界温度 1 自发辐射 1 脉泽 1 能级方程 1 绝对自行 1 类星体 1 瞬时辐射功率 1 球对称动态黑洞 1 熵密度 1 测地线 1 活动星系核(agns) 1 活动星系核 1 极端黑洞 1 暗物质 1 星系:赛弗特 1 星系 1 时间延迟 1 时标 1 方法:数值 1 整体单极子 1 拟正则模 1 引力波 1 广义球对称带电静态黑洞 1 天体测量学 1 多谱勒因子 1 多波段辐射流量 1 外星行星 1 吸积率 1 可观测性 1 中心黑洞质量 1 个别 1 x射线 1 tortoise变换 1 schwarzschild黑洞 1 reissner-nordstrom黑洞 1 quintessence 1 oj 287 1 bl lac天体 1 barriola-vilenkin黑洞 1
推荐指数 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
2010年 序号 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50
2011年 序号 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26

【电子技术应用】_设计创新_期刊发文热词逐年推荐_20140725

【电子技术应用】_设计创新_期刊发文热词逐年推荐_20140725

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
53 cadence设计系统公司
107 avc 108 altera公司
1 1
推荐指数 2 2 2 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
开拓创新 开发人员 开发 度分布 差分进化 局域谐振 媒体处理器 奥林匹克竞赛 套装软件 套件 多agent系统 基本理念 可配置性 可持续性 变电站自动化系统 原材料 印刷电路板 卡尔 半导体器件 医疗产品 创新设计 创新 分布式 光学辐射 便携设备 低密度奇偶校验码 低功耗设计技术 产品开发 产品外形 交指结构 亚太区 中国 ⅱ world sopc soc quicklogic公司 proⅱ processor polar p89c58x2 nios(r) ⅱprocessor nios mc68hc908 iec61850 ics i/o结构 fpga fifo ddr存储控制器 csos can总线 bragg散射
科研热词 长期演进 无线技术 射频 lte基站 lte imt-advanced 首席执行官 面阵ccd 键位 行电路 节能技术 电源优化 电力系统 电力分布式计算总线 混合信号设计 模拟 格雷码 数据采集与传输 数字隔离器 录井 异步fifo 密码保护 太阳能系统 太阳能电池板 太阳能发电系统 图形化 图像采集 发电量 双线性插值 双口ram 半导体 医疗电子 分布式计算 光伏系统 传真通信 优化器 仿真器 仿真 亚稳态 ward等值 virtuoso vhdl t.30建议书 soa simulation niosⅱ modem link ic设计 elvis ecg camera

DIN_EN_ISO_527-3_D

DIN_EN_ISO_527-3_D

DEUTSCHE NORMJuli 2003KunststoffeBestimmung der ZugeigenschaftenTeil 3: Prüfbedingungen für Folien und Tafeln(ISO 527-3:1995 + Corr 1:1998 + Corr 2:2001) (enthält Berichtigung AC: 1998 + AC:2002)Deutsche Fassung EN ISO 527-3:1995 + AC:1998 + AC:2002EN ISO 527-3ICS 83.140Plastics — Determination of tensile properties —Part 3: Text conditions for films and sheets (ISO 527-3:1995 + Corr 1:1998 + Corr 2:2001(includes Corrigendum AC:1998 + AC:2002);Germann version EN ISO 527-3:1995 + AC:1998 + AC:2002Plastiques — Détermination des propriétés en traction—Partie 3: Conditions d'essai pour films et feuilles (ISO 527-3:1995 + Corr 1:1998 + Corr 2:2001)(inclut Corrigendum AC:1998- AC:2002);Version allemande EN ISO 527-3:1995 + AC:1998 + AC: 2002Ersatz fürDIN EN ISO 527-3:1995-10 und DIN EN ISO 527-3 Ber 1:1998-09Die Europäische Norm EN ISO 527-3:1995 hat den Status einer Deutschen Norm einschließlich der eingearbeiteten Berichtigungen AC:1998 und AC:2002, die von CEN getrennt verteilt wurden.Nationales VorwortDie Mitarbeit des DIN im CEN/TC 249 …Kunststoffe“ wird über den Normenausschuss Kunststoffe wahrgenommen.An der Erstellung dieser Europäische Norm war seitens des DIN der folgende Arbeitsausschuss beteiligt:FNK-AA 403.3 …Kunststoff-Folien und kunststoffbeschichtete Flächengebilde (Kunstleder); allgemeine Eigenschaften“.Für die Abschnitt 2 angegebenen Internationalen Normen wird im Folgenden auf die entsprechenden Deutschen Normen hingewiesen.ISO 527-1seihe DIN EN ISO 527-1ISO 4593siehe DIN 53360ÄnderungenGegenüber DIN 53455:1981-08 wurden folgende Änderungen vorgenommen: Europäische Norm EN ISO 527-3:1995 übernommen.Gegenüber DIN EN ISO 527-3:1995-10 und DIN EN ISO 527-3 Ber 1:1998-09 wurden folgende Änderungen vorgenommen:a) EN ISO 527-3:1995/AC:2002 undb) DIN EN ISO 527-3 Ber 1:1998-09 eingearbeitet.Fortsetzung Seite 2und 8 Seiten ENNormenausschuss Kunststoffe (FNK) im DIN Deutsches Institut für Normung e. V.©DIN Deutsches Institut für Normung e.V. . Jede Art der Vervielfältigung, auch auszugsweise,Ref. Nr. DIN EN ISO 527-3:2003-07nur mit Genehmigung des DIN Deutsches Institut für Normung e. V., Berlin, gestattet.Preisgr. 07Vertr.-Nr. 2307Alleinverkauf der Normen durch Beuth Verlag GmbH, 10772 BerlinKlass.Nr: 55104Q U E L L E : N O L I S (N o r m v o r A n w e n d u n g a u f A k t u a l i t ät p r üf e n !/C h e c k s t a n d a r d f o r c u r r e n t i s s u e p r i o r t o u s a g e )DIN EN ISO 527-3:2003-07Frühere AusgabenDIN 53371: 1955-10, 1959-09DIN 53455: 1952-10, 1968-04, 1981-08DIN EN ISO 527-3: 1995-10DIN EN ISO 527-3 Berichtigung 1: 1998-09Nationaler Anhang NA(informativ)Literaturhinweise in nationalen ZusätzenDIN 53370, Prüfung von Kunststoff-Folien — Bestimmung der Dicke durch mechanische Abtastung.DIN EN ISO 527-1, Kunststoffe — Bestimmung der Zugeigenschaften — Teil 1: Allgemeine Grundsätze (ISO 527-1:1993 einschließlich Corr 1:1994); Deutsche Fassung EN ISO 527-1:1996.2EN ISO 527-3August 1995EUROPÄISCHE NORM EUROPEAN STANDARD NORME EUROPÉENNE+ACJuni 1998+ACJuli 2002ICS 83.140.00Deutsche FassungKunststoffeBestimmung der ZugeigenschaftenTeil 3: Prüfbedingungen für Folien und Tafeln (ISO 527-3:1995 + Corr 1:1998 + Corr 2:2001)(enthält Berichtigung AC:1998 + AC:2002)Plastics –Determination of tensile properties –Part 3: Test conditions for films and sheets (ISO 527-3:1995 + Corr 1:1998 + Corr 2:2001)(includes corrigendum AC:1998 + AC:2002)Plastiques –Détermination des propriétés en traction –Partie 3: Conditions d'essai pour films et feuilles (ISO 527-3:1995 + Corr 1:1998 + Corr 2:2001)(inclut corrigendum AC:1998 + AC:2002)Diese Europäische Norm wurde von CEN am 1995-07-29 angenommen.Die Berichtigung AC :1998 trat am 18. Juni 1998 in Kraft und AC:2002 am 24. Juli 2002.Die CEN-Mitglieder sind gehalten, die CEN/CENELEC-Geschäftsordnung zu erfüllen, in der die Bedingungen festgelegt sind, unter denen dieser Europäischen Norm ohne jede Änderung der Status einer nationalen Norm zu geben ist.Diese Europäische Norm wurde vom CEN in drei offiziellen Fassungen (Deutsch, Englisch, Französisch) erstellt. Eine Fassung in einer anderen Sprache, die von einem CEN-Mitglied in eigener Verantwortung durch Übersetzung in seine Landessprache gemacht und dem Management-Zentrum mitgeteilt worden ist, hat den gleichen Status wie die offiziellen Fassungen.CEN-Mitglieder sind die nationalen Normungsinstitute von Belgien, Dänemark, Deutschland, Finnland, Frankreich, Griechenland, Irland,Island, Italien, Luxemburg, Malta, Niederlande, Norwegen, Österreich, Portugal, Schweden, Schweiz, Spanien, der Tschechischen Republik und dem Vereinigten Königreich.EUR OP ÄIS C HES KOM ITEE FÜR NOR M UNG EUROPEAN COMMITTEE FOR STANDARDIZATION C O M I T É E U R O P ÉE N D E N O R M A LI S A T I O NManagement-Zentrum: rue de Stassart, 36 B-1050 Brüssel© 2002 CENAlle Rechte der Verwertung, gleich in welcher Form und in welchemVerfahren, sind weltweit den nationalen Mitgliedern von CEN vorbehalten.Ref. Nr. EN ISO 527-3:1995 + AC:1998 +AC:2002 DEN ISO 527-3:1995 + AC:1998 + AC:2002 (D)VorwortDer Text der Internationalen Norm ISO 527-3:1995 wurde vom Technischen Komitee ISO/TC 61 …Plastics“ in Zusammenarbeit mit CEN/TC 249 …Kunststoffe“ erarbeitet.Diese Europäische Norm muss den Staus einer nationalen Norm erhalten, entweder durch Veröffentlichung eines identischen Textes oder durch Anerkennung bis Februar 1996, und etwaige entgegenstehende nationale Normen müssen bis Februar 1996 zurückgezogen werden.Entsprechend der CEN/CENELEC-Geschäftsordnung sind folgende Länder gehalten, diese Europäische Norm zu übernehmen:Belgien, Dänemark, Deutschland, Finnland, Frankreich, Griechenland, Irland, Island, Italien, Luxemburg, Niederlande, Norwegen, Österreich, Portugal, Schweden, Schweiz, Spanien und das Vereinigte Königreich.AnerkennungsnotizDer Text der Internationalen Norm ISO 527-3:1995 wurde vom CEN als Europäische Norm ohne irgendeine Abänderung genehmigt.2EN ISO 527-3:1995 + AC:1998 + AC:2002 (D)1 Anwendungsbereich1.1Dieser Teil der Norm ISO 527 legt die Bedingungen für die Bestimmung der Zugeigenschaften von Kunststofffolien und –tafeln mit einer Dicke von weniger als 1 mm fest und basiert auf den im Teil 1 angegebenen allgemeine Grundsätzen.ANMERKUNG Es wird hinsichtlich Tafeln mit einer Dicke größer als 1 mm auf Teil 2 verwiesen.1.2Siehe ISO 527-1, Abschnitt 1.2.1.3Dieser Teil der Norm ist normalerweise nicht geeignet für die Bestimmung der Zugeigenschaften von:a) Schaumstoffen;b) mit textilen Fasern verstärkten Kunststoffen.1.4Siehe ISO 527-1, Abschnitt 1.5.2 Normative VerweisungenDie folgenden Normen enthalten Festlegungen, die durch Verweisung in diesem Text zu Bestandteilen dieses Teils der ISO 527 werden. Zur Zeit der Veröffentlichung waren die angegebenen Ausgaben gültig. Alle Normen unterliegen Überarbeitungen, und alle Beteiligten von Vereinbarungen, die auf diesem Teil der Internationalen Norm beruhen, sind angehalten, die neuesten Ausgaben der unten aufgelisteten Normen anzuwenden. Die Mitglieder von IEC und ISO führen Listen der gegenwärtig gültigen Internationalen Normen. ISO 527-1:1993, Plastics — Determination of tensile properties — Part 1: General principles.ISO 4591:1992, Plastics — Film and sheeting — Determination of average thickness of a sample, and average thickness and yield of a roll, by gravimetric techniques (gravimetric thickness).ISO 4593:1993, Plastics — Film and sheeting — Determination of thickness by mechanical scanning.3 MessprinzipSiehe ISO 527-1, Abschnitt 3.4 DefinitionenSiehe ISO 527-1, Abschnitt 4.5 MessgerätSiehe ISO 527-1, Abschnitt 5. Außerdem gelten folgende zusätzliche Anforderungen.Zu 5.1.2Die Zugprüfmaschine muss die in ISO 527-1, Tabelle 1, festgelegten Prüfgeschwindigkeiten haben. Üblicher-weise werden Folien und Tafeln mit einer Geschwindigkeit von 5 mm/min, 50 mm/min, 100 mm/min, 200 mm/min, 300 mm/min oder 500 mm/min geprüft. Die in ISO 527-1, Abschnitt 9.6, enthaltenen Angaben gelten ebenfalls.3EN ISO 527-3:1995 + AC:1998 + AC:2002 (D)Zu 5.1.5Bei Prüfung dünner Tafeln oder Folien darf der Probekörper nicht mit der Masse der Längenänderungs-messeinrichtung belastet werden.Zu 5.2Zur Messung der Dicke müssen Messeinrichtungen verwendet werden, die den Anforderungen nach ISO 4593 entsprechen, außer bei sehr dünnen (dünner als 0,01 mm) oder geprägten Folien. In diesen Fällen muss die Dicke nach dem Verfahren bestimmt werden, das in ISO 4591 festgelegt ist. Falls ISO 4591 angewendet wird, gilt die mittlere Dicke des Folienwerkstoffes als die Dicke des Probekörpers.6 Probekörper6.1 Form und Maße6.1.1Die empfohlene Form der Probekörper für die Bestimmung der Zugeigenschaften nach diesem Verfahren ist ein Streifen, Probekörper Typ 2 (siehe Bild 1), 10 mm bis 25 mm breit und nicht kürzer als 150 mm, mit zwei parallelen Messmarken in einem Abstand von 50 mm auf der Mitte des Probekörpers.Einige Folienwerkstoffe besitzen eine sehr hohe Reißdehnung, so dass der Dehnungsbereich der Prüfmaschine überschritten würde. In diesem Fall darf der Anfangsabstand zwischen den Einspannklemmen auf 50 mm zu verringert werden.6.1.2Wenn es durch die Festlegungen für den zu prüfenden Werkstoff gefordert wird, oder bei Regelprüfungen im Rahmen der Qualitätskontrolle, dürfen Probekörper der Typen 5, 1B und 4 mit Form und Maßen nach Bild 2, 3, und 4 verwendet werden. Diese Probekörper sind für eine schnelle und einfache Prüfung im Rahmen der Qualitätskontrolle geeignet.Der Probekörper Typ 5 (Bild 2) ist für eine Folie und Tafel mit sehr hoher Bruchdehnung geeignet. Der Probekörper Typ 4 wird für andere Arten flexibler thermoplastischer Tafeln empfohlen.Der Probekörper Typ 1B (Bild 3) wird für steife Tafeln empfohlen.6.2 Herstellung der Probekörper6.2.1Die in 6.1.1 beschriebenen Probkörper müssen so geschnitten oder ausgestanzt werden, dass die Kanten glatt und frei von Kerben sind; es wird empfohlen, die Kerbfreiheit mit kleiner Vergrößerung zu überprüfen. Zur Erzeugung der richtigen Breite sind Rasierklingen, geeignete Papierschneidmaschinen, Zeichnungsschneidmaschinen oder andere zum Schneiden der Probekörper geeignete Einrichtungen zu verwenden, um die richtige Breite und gerade, saubere, parallele Kanten ohne sichtbare Fehler zu erzeugen. Stanzmatrizen müssen durch regelmäßiges Ziehschleifen scharf gehalten und es muss zur Erzielung einer sauberen Schnittkante bei Verwendung einer Stanzmatrize ein geeigneter Auflagewerkstoff verwendet werden.6.2.2Die in 6.1.2 beschriebenen Probekörper müssen zur Erzielung einer sauberen Schnittkante unter Verwendung einer Stanzmatrize und eines geeigneten Auflagewerkstoffes hergestellt werden. Die Matrizen müssen durch regelmäßiges Ziehschleifen scharf gehalten und die Kanten des Probekörpers mit einer kleinen Vergrößerung überprüft werden, um die Kerbfreiheit sicherzustellen. Probekörper mit sichtbaren Fehlern an den Schnittkanten sind zu verwerfen.4EN ISO 527-3:1995 + AC:1998 + AC:2002 (D)6.3 MessmarkenSiehe ISO 527-1, Abschnitt 6.3.Es muss eine Markierhilfe verwendet werden, um die Messmarken aufzubringen. Diese muss zwei parallele Schneiden besitzen, die glatt und maßgerecht an der Kante geschliffen sind, 0,05 mm bis 0,1 mm breit und mit einem Winkel von nicht mehr als 15° abgeschrägt. Stempel und Tinte dürfen keine schädigende Wirkung auf die zu prüfende Folie ausüben und müssen eine ausreichend kontrastreiche Farbe besitzen.6.4 Prüfung der ProbekörperJeder Probekörper mit sichtbaren Fehlern an den Schnittkanten ist zu verwerfen.6.5 AnisotropieDie Eigenschaften bestimmter Typen von Folienwerkstoffen ändern sich mit der Richtung in der Ebene der Folie (Anisotropie). In diesen Fällen ist es notwendig, zwei Gruppen von Probekörpern herzustellen, deren Hauptachsen entsprechend parallel oder senkrecht zur Orientierungsrichtung der Folie verlaufen.7 Anzahl der ProbekörperSiehe ISO 527-1, Abschnitt 7.8 VorbehandlungSiehe ISO 527-1, Abschnitt 8.9 DurchführungSiehe ISO 527-1, Abschnitt 9.10 Berechnung und Angabe der ErgebnisseSiehe ISO 527-1, Abschnitt 10, außer für …10.3 Modulberechnung“ und …10.4 Poissonzahl, µ“.11 PräzisionDie Präzision des Prüfverfahrens ist nicht bekannt, weil Werte aus Laborrundversuchen nicht verfügbar sind. Wenn solche Werte vorliegen, wird eine entsprechende Angabe bei der nächsten Überarbeitung ergänzt.5EN ISO 527-3:1995 + AC:1998 + AC:2002 (D)612 PrüfberichtDer Prüfbericht muss folgende Angaben enthalten:a) einen Hinweis auf diesen Teil der ISO 527, einschließlich des Typs des Probekörpers und derPrüfgeschwindigkeit, in folgender Form:Typ des Probekörpers Für die Punkte b) bis q) siehe ISO 527-1, Abschnitt 12 b) bis q).Legende1Messmarken b Breite:10 mm bis 25 mm h Dicke:≤ 1 mm L 0Messlänge:50 mm ± 0,5 mm L Anfangsabstand der Einspannklemmen:100 mm ± 5 mm l 3Gesamtlänge:≥ 150 mmBild 1 — Probekörper Typ 2EN ISO 527-3:1995 + AC:1998 + AC:2002 (D)7Legende1Messmarkenb 1Breite des engen parallelen Teils:6 mm ± 0,4 mm b 2Breite an den Enden:25 mm ± 1 mm h Dicke:≤ 1 mm L 0Messlänge:25 mm ± 0,25 mm L 1Länge des engen parallelen Teils:33 mm ± 2 mm L Anfangsabstand der Einspannklemmen:80 mm ± 5 mml 3Gesamtlänge:≥ 115 mm r 1kleiner Radius:14 mm ± 1 mm r 2großer Radius:25 mm ± 2 mmBild 2 — Probekörper Typ 5Legende1Messmarkenb 1Breite des engen parallelen Teils:10 mm ± 0,2 mm b 2Breite an den Enden:20 mm ± 0,5 mm h Dicke:≤ 1 mmL 0Messlänge:50 mm ± 0,5 mm L 1Länge des engen parallelen Teils:60 mm ± 0,5 mm L Anfangsabstand der Einspannklemmen:115 mm ± 5 mm l 3Gesamtlänge:≥ 150 mm r Radius:≥ 60 mm (empfohlener Radius 60,0 mm ± 0,5 mm)Bild 3 — Probekörper Typ 1BEN ISO 527-3:1995 + AC:1998 + AC:2002 (D)8Legende1Messmarkenb 1Breite des engen parallelen Teils:25,4 mm ± 0,1 mm b 2Breite an den Enden:38 mm h Dicke:≤ 1 mm L 0Messlänge:50 mm ± 0,5 mm L Anfangsabstand der Einspannklemmen:98 mm l 3Gesamtlänge:≥ 152 mmr 1kleiner Radius:22 mm r 2großer Radius:25,4 mmBild 4 — Probekörper Typ 4。

Springer Computer Science Proceedings说明书

Springer Computer Science Proceedings说明书

to Springer Computer Science Proceedings Alfred Hofmann1,*, Brigitte Apfel1, Ursula Barth1, Christine Günther1, Ingrid Haas1, Frank Holzwarth1, Anna Kramer1, Leonie Kunz1,Nicole Sator1, Erika Siebert-Cole1 and Peter Straßer11 Springer-Verlag, Computer Science Editorial, Tiergartenstr. 17,69121 Heidelberg, Germany{Alfred.Hofmann, Brigitte.Apfel, Ursula.Barth, Christine.Guenther,Ingrid.Haas, Frank.Holzwarth, Anna.Kramer, Leonie.Kunz,Nicole.Sator, Erika.Siebert-Cole, Peter.Strasser, LNCS}@ Abstract. The abstract should summarize the contents of the paper and shouldcontain at least 70 and at most 150 words. It should be set in 9-point font size andshould be inset 1.0 cm from the right and left margins. There should be two blank(10-point) lines before and after the abstract. 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2016年林菲尔ンMK X车型价格清单说明书

2016年林菲尔ンMK X车型价格清单说明书

PREMIERE EQUIPMENT GROUPPRICING2016 LI N CO LN M KXFor news, photos and video, visit .Follow us on Facebook at /lincoln .INTERIOR FEATURES •S eat features:– H eated front seats – 10-way power driver’s/front passenger seat with two-way power lumbar and driver’s side memory – F our-way manual adjustable front head restraints – 60/40 split rear seat –L incoln Luxury Soft-Touch Seating Surfaces • L incoln Experiences includes:– L incoln welcome mat – D oor handle illumination – A pproach detection – S ignature lighting fade-up • D ual-zone electronic automatic temperature control •C upholders • P ower door locks • D ual illuminated front visor mirrors • P ower windows with one-touch-up/-down for all four windows • D river’s/front passenger seat back map pockets • F ront and rear floor mats • F ront floor console with storage and two cupholders • L ED map lights • L eather-wrapped steering wheel with cruise and redundant audio controls; manual tilt/telescoping steering column • A uto-dimming rearview mirror • O verhead console with sunglasses holder • P articulate air filter POWER AND HANDLING • 3.7-liter Ti-VCT V6 engine •F ront-wheel drive • E lectric power-assisted steering•E lectronic parking brake • A ctive noise control • H ill start assist •P ush-button shift • T orque Vectoring Control •S ix-speed SelectShift®automatic transmission with paddle activation • 18-inch spare tire and wheel • Auto Hold featureEXTERIOR FEATURES•B ody-color bumpers/fascias,door handles and spoiler • B right beltline molding and door handle inserts • D ual chrome exhaust tips • S olar tinted windshield and front door glass • R ear privacy glass • H ID automatic headlamps with LED signature lamps • B ody-color dual power, heated sideview mirrors with memory, integrated blind spot mirrors and LED turn signals • L ED taillamps with LED backup lights • 18-inch painted aluminum wheels SAFETY/SECURITY • M yKey®• F our-wheel disc anti-lock brakes • A dvanceTrac® with RSC® (Roll Stability Control™)• D ual-stage front airbags • F ront seat-mounted side airbags • S afety Canopy® side-curtain airbags • D river and front passenger knee airbags • L ATCH (Lower Anchors and Tether Anchors for Children)•P erimeter alarm • R ear view camera• S ecuriCode™ invisible keypad • S ecuriLock® Passive Anti-Theft System • S OS Post-Crash Alert System™• T ire Pressure Monitoring System •T raction controlFUNCTIONALITY • P remium Sound System with 10 speakers, subwoofer, single-CD player and auxiliary input jack • S iriusXM Satellite Radio with six-month prepaid subscription. Service not available in Alaska and Hawaii •C ruise control • E asy Fuel® capless fuel filler • I ntelligent Access with push-button start •M anual liftgate • 18-gallon fuel tank•R ear-window defroster/wiper • R emote Start System • R everse Sensing System • S YNC® with MyLincoln Touch™ includes 911 Assist,® Vehicle Health Report and SYNCServices. Vehicle Health Report and SYNC Services include complimentary one-year nonrenewable subscription • M edia hub includes two USB ports and SD card reader • 8-inch LCD touch screenSELECTEQUIPMENT GROUPALL PREMIERE EQUIPMENT GROUP CONTENT, PLUS:• 18-inch premium painted aluminum wheels • L ED daytime running lamps• A uto-dimming driver’s sideviewmirror • Wood trim • B ridge of Weir Deepsoft™ leather seating surfaces • P ower tilt/telescoping steering column with memory• Hands-free power liftgate • U pgraded Lincoln Experiences includes:– H eadlamp signature lighting light-up sequence – A mbient lighting with light-up sequence– P ower-folding sideview mirrors – R emote software update functionality – P ersonalized service write-up • U niversal garage door openerRESERVEEQUIPMENT GROUPALL SELECT EQUIPMENT GROUP CONTENT, PLUS:• 20-inch premium painted 10-spoke aluminum wheel (2.7L engine, AWD)• 20-inch premium painted 20-spoke aluminum wheel (2.7L engine, FWD and 3.7L engine, FWD/AWD)• A daptive HID headlamps • H eated and cooled front seats • P anoramic Vista Roof® with power sunshade • B LIS® (Blind Spot Information System) with cross-traffic alert •V oice-activated Navigation System•E mbedded modemPERFORMANCE•F ront-wheel drive• 3.7-liter Ti-VCT V6 engine • S ix-speed SelectShift® automatic transmission • 20-inch premium painted aluminum with chrome insert wheels • 21-inch polished aluminum wheels ($1,300)6INTERIOR • C hoice of four exclusive designer themes: Modern Heritage, Indulgence, Thoroughbred and The Muse • E ach includes Alcantara® headliner, exclusive leather seating and perforation patterns, leather-wrapped console and instrument panels, unique stitching, and genuine wood or Artesian aluminum appliqués • R evel Ultima system with 19 speakers • I nflatable rear outboard safety beltsCARGO ACCESSORY PACKAGE – $175• D urable lightweight rubber cargo mat • R ear bumper anti-scratch pad/load protector CARGO UTILITY PACKAGE – $365• R ear Cargo Management System with liftgate scuff plate, cargo net and two chrome cargo tie-down hooks • M olded plastic storage bins and spare tire vanity cover under cargo floor • C argo compartment with reversible mat • 110-volt power outlet • C argo area tonneau cover CLIMATE PACKAGE – $5951• H eated rear outboard seats • H eated steering wheel • R ain-sensing front wipers • A uto high-beam headlamps TRAILER TOW PACKAGE – $645• T railer sway control • Hitch receiverSELECT PLUS PACKAGE – $1,1002• V oice-activated Navigation System • B LIS® (Blind Spot Information System) with cross-traffic alertTECHNOLOGY PACKAGE – $1,7203• E nhanced active park assist • F orward Sensing System •360-degree cameraDRIVER ASSISTANCE PACKAGE – $1,6503•L ane-Keeping System • A daptive cruise control • P re-Collision Assist with Pedestrian Detection LUXURY PACKAGE – $4,4003• R evel® Ultima system with 19 speakers and HD Radio™ Technology • A daptive LED headlamps FREESTANDING FEATURES • A ll-weather rubber floor mats – $75• S atin roof-rack side rails without crossbars – $195• I nflatable rear outboard safety belts – $250• A daptive steering 4 – $625• 21-inch summer tires 4 –$995• R evel® audio system with 13 speakers and HD Radio Technology – $1,155• 21-inch premium painted aluminum wheels 5 – $1,165• 21-inch polished aluminum wheels 6 – $1,300•22-way adjustable front seats 5 – $1,500• P anoramic Vista Roof®2 – $1,895• F actory-installed Dual-Headrest DVD Entertainment System – $1,995• 2.7-liter EcoBoost® V6 engine – $2,000• I ntelligent all-wheel drive with continuously controlled damping – $2,495• E nhanced security – $60•S onata Spin aluminum trim – N/CAVAILABLE EXTERIOR COLORS • B lack Velvet – N/C • I ngot Silver Metallic – N/C • L uxe Metallic – N/C • A llure Blue Metallic – N/C • R uby Red Metallic Tinted Clearcoat – $495• B ronze Fire Metallic Tinted Clearcoat – $495• P latinum Dune Metallic Tri-coat – $695• W hite Platinum Metallic Tri-coat – $695AVAILABLE INTERIOR COLORS • E bony – N/C • C offee/Cappuccino – $375• H azelnut – $375• T erracotta – N/CFREESTANDING PACKAGESALL PRICES MSRP AND DO NOT INCLUDE TAXES OR OTHER FEES 2016 LINCOLN MK X1Available on Select and Reserve only. 2Available on Select only. 3Available on Reserve only. 4Requires Reserve; available fall 2015. 5Requires Reserve or Black Label. 6Available Fall 2015; requires Reserve and 2.7-liter EcoBoost V6 engine. HD Radio is a proprietary trademark of iBiquity Digital Corp. Chroma is a registered trademark of JDS Uniphase Corporation. Bridge of Weir is a trademark of Bridge of Weir Leather Company Limited.LINCOLN BLACK LABELFor news, photos and video, visit .Follow us on Facebook at /lincoln .EXTERIOR• Unique Lincoln MKX Black Label badging • Panoramic Vista Roof • Adaptive LED headlamps• Colors exclusive to Lincoln Black Label Core colors:– C onfidential White – C rystal Silver – B lack TieChromaFlair® colors:– C hroma® Elite – $1,750– C hroma Quartz – $1,750– C hroma Couture – $1,750PRIVILEGES • F our-year or 50,000-mile extended premium service and maintenance coverage on wear items, such as shockabsorbers, engine belts and hoses, brake pads and linings, windshield wiper blades and spark plugs • N o-cost rental vehicle while any covered maintenance is performed •R emote service that lets Lincoln Black Label customers have their vehicles picked up and returned (within 30-mile radius) when maintenance is performed • A nnual vehicle detailing • A nytime car washes •C ulinary Collection membership: Lincoln Black Label customers enjoy access to curated list of restaurants from coast to coast, with noted chefs who provide at-your-service dining experiences。

大功率直流母线设计

大功率直流母线设计

2009年 10月 年 月Norbert Pluschke09101开关电路中存在的寄生元素iK L11C11 L21L61 C31L71 C41DriverC21 Cd Vd (VK) L62 L22 L31 L41T1L51D1L72 iLDriverC22 L12 L32 L42C32C42T2L52D2Norbert Pluschke09102IGBT模块和电容组作为 一个单元 模块和电容组作为“一个单元 模块和电容组作为 一个单元”四象限 逆变桥独立分析单逆变桥每个桥臂对应部分电容值 (SKiiP)Norbert Pluschke09103功率模块 – 将模块和电容组组合为一个单元Norbert Pluschke09104直流母线以及功率模块的多种形式-采用不同的SKiiP模块--------- 不同的功率单元 -灵活的电容单元----------------- 不同的功率单元Norbert Pluschke09105半桥模块并联的直流母线结构IGBT1 IGBT2 IGBT3-IGBT1以及IGBT3具有不同的杂散电感 -电容的位置相对模块不对称 -杂散电感会使电容产生振荡并可能导致过电压 -必须采用缓冲电容优化Norbert Pluschke09106电容方块” 我们不推荐采用 “电容方块 电容方块- 这种结构将会产生振荡并可能产生过电压特殊的薄膜电容 3 mF/1100VNorbert Pluschke09107直流母线设计 – 不是最优化的 !1. 电容方向错误 2. 电容的位置相对 IGBT是不对称的 3. 不同的纹波电流 产生不同的电容 温度Norbert Pluschke09108直流母线设计 – 优化结构 !1. 电容方向正确 2. 电容相对于IGBT对称 3. 没有不同的纹波电流 也没有不同的电容温度Norbert Pluschke09109巨型电容组” 请不要设计一个 “巨型电容组 巨型电容组-机械应力, 生产要求非常高 -温度分布不均匀Norbert Pluschke091010“中心点 的连接 中心点” 中心点Norbert Pluschke091011不推荐电容间不同的距离会增加杂散电感,Norbert Pluschke091012“中心点 的板式连接 中心点”的板式连接 中心点Norbert Pluschke091013直流母线绝缘层的影响-绝缘层的厚度非常重要 绝缘层的厚度非常重要 -绝缘层厚度会影响杂散电感 绝缘层厚度会影响杂散电感 -绝缘层的厚度会影响高频电容 绝缘层的厚度会影响高频电容 -灰尘放电 灰尘放电铜层 绝缘层 铜层Norbert Pluschke091014直流母线电感值 – 绝缘层的厚度不同绝缘片厚度下的电感值35302520 L in nH0.4mm 1mm 2.4mm 5mm151050 0 50 100 150 200 250 distance in m m 300 350 400 450 500Norbert Pluschke091015采用标准模块设计的直流母线-端子不是最优化的 -不同的电容组有不同的温度 -不同的杂散电感直流母线设计 并不对称-端子最优化 -低杂散电感设计Norbert Pluschke091016将电容和SKiiP组合在一起 组合在一起 将电容和一个功率单元直流环节电容, 3个并联,3个串联Norbert Pluschke091017电解电容可以达到的最高电压电解电容: 350V …500V (新产品) 聚丙烯电容: …2000V母线最大直流电压 <= 电容组的额定电压超出电容额定电压会极大的减少其寿命例如 VCC(nom)= 1100V -> 3 x 400V 电解电容串联 每个电容过电压的能力(短时间) 为 50V最大 1350V来源: 日立 AIC, 产品手册Norbert Pluschke091018聚丙烯电容单相结构单元性能参数来源: Epcos 产品手册尺寸参数 尺寸 l x w x h 约重C IC(rms) Lphase 重量 体积 T电解电容 23mF 550A 38nH 50 kg 37 l 40.000h聚丙烯电容 3mF 600A 15nH 13,5kg 11 l 80.000h13% 110% 40% 37% 40% 200%电压控制能力是否足够?Norbert Pluschke091019优秀的结构设计分压电阻 电压平衡 =>R=Rleak/10母排 (金属板):• 尽可能靠近容性 (低感性) • 更低的电阻值缓冲电容 : 金属板电感量的 补偿Norbert Pluschke091020我们的建议采用母线端子优化的功率模块以减少杂散电感 (GB 版本) 将直流母线电容组和功率模块组合成一个单元 采用缓冲电容优化,实际值较难计算,可以通过实际测试来选取 合适的电容值。

NOM-121-SCT1-2009 (Mexico) - User Manual Requireme

NOM-121-SCT1-2009 (Mexico) - User Manual Requireme

Product Compliance Specialists Ltd Tel: +44 1844 273 277 The Malthouse, Malthouse Square, Fax: +44 1844 273 278 Princes Risborough Bucks, HP27 9AZ ************************************* United KingdomRegistered Office: 73 Southern Road, Thame, Oxon, OX9 2EDCompany Registration Number: 5101011 Registered in England and Wales Doc ref: RU1204005Regulatory UpdateMexicoFollowing publication of NOM-121-SCT1-2009 in Mexico (the Standard which introduced mandatory local testing for any 902 - 928MHz, 2.4GHz or 5725 – 5850MHz RF products) recent advice from PCS’s local contacts advises that COFETEL are now more strictly enforcing the User Manual requirements found in Section 4.6.1 and 4.6.2 of NOM-121-SCT1-2009.Accordingly, we advise that the following requirements should be adhered to with immediate effect:∙ The User Manual must be provided in Spanish language.∙ The User Manual must feature the following mandatory statement :“La operación de este equipo está sujeta a lassiguientes dos condiciones: (1) es posible que esteequipo o dispositivo no cause interferencia perjudicialy (2) este equipo o dispositivo debe aceptar cualquierinterferencia, incluyendo la que pueda causar suoperación no deseada.”The statement can be interpreted, as follows:The operation of this device is subject to the following two conditions:(1) this equipment or device must not cause harmful interference and(2) this equipment or device must accept any interference, includinginterference which could otherwise cause its undesired operation.Despite similarity to the FCC Regulatory statement (already included in most User Manuals for RF products, often in Spanish), COFETEL advisePage 2 of 2 Doc ref: RU1204005 re-using the FCC statement wording is not acceptable: the exact wording above (Spanish text) should be used.For additional information on the above article please contact:Jamie HarperProduct Compliance SpecialistsEmail: **************************************。

AAV HELPER PLASMIDS FOR HELPER VIRUS-FREE PACKAGI

AAV HELPER PLASMIDS FOR HELPER VIRUS-FREE PACKAGI

专利名称:AAV HELPER PLASMIDS FOR HELPER VIRUS-FREE PACKAGING AND PSEUDOTYPIFICATION OF AAV VECTORS发明人:GRIMM, Dirk,KLEINSCHMIDT, Jürgen申请号:DE2002001502申请日:20020424公开号:WO02/088347P1公开日:20021107专利内容由知识产权出版社提供摘要:The invention relates to AAV helper plasmids for helper virus-free packaging of AAV vectors. Said AAV helper plasmids contain the following DNA sequences: (a1) The rep gene of AAV-2 and (a2) the cap gene of AAV-1, AAV-3, AAV-4, AAV-5 or AAV-6, or (b) the cap gene and the rep gene of AAV-1, AAV-3, AAV-4, AAV-5 or AAV-6, and (c) all other helper virus DNA sequences needed for the formation of AAV particles. The invention also relates to the use of said AAV helper plasmids or AAV particles with an envelope coded for by one of said AAV helper plasmids and an AAV expression vector for gene therapy.申请人:GRIMM, Dirk,KLEINSCHMIDT, Jürgen地址:DE,DE,DE国籍:DE,DE,DE代理机构:HUBER, Bernard更多信息请下载全文后查看。

TA Instruments – 微量盒胶体热力学计 (ITC) 有限体积比较:TA Instrum

TA Instruments – 微量盒胶体热力学计 (ITC) 有限体积比较:TA Instrum

TA Instruments – Application Note__________________________________________________________________________________Isothermal Titration Calorimetry (ITC) with Reduced Cell Volumes: A Comparison of the TA Instruments Nano ITC-Low Volume with the GE Healthcare Auto-iTC200.Colette F. Quinn (a) Neil A. Demarse(a), Phillip W. Synder(b)(a) TA Instruments, 890 West 410 North, Lindon, UT 84042, USA(b) Department of Chemistry and Chemical Biology, 253 Mallinckrodt Hall, Harvard University,12 Oxford Street, Cambridge, MA 02138, USAThis study directly compares the performance of the Nano ITC-LV from TA Instrumentsto the Auto-iTC200 of GE Healthcare and evaluates the overall performance and datareproducibility for each instrument. The evaluation reaches beyond simple numericalspecification comparisons by completing multiple identical titrations with identical chemicals oneach instrument. The accuracy of the instruments was determined via an acid-base titration(Figure 1), followed by a biological test system. All the data were fit using the NanoAnalyze™data analysis software package from TA Instruments. In addition, the quality of the data and thegoodness of the fit to the data were statistically evaluated for its precision.TA Instruments – Application Note__________________________________________________________________________________ BackgroundThe accurateness of data collected on each instrument, was validated with an acid-base titration of hydrochloric acid (HCl) and potassium bicarbonate (KHCO3). This acid-base titration enables calculation of the effective cell volume as well as the accuracy of the heat calibration of each instrument. The effective cell volume should be lower than the total cell volume as it takes into consideration the displacement of solution from the injection syringe.Following the acid-base titrations a set of ten experiments were completed on each instrument with two well-defined thermodynamic systems, bovine carbonic anhydrase ii (bCAii) and acetazolamide (ACTAZ) and bCAii and p-aminomethylbenzylsulfonamide (PAMBS) (1). The thermodynamic properties of these systems, like many other protein–ligand interactions, is dependent on variables such pH, ionic strength, buffer, and temperature. The sample preparation and titration parameters used in this study were chosen so that the bCAii and ACTAZ would have a K a of approximately 106 to 107 and the bCAii and PAMBS would have a K a of approx 104 to 105. The samples used in these series of titrations were prepared by the same lab as a single lot of samples.Experimental DesignFor all titration experiments, the stirring speed for each instrument was set at the manufacturer’s recommended value, 300 rpm (Nano ITC-LV) or 1000 rpm (Auto-iTC200) at 25 ˚C. Each titration on each instrument was also programmed through the manufacturer’s software “auto-equilibrate” function to start automatically when the pre-set equilibration conditions were met.To calculate the active cell volume of both instruments, titration experiments consisted of 15 or 20, 2.5 µL incremental aliquots of 1.036 mM HCl (Sigma-Aldrich) injected into either 0.179 mM KHCO3 or 0.0895 mM KHCO3 (Malinnckrodt). The stock solutions were made gravimetrically with water that had been boiled in order to remove the majority of dissolvedCO2, which can be a concern when completing chemical calibrations (2). Each experiment was performed in triplicate and the data underwent iterative refinement of the apparent cell volume until convergence stoichiometric ratio (n) equal to one.For the bCAii study, the instruments were set to deliver 19, 2 µL injections with a first injection of 0.5 µL. ACTAZ, PAMBS and bCAii were purchased from Sigma Aldrich and prepared by dissolving each in 100 mM NaPi, where the pH of the solutions was adjusted to 7.00 ± 0.03 as needed. The protein concentration was determined via UV-Vis using its absorbance at 280 nm. All solutions, 100 mM NaPi pH 7.0, 3 mM PAMBS, 30 µM ACTAZ, 0.222 mM bCAii and 2.7 µM bCAii were prepared in one lab and dispensed to the partner lab to minimize variability due to sample preparation inconsistencies.Before comparing the data, each set was standardized. Auto-iTC200 raw data were converted to µW (µJ/sec). Because raw data collected on the Auto-iTC200 is collected every 5TA Instruments – Application Note__________________________________________________________________________________ seconds and the Nano ITC-LV data was collected every 1 second (user defined), Nano ITC-LV data was averaged and then decimated so that only 1 data point every 5 seconds was used. Also, since the first injection volume of 0.5 µL for the Auto-iTC200 could not be changed, the first injection for the Nano ITC-LV was set to deliver 0.5 µL. This first injection is not displayed in the thermogram of the Auto-iTC200 and was not in the raw data file that was imported into NanoAnalyze from Origin ®.The data was analyzed with a one-site model: , where K a is the association constant, ML is the complex and M and L are the respective free macromolecule and free ligand concentrations. The background was subtracted by averaging the last 3-5 injections that correspond to heat of dilution for the reactants at the end of the titration experiment.ResultsThe Nano ITC-LV effective cell volume was calculated to be 170 µL, which is consistent with the syringe displacing 20 µL from the 190 µL total active cell volume. The effective cell volume of the Auto-iTC200 was calculated to be 225 µL, which is substantially larger than the manufacturer published instrument cell volume of 200 µL. (Table 1). For this study it was critical to determine an accurate active cell volume as this value is used in the data fitting algorithms and would have a large effect on the stoichiometric values (n) calculated for each titration and the association constant (K a). An inaccurate cell volume would lead to inaccurate fit values throughout the experiments in this comparison.Table 1. Average best-fit values associated with fitting ITC data to an independent model, where HCl was titrated into KHCO3at 25 ˚C.When the acid-base titrations were performed on the Auto-iTC200, the resulting cell volumes calculated for the Auto-iTC200 gave an unexpected large range, which can be visually seen in the inflection of the binding curves in Figure 1. Even though the difference in the calculated cell volume was almost 10% greater than the volume reported by the manufacturer, when the cell volume of 225 µL was used in the data analysis in this study it did not translate to any apparent problems later on with the data analysis of the biological systems. The stoichiometries reported in later tables (Appendix A) are consistent with what was expected for the system, which is 1.00.TA Instruments – Application Note__________________________________________________________________________________ The enthalpy (ΔH) from the fit for the Nano ITC-LV data was -9.14 ± 0.06 kJ/mol which is consistent with the literature value of -9.15 kJ/mol (3) (Table 1). Both instruments agreed with this ΔH value within ≤ 3% than the actual value and with this data it was decided that each instrument is producing valid data with their current calibration factors. However, the enthalpy for the Auto-iTC200 was significantly different from the published value.The titration thermograms for PAMBS generated from both instruments are shown in Figure 2 and the fit of each data is in Appendix A. For each thermogram, the injection interval of 120 seconds was included in the analysis and the data was successfully fit without any individual modifications to the fit or the baseline.During the analysis of the data files, it became apparent that although the same injection interval of 120 seconds had been set in the instrument control software for each instrument, the actual amount of time executed during the titrations for the injection interval on each instrument was different. For a Nano ITC-LV the injection interval is defined as the time from the beginning of one injection to the beginning of the subsequent injection. When the same 120 second injection interval time was set in the data acquisition software of the Auto-iTC200,the time interval reflected in the raw data file was 150 seconds. Although the interval for the Nano ITC-LV was in effect shorter by 30 seconds than that for the Auto-iTC200, the data collected on the Nano ITC-LV still appears baseline resolved in both instruments (Figure 2, inset). The resolution of the baseline is further addressed by Figure 3, where the time interval was increased to 200 seconds. This data with the increased time interval was fit with the entire 200 second interval. If the K a and ΔH fit of this data did not agree with the data collected with a 120 second interval, then it could be assumed that the data from the 120 second interval was not fully baseline resolved. This was not the case as the fit of this data provided a K a = 8.6 x 104 and a ΔH = -21.8 kJ/mol, values that are essentially identical with those listed in Table 2 for the 120 second injection interval data.The bottom graph on both Figure 2A and 2B display the integrated areas of the injection peaks for each titration on each instrument. Prior to any fitting function being applied to the data sets, the display indicates there is some obvious undesirable variability run-to-run for the Auto-iTC200 data that is not seen in the data sets for the Nano ITC-LV.For each instrument, the fit parameters, K a, n and ΔH, from the ten titrations were averaged and the results compared (Table 2). Although the overall the quality of data was good, the Auto-iTC200 data had two experimental K a values that fell outside of the standard error, meaning that only 80 % of the data collected provided consistent results. This is even when the concentration of the chemicals were high and the K a value in the optimal operating range of the instrument and the error was 10%, not 2% like the Nano ITC-LV. Although it is not shown in Table 2, there was a clear trend seen with the n fit value of each subsequent data set collected on the Auto-iTC200 (see Appendix A). The n value gradually became smaller for each subsequent titration, with the first titration exhibiting an “n” value of 1.1 and the tenth titration exhibiting an “n” value of 0.8. The ten Nano ITC-LV data sets did not exhibit trends in the “n” values.TA Instruments – Application Note__________________________________________________________________________________A.B.Figure 2. 3 mM PAMBS titrations into 0.222 mM bCAii in 100 mM NaPi, pH 7.0. The top thermogram of each is the raw data and the bottom is the integrated data. A. Nano ITC-LV data. Inset: zooming in between injection 7 and 8. B. Auto-iTC200.TA Instruments – Application Note__________________________________________________________________________________ Figure 3. 3 mM PAMBS titrations into 0.222 mM bCAii in 100 mM NaPi, pH 7.0 collected on a Nano ITC-LV. Inset: zooming in between injection 6 and 7 the baseline is resolved after 150 s; inset is plotted as differential power (µW) v. time (s).Table 2. Average best-fit values associated fitting ITC data to an independent model, where 3 mM PAMBS was titrated into 0.222 mM b CAii at 25 ˚C. The error generated was the standard error of all ten sets of data.TA Instruments – Application Note__________________________________________________________________________________ The binding thermograms for the ACTAZ-bCAii are shown in Figure 4 and the fit of each data file is shown in Appendix A. The ACTAZ data were more difficult to analyze because the heat signal for each injection was smaller and the integration region contained fewer data points, which is due to the larger K a value (106– 107) for this ligand and protein. With fewer points through the inflection region the error associated with the fit becomes greater. Because of the increase in baseline noise due to the smaller heats, during the data analysis, for both instruments many of the baselines for the 120 second injection intervals were evaluated to make sure that the baseline pivot points that delineate the injection intervals had been appropriately placed. In some cases, several of these points were manually moved to ensure the inclusion of the entire injection region and to minimize the noise that had the potential of inaccurately being included with the signal, leading to inaccurate fit values. The final fit parameter calculated for ΔH over the ten titrations gave clear indication that any manual adjustments that had been made were most likely appropriately placed (Table 3).Table 3. Average best-fit values associated fitting ITC data to an independent model, where 30 µM ACTAZ was titrated into 2.7µM bCAii at 25 ˚C. Data were fit with the independent model in NanoAnalyze and the error generated was the standard error for all ten sets of data.As was expected, the % error in the binding constant for the data collected for ACTAZ with both instruments was significantly larger than the error associated with the PAMBS data. The titrations with ACTAZ were designed to test the sensitivity of the instrument and the upper range of the binding constants that can be effectively measured. The ACTAZ binding data collected in this study on both low volume ITC instruments suggests that for ligands with binding constants at 107 or higher, experimental methods that utilize either a single continuous injection or a smaller injection volume, both of which can be executed in the instrument operational software, might decrease the variability. Since the heat signal for each injection for both instruments is well above the baseline noise level (Figure 4, inset) another way to reduce the % error would be to collect more data points in the integration region. Also, with regards to the baseline noise, both the Nano ITC-LV and the Auto-iTC200 have comparable values when using ACTAZ-bCAii. For the ACTAZ-bCAii titrations, the % error for the K a was significantly better for the titrations performed on the Nano ITC-LV. The % erro r for ΔH and n values for the ACTAZ-bCAii were not significantly different for either instrument.TA Instruments – Application Note__________________________________________________________________________________A.B.Figure 4. Baseline resolved ITC thermogram for 30 µM ACTAZ titrations into 2.7 µM bCAii in 100 mM NaPi, pH 7.0. A. Nano ITC-LV data. B. Auto-iTC200 data. The inset in both A and B is an enhanced view between injection 7 and 8, showing the difference between the signal and noise.TA Instruments – Application Note__________________________________________________________________________________ SummaryRecent advances in ITC instrumentation that have decreased the amount of sample required to perform an experiment have thereby enabled the effective measurement of thermodynamics to many biological applications. The Nano ITC-LV with a cell volume of 190 µL from TA Instruments and the Auto-iTC200 with a cell volume of 200 µL from GE Healthcare are the only low volume ITC instruments currently available. This comparative study was undertaken to determine any performance differences that might exist when completing standard incremental titration experiments in these two low volume ITC instruments.The acid-base titrations used in this study revealed that the Nano ITC-LV has a significantly lower effective cell volume at 170 µL than the Auto-iTC200 instrument at 225 µL, which was somewhat higher than the manufacturer published volumetric cell volume of 200 µL. It was also noted that the precision and the accuracy of the data collected for the acid-base calibration on the Nano ITC-LV were more consistent with the published literature values than the data collected on the Auto-iTC200.Another titration parameter that is important in ensuring the maximum data definition for ITC measurements is the data point collection frequency. Methods that include setting data collection time intervals at multi-second intervals or averaging multiple short time intervals have a tendency to smooth the data which may have a negative influence on the accuracy. The Nano ITC-LV data collection frequency of 1 second gave more data definition than the 5 second data collection frequency default setting on the Auto-iTC200.The analysis of the titration data collected on both instruments indicated the following:a)Both instruments performed well and provided comparable precision ( ≤ 10% error)for ΔH, and n for both the PAMBS-bCAii and the ACTAZ-bCAii binding reactions.b)The precision for the binding constant (K a) for both PAMBS and ACTAZ datagenerated on a Nano ITC-LV was better than that determined from the data generatedon the Auto-iTC200. The PAMBS data had a 2% error for Nano ITC-LV vs 10% errorfor Auto-iTC200 and the ACTAZ data had a 28% error for Nano ITC-LV vs 45% errorfor Auto-iTC200.c)Seven out of the eight % error values reported in this study were smaller for the datagenerated in the Nano ITC-LV than the data generated in the Auto-iTC200.d)In this direct comparison the Nano ITC-LV demonstrated itself to be a powerful lowvolume instrument that provides the lowest sample cell volume available, producessuperior data precision and is the most flexible low volume ITC available.TA Instruments – Application Note__________________________________________________________________________________ References1.Krishnamurthy, V.M.; Kaufman, G.K.; Urbach, A.R.; Gitlin, I.; Gudiksen, K.L.; Weibel,D.B.; Whitesides, G.M. Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem. Rev. 108(3) (2008) 946-1051.2.Wadsö, R.N. Goldberg, Standards in isothermal microcalorimetry, Pure & AppliedChem. 73(10) (2001) 1625-1639.3.R.N. Goldberg, N. Kishore, R.M. Lennen, Thermodynamic quantities for the ionizationreactions of buffers. J. Phys. Chem. Ref. Data 31 (2002) 231-370.TA Instruments – Application Note______________________________________________________________________________________________________________________________________________________________________ TA Instruments – Waters LLC Page 11 of 11 MCAPN-2011-04Appendix A . Fit data。

9CE98E26素材文档

9CE98E26素材文档

课外研读推荐书目:必读书目:1.《乌托邦》,(英) 托马斯·莫尔著戴镏龄译,商务印书馆,2009年;2. 《动物庄园》,(英) 乔治·奥威尔著隗静秋译,上海三联书店,2009.063.《科学社会主义的理论与实践》(第5版),高放著,人民大学出版社2008年;4.《中国模式与中国制度》,陈锦华等著,北京:人民出版社,2012.045.《中国震撼——一个“文明型国家”的崛起》,张维为,世纪出版集团,2011年6.《苏联解体——二十年后的回忆与反思》,李慎明主编:社会科学文献出版社,2012年。

选读书目:7.《斯大林评传》,(俄)列夫·托洛斯基著,三联书店2011版(图书馆有);8.《尚未结束的历史—戈尔巴乔夫访谈录》,(俄)戈尔巴乔夫,斯拉文著孙凌齐等译;9.《俄国人》,(美)赫德里克·史密斯,上海《国际问题资料》编译组译,上海人民出版社1977年第1版;10.《彭德怀自述》,彭德怀著,电子版(南农图书馆电子资源可以下载);11.《若干重大决策与事件的回顾》(上下卷),薄一波,中共中央党校出版社1991,1993年;12.《邓小平文选》第3卷,人民出版社;13.《中国特色社会主义理论体系研究》,聂运麟等主编,北京:人民出版社,201114.《资本主义精神和社会主义改革》,郎咸平, 杨瑞辉著北京:东方出版社,2012.115.《中国传统伦理与社会主义先进文化》,陈瑛著,北京:中国社会科学出版社,201216.《中国特色社会主义民主政治发展道路研究》,王民朴, 万远英, 钟兴明著,北京:人民出版社,201117.《反思“中国模式”》,何迪, 鲁利玲编北京:社会科学文献出版社,201218.《生活世界的民主:探询当代中国的新政治文化》,潘一禾著北京:社会科学文献出版社,2010.1019.《社会主义思潮史话》,张武, 张艳国, 喻承久著北京:社会科学文献出版社,201220.《社会主义通史(1-8卷)》,主编王伟光北京:人民出版社,201120.《社会矛盾论:我国社会主义现阶段阶级、阶层和利益群体的分析》,王伟光著北京:中国社会科学出版社,2011.0522《社会主义的现代解析》,主编谷军, 李启英北京:社会科学文献出版社,201123.《中国发展道路的理论支撑》,夏禹龙[等] 著上海:学林出版社,201124.《解开马克思“个人所有制”之迷》,孔陆泉著呼和浩特:内蒙古人民出版社,200325.《发展与公平:中国社会发展的历史抉择》,黄秀华著北京:中国社会科学出版社,2010.1226.《社会主义的未来》,(英) 安东尼·克罗斯兰著轩传树, 朱美荣, 张寒译上海:上海人民出版社,2011.1027.《社会主义向何处去》,(美) 约瑟夫·E·斯蒂格利茨著,吉林人民出版社2011;28.《时间简史》(英)史蒂芬·霍金著,许明贤,吴忠超译,湖南科学技术出版社;29.《增长的极限》,(美)丹尼斯·米都斯等著李宝恒译;30.《科学研究方法论》,(美) E.B. 威尔逊著,石大中,鲁素珍等译;31.《历史在这里沉思——苏联解体20周年祭》,李慎明主编:社会科学出版社,2011年;32. 《做好社会研究的10个关键》,(英)马丁·丹斯考姆著,杨子江译,北京大学出版社2007年。

专访:Simone Legno

专访:Simone Legno

专访:Simone Legno
佚名
【期刊名称】《《计算机光盘软件与应用:COMPUTER ARTS数码艺术》》【年(卷),期】2009(000)001
【摘要】意大利插画师配上日本人的灵魂会是怎么样的组合呢?Dean Evans采访传奇人物设计师Simone Legno,探究tokidoki的精髓。

【总页数】7页(P66-72)
【正文语种】中文
【中图分类】TB47
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线索手册11

线索手册11

线索检查汉斯•里莫瑞特的尸体(第一次)从尸体的温度可以推出死亡时间为下午6:30。

凶手在背后开了两枪。

第一枪子弹击中了肩膀,第二枪是致命一击,子弹从后背进入,从腹部射出,应该击中了某个重要器官。

一条细微的血迹让你相信要么有人轻微地移动过尸体,要么汉斯没有马上丧命,并且试图向门外求救。

一颗子弹从尸体中被取了出来。

(1#线索)检查汉斯•里莫瑞特的尸体(第二次)更深层次的检查让你发现了比第一次检查更多地细节。

第一,你注意到汉斯的衬衫衣领沾染了血迹。

你觉得那是因为他在做手术时没有系好大褂,病人的血弄脏了衣领。

你还注意到汉斯没有带上他的结婚戒指。

此外,在他身上没有发现任何能够证明他身份的东西,很有可能是被杀手偷走了。

难道是有人想让大家相信这只是个简单的犯罪?检查汉斯•里莫瑞特的纹身你检查了一下死去的男人的右后肩,希望找到纹身。

不幸的是,一颗子弹正好击中了那个部位。

如果那里有个纹身,也被枪击带了的创伤毁坏了。

(2#线索)检查汉斯•里莫瑞特的手指在汉斯的左手中指上没有可见的戒指痕迹。

不过有许多外科医生在需要做手术时都不会带戒指。

也许汉斯只会在工作以外的时候戴戒指。

走廊线索1你注意到这是出入急诊病房唯一的一条路,走廊尽头被一个大型衣柜挡住了,被很明显是绑匪把它推到这里来阻止警察进入。

线索2在被大型衣柜挡住的急诊病房出口旁边,你找到了少量空腔外壳,随着膛线看去,一颗子弹!(3#线索)德雷克•里莫瑞特的衣帽柜线索1你发现了大量关于器官移植的复杂的医学文本,显然德雷克医生对器官移植相当感兴趣。

线索2你发现了一张雄性激素的订单,通常是用来与其他药品配合治疗严重阳痿的。

难道德雷克这方面有问题?(4#线索)线索3你发现了一张超声波检查结果。

上面是一张非常清晰的足月的婴儿影像。

在这检查结果上面写着病人的名字是“盖尔•里莫瑞特”。

(5#线索)线索4你发现了一份保险合同,内容是如果汉斯死亡,盖尔•里莫瑞特、德雷克•里莫瑞特和布莱特医院一起将获得约六百万美元的赔偿。

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(Chancellor of the Exchequer in his March 2004 Budget
How did we get here?
• Original proposal was for an RRO.
• Formal consultations in 2005 & 2007.
• Draft Construction Contracts Bill published for consultation in July 2008.
Sections 111 & 112 are wholly dependent on there being an “adequate Payment mechanism”
“A party…. may not withhold payment after the final date for payment of a sum due under the contract unless he has given a effective notice of intention to withhold payment” [s.111(1)]
PAYER’S FAILURE TO ISSUE NOTICE
• Payee can issue notice instead but final date for payment extended from expiry of 5 days.
• But final date for payment intact if payee issues application before payment due date (provided such application is required/ permitted by contract).
ADEQUATE MECHANISM
“This legislation requires that payment should be defined in terms of amount and date”
(emphasis added)
Lord Lucas, in HL Debate on Construction Bill, 26 February 1996
Certainty that cash is Secure
• ? • ?
CURRENT WEAKNESSES
• S.110(1)(a) Contracts must have adequate mechanism for determining what payments become due and when.
“[Section 111] is designed simply to ensure that once a certificate is issued, payment follows unless proper notice of withholding is given. It has no legal effect even, presumably, on the true incidence of liability.”
A DUE SUM
“In [the Architecture and Surveying Institutes] contract, the sum is determined by the certificate”
Jacob L.J. In Rupert Morgan Building Services Ltd .v. Jervis 2004 BLR 18
THE CHANGES NEW S.111
PAYER MUST PAY NOTIFIED SUM ON OR BEFORE THE FINAL DATE FOR PAYMENT
NOTIFIED SUM
• The sum specified in notice issued by: – Payer – Payee – Payee, where payer fails to issue notice.
“The Four Certainties”
• Adequate mechanism
Certainty of Enforcement
• No withholding unless effective notice
• Right of suspension • Limited abolition of pay when paid.
Sedley L.J. in Rupert Morgan Building Services v. Jervis
“The absence of….a means for resolving deadlock….renders inadequate the machinery for determining when payments are due”.
• Must be given no later than the “prescribed period” before date for payment.
Payment Procedure
Option A
Notified sum to be discharged
Payer/payee to issue notified sum (on/before final day for payment
Chartered Institute of Arbitrators
Western Counties Branch
1 October 2009
Construction Act Reforms
Professor Rudi Klein, Barrister Chief Executive, Specialist Engineering Contractors’ Group
How did we get here?
“Following concerns expressed by the construction industry on unreasonable delays in payment, the Government will review the operation of the adjudication and payment provisions in the Housing Grants, Construction and Regeneration Act 1996 to identify what improvements can be made”.
NOTICE TO PAY LESS
• Payer can issue notice of intention to pay less than notified sum. • Notice must indicate sum payer considers due on date notice is served and basis of calculation.
“Where a sum due … is not paid in full by the final date for payment and no effective notice to withhold payment is given the person to whom the sum is due has the right to…. suspend performance….” [s.112(1)]
• Revised Bill receives 1st Reading in the House of Lords on 4 December 2008 (some changes from original draft).
“Our amendments….will create greater certainty and clarity of cash flow for all in the construction supply chain” (emphasis added).
Certainty of Timing
Certainty of Amount
• Right to progress payments • Contracts to state final date for payments • Limited abolition of pay wheNESSES
• Likelihood is that majority of contracts do not have an adequate mechanism.
• Scheme not helpful: there is only a list of what may be included in interim payments together with due dates and final payment dates.
Notices must comply with new s.110(A) – replacing s.110(2) requiring payer to issue payment notice
NOTICE REQUIREMENTS
• Contracts to indicate which party to issue notices. • Notices to be issued no later than 5 days after payment due date. • Amount of sum considered due must be stated together with basic calculation.
Lord Macfadyen in Maxi Construction v Merton Rolls [2001] CILL 1784
NEW ZEALAND APPROACH
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