达标调脂治疗对新诊断2型糖尿病亚临床动脉粥样硬化进展的影响

达标调脂治疗对新诊断2型糖尿病亚临床动脉粥样硬化进展
的影响
付颖瑜;陈小燕;汤庆;黄晓淳;肖文霞
【期刊名称】《实用医学杂志》
【年(卷),期】2011(27)17
【摘要】目的:探讨以达标为靶目标的调脂治疗对新诊断2型糖尿病(T2DM)患者亚临床动脉粥样硬化(AS)进展的影响.方法:84例病程在1年以内、无AS的T2DM 患者,在进行抗血小板聚集、强化血糖、血压迭标治疗的基础上,随机分为达标调脂治疗组和对照组.采用高分辨血管外超声方法分别于治疗前及治疗2年后检测颈动脉的内中膜厚度(IMT)及血管内AS斑块情况.结果:治疗2年后两组颈动脉IMT变化差异无显著性(P>0.05),迭标调脂治疗组颈动脉内AS斑块发生的比例显著低于对照组(P<0.05).Logistic回归分析提示是否接受达标调脂治疗是影响颈动脉血管内AS斑块发生的独立危险因素.结论:对新诊断、已经接受强化血糖及血压达标治疗的T2DM患者,进一步采取以达标为靶目标的调脂治疗能有效减少颈动脉内AS 斑块的发生.%Objective To explore the progress of subclinical atherosclerosis(AS) of newly diagnosed type 2 diabetic patients undergoing targeted lipid-lowering intervention. Methods Eighty-four diabetic patients (duration ≤ 1 year)without AS were divided into two groups (group A and B) randomly, and group A was designed to undergo targeted lipid-lowing treatment. The two groups were all underwent the targeted intervention including the controlling of blood glucose, blood pressure and taking asprin as well. Noninvasive high
resolution B mode ultrasonography was used to measure the intima medial thickness (IMT) and atherosclerotic plaques of common carotid artery (CCA) at baseline and after 2-year intervention. Results No significant difference of IMT change between two groups (P ＞ 0.05)after 2-year, and ratio of AS plaques of CCA in group A was significantly lower than group B (P＜ 0.05). Logistic stepwise regression analysis showed that "if undergo targeted lipid- lowing treatment"itself was the independent risk factor for AS plaques development of CCA. Conclusion To newly diagnosed type 2 diabetics have already at intensified blood glucose and blood pressure control, taking further treatment such as targeted lipid-lower intervention will effectively reduce carotid plaques development.【总页数】3页(P3118-3120)
【作者】付颖瑜;陈小燕;汤庆;黄晓淳;肖文霞
【作者单位】510120,广州医学院第一附属医院内分泌科;510120,广州医学院第一附属医院内分泌科;510120,广州医学院第一附属医院超声诊断科;510120,广州医学院第一附属医院内分泌科;510120,广州医学院第一附属医院内分泌科
【正文语种】中文
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