BIOMARKER TEST AND METHOD FOR ASSESSING MUCOSAL HE
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专利名称：BIOMARKER TEST AND METHOD FOR
ASSESSING MUCOSAL HEALING IN
RESPONSE TO TREATMENT OF ULCERATIVE
COLITIS
发明人：DUKLER, Avinoam,RINGOLD,
Randy,VERMEIRE, Severine,DE BRUYN,
Magali,OPDENAKKER, Ghislain
申请号：US2017/064029
申请日：20171130
公开号：WO2018/102591A1
公开日：
20180607
专利内容由知识产权出版社提供专利附图：
摘要：Mucosal healing is an indication to the disease activity level in patients affected by inflammatory bowel diseases, and it is thus far mainly monitored by endoscopy. Instead or in addition to endoscopy, the invention provides blood test using biomarkers and an index that allows a practitioner to assess the status of mucosal healing, to change or adapt dosage of treatment and to predict which patient will become responder versus non-responder to treatment as assessed by endoscopy. While none of neutrophils cell count, c-reactive protein (CRP), Human type of Cathelicidin (LL-37), or Chitinase 3-like 1 (CHI3L1) alone is able to provide an assessment means of mucosal healing, the invention provides a novel combination of the levels of these biomarkers to assess the level of mucosal healing in relation to endoscopic healing.
申请人：KEPLER DIAGNOSTICS, INC.,KATHOLIEKE UNIVERSITEIT LEUVEN
地址：4685 Runway Street Suite K Simi Valley, California 93063 US,Katholieke Universiteit Leuven KU Leuven Research & Development Waaistraat 6, box 5105 3000 Leuven BE
国籍：US,BE
代理人：LAGOBI, Karim 更多信息请下载全文后查看。