STABILITY-ENHANCED VARIANTS OF PARATHYROID HORMONE
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专利名称：STABILITY-ENHANCED VARIANTS OF
PARATHYROID HORMONE
发明人：KRONIS, K., ANNE,BOZZATO, RICHARD, P.申请号：CA9300136
申请日：19930331
公开号：WO9320203A3
公开日：
19931125
专利内容由知识产权出版社提供
摘要：Herein described are variants of parathyroid hormone that retain significant PTH activity and are substantially resistant to trypsin and trypsin-like enzymes. The variants are useful pharmaceutically, to treat bone disorders such as osteoporosis and in other therapeutic applications. Specific embodiments of the invention include [His25]PTH, [His26G1n27]PTH and [His?25His26Leu27¿]PTH.
申请人：ALLELIX BIOPHARMACEUTICALS INC.,GLAXO CANADA INC.
地址：6850 GOREWAY DRIVE;MISSISSAUGA, ONTARIO L4V 1P1,7333 MISSISSAUGA ROAD NORTH;MISSISSAUGA, ONTARIO L5N 6L4
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