MAPKs信号通路参与疼痛中枢敏感化的研究进展

MAPKs信号通路参与疼痛中枢敏感化的研究进展
逯素芬
【期刊名称】《医学综述》
【年(卷),期】2012(018)016
【摘要】丝裂原活化蛋白激酶(MAPKs)对细胞内信号转导非常重要,在调控神经系统可塑性和炎性反应中发挥着重要作用.MAPKs家族由细胞外信号调节激酶(ERK),p38和c-Jun氨基末端激酶(JNK)组成.组织和神经损伤后它们通过特定的细胞内机制增强疼痛的敏感性.伤害性刺激所引起的脊髓背角神经元ERK的磷酸化在中枢敏感化中起着重要作用.它通过多种神经递质受体,并利用不同第二信使通路调节谷氨酸受体活性、K+通道和诱导基因的转录.神经损伤后ERK、p38和JNK引起脊髓神经胶质细胞炎症/疼痛介质的合成,从而增强疼痛敏感.通过对MAPK信号传导通路特异性抑制剂的研发可能为疼痛治疗增加新的思路.%Mitogen-activated protein kinases( MAPKs )are important for intracellular signal transduction and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK family consists of three major members:extracellular signal-regulated kinases( ERK),p38,and c-Jun N-terminal kinase( JNK). Accumulating evidence shows that all three MAPK pathways contribute to pain sensitization after tissue and nerve injury via distinct molecular and cellular mechanisms. ERK activation in spinal cord dorsal horn neurons by no-ciceptive activity,via multiple neurotransmitter receptors,and using different second messenger pathways plays a critical role in central sensitization by regulating the activity of glutamate receptors and
potassium channels and inducing gene transcription. After nerve injury, ERK, p38, and JNK lead to the synthesis of proinflammatory/ pronociceptive mediators in spinal glial cells, thereby enhancing and prolonging pain. Development of specific inhibitors for MAPK pathways may lead to new therapies for pain management.
【总页数】3页(P2575-2577)
【作者】逯素芬
【作者单位】徐州医学院麻醉学院,江苏,徐州,221000;山东省聊城市人民医院麻醉科,山东,聊城,252000
【正文语种】中文
【中图分类】R651.2;R441.1
【相关文献】
1.MAPK级联通路与病理性疼痛的中枢敏感化 [J], 余炜昶;黄光英;张明敏
2.DREAM信号通路调控疼痛敏感化的研究进展 [J], 张永福;项红兵
3.胶质细胞参与疼痛中枢敏感化的机制 [J], 陈敏;项红兵
4.PI3K信号通路调控中枢敏感化的研究进展 [J], 李荣春
5.丝裂原活化蛋白激酶在糖尿病神经病理性疼痛中枢敏化和外周敏化中作用的研究进展 [J], 张欣;申乐;黄宇光
因版权原因，仅展示原文概要，查看原文内容请购买。