Pizotifen_15574-96-6_DataSheet_MedChemExpress

Product Name:
Pizotifen CAS No.:
15574-96-6Cat. No.:
HY-B0115Product Data Sheet
MWt:
295.44Formula:
C19H21NS Purity :>98%
Solubility:
DMSO 21 mg/mL; Water <1 mg/mL
Mechanisms:Biological Activity:
Pizotifen(Pizotyline)is a highly selective 5HT receptor blocking agent which is a
Pathways:GPCR/G protein; Target:5-HT Receptor
Pathways:Neuronal Signaling; Target:5-HT Receptor Pizotifen(Pizotyline) is a highly selective 5-HT receptor blocking agent, which is a
benzocycloheptane based drug.
Target: 5-HT receptor Pizotifen, is a benzocycloheptane based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches [1]. Pizotifen proved to be a highly selective 5-HT receptor blocking agent both in vivo (on saphenous veins) and in vitro (on saphenous veins
and basilar arteries) from dogs and humans [2].Three groups of pregnant mice were treated daily with oral doses (0.24, 0.6 and 1.2 mg/kg) of pipethiadene and pizotifen from day 4 to day 16 of gestation. The following parameters were References:
[1]. Stark RJ, et al. Management of migraine in Australian general practice. Med J Aust. 2007 Aug
6;187(3):142-6.[2]. Müller-Schweinitzer E, Pizotifen, an antimigraine drug with venoconstrictor activity in vivo. J p p p y y g g p
investigated: reproductive health of the dams, external, skeletal and visceral malformations of
fetuses and frequencies of micronuclei and chromosome aberrations in bone marrow cells of dams.Oral administration of Pi...
[],,g g y
Cardiovasc Pharmacol. 1986 Jul-Aug;8(4):805-10.[3]. Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene
and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23(3-4):376-8.
Caution: Not fully tested. For research purposes only
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