PREPARATION OF MICROCAPSULES
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专利名称：PREPARATION OF MICROCAPSULES 发明人：SUTTON, Andrew Derek, Delta
Biotechnology Limited,JOHNSON, Richard Alan, Delta Biotechnology Limited 申请ห้องสมุดไป่ตู้：EP93922577.7 申请日：19931008 公开号：EP 066384 0B 1 公开日：20031210
摘要：Microspheres are prepared by a process comprising the steps of (i) spraydrying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microsphere have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 νm, targeted to selected areas of the body or of prolonged life in the circulation.
申请人：QUADRANT DRUG DELIVERY LTD 地址：GB 国籍：GB 代理机构：Bassett, Richard Simon 更多信息请下载全文后查看
专利名称：PREPARATION OF MICROCAPSULES 发明人：SUTTON, Andrew Derek, Delta
Biotechnology Limited,JOHNSON, Richard Alan, Delta Biotechnology Limited 申请ห้องสมุดไป่ตู้：EP93922577.7 申请日：19931008 公开号：EP 066384 0B 1 公开日：20031210
摘要：Microspheres are prepared by a process comprising the steps of (i) spraydrying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microsphere have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 νm, targeted to selected areas of the body or of prolonged life in the circulation.
申请人：QUADRANT DRUG DELIVERY LTD 地址：GB 国籍：GB 代理机构：Bassett, Richard Simon 更多信息请下载全文后查看