腹腔灌洗术联合持续血液净化对重症急性胰腺炎患者t辅助淋巴细胞

明显高于对照组（P约0.05）。治疗前，两组 Th2 细胞因子 IL-4 水平无显著差异（P跃0.05）；治疗 1、3 d，两组 Th2 细胞因子 IL-4
水平均明显下降，且观察组明显低于对照组（P约0.05）。结论 腹腔灌洗术联合持续血液净化可有效调整并促进 SAP 患者机体
Th1/Th2 平衡，提高机体免疫力。
外周血 Th1/Th2 无显著差异（P跃0.05）；治疗 1、3 d，两组外周血 Th1/Th2 均明显增高，且观察组明显高于对照组（P约0.05）。治
疗前，两组 Th1 细胞因子 IFN-酌 水平无显著差异（P跃0.05）；治疗 1、3 d，两组 Th1 细胞因子 IFN-酌 水平均明显上升，且观察组
ZHANG Hui-qing, ZHANG Xin-yuan, WANG Dong-jun * (General Surgery Department, Xi'an Fengcheng Hospital, Xi'an 710016, China)
ABSTRACT: Objective To explore the effects of peritoneal lavage combined with continuous blood purification on T helper lymphocytes (Th) and cytokines of patients with severe acute pancreatitis (SAP). Methods A total of 102 patients with SAP who met the diagnostic and inclusion criteria were divided into control group and observation group by a completely random number grouping method. The control group was treated with continuous blood purification treatment on the basis of routine symptomatic treatment. The observation group was treated with peritoneal lavage on the basis of continuous blood purification of the control group. The peripheral blood T1/Th2, the expression levels of Th1 cytokines interferon-酌 (IFN-酌) and Th2 cytokines interleukin-4 (IL-4) before and on the first and third day of treatment were compared. Results Before treatment, there was no significant difference in peripheral blood Th1/Th2 between the two groups (P>0.05); on the first and third day of treatment, peripheral blood Th1/Th2 of the two groups increased significantly, and those of the observation group were significantly higher than the control group (P<0.05). Before treatment, there was no significant difference in Th1 cytokines IFN -酌 level between the two groups (P >0.05); on the first and third day of treatment, Th1 cytokines IFN-酌 level of the two groups increased significantly, and those of the observation group were significantly higher than the control group (P<0.05). Before treatment, there was no significant difference in Th2 cytokines IL-4 level between the two groups (P>0.05); on the first and third day of treatment, Th2 cytokines IL-4 level in both groups decreased significantly, and those in the observation group were significantly lower than the control group (P<0.05). Conclusion Peritoneal lavage combined with continuous blood purification can effectively adjust and promote the Th1/Th2 balance of SAP patients and improve immunity of patients. KEYWORDS: severe acute pancreatitis; peritoneal lavage; continuous blood purification; T helper lymphocytes; cytokines
关键词：重症急性胰腺炎；腹腔灌洗；持续血液净化；T 辅助淋巴细胞；细胞因子
中图分类号：R576
文献标志码：A
文章编号：2096-1413(2020)03-0063-03
Effects of peritoneal lavage combined with continuous blood purification on T helper lymphocytes and cytokines of patients with severe acute pancreatitis
响。方法 以完全随机数字分组法将符合诊断及纳入标准的 102 例 SAP 患者分为对照组和观察组。对照组在常规对症处理基
础上采用连续性血液净化治疗，观察组在对照组连续血液净化治疗基础上，采用腹腔灌洗术进行治疗。比较两组治疗前及
1、3 d 外周血 Th1/Th2 及 Th1 细胞因子干扰素-酌（IFN-酌）和 Th2 细胞因子白细胞介素-4（IL-4）表达水平。结果 治疗前，两组
2020 年 1 月
临床医学
腹腔灌洗术联合持续血液净化对重症急性胰腺炎患者
T 辅助淋巴细胞及其细胞因子的影响

张 惠 清 ，张 新 元 ，王 东 君 * （西安凤城医院普外科，陕西 西安，710016）
摘要：目 的 探讨腹腔灌洗术联合持续血液净化对重症急性胰腺炎（SAP）患者 T 辅助淋巴细胞（Th）及其细胞因子的影