鼠神经生长因子联合神经节苷脂对脑损伤患者神经功能修复的影响
合集下载
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
浙江医学 2018 年第 40 卷第 20 期
鼠神经生长因子联合神经节苷 脂对脑损伤患者神经功能修复 的影响
张行泉
【 摘要 】 目的 探讨鼠神经生长因子联合神经节苷脂对脑损伤患者神经功能修复的影响。 方法 将 90 例颅脑脑损伤患 者采用随机数字表法分为 A 组、B 组、C 组，每组 30 例。在常规治疗基础上，A 组患者加用神经节苷脂治疗，B 组患者加用鼠神经生长 因子治疗，C 组患者加用神经节苷脂联合鼠神经生长因子治疗。比较 3 组患者的临床疗效、神经功能评分、日常生活能力评分及肌力评 分。 结果 C 组患者的总有效率为 93.33%，高于 A、B 组（P＜0.05），而 A 组与 B 组的总有效率比较无统计学差异（P ＞0.05）；3 组 患者治疗后的神经功能评分、日常生活能力评分、肌力评分均较治疗前显著增高（均 P＜0.05）；C 组患者治疗后神经功能评分、日常 生活能力评分、肌力评分均高于 A、B 组（均 P＜0.05），A 组与 B 组比较无统计学差异（P ＞0.05）。 结论 采用神经节苷脂、鼠神经 生长因子联合治疗脑损伤患者的临床疗效显著，不仅可有效修复患者的神经功能及受损的肌力，还能提高其日常生活能力，可推广应 用于临床。
【 Key words 】 Brain injury Ganglioside Nerve growth factor Neural function
颅脑损伤是脑外科常见疾病，其死亡率在目前外伤 性疾病的死亡率中高居首位，且随着工业化进程的加快 和社会经济的发展，交通事故频发，颅脑损伤的发生率 也逐年增高，因此，临床上对颅脑损伤进行积极治疗十
【 关键词 】 脑损伤 神经节苷脂 鼠神经生长因子 神经功能
Efficiency of mouse nerve growth factor combined with ganglioside in treatment of patients with brain injury China
【 Abstract 】 Objective To investigate the efficacy of mouse nerve growth factor combined with ganglioside in treatment of patients with brain injury. Methods Ninety patients with brain injury patients admitted from January 2016 to June 2017 were randomly assigned in three groups with 30 patients in each group. All patients were treated with conventional therapy; in addition, patients in group A also received ganglioside, patients in group B received mouse nerve growth factor and patients in group C received ganglioside plus mouse nerve growth factor. The clinical efficacy was evaluated with the neurological function score, ADL score and muscle strength score before and after treatment in three groups. Results The overall effective rate of group C (93.33%) was higher than that of group A and group B (P＜0.05), while there was no significant difference in effective rate between group A and group B (P ＞0.05). The neurological function score, ADL score and muscle strength scores were significantly improved after treatment in all three groups (P＜0.05); the scores in group C were higher than those of other two groups (P＜0.05), however, there was no significant difference between groups A and B (P ＞0.05). Conclusion Ganglioside combined with mouse nerve growth can more effectively improve nerve function than use of single drug in treatment of patients with brain Injury.
doi：10.12056/j.issn.1006-2785.2018.40.20.2018-1840 作者单位：316000 舟山医院神经外科 通信作者：张行泉，种在机体内广泛分布的糖鞘 脂，对神经与多类脑损伤均有保护作用。鼠神经生长因 子也是一种神经保护剂、神经营养剂和神经再生剂，它 对受伤的运动神经元有保护作用。神经节苷脂与神经细 胞膜结合后能明显增强神经生长因子的功能，有效促进 神经再生。近年来，有研究者采用神经节苷脂、鼠神经生 长因子治疗小儿脑损伤取得了显著的效果，但临床上关 于神经节苷脂、鼠神经生长因子联合治疗成年人颅脑损
鼠神经生长因子联合神经节苷 脂对脑损伤患者神经功能修复 的影响
张行泉
【 摘要 】 目的 探讨鼠神经生长因子联合神经节苷脂对脑损伤患者神经功能修复的影响。 方法 将 90 例颅脑脑损伤患 者采用随机数字表法分为 A 组、B 组、C 组，每组 30 例。在常规治疗基础上，A 组患者加用神经节苷脂治疗，B 组患者加用鼠神经生长 因子治疗，C 组患者加用神经节苷脂联合鼠神经生长因子治疗。比较 3 组患者的临床疗效、神经功能评分、日常生活能力评分及肌力评 分。 结果 C 组患者的总有效率为 93.33%，高于 A、B 组（P＜0.05），而 A 组与 B 组的总有效率比较无统计学差异（P ＞0.05）；3 组 患者治疗后的神经功能评分、日常生活能力评分、肌力评分均较治疗前显著增高（均 P＜0.05）；C 组患者治疗后神经功能评分、日常 生活能力评分、肌力评分均高于 A、B 组（均 P＜0.05），A 组与 B 组比较无统计学差异（P ＞0.05）。 结论 采用神经节苷脂、鼠神经 生长因子联合治疗脑损伤患者的临床疗效显著，不仅可有效修复患者的神经功能及受损的肌力，还能提高其日常生活能力，可推广应 用于临床。
【 Key words 】 Brain injury Ganglioside Nerve growth factor Neural function
颅脑损伤是脑外科常见疾病，其死亡率在目前外伤 性疾病的死亡率中高居首位，且随着工业化进程的加快 和社会经济的发展，交通事故频发，颅脑损伤的发生率 也逐年增高，因此，临床上对颅脑损伤进行积极治疗十
【 关键词 】 脑损伤 神经节苷脂 鼠神经生长因子 神经功能
Efficiency of mouse nerve growth factor combined with ganglioside in treatment of patients with brain injury China
【 Abstract 】 Objective To investigate the efficacy of mouse nerve growth factor combined with ganglioside in treatment of patients with brain injury. Methods Ninety patients with brain injury patients admitted from January 2016 to June 2017 were randomly assigned in three groups with 30 patients in each group. All patients were treated with conventional therapy; in addition, patients in group A also received ganglioside, patients in group B received mouse nerve growth factor and patients in group C received ganglioside plus mouse nerve growth factor. The clinical efficacy was evaluated with the neurological function score, ADL score and muscle strength score before and after treatment in three groups. Results The overall effective rate of group C (93.33%) was higher than that of group A and group B (P＜0.05), while there was no significant difference in effective rate between group A and group B (P ＞0.05). The neurological function score, ADL score and muscle strength scores were significantly improved after treatment in all three groups (P＜0.05); the scores in group C were higher than those of other two groups (P＜0.05), however, there was no significant difference between groups A and B (P ＞0.05). Conclusion Ganglioside combined with mouse nerve growth can more effectively improve nerve function than use of single drug in treatment of patients with brain Injury.
doi：10.12056/j.issn.1006-2785.2018.40.20.2018-1840 作者单位：316000 舟山医院神经外科 通信作者：张行泉，种在机体内广泛分布的糖鞘 脂，对神经与多类脑损伤均有保护作用。鼠神经生长因 子也是一种神经保护剂、神经营养剂和神经再生剂，它 对受伤的运动神经元有保护作用。神经节苷脂与神经细 胞膜结合后能明显增强神经生长因子的功能，有效促进 神经再生。近年来，有研究者采用神经节苷脂、鼠神经生 长因子治疗小儿脑损伤取得了显著的效果，但临床上关 于神经节苷脂、鼠神经生长因子联合治疗成年人颅脑损