血清CEA和CA19-9表达水平对胃癌分期的临床意义

血清CEA和CA19-9表达水平对胃癌分期的临床意义
戈军刚;钱雷敏
【期刊名称】《医学综述》
【年(卷),期】2012(18)21
【摘要】Objective To study the value of detection of serum CEA and
CA19-9 in diagnosis and prognosis in patients with gastric cancer. Methods Serum levels of CEA and CA19-9 of gastric cancer patients at different stages were measured by electrochemiluminescence assay. Results The levels of two kinds of tumor marker in gastric cancer group at stage IV were obviously higher than those in three other groups( P < 0. 01 ). The positive rate of serum CEA and CA19-9 was 31.1% and 39. 5% respectively. The total positive rate of gastric cancer was 53. 5%( CEA and/or CA19-9 ). Conclusion Positive correlation between serum levels of CEA or CA19-9 and the clinicopathological staging of gastric cancer was observed. The combined detection of CEA and CA19-9 can significantly improve the sensitivity of diagnosis of gastric cancer, which also has a certain value in monitoring patient's condition and prognosis.%目的探讨术前血清癌胚抗原(CEA)、糖链抗原19-9(CA19-9)表达水平的变化对胃癌诊断和预后的价值.方法采用全自动化学发光免疫分析法,测定不同分期胃癌患者术前血清CEA和CA19-9含量变化.结果 CEA及CA19-9水平在Ⅳ期胃癌患者均显著高于Ⅰ～Ⅲ期胃癌(P＜0.01).CEA及CA19-9检测的阳性率分别为31.1%和39.5%,而CEA 及CA19-9的阳性率为53.5%.结论血清CEA和CA 19-9水平与胃癌的病理
分期呈正相关,联合检测血清CEA及CA19-9有助于胃癌的临床诊断,对病情的估计及预后的判断具有一定的指导意义.
【总页数】2页(P3693-3694)
【作者】戈军刚;钱雷敏
【作者单位】江阴市人民医院胃肠外科,江苏,江阴,214400;江阴市人民医院胃肠外科,江苏,江阴,214400
【正文语种】中文
【中图分类】R735.2
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